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The map label for this gene is rtcA [H]

Identifier: 15899191

GI number: 15899191

Start: 2218528

End: 2219565

Strand: Reverse

Name: rtcA [H]

Synonym: SSO2446

Alternate gene names: 15899191

Gene position: 2219565-2218528 (Counterclockwise)

Preceding gene: 15899193

Following gene: 15899190

Centisome position: 74.18

GC content: 38.34

Gene sequence:

>1038_bases
TTGATCTTCAAGATAATTCACCTAATGATTGAAATAGATGGTTCATTTGGCGAAGGTGGAGGACAAATTCTGAGAACGTC
TCTAACGCTCTCTGTCATAACCGGTAAACCCTTTAGAATATTTAATATAAGGGCTAATAGACCTAATCCTGGATTACAGA
GGCAACATCTGTGGGCAGTAAGGGCGATGAAAATGATATCGAATGCGGAAACTAAAGGAGATGAAGTAGGATCTAAAGAA
CTAACATTTATCCCCCATGAAATCAAGGGAAATTCTATTATAGACATAGACATTGGAACAGCGGGCAGTGTAACTCTAAT
AATGCAAACTATGATACCAGCCATAATTAACAAGAATATGAGAATTAAAATAAAAGGTGGTACTGACGTTCCAAAATCCC
CCACCATAGATTACATTAGACTAGTGTATCTGGAAATCTTAAGGAAAATAGGGATTGAGTCGAAGGTAAATTTGATAAAA
AGAGGTCACTATCCAGAAGGTGGAGGAGAGGTGATAATTGAAAATGTAAATGGAAACCCATCCGACTTTAGTTTACTAGA
GCTAGGTAAATTGATAATGATCAAGGGAATTTCACATGTCTCATCCTTACCTTCACATATTGCCGAAAGACAAAAGGACT
CAGCAAAAGCGATCCTTTCTAAACTTGGGGTGCAGATAGAAATAGAAACTGACGTAAGACAAGGTGAAGTAAGTAAAGGT
AGCGGTATTGCATTGGCAGCCATAGGGGAGAAGAGTATTATAGGCGCTGATTCGCTGGGTGAAAGAGGTAAAAGAGCTGA
GATAGTTGGAGAAGAGGCTGCAAGGAAACTTATCGACAATCTCAATACCAAAGCTGCTGTGGATGTGCATATGAGCGATA
TGCTCATGATATTCACATCGCTCTTTGGTGGGGAGTACATCGGTGCTGAACTAACGTCCCACGCATATACGAATATGGAA
ATAATAAGAAAGTTTTTAGATGTTAAAATTGAGATTAGCGGTAAGAGACCATTTAGATTTAAAGCTAAAATCTTTTAA

Upstream 100 bases:

>100_bases
GTCTTCATAAAAATTTAGGCACTCCACATAATACTCGTTCTCTGCTAGAGGAATTACCGCTAGCTCCTCTTCTCCAATAA
CTCTTACAAGAGACTTTAAT

Downstream 100 bases:

>100_bases
AGGAACTACGTTACTTGATTATGGGGGGACTCCTATGGAGTTCCCTAAAGCTGTAATAAAAAGACCTAATTATCATTTCG
AATACCCGCACAAGAGAAAA

Product: RNA 3'-terminal-phosphate cyclase

Products: NA

Alternate protein names: RNA cyclase; RNA-3'-phosphate cyclase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MIFKIIHLMIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAVRAMKMISNAETKGDEVGSKE
LTFIPHEIKGNSIIDIDIGTAGSVTLIMQTMIPAIINKNMRIKIKGGTDVPKSPTIDYIRLVYLEILRKIGIESKVNLIK
RGHYPEGGGEVIIENVNGNPSDFSLLELGKLIMIKGISHVSSLPSHIAERQKDSAKAILSKLGVQIEIETDVRQGEVSKG
SGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARKLIDNLNTKAAVDVHMSDMLMIFTSLFGGEYIGAELTSHAYTNME
IIRKFLDVKIEISGKRPFRFKAKIF

Sequences:

>Translated_345_residues
MIFKIIHLMIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAVRAMKMISNAETKGDEVGSKE
LTFIPHEIKGNSIIDIDIGTAGSVTLIMQTMIPAIINKNMRIKIKGGTDVPKSPTIDYIRLVYLEILRKIGIESKVNLIK
RGHYPEGGGEVIIENVNGNPSDFSLLELGKLIMIKGISHVSSLPSHIAERQKDSAKAILSKLGVQIEIETDVRQGEVSKG
SGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARKLIDNLNTKAAVDVHMSDMLMIFTSLFGGEYIGAELTSHAYTNME
IIRKFLDVKIEISGKRPFRFKAKIF
>Mature_345_residues
MIFKIIHLMIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAVRAMKMISNAETKGDEVGSKE
LTFIPHEIKGNSIIDIDIGTAGSVTLIMQTMIPAIINKNMRIKIKGGTDVPKSPTIDYIRLVYLEILRKIGIESKVNLIK
RGHYPEGGGEVIIENVNGNPSDFSLLELGKLIMIKGISHVSSLPSHIAERQKDSAKAILSKLGVQIEIETDVRQGEVSKG
SGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARKLIDNLNTKAAVDVHMSDMLMIFTSLFGGEYIGAELTSHAYTNME
IIRKFLDVKIEISGKRPFRFKAKIF

Specific function: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A;

COG id: COG0430

COG function: function code A; RNA 3'-terminal phosphate cyclase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4506589, Length=306, Percent_Identity=36.9281045751634, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI195927044, Length=319, Percent_Identity=35.423197492163, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI157426877, Length=303, Percent_Identity=25.4125412541254, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI48994937, Length=333, Percent_Identity=36.3363363363363, Blast_Score=197, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32564710, Length=332, Percent_Identity=22.8915662650602, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324564, Length=299, Percent_Identity=25.4180602006689, Blast_Score=86, Evalue=7e-18,
Organism=Drosophila melanogaster, GI18543269, Length=338, Percent_Identity=32.2485207100592, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI18860065, Length=336, Percent_Identity=21.7261904761905, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000228
- InterPro:   IPR020719
- InterPro:   IPR013796
- InterPro:   IPR020723
- InterPro:   IPR017770
- InterPro:   IPR013792 [H]

Pfam domain/function: PF01137 RTC; PF05189 RTC_insert [H]

EC number: =6.5.1.4 [H]

Molecular weight: Translated: 37842; Mature: 37842

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS01287 RTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFKIIHLMIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAV
CHHEEEEEEEEECCCCCCCCCCEEEEEEEEEEEECCCEEEEEEECCCCCCCCCHHHHHHH
RAMKMISNAETKGDEVGSKELTFIPHEIKGNSIIDIDIGTAGSVTLIMQTMIPAIINKNM
HHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCC
RIKIKGGTDVPKSPTIDYIRLVYLEILRKIGIESKVNLIKRGHYPEGGGEVIIENVNGNP
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEECCCCCC
SDFSLLELGKLIMIKGISHVSSLPSHIAERQKDSAKAILSKLGVQIEIETDVRQGEVSKG
CCCHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
SGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARKLIDNLNTKAAVDVHMSDMLMIFTS
CCEEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHH
LFGGEYIGAELTSHAYTNMEIIRKFLDVKIEISGKRPFRFKAKIF
HHCCCCCCHHHHHHHHCCHHHHHHHHCEEEEECCCCCEEEEEECC
>Mature Secondary Structure
MIFKIIHLMIEIDGSFGEGGGQILRTSLTLSVITGKPFRIFNIRANRPNPGLQRQHLWAV
CHHEEEEEEEEECCCCCCCCCCEEEEEEEEEEEECCCEEEEEEECCCCCCCCCHHHHHHH
RAMKMISNAETKGDEVGSKELTFIPHEIKGNSIIDIDIGTAGSVTLIMQTMIPAIINKNM
HHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCC
RIKIKGGTDVPKSPTIDYIRLVYLEILRKIGIESKVNLIKRGHYPEGGGEVIIENVNGNP
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEECCCCCC
SDFSLLELGKLIMIKGISHVSSLPSHIAERQKDSAKAILSKLGVQIEIETDVRQGEVSKG
CCCHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCC
SGIALAAIGEKSIIGADSLGERGKRAEIVGEEAARKLIDNLNTKAAVDVHMSDMLMIFTS
CCEEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHH
LFGGEYIGAELTSHAYTNMEIIRKFLDVKIEISGKRPFRFKAKIF
HHCCCCCCHHHHHHHHCCHHHHHHHHCEEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA