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The map label for this gene is acsA-5 [H]

Identifier: 15898832

GI number: 15898832

Start: 1856348

End: 1857844

Strand: Direct

Name: acsA-5 [H]

Synonym: SSO2041

Alternate gene names: 15898832

Gene position: 1856348-1857844 (Clockwise)

Preceding gene: 15898831

Following gene: 15898834

Centisome position: 62.04

GC content: 36.74

Gene sequence:

>1497_bases
ATGGCTAGTTATGAAGAAGTTAGGAGAAGTTTTTCGTGGAGTGAGGTAATTAGATATTTAGACGAGAACCCATTAGACGT
TTTGACTTCTCATGACGGTATAGCAGTTAAGAGATTCACTAAGAACGCTATGGAGGAGATAAGCTTCTCAGATCTTAAAA
GAAAGGCATTAAGACTTGCCTTATATCTCAAGGAGTTTCATAACATTAAAAAGGGTGATGTAATAGCAATATTAGCTTCA
AAGAAGATTCAACAAATCATAGTATTTTTAGCAACTCTCTCCCTAGGAGCAATTTATCAACCATTATTTACTGCATTTGG
GCCAGAGGCAATTAAGATGAGGACTAGAGATGTAAAACCAAAAATTATCTTTTGTCAAGATGACCAAAAGGATAAGATAA
ATGATGCAATACTCTTCTCCAAGTTTGATGAATTATTAAGTTACGGTGAATTGAAAGAGATTGAAAAGATAAATTGGGAT
GATGCAATAATTTTACTTTACACTTCTGGTACTACGGGAACACCTAAAGGGGCCCTAATCGCTAAGAGGCTATTTCTTAA
CATTTATGTCTACATGAAATATGGTATAGGTGTTAGGGAAAATGACGTGTTTTGGAACCCCGCAGATCCTGGATGGGCTT
ATGGGCTATATTATGGTATAATAGGACCGCTAATGTTTGGGAAAACTATAATCTTTCTTGACGAACCATTTAACCCAGAA
AGGACAATGGAGTTCATGGAGGAAAATAAGGTTACTAATTTTGCTTTCGCACCTACGGCATATAGAATGATAGCTGGAAC
GGTTAAGAAGAAGTATGATTTAGTATTGGAAAGAGCGAGTTCTGCAGGTGAACCACTTAACCCAGAAGTTATAAGATGGT
TTATGGATAAGTACAATGTTACTATCAAGGATCATTATGGACAAACTGAAGTTGGAATGGTAGTTTATAATGGCTGGGGA
TATGACGCAAAAGTAAAAATAGGGAGTATGGGACTACCTGCACCTGGTTATGAGGTCGATATAATAGAGGATATTATAGC
TGTCAAGAGAGATTCTCCAGGTTTCCACTTCTTGGGATATCTAAACAATCCAGAGAAGACCAAGGAATCATTTCGAGGCG
ATTGGTACTTGACTGGTGATAATGCGTATAAAGATGAGGAAGGATATTTATGGTTTGTTGGAAGGAAGGACGATGTGGTT
AAGGTATCTGGTTACAGGATAGGTCCATTTGAAGTTGAGAGCGTACTTCTAGAATTTCCCGCAGTACTAGAATCTGCTGT
TGTTGCCGATGAAGATCCAATACGAGGACATGTATTACATGCTTATATTGTACTCAAAAGTGGATATACTCCAAGTGAGG
AACTAAAGAAGGAGATTATTGATTTTGTAAATACTAAATATTCTAGGCACGTACATCTAGAAAGGGTTGACTTTGTTGAT
AAATTGCCAAAGACTGAGAGTGGTAAAATACAAAGATATCTACTTAGAAAGAAATAA

Upstream 100 bases:

>100_bases
CATGTAGTCAAGAATGGAAAATTAACGGTGGAGAATAAGTCAATTAAGGGTTAGTTTTTCTTTTTATAAACCTTTTAAGT
TTTAAATGTATAATTAACTT

Downstream 100 bases:

>100_bases
AAAATTAAGGTTCCATTTTCACTTCTCTTTTTCTCTCCAATCCCAAATATATTGCTATACTCAAAAATAATCCAAGATAC
CAACCATAGTCATATAGCAA

Product: Acetyl-CoA synthetase (acetate-CoA ligase) (acsA-5)

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MASYEEVRRSFSWSEVIRYLDENPLDVLTSHDGIAVKRFTKNAMEEISFSDLKRKALRLALYLKEFHNIKKGDVIAILAS
KKIQQIIVFLATLSLGAIYQPLFTAFGPEAIKMRTRDVKPKIIFCQDDQKDKINDAILFSKFDELLSYGELKEIEKINWD
DAIILLYTSGTTGTPKGALIAKRLFLNIYVYMKYGIGVRENDVFWNPADPGWAYGLYYGIIGPLMFGKTIIFLDEPFNPE
RTMEFMEENKVTNFAFAPTAYRMIAGTVKKKYDLVLERASSAGEPLNPEVIRWFMDKYNVTIKDHYGQTEVGMVVYNGWG
YDAKVKIGSMGLPAPGYEVDIIEDIIAVKRDSPGFHFLGYLNNPEKTKESFRGDWYLTGDNAYKDEEGYLWFVGRKDDVV
KVSGYRIGPFEVESVLLEFPAVLESAVVADEDPIRGHVLHAYIVLKSGYTPSEELKKEIIDFVNTKYSRHVHLERVDFVD
KLPKTESGKIQRYLLRKK

Sequences:

>Translated_498_residues
MASYEEVRRSFSWSEVIRYLDENPLDVLTSHDGIAVKRFTKNAMEEISFSDLKRKALRLALYLKEFHNIKKGDVIAILAS
KKIQQIIVFLATLSLGAIYQPLFTAFGPEAIKMRTRDVKPKIIFCQDDQKDKINDAILFSKFDELLSYGELKEIEKINWD
DAIILLYTSGTTGTPKGALIAKRLFLNIYVYMKYGIGVRENDVFWNPADPGWAYGLYYGIIGPLMFGKTIIFLDEPFNPE
RTMEFMEENKVTNFAFAPTAYRMIAGTVKKKYDLVLERASSAGEPLNPEVIRWFMDKYNVTIKDHYGQTEVGMVVYNGWG
YDAKVKIGSMGLPAPGYEVDIIEDIIAVKRDSPGFHFLGYLNNPEKTKESFRGDWYLTGDNAYKDEEGYLWFVGRKDDVV
KVSGYRIGPFEVESVLLEFPAVLESAVVADEDPIRGHVLHAYIVLKSGYTPSEELKKEIIDFVNTKYSRHVHLERVDFVD
KLPKTESGKIQRYLLRKK
>Mature_497_residues
ASYEEVRRSFSWSEVIRYLDENPLDVLTSHDGIAVKRFTKNAMEEISFSDLKRKALRLALYLKEFHNIKKGDVIAILASK
KIQQIIVFLATLSLGAIYQPLFTAFGPEAIKMRTRDVKPKIIFCQDDQKDKINDAILFSKFDELLSYGELKEIEKINWDD
AIILLYTSGTTGTPKGALIAKRLFLNIYVYMKYGIGVRENDVFWNPADPGWAYGLYYGIIGPLMFGKTIIFLDEPFNPER
TMEFMEENKVTNFAFAPTAYRMIAGTVKKKYDLVLERASSAGEPLNPEVIRWFMDKYNVTIKDHYGQTEVGMVVYNGWGY
DAKVKIGSMGLPAPGYEVDIIEDIIAVKRDSPGFHFLGYLNNPEKTKESFRGDWYLTGDNAYKDEEGYLWFVGRKDDVVK
VSGYRIGPFEVESVLLEFPAVLESAVVADEDPIRGHVLHAYIVLKSGYTPSEELKKEIIDFVNTKYSRHVHLERVDFVDK
LPKTESGKIQRYLLRKK

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=490, Percent_Identity=34.0816326530612, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI122937307, Length=489, Percent_Identity=31.6973415132924, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI38505220, Length=489, Percent_Identity=31.6973415132924, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI58082049, Length=490, Percent_Identity=30.6122448979592, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI157311624, Length=490, Percent_Identity=29.7959183673469, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI157311622, Length=490, Percent_Identity=29.7959183673469, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI115511026, Length=491, Percent_Identity=30.3462321792261, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI13375727, Length=519, Percent_Identity=29.4797687861272, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI28416953, Length=516, Percent_Identity=28.4883720930233, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI253970489, Length=411, Percent_Identity=31.1435523114355, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI8923896, Length=403, Percent_Identity=31.5136476426799, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI156151445, Length=387, Percent_Identity=29.9741602067183, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI42544134, Length=349, Percent_Identity=27.2206303724928, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI187761345, Length=514, Percent_Identity=23.5408560311284, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI187761343, Length=514, Percent_Identity=23.5408560311284, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI195947378, Length=414, Percent_Identity=23.1884057971014, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI38524616, Length=415, Percent_Identity=23.1325301204819, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790505, Length=515, Percent_Identity=29.9029126213592, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI145693145, Length=503, Percent_Identity=26.2425447316103, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786529, Length=566, Percent_Identity=25.9717314487633, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788107, Length=514, Percent_Identity=24.7081712062257, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786801, Length=436, Percent_Identity=23.1651376146789, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786810, Length=529, Percent_Identity=23.8185255198488, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI221142682, Length=468, Percent_Identity=23.0769230769231, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1789201, Length=329, Percent_Identity=24.9240121580547, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983001, Length=523, Percent_Identity=26.3862332695985, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71982997, Length=523, Percent_Identity=26.9598470363289, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI32563687, Length=460, Percent_Identity=29.5652173913043, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17558820, Length=474, Percent_Identity=28.4810126582279, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17559526, Length=520, Percent_Identity=26.1538461538462, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17560140, Length=358, Percent_Identity=28.4916201117318, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17557194, Length=487, Percent_Identity=25.6673511293634, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=363, Percent_Identity=26.1707988980716, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71996755, Length=472, Percent_Identity=25.2118644067797, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17531443, Length=502, Percent_Identity=23.1075697211155, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71994690, Length=402, Percent_Identity=26.3681592039801, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994694, Length=402, Percent_Identity=26.3681592039801, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994703, Length=402, Percent_Identity=26.3681592039801, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538037, Length=496, Percent_Identity=24.7983870967742, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17560308, Length=390, Percent_Identity=25.1282051282051, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25141359, Length=358, Percent_Identity=22.3463687150838, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319264, Length=525, Percent_Identity=29.7142857142857, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6323182, Length=526, Percent_Identity=30.0380228136882, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319699, Length=355, Percent_Identity=27.887323943662, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24667955, Length=525, Percent_Identity=28.7619047619048, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI62472339, Length=525, Percent_Identity=28.7619047619048, Blast_Score=195, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24667959, Length=485, Percent_Identity=28.8659793814433, Blast_Score=179, Evalue=5e-45,
Organism=Drosophila melanogaster, GI21355225, Length=522, Percent_Identity=26.4367816091954, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24581924, Length=390, Percent_Identity=28.2051282051282, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19922652, Length=505, Percent_Identity=24.950495049505, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI21356947, Length=486, Percent_Identity=25.7201646090535, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24648260, Length=482, Percent_Identity=27.3858921161826, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653035, Length=485, Percent_Identity=24.3298969072165, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI18859661, Length=504, Percent_Identity=24.8015873015873, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24656500, Length=491, Percent_Identity=24.2362525458248, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI20130357, Length=484, Percent_Identity=26.6528925619835, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI21356441, Length=495, Percent_Identity=25.4545454545455, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21358303, Length=457, Percent_Identity=23.4135667396061, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24648257, Length=488, Percent_Identity=24.7950819672131, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI161076582, Length=494, Percent_Identity=23.6842105263158, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI21355181, Length=495, Percent_Identity=25.4545454545455, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24648253, Length=481, Percent_Identity=25.5717255717256, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24648255, Length=481, Percent_Identity=25.3638253638254, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281365686, Length=429, Percent_Identity=23.3100233100233, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 57092; Mature: 56961

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASYEEVRRSFSWSEVIRYLDENPLDVLTSHDGIAVKRFTKNAMEEISFSDLKRKALRLA
CCCHHHHHHCCCHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHCCHHHHHHHHHHHH
LYLKEFHNIKKGDVIAILASKKIQQIIVFLATLSLGAIYQPLFTAFGPEAIKMRTRDVKP
HHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCC
KIIFCQDDQKDKINDAILFSKFDELLSYGELKEIEKINWDDAIILLYTSGTTGTPKGALI
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEECCCCCCCCHHHH
AKRLFLNIYVYMKYGIGVRENDVFWNPADPGWAYGLYYGIIGPLMFGKTIIFLDEPFNPE
HHHHHHHEEEEEEECCCEECCCEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHH
RTMEFMEENKVTNFAFAPTAYRMIAGTVKKKYDLVLERASSAGEPLNPEVIRWFMDKYNV
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCE
TIKDHYGQTEVGMVVYNGWGYDAKVKIGSMGLPAPGYEVDIIEDIIAVKRDSPGFHFLGY
EEEECCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEE
LNNPEKTKESFRGDWYLTGDNAYKDEEGYLWFVGRKDDVVKVSGYRIGPFEVESVLLEFP
CCCCHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCEEEECCEEECHHHHHHHHHHHH
AVLESAVVADEDPIRGHVLHAYIVLKSGYTPSEELKKEIIDFVNTKYSRHVHLERVDFVD
HHHHHHHCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHCCCHHCEEEEHHHHHHH
KLPKTESGKIQRYLLRKK
HCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
ASYEEVRRSFSWSEVIRYLDENPLDVLTSHDGIAVKRFTKNAMEEISFSDLKRKALRLA
CCHHHHHHCCCHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHCCHHHHHHHHHHHH
LYLKEFHNIKKGDVIAILASKKIQQIIVFLATLSLGAIYQPLFTAFGPEAIKMRTRDVKP
HHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCC
KIIFCQDDQKDKINDAILFSKFDELLSYGELKEIEKINWDDAIILLYTSGTTGTPKGALI
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEEECCCCCCCCHHHH
AKRLFLNIYVYMKYGIGVRENDVFWNPADPGWAYGLYYGIIGPLMFGKTIIFLDEPFNPE
HHHHHHHEEEEEEECCCEECCCEEECCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHH
RTMEFMEENKVTNFAFAPTAYRMIAGTVKKKYDLVLERASSAGEPLNPEVIRWFMDKYNV
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCE
TIKDHYGQTEVGMVVYNGWGYDAKVKIGSMGLPAPGYEVDIIEDIIAVKRDSPGFHFLGY
EEEECCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEE
LNNPEKTKESFRGDWYLTGDNAYKDEEGYLWFVGRKDDVVKVSGYRIGPFEVESVLLEFP
CCCCHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCCEEEECCEEECHHHHHHHHHHHH
AVLESAVVADEDPIRGHVLHAYIVLKSGYTPSEELKKEIIDFVNTKYSRHVHLERVDFVD
HHHHHHHCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHCCCHHCEEEEHHHHHHH
KLPKTESGKIQRYLLRKK
HCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]