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The map label for this gene is mtaP [C]

Identifier: 15899099

GI number: 15899099

Start: 2139054

End: 2139866

Strand: Direct

Name: mtaP [C]

Synonym: SSO2343

Alternate gene names: 15899099

Gene position: 2139054-2139866 (Clockwise)

Preceding gene: 15899097

Following gene: 15899100

Centisome position: 71.49

GC content: 38.75

Gene sequence:

>813_bases
ATGATTGAGCAAAATGAAAAAGCCTCGATTGGGATTATTGGCGGATCTGGACTATACGATCCGGGTATCTTTTCGGAGAG
TAAGGAGATAAAGGTGTATACACCTTATGGGCAACCGAGTGATTTTATAACTATAGGTAAAATAGGGAATAAATCTGTAG
CCTTTTTACCTAGACACGGAAGGGGACATAGAATTCCTCCTCATAAAATAAACTATAGGGCCAATATTTGGGCATTAAAA
GAACTTGGTGTTAGGTGGGTGATTTCAGTTTCTGCAGTAGGTAGTTTAAGAATGGATTATAAACTTGGAGATTTTGTTAT
ACCAGATCAATTTATAGATATGACTAAGAATAGAGAATACAGCTTCTTTGATGGTCCTGTAGTAGCTCATGTCTCAATGG
CTGATCCATTTTGTAATAGCTTAAGGAAATTGGCAATAGAGACCGCAAAAGAATTAAACATAAAGACGCATGAAAGTGGT
ACCTATATATGTATTGAGGGTCCTAGGTTTTCTACAAGGGCTGAGAGTAGAACGTGGAGAGAAGTTTATAAGGCTGATAT
AATTGGTATGACGCTAGTCCCAGAGGTTAATCTTGCGTGTGAGGCACAAATGTGTTATGCCACTATTGCTATGGTAACTG
ATTACGATGTTTTCGCTGAGATCCCTGTGACAGCAGAGGAGGTTACTAGAGTTATGGCAGAGAATACGGAAAAAGCTAAG
AAACTTTTATATGCGTTAATTCAAAAACTACCGGAAAAACCAGAAGAGGGGTCGTGTTCCTGTTGCAACAGTCTGAAGAC
AGCACTAGTATAA

Upstream 100 bases:

>100_bases
CTGGTATTTTTTGCAAAATTAACTCCCCAAAAAATCTCTGTTAAAACTTTATCAATTTTTTGGTTTATACTTTATAAGGT
ATGTTAGTGTATTTCATCTT

Downstream 100 bases:

>100_bases
AGAAATTAGTGAGGTTTTTTAACATTAATTTTCCTCAAATGGATTTAATAGTATACGGTCGTGGTTTGGAGCTTCCTGCA
TTTACTCTTGGAAGAGCTCT

Product: 5'-methylthioadenosine phosphorylase II

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MIEQNEKASIGIIGGSGLYDPGIFSESKEIKVYTPYGQPSDFITIGKIGNKSVAFLPRHGRGHRIPPHKINYRANIWALK
ELGVRWVISVSAVGSLRMDYKLGDFVIPDQFIDMTKNREYSFFDGPVVAHVSMADPFCNSLRKLAIETAKELNIKTHESG
TYICIEGPRFSTRAESRTWREVYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAK
KLLYALIQKLPEKPEEGSCSCCNSLKTALV

Sequences:

>Translated_270_residues
MIEQNEKASIGIIGGSGLYDPGIFSESKEIKVYTPYGQPSDFITIGKIGNKSVAFLPRHGRGHRIPPHKINYRANIWALK
ELGVRWVISVSAVGSLRMDYKLGDFVIPDQFIDMTKNREYSFFDGPVVAHVSMADPFCNSLRKLAIETAKELNIKTHESG
TYICIEGPRFSTRAESRTWREVYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAK
KLLYALIQKLPEKPEEGSCSCCNSLKTALV
>Mature_270_residues
MIEQNEKASIGIIGGSGLYDPGIFSESKEIKVYTPYGQPSDFITIGKIGNKSVAFLPRHGRGHRIPPHKINYRANIWALK
ELGVRWVISVSAVGSLRMDYKLGDFVIPDQFIDMTKNREYSFFDGPVVAHVSMADPFCNSLRKLAIETAKELNIKTHESG
TYICIEGPRFSTRAESRTWREVYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAK
KLLYALIQKLPEKPEEGSCSCCNSLKTALV

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=248, Percent_Identity=51.6129032258064, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71980569, Length=247, Percent_Identity=42.5101214574899, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17541190, Length=276, Percent_Identity=25.3623188405797, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323045, Length=265, Percent_Identity=36.9811320754717, Blast_Score=154, Evalue=1e-38,
Organism=Drosophila melanogaster, GI20130079, Length=273, Percent_Identity=41.3919413919414, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI221459247, Length=248, Percent_Identity=38.7096774193548, Blast_Score=177, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 30141; Mature: 30141

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEQNEKASIGIIGGSGLYDPGIFSESKEIKVYTPYGQPSDFITIGKIGNKSVAFLPRHG
CCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCEEEEEECCC
RGHRIPPHKINYRANIWALKELGVRWVISVSAVGSLRMDYKLGDFVIPDQFIDMTKNREY
CCCCCCCCEECEEEEEEEHHHCCEEEEEEEECCCCEEEEEECCCEECCHHHHHHHCCCCC
SFFDGPVVAHVSMADPFCNSLRKLAIETAKELNIKTHESGTYICIEGPRFSTRAESRTWR
EEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCCCHHHHHHH
EVYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAK
HHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHCCHHHHH
KLLYALIQKLPEKPEEGSCSCCNSLKTALV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MIEQNEKASIGIIGGSGLYDPGIFSESKEIKVYTPYGQPSDFITIGKIGNKSVAFLPRHG
CCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCEEEEEECCC
RGHRIPPHKINYRANIWALKELGVRWVISVSAVGSLRMDYKLGDFVIPDQFIDMTKNREY
CCCCCCCCEECEEEEEEEHHHCCEEEEEEEECCCCEEEEEECCCEECCHHHHHHHCCCCC
SFFDGPVVAHVSMADPFCNSLRKLAIETAKELNIKTHESGTYICIEGPRFSTRAESRTWR
EEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCEEEEECCCCCCCHHHHHHH
EVYKADIIGMTLVPEVNLACEAQMCYATIAMVTDYDVFAEIPVTAEEVTRVMAENTEKAK
HHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHCCHHHHH
KLLYALIQKLPEKPEEGSCSCCNSLKTALV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]