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The map label for this gene is ppcB [H]

Identifier: 15899207

GI number: 15899207

Start: 2233902

End: 2235473

Strand: Reverse

Name: ppcB [H]

Synonym: SSO2463

Alternate gene names: 15899207

Gene position: 2235473-2233902 (Counterclockwise)

Preceding gene: 15899208

Following gene: 15899205

Centisome position: 74.71

GC content: 39.38

Gene sequence:

>1572_bases
ATGGCTCTATATGAAAAGCCTTCAATGGATAAATTAATTGAAGATTTGAAAATATTAAAGGAAAAGGTATATAAGGGTGG
AGGAGAAGAGAAGATAAACTTCCAGCATGGTAAAGGTAAACTAACGGCAAGGGAGAGATTAAATCAGCTGTTCGATGAAG
GAAAGTTCAATGAAATATTGACTTTTGCCACTACTAGAGCAACTGAATTTGGGTTGGATAAGAATAGGTTTTACGGAGAT
GGAGTAATAGCTGGATGGGGAAAAATTGATGGTAGACAAGTTTTCGCCTATGCTCAAGACTTTACGATACTCGGAGGAAG
CCTAGGAGAAACACACGCAAATAAGATAGTTAGAGCTTATGAGCTAGCCCTAAAAGTTGGTGCTCCAGTAATAGGAATAA
ACGATTCTGGTGGAGCAAGAATACAAGAGGGTGCACTATCGCTAGAAGGATATGGTGCAGTGTTCAAGATGAACGTAATG
GCTTCTGGAGTAATTCCACAAATTACCATTATGGCAGGACCGGCAGCTGGAGGTGCAGTCTACTCTCCTGCTCTTACTGA
CTTCTTAATAATGATAAAAGGAGACGCATATTACATGTTTGTAACCGGACCAGAGATTACTAAAGTGTCAATAGGCGAAG
AAGTGAGTTATCAAGACCTAGGTGGTGCAATAATACACGCAACAAAATCTGGAGTAGTTCACTTTGTGGCTGAAAATGAA
CAAGATGCAATAAACATAACTAAGAGGTTATTGTCTTACTTGCCTTCAAACAATATGGAAGAACCTCCATATGTTGATAC
CGGTGATCCTGCTGATAGGGCAGTGCAGAGTGCTGAATCGATTGTACCTACAGACTCAGTAAAACCATTTGATATAAGGG
ACTTAATATACAATATAGTTGACAATAGCGAATTCCTGGAAGTTCACAAATTGTGGGCGCAAAATATTACTGTGGGATTT
GGAAGGATAAATGGGAACGTTGTGGGAATTGTCGCAAATAATTCAGCATATTATGGAGGAGCAATAGATATTGACGCTGC
GGATAAGGCTGCTAGATTTATCAGATTCTGCGATGCGTTCAATATACCGGTAATAAGCTTAGTTGACACTCCAGGATATG
TTCCAGGGACGGACCAAGAGTATAAAGGGATAATAAGGCATGGTGCTAAAATGTTATACGCATTCGCTGAGGCCACAGTA
CCAAAAATTACGGTTATTGTAAGAAGGTCTTATGGTGGTGCTCATATTGCAATGAGCATTAAAAGTTTAGGTGCTGATTT
AGTTTATGCTTGGCCTTCTGCGGAGATAGCTGTAACTGGTCCAGAAGGTGCAGTTAGAATATTATATAGAAGGGAAATAC
AAAGTGCTCAAAATCCAGAGGAACTCTTGAAACAAAAAATTACAGAATACAAGAAATTGTTCGCTAATCCTTATTGGGCA
GCTGAGAAAGGTTTAATAGATGACGTCATTGAGCCTAAGGACACCAGAAATGTAATAGCTAGAGGATTAGAAATGTTAAG
AAATAAGAGGGAATTCAGATACCCCAAGAAACATGGCAACATACCTCTCTGA

Upstream 100 bases:

>100_bases
TGGGATCGTGCAAAAAATTCTGATCAAGGAAGGACAAGGTGTAAAGAAGGGAGATATTTTAATTGTTATAAAATAGTTTT
ACAGTTATGAGGTGAGATAA

Downstream 100 bases:

>100_bases
TCAAATCTTTTTTCTACAAATCAACTCTTCACAATTGTTAAGTTGTACCTCTTGACCCAAGGCTAAAAGGATTAGCCTAA
GCCTTTTTAATGTATTACAC

Product: propionyl-CoA carboxylase beta subunit (ppcB)

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MALYEKPSMDKLIEDLKILKEKVYKGGGEEKINFQHGKGKLTARERLNQLFDEGKFNEILTFATTRATEFGLDKNRFYGD
GVIAGWGKIDGRQVFAYAQDFTILGGSLGETHANKIVRAYELALKVGAPVIGINDSGGARIQEGALSLEGYGAVFKMNVM
ASGVIPQITIMAGPAAGGAVYSPALTDFLIMIKGDAYYMFVTGPEITKVSIGEEVSYQDLGGAIIHATKSGVVHFVAENE
QDAINITKRLLSYLPSNNMEEPPYVDTGDPADRAVQSAESIVPTDSVKPFDIRDLIYNIVDNSEFLEVHKLWAQNITVGF
GRINGNVVGIVANNSAYYGGAIDIDAADKAARFIRFCDAFNIPVISLVDTPGYVPGTDQEYKGIIRHGAKMLYAFAEATV
PKITVIVRRSYGGAHIAMSIKSLGADLVYAWPSAEIAVTGPEGAVRILYRREIQSAQNPEELLKQKITEYKKLFANPYWA
AEKGLIDDVIEPKDTRNVIARGLEMLRNKREFRYPKKHGNIPL

Sequences:

>Translated_523_residues
MALYEKPSMDKLIEDLKILKEKVYKGGGEEKINFQHGKGKLTARERLNQLFDEGKFNEILTFATTRATEFGLDKNRFYGD
GVIAGWGKIDGRQVFAYAQDFTILGGSLGETHANKIVRAYELALKVGAPVIGINDSGGARIQEGALSLEGYGAVFKMNVM
ASGVIPQITIMAGPAAGGAVYSPALTDFLIMIKGDAYYMFVTGPEITKVSIGEEVSYQDLGGAIIHATKSGVVHFVAENE
QDAINITKRLLSYLPSNNMEEPPYVDTGDPADRAVQSAESIVPTDSVKPFDIRDLIYNIVDNSEFLEVHKLWAQNITVGF
GRINGNVVGIVANNSAYYGGAIDIDAADKAARFIRFCDAFNIPVISLVDTPGYVPGTDQEYKGIIRHGAKMLYAFAEATV
PKITVIVRRSYGGAHIAMSIKSLGADLVYAWPSAEIAVTGPEGAVRILYRREIQSAQNPEELLKQKITEYKKLFANPYWA
AEKGLIDDVIEPKDTRNVIARGLEMLRNKREFRYPKKHGNIPL
>Mature_522_residues
ALYEKPSMDKLIEDLKILKEKVYKGGGEEKINFQHGKGKLTARERLNQLFDEGKFNEILTFATTRATEFGLDKNRFYGDG
VIAGWGKIDGRQVFAYAQDFTILGGSLGETHANKIVRAYELALKVGAPVIGINDSGGARIQEGALSLEGYGAVFKMNVMA
SGVIPQITIMAGPAAGGAVYSPALTDFLIMIKGDAYYMFVTGPEITKVSIGEEVSYQDLGGAIIHATKSGVVHFVAENEQ
DAINITKRLLSYLPSNNMEEPPYVDTGDPADRAVQSAESIVPTDSVKPFDIRDLIYNIVDNSEFLEVHKLWAQNITVGFG
RINGNVVGIVANNSAYYGGAIDIDAADKAARFIRFCDAFNIPVISLVDTPGYVPGTDQEYKGIIRHGAKMLYAFAEATVP
KITVIVRRSYGGAHIAMSIKSLGADLVYAWPSAEIAVTGPEGAVRILYRREIQSAQNPEELLKQKITEYKKLFANPYWAA
EKGLIDDVIEPKDTRNVIARGLEMLRNKREFRYPKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=502, Percent_Identity=51.394422310757, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI295821216, Length=522, Percent_Identity=49.4252873563218, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI11545863, Length=516, Percent_Identity=33.1395348837209, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI38679971, Length=432, Percent_Identity=23.8425925925926, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI38679960, Length=432, Percent_Identity=23.8425925925926, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI38679977, Length=432, Percent_Identity=23.8425925925926, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI38679967, Length=432, Percent_Identity=23.8425925925926, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI38679974, Length=432, Percent_Identity=23.8425925925926, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI134142062, Length=394, Percent_Identity=23.8578680203046, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788655, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25147362, Length=513, Percent_Identity=50.2923976608187, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI25147359, Length=513, Percent_Identity=50.2923976608187, Blast_Score=541, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17552936, Length=521, Percent_Identity=32.4376199616123, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71997163, Length=432, Percent_Identity=23.3796296296296, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324343, Length=348, Percent_Identity=24.7126436781609, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323863, Length=348, Percent_Identity=24.1379310344828, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24586065, Length=544, Percent_Identity=31.8014705882353, Blast_Score=252, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 57362; Mature: 57231

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYEKPSMDKLIEDLKILKEKVYKGGGEEKINFQHGKGKLTARERLNQLFDEGKFNEIL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEE
TFATTRATEFGLDKNRFYGDGVIAGWGKIDGRQVFAYAQDFTILGGSLGETHANKIVRAY
EEEEHHHHHCCCCCCCEECCCEEEECCCCCCCEEEEEECCEEEECCCCCCHHHHHHHHHH
ELALKVGAPVIGINDSGGARIQEGALSLEGYGAVFKMNVMASGVIPQITIMAGPAAGGAV
HHHHHHCCCEEEECCCCCCEEECCCEEECCCCEEEEEEEHHCCCCCEEEEEECCCCCCCE
YSPALTDFLIMIKGDAYYMFVTGPEITKVSIGEEVSYQDLGGAIIHATKSGVVHFVAENE
ECHHHHEEEEEEECCEEEEEEECCCEEEEECCCCCCHHHCCCEEEEEECCCEEEEEECCC
QDAINITKRLLSYLPSNNMEEPPYVDTGDPADRAVQSAESIVPTDSVKPFDIRDLIYNIV
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
DNSEFLEVHKLWAQNITVGFGRINGNVVGIVANNSAYYGGAIDIDAADKAARFIRFCDAF
CCCHHHHHHHHHHCCEEEEEEEECCEEEEEEECCCEEECCEEEECCHHHHHHHHHHHHCC
NIPVISLVDTPGYVPGTDQEYKGIIRHGAKMLYAFAEATVPKITVIVRRSYGGAHIAMSI
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEH
KSLGADLVYAWPSAEIAVTGPEGAVRILYRREIQSAQNPEELLKQKITEYKKLFANPYWA
HHCCCCEEEECCCCCEEEECCCCCEEHEEHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
AEKGLIDDVIEPKDTRNVIARGLEMLRNKREFRYPKKHGNIPL
CCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ALYEKPSMDKLIEDLKILKEKVYKGGGEEKINFQHGKGKLTARERLNQLFDEGKFNEIL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEE
TFATTRATEFGLDKNRFYGDGVIAGWGKIDGRQVFAYAQDFTILGGSLGETHANKIVRAY
EEEEHHHHHCCCCCCCEECCCEEEECCCCCCCEEEEEECCEEEECCCCCCHHHHHHHHHH
ELALKVGAPVIGINDSGGARIQEGALSLEGYGAVFKMNVMASGVIPQITIMAGPAAGGAV
HHHHHHCCCEEEECCCCCCEEECCCEEECCCCEEEEEEEHHCCCCCEEEEEECCCCCCCE
YSPALTDFLIMIKGDAYYMFVTGPEITKVSIGEEVSYQDLGGAIIHATKSGVVHFVAENE
ECHHHHEEEEEEECCEEEEEEECCCEEEEECCCCCCHHHCCCEEEEEECCCEEEEEECCC
QDAINITKRLLSYLPSNNMEEPPYVDTGDPADRAVQSAESIVPTDSVKPFDIRDLIYNIV
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
DNSEFLEVHKLWAQNITVGFGRINGNVVGIVANNSAYYGGAIDIDAADKAARFIRFCDAF
CCCHHHHHHHHHHCCEEEEEEEECCEEEEEEECCCEEECCEEEECCHHHHHHHHHHHHCC
NIPVISLVDTPGYVPGTDQEYKGIIRHGAKMLYAFAEATVPKITVIVRRSYGGAHIAMSI
CCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEEEH
KSLGADLVYAWPSAEIAVTGPEGAVRILYRREIQSAQNPEELLKQKITEYKKLFANPYWA
HHCCCCEEEECCCCCEEEECCCCCEEHEEHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
AEKGLIDDVIEPKDTRNVIARGLEMLRNKREFRYPKKHGNIPL
CCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]