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The map label for this gene is codB [H]

Identifier: 15898482

GI number: 15898482

Start: 1519887

End: 1521248

Strand: Direct

Name: codB [H]

Synonym: SSO1665

Alternate gene names: 15898482

Gene position: 1519887-1521248 (Clockwise)

Preceding gene: 15898481

Following gene: 15898483

Centisome position: 50.79

GC content: 38.33

Gene sequence:

>1362_bases
ATGACTGGAAAGGAGGAAATTAGCTCAAAATACGACGATTATTCACTGAAGGAAGTTCCTAAAGATTCCAGATACGGCTT
CTTTAACGTTTTTCTAGTATTTTCATCTGTATATGGTGCAATAGCTGTAATATGGGCTGGAGGAGCACTAGGTTACGGTC
TCACATTTTCTCAAGCTATAATTGCAGTATTGTCGGGAACAGTAGTATTAGGCATCTTAGGTTCATTGACTGCAGCTGTG
GGAGCTTATAGTGGCCTTTCCACTTATGTTATGTGGAGACATCCTTTAGGAAGATGGGGAGGTAAAATTGCTGGATTGTT
ACTGATAACTATAACCACGGGAATAGGGTGGTATGCAGTAGAAACATGGCTATTTGGTATAGTAATGAGCGAGATATTCC
CAAATAATCCATTCTTTTCAGTTGGGGTAGCTGCGATTTGGGGAGGAATTTTGATGACAATAATGACATATGTAGGGTAT
AGAATGCTGTCTTTCCTAAGTTACTTTACAATTCCATTTCATATATGGCTGATAGCAATAGGAATAGCAATAGTGTTAGC
ACTAAAAGGGGGATTCCACACAGTTATGGCTGCTGTCCCAACAAGCCATATGAGCTTGCTTGACGGTATATCTGCTACCA
TAGGACTATATAGCGCTGGGACTATAATTTCTCCCGATATCTCCAGATTTGCCAAATCAGCTAAGGACGCTGGATATGCG
TGGTTTGCTCACATTATTTTCCTATATCCATTCTTAATATTGGGGGGAGTTGCAATAGTGTTAGCAACTGGTTCCTATTT
AATAACTAACGCAATGTTAGAGTTAGGTATGGGAGTTGGTGTTTTACTAATTATAGTCTTTGGTCAGTTCATAATAAACA
CTGATAATCTATATAGTGGTTCCTTATCTTTAGTTAACCTAATTCCAATGAGGCGTGAAATCGCCTCTGTGATCAACGGT
GTCATAGGTACTGCTATTGCTGCATACGTCGGATTCTCAGCAGGTTCATCCATAACCCCCTTTGAGAACTTTATCTCTTT
ACTAGGAGACTTTCTACCAGCAATGGGAGGAATTGTACTAGCCGACTTCTACATTGTGAAGAAATATGTTAATAAAATCC
AAGATCCTCATAAACGGTATGAATTCGTACCAAATAATAAGTATTACAATATAAATATTGCAGGAATATTAGCTCTAGCA
TTAGGTTCAATAATAGGTTACTTCGTAAATGCAGGTATACCCGCCATAAACTCCTTAGTTACTGGCTTCCTATCCTACAT
AATAATATATTACATTATCAAAGCAATGGGTAAGAGTCCAGAAATATTGCCGTTTAACTATGAAGGGGGGATATTAAGAT
GA

Upstream 100 bases:

>100_bases
AGTTGACAAAATAGTAGCGTTAATAATAGTTATTTTCCTAAAAAACCATTTCTTCTGAACTATCATAATGCTTTTATTTC
ATATTTAAACATTAGAAAAT

Downstream 100 bases:

>100_bases
AATTATCTGATAACTACAGAATATTTACTATATCTAACATTATAGTGGGATTAATCTTTAGTATTCTGTATTTCATTACA
AGTGGATTTATACAATACTA

Product: cytosine permease (codB)

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTGKEEISSKYDDYSLKEVPKDSRYGFFNVFLVFSSVYGAIAVIWAGGALGYGLTFSQAIIAVLSGTVVLGILGSLTAAV
GAYSGLSTYVMWRHPLGRWGGKIAGLLLITITTGIGWYAVETWLFGIVMSEIFPNNPFFSVGVAAIWGGILMTIMTYVGY
RMLSFLSYFTIPFHIWLIAIGIAIVLALKGGFHTVMAAVPTSHMSLLDGISATIGLYSAGTIISPDISRFAKSAKDAGYA
WFAHIIFLYPFLILGGVAIVLATGSYLITNAMLELGMGVGVLLIIVFGQFIINTDNLYSGSLSLVNLIPMRREIASVING
VIGTAIAAYVGFSAGSSITPFENFISLLGDFLPAMGGIVLADFYIVKKYVNKIQDPHKRYEFVPNNKYYNINIAGILALA
LGSIIGYFVNAGIPAINSLVTGFLSYIIIYYIIKAMGKSPEILPFNYEGGILR

Sequences:

>Translated_453_residues
MTGKEEISSKYDDYSLKEVPKDSRYGFFNVFLVFSSVYGAIAVIWAGGALGYGLTFSQAIIAVLSGTVVLGILGSLTAAV
GAYSGLSTYVMWRHPLGRWGGKIAGLLLITITTGIGWYAVETWLFGIVMSEIFPNNPFFSVGVAAIWGGILMTIMTYVGY
RMLSFLSYFTIPFHIWLIAIGIAIVLALKGGFHTVMAAVPTSHMSLLDGISATIGLYSAGTIISPDISRFAKSAKDAGYA
WFAHIIFLYPFLILGGVAIVLATGSYLITNAMLELGMGVGVLLIIVFGQFIINTDNLYSGSLSLVNLIPMRREIASVING
VIGTAIAAYVGFSAGSSITPFENFISLLGDFLPAMGGIVLADFYIVKKYVNKIQDPHKRYEFVPNNKYYNINIAGILALA
LGSIIGYFVNAGIPAINSLVTGFLSYIIIYYIIKAMGKSPEILPFNYEGGILR
>Mature_452_residues
TGKEEISSKYDDYSLKEVPKDSRYGFFNVFLVFSSVYGAIAVIWAGGALGYGLTFSQAIIAVLSGTVVLGILGSLTAAVG
AYSGLSTYVMWRHPLGRWGGKIAGLLLITITTGIGWYAVETWLFGIVMSEIFPNNPFFSVGVAAIWGGILMTIMTYVGYR
MLSFLSYFTIPFHIWLIAIGIAIVLALKGGFHTVMAAVPTSHMSLLDGISATIGLYSAGTIISPDISRFAKSAKDAGYAW
FAHIIFLYPFLILGGVAIVLATGSYLITNAMLELGMGVGVLLIIVFGQFIINTDNLYSGSLSLVNLIPMRREIASVINGV
IGTAIAAYVGFSAGSSITPFENFISLLGDFLPAMGGIVLADFYIVKKYVNKIQDPHKRYEFVPNNKYYNINIAGILALAL
GSIIGYFVNAGIPAINSLVTGFLSYIIIYYIIKAMGKSPEILPFNYEGGILR

Specific function: Required for cytosine transport into the cell [H]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=433, Percent_Identity=26.3279445727483, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248
- InterPro:   IPR012681 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 48817; Mature: 48686

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
>Mature Secondary Structure 
TGKEEISSKYDDYSLKEVPKDSRYGFFNVFLVFSSVYGAIAVIWAGGALGYGLTFSQAI
CCHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHH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HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]