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The map label for this gene is ribD [C]

Identifier: 15898882

GI number: 15898882

Start: 1918567

End: 1919208

Strand: Direct

Name: ribD [C]

Synonym: SSO2097

Alternate gene names: 15898882

Gene position: 1918567-1919208 (Clockwise)

Preceding gene: 15898880

Following gene: 15898883

Centisome position: 64.12

GC content: 35.67

Gene sequence:

>642_bases
ATGGTTATGAAACCCTATGTAATAATATTTAGCACAGTATCGATAGATGGTAGACTCGCAACGAAAACTGGTTATAGCGA
ATTGAGTTGCCCTTATGATAAGCAAAGACAACATGAGATAAGAAGTGAGGTTGATGCAGTAATGGTGGGAGCTAATACGG
TAAGAGTAGACAACCCATCATTAACTGTAAAGTATGGTAAAAATAGGAGAAACCCCATTAGAGTAGTGGTGACTAGAAGT
TTCAATCTAGACCCTTCATACAAGATATTCACCACACCACCATCAACAGTAATCTATACTTCTAATTACGAAAGTGAAAA
AGTTGAGGAGTTTATTAGAAAAGGAGTTATCGTTAGGAAATTCCTTCATTTAGATGATCTTTTAGAGGACTTATACGACA
ACTTCAACGTTAGAAGACTAATGGTTGAAGGAGGTGGACATTTAATATGGTGGTTTATAAAAGACAATCTTTATGACGAA
ATTAGGATAACAATTTCTCCTAGAATTTTTGGAAATGGAGTCAGTTTTACACAAGGAGAAGGATTTATTGGTGAGGATTC
GCCTAGGCTCGAGTTAATTGATGCCAAAATTTGTGAATGTGGGAACGAAGTCCATCTTACGTACAAGAAATATATGACAT
AA

Upstream 100 bases:

>100_bases
CCCTAATATCAGGGTACATATAGTATGCTTTCATATGATAATGTATAATTTTGAGTATATAGTGTTTTCCACAAAACTCT
TTTACTCCAATTAGATCCTT

Downstream 100 bases:

>100_bases
AAAATATTTAGATCATATTATTAGCGATTATTCGAAACTTTTCTCCAATTCAGTTGCATGTTGGATACTCAATAGAACGT
AAATATTTTTGCGAAAAATA

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase

Products: NA

Alternate protein names: HTP reductase

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MVMKPYVIIFSTVSIDGRLATKTGYSELSCPYDKQRQHEIRSEVDAVMVGANTVRVDNPSLTVKYGKNRRNPIRVVVTRS
FNLDPSYKIFTTPPSTVIYTSNYESEKVEEFIRKGVIVRKFLHLDDLLEDLYDNFNVRRLMVEGGGHLIWWFIKDNLYDE
IRITISPRIFGNGVSFTQGEGFIGEDSPRLELIDAKICECGNEVHLTYKKYMT

Sequences:

>Translated_213_residues
MVMKPYVIIFSTVSIDGRLATKTGYSELSCPYDKQRQHEIRSEVDAVMVGANTVRVDNPSLTVKYGKNRRNPIRVVVTRS
FNLDPSYKIFTTPPSTVIYTSNYESEKVEEFIRKGVIVRKFLHLDDLLEDLYDNFNVRRLMVEGGGHLIWWFIKDNLYDE
IRITISPRIFGNGVSFTQGEGFIGEDSPRLELIDAKICECGNEVHLTYKKYMT
>Mature_213_residues
MVMKPYVIIFSTVSIDGRLATKTGYSELSCPYDKQRQHEIRSEVDAVMVGANTVRVDNPSLTVKYGKNRRNPIRVVVTRS
FNLDPSYKIFTTPPSTVIYTSNYESEKVEEFIRKGVIVRKFLHLDDLLEDLYDNFNVRRLMVEGGGHLIWWFIKDNLYDE
IRITISPRIFGNGVSFTQGEGFIGEDSPRLELIDAKICECGNEVHLTYKKYMT

Specific function: Converts 2,5-Diamino-6-(Ribosylamino)-4(3h)-Pyrimidinone 5'-Phosphate Into 5-Amino-6-(Ribosylamino)-2,4(1h,3h)- Pyrimidinedione 5'-Phosphate. [C]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTP reductase family

Homologues:

Organism=Escherichia coli, GI1786616, Length=182, Percent_Identity=25.8241758241758, Blast_Score=74, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319629, Length=181, Percent_Identity=28.1767955801105, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIB7_SULSO (P95872)

Other databases:

- EMBL:   Y08256
- EMBL:   AE006641
- PIR:   S74011
- RefSeq:   NP_343487.1
- ProteinModelPortal:   P95872
- SMR:   P95872
- GeneID:   1453604
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO2097
- NMPDR:   fig|273057.1.peg.1910
- HOGENOM:   HBG668075
- OMA:   DEIRLIH
- PhylomeDB:   P95872
- ProtClustDB:   PRK05625
- BioCyc:   SSOL273057:SSO2097-MONOMER
- BRENDA:   1.1.1.193
- InterPro:   IPR004794
- InterPro:   IPR006401
- InterPro:   IPR011549
- InterPro:   IPR002734
- PANTHER:   PTHR11079:SF10
- TIGRFAMs:   TIGR01508
- TIGRFAMs:   TIGR00227

Pfam domain/function: PF01872 RibD_C

EC number: =1.1.1.193

Molecular weight: Translated: 24561; Mature: 24561

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMKPYVIIFSTVSIDGRLATKTGYSELSCPYDKQRQHEIRSEVDAVMVGANTVRVDNPS
CCCCCEEEEEEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCEEEECCEEEEECCCE
LTVKYGKNRRNPIRVVVTRSFNLDPSYKIFTTPPSTVIYTSNYESEKVEEFIRKGVIVRK
EEEEECCCCCCCEEEEEEEECCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHCCHHHHH
FLHLDDLLEDLYDNFNVRRLMVEGGGHLIWWFIKDNLYDEIRITISPRIFGNGVSFTQGE
HHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEECCCCEEEEEEECCEEEECCCCEECCC
GFIGEDSPRLELIDAKICECGNEVHLTYKKYMT
CCCCCCCCCEEEEECHHHHCCCEEEEEEEECCC
>Mature Secondary Structure
MVMKPYVIIFSTVSIDGRLATKTGYSELSCPYDKQRQHEIRSEVDAVMVGANTVRVDNPS
CCCCCEEEEEEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCEEEECCEEEEECCCE
LTVKYGKNRRNPIRVVVTRSFNLDPSYKIFTTPPSTVIYTSNYESEKVEEFIRKGVIVRK
EEEEECCCCCCCEEEEEEEECCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHCCHHHHH
FLHLDDLLEDLYDNFNVRRLMVEGGGHLIWWFIKDNLYDEIRITISPRIFGNGVSFTQGE
HHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEECCCCEEEEEEECCEEEECCCCEECCC
GFIGEDSPRLELIDAKICECGNEVHLTYKKYMT
CCCCCCCCCEEEEECHHHHCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726