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The map label for this gene is pcp

Identifier: 15898298

GI number: 15898298

Start: 1324545

End: 1325180

Strand: Reverse

Name: pcp

Synonym: SSO1465

Alternate gene names: 15898298

Gene position: 1325180-1324545 (Counterclockwise)

Preceding gene: 15898299

Following gene: 15898296

Centisome position: 44.29

GC content: 36.64

Gene sequence:

>636_bases
ATGACAGTTCTCTTGTTTGGTTTTGAACCCTTTTTGGAATACAAGGAAAATCCATCTCAGTTAATTGTTGAAGCCTTAAA
TAGAAGTACCATATTAAAGGAAGAGGTCAAAGGTGTGATACTGCCAGTTGAGTATAAGAAGATAGAGGATGTGATAGTTA
CGAAAATTAGGGAGACGAAACCAATATTAACTTTGGGAATTGGTTTAGCCCCGGGTAGAGCGAAGATAACTCCAGAGAAG
ATAGCCATAAACTATAGGTATTCAAGGGAAGGAGATAACGCTGGAAAGAAGTATAGGGGAGAGAAGATTGACCCCTTAGG
GCAAGACGGTATCTTTACGAATATACCAGTAGAGGACCTTGTAGACTTATTAAATGAAAACGGAATACCAGCTGAATTAA
GCTTAAGTGCTGGTAGCTATCTTTGTAATAACGCAATGTACATCATAATTAGGGAAGCTAGAAAGTACAATAGCTTAGGT
GGTTTCATTCACGTTCCCTTACACGAGTCATATGCCGCGAGAATACAACGATCTATTCCATCCATGAGTTTAGATACTAT
GATAAGGGGAATAAAGTTATCAATAGAATTTATATTAACAAATAAAAATAAAAAAGAGAATCTTACCTTATCCTAG

Upstream 100 bases:

>100_bases
GCTAGAGAAAGGTCTTTTCTAAACTCTCCCCAACCTTCGTAAGAGGAGAGAGAAAAGAAAAAAAAATAAAGTTAATAGTC
TGAGCGTTAAAGAGATTAGT

Downstream 100 bases:

>100_bases
TTGCCAAGTTAGCTCCTCCATATTCATGACAAACCTCGTGAAGGGCATTGAATAGTAAAGTAGAGCCAAATTGTGAGTCT
GCATTCCATGACTCATCATT

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase 1; Pyroglutamyl-peptidase I 1; PGP-I 1; Pyrase 1

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MTVLLFGFEPFLEYKENPSQLIVEALNRSTILKEEVKGVILPVEYKKIEDVIVTKIRETKPILTLGIGLAPGRAKITPEK
IAINYRYSREGDNAGKKYRGEKIDPLGQDGIFTNIPVEDLVDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSLG
GFIHVPLHESYAARIQRSIPSMSLDTMIRGIKLSIEFILTNKNKKENLTLS

Sequences:

>Translated_211_residues
MTVLLFGFEPFLEYKENPSQLIVEALNRSTILKEEVKGVILPVEYKKIEDVIVTKIRETKPILTLGIGLAPGRAKITPEK
IAINYRYSREGDNAGKKYRGEKIDPLGQDGIFTNIPVEDLVDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSLG
GFIHVPLHESYAARIQRSIPSMSLDTMIRGIKLSIEFILTNKNKKENLTLS
>Mature_210_residues
TVLLFGFEPFLEYKENPSQLIVEALNRSTILKEEVKGVILPVEYKKIEDVIVTKIRETKPILTLGIGLAPGRAKITPEKI
AINYRYSREGDNAGKKYRGEKIDPLGQDGIFTNIPVEDLVDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSLGG
FIHVPLHESYAARIQRSIPSMSLDTMIRGIKLSIEFILTNKNKKENLTLS

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP1_SULSO (P58201)

Other databases:

- EMBL:   AE006641
- PIR:   F90304
- RefSeq:   NP_342903.1
- ProteinModelPortal:   P58201
- SMR:   P58201
- MEROPS:   C15.001
- GeneID:   1454472
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO1465
- NMPDR:   fig|273057.1.peg.1326
- HOGENOM:   HBG360405
- OMA:   LERCATN
- ProtClustDB:   PRK13193
- BioCyc:   SSOL273057:SSO1465-MONOMER
- BRENDA:   3.4.19.3
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 23681; Mature: 23550

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 79-79 ACT_SITE 142-142 ACT_SITE 164-164

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLLFGFEPFLEYKENPSQLIVEALNRSTILKEEVKGVILPVEYKKIEDVIVTKIRETK
CEEEEEECCHHHHCCCCHHHHHHHHHCCHHHHHHHHCEEEEEECHHHHHHHHHHHHHCCC
PILTLGIGLAPGRAKITPEKIAINYRYSREGDNAGKKYRGEKIDPLGQDGIFTNIPVEDL
CEEEEEEECCCCCCEECHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHH
VDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSLGGFIHVPLHESYAARIQRSIP
HHHHCCCCCCEEEEECCCCEECCCEEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHCC
SMSLDTMIRGIKLSIEFILTNKNKKENLTLS
CCCHHHHHCEEEEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TVLLFGFEPFLEYKENPSQLIVEALNRSTILKEEVKGVILPVEYKKIEDVIVTKIRETK
EEEEEECCHHHHCCCCHHHHHHHHHCCHHHHHHHHCEEEEEECHHHHHHHHHHHHHCCC
PILTLGIGLAPGRAKITPEKIAINYRYSREGDNAGKKYRGEKIDPLGQDGIFTNIPVEDL
CEEEEEEECCCCCCEECHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHH
VDLLNENGIPAELSLSAGSYLCNNAMYIIIREARKYNSLGGFIHVPLHESYAARIQRSIP
HHHHCCCCCCEEEEECCCCEECCCEEEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHCC
SMSLDTMIRGIKLSIEFILTNKNKKENLTLS
CCCHHHHHCEEEEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726