Click here to switch to the map view.

The map label for this gene is glxR [H]

Identifier: 15898379

GI number: 15898379

Start: 1406046

End: 1406915

Strand: Direct

Name: glxR [H]

Synonym: SSO1560

Alternate gene names: 15898379

Gene position: 1406046-1406915 (Clockwise)

Preceding gene: 15898378

Following gene: 15898380

Centisome position: 46.99

GC content: 39.31

Gene sequence:

>870_bases
ATGAAAGTGGGTTTCATTGGCTTAGGAATAATGGGTTTCCCAATGGCAAGTAATCTACTAAAAGCTGGATACGATTTAAC
GGTTTATAATAGAACAATTGAAAAAGCGGAAAAATTAGGAAAAATGGGTGCAAAAGTTGCTCACTCACCAAAAGAAGTTG
CTGAAGTCTCGGAAATTGTCATATCAATGGTAACCGACGCTCCAGATGTCGAGGAGGTGCTATTTGGAGAAAACGGAGTT
GTGAAAAGTAATAAGAGGGGTTTAATTTTCGTTGATATGAGTACGAATTCACCGGAGTTTGCCAAGAAGGTAACTAAAAG
GTTAAGCGAATATGGAATGGAATTCTTGGATGCTCCAGTTACTGGAGGGGATAAGGGGGCTAGAGAGGGAACATTAACCA
TAATGGTGGGAGGAAAGGAAGACGTATTCAAACGAGTCGAACCCATATTTAAGGCAATGGGTAAGAATATAATTCACGTA
GGAGATGTGGGATCTGGGCAGGCGTTAAAACTATGTAACCAGGTCGTTGTAGCATTAAATATGGTATCAGTAGTGGAGGG
TCTATTGTTGGCTAGATCATTGGGGATAGATGATGATAAATTATTTTCTGTACTTTCTACCGGAGCAGCTAATTCATTTA
CAGTACAGTATTATTTACCTAAGATAATGAAGGGCGATCTAAATCCTGGATTTAAGGCTGCACATTTAAAGAAGGATCTG
AAATACGCAATGGAAATCGCTAACTCGAAATCACTTCCACTTCTAGGGACTTCCCTAGCGCTACAGTTATACAATGCAAT
GGTGTCCTTAGGAATTGGCGAATTGGGTACTCAAGGTTTAGTAAAGGTTTATGAAAAATTGGTTAAATGA

Upstream 100 bases:

>100_bases
GTCTTTTATGATTGAGGGGCGGTTTAGGGTAAAATATTGAATAAGCCAATTTAACATATAATAAGCTAAGCTTTATATTC
CTATTTTCGCTCTCTGTAAT

Downstream 100 bases:

>100_bases
TGTTTTATTGATCTATTTTACACTAAACTGCTATTATCTTCCCTTCAACCAACGTTAGGGTGATTCAGGTCTCCTTTGTG
AATTGTAATTTGTAAATATG

Product: oxidoreductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKVGFIGLGIMGFPMASNLLKAGYDLTVYNRTIEKAEKLGKMGAKVAHSPKEVAEVSEIVISMVTDAPDVEEVLFGENGV
VKSNKRGLIFVDMSTNSPEFAKKVTKRLSEYGMEFLDAPVTGGDKGAREGTLTIMVGGKEDVFKRVEPIFKAMGKNIIHV
GDVGSGQALKLCNQVVVALNMVSVVEGLLLARSLGIDDDKLFSVLSTGAANSFTVQYYLPKIMKGDLNPGFKAAHLKKDL
KYAMEIANSKSLPLLGTSLALQLYNAMVSLGIGELGTQGLVKVYEKLVK

Sequences:

>Translated_289_residues
MKVGFIGLGIMGFPMASNLLKAGYDLTVYNRTIEKAEKLGKMGAKVAHSPKEVAEVSEIVISMVTDAPDVEEVLFGENGV
VKSNKRGLIFVDMSTNSPEFAKKVTKRLSEYGMEFLDAPVTGGDKGAREGTLTIMVGGKEDVFKRVEPIFKAMGKNIIHV
GDVGSGQALKLCNQVVVALNMVSVVEGLLLARSLGIDDDKLFSVLSTGAANSFTVQYYLPKIMKGDLNPGFKAAHLKKDL
KYAMEIANSKSLPLLGTSLALQLYNAMVSLGIGELGTQGLVKVYEKLVK
>Mature_289_residues
MKVGFIGLGIMGFPMASNLLKAGYDLTVYNRTIEKAEKLGKMGAKVAHSPKEVAEVSEIVISMVTDAPDVEEVLFGENGV
VKSNKRGLIFVDMSTNSPEFAKKVTKRLSEYGMEFLDAPVTGGDKGAREGTLTIMVGGKEDVFKRVEPIFKAMGKNIIHV
GDVGSGQALKLCNQVVVALNMVSVVEGLLLARSLGIDDDKLFSVLSTGAANSFTVQYYLPKIMKGDLNPGFKAAHLKKDL
KYAMEIANSKSLPLLGTSLALQLYNAMVSLGIGELGTQGLVKVYEKLVK

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=276, Percent_Identity=37.3188405797101, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=29.3286219081272, Blast_Score=151, Evalue=6e-37,
Organism=Escherichia coli, GI1786719, Length=286, Percent_Identity=45.4545454545455, Blast_Score=234, Evalue=4e-63,
Organism=Escherichia coli, GI145693186, Length=289, Percent_Identity=38.0622837370242, Blast_Score=216, Evalue=1e-57,
Organism=Escherichia coli, GI1790315, Length=275, Percent_Identity=34.5454545454545, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789092, Length=288, Percent_Identity=27.4305555555556, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17557316, Length=270, Percent_Identity=34.0740740740741, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24655230, Length=285, Percent_Identity=35.7894736842105, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI19922568, Length=285, Percent_Identity=35.7894736842105, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI28574115, Length=277, Percent_Identity=27.7978339350181, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31026; Mature: 31026

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGFIGLGIMGFPMASNLLKAGYDLTVYNRTIEKAEKLGKMGAKVAHSPKEVAEVSEIV
CCEEEEECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ISMVTDAPDVEEVLFGENGVVKSNKRGLIFVDMSTNSPEFAKKVTKRLSEYGMEFLDAPV
HHHHCCCCCHHHHHCCCCCCEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCHHHHCCCC
TGGDKGAREGTLTIMVGGKEDVFKRVEPIFKAMGKNIIHVGDVGSGQALKLCNQVVVALN
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHH
MVSVVEGLLLARSLGIDDDKLFSVLSTGAANSFTVQYYLPKIMKGDLNPGFKAAHLKKDL
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECHHHHCCCCCCCCHHHHHHHHH
KYAMEIANSKSLPLLGTSLALQLYNAMVSLGIGELGTQGLVKVYEKLVK
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKVGFIGLGIMGFPMASNLLKAGYDLTVYNRTIEKAEKLGKMGAKVAHSPKEVAEVSEIV
CCEEEEECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
ISMVTDAPDVEEVLFGENGVVKSNKRGLIFVDMSTNSPEFAKKVTKRLSEYGMEFLDAPV
HHHHCCCCCHHHHHCCCCCCEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCHHHHCCCC
TGGDKGAREGTLTIMVGGKEDVFKRVEPIFKAMGKNIIHVGDVGSGQALKLCNQVVVALN
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHH
MVSVVEGLLLARSLGIDDDKLFSVLSTGAANSFTVQYYLPKIMKGDLNPGFKAAHLKKDL
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECHHHHCCCCCCCCHHHHHHHHH
KYAMEIANSKSLPLLGTSLALQLYNAMVSLGIGELGTQGLVKVYEKLVK
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]