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The map label for this gene is ilvC-2

Identifier: 15898165

GI number: 15898165

Start: 1152745

End: 1153746

Strand: Reverse

Name: ilvC-2

Synonym: SSO1322

Alternate gene names: 15898165

Gene position: 1153746-1152745 (Counterclockwise)

Preceding gene: 15898166

Following gene: 15898162

Centisome position: 38.56

GC content: 39.92

Gene sequence:

>1002_bases
ATGGATAAAACAGTTTTAGATGCGAATTTAGATCCGTTAAAGGGAAAGACAATAGGTGTAATTGGTTACGGCAATCAAGG
AAGGGTTCAAGCTACTATCATGAGGGAAAATGGTCTAAACGTTATTGTAGGAAATGTTAAGGATAAATATTATGAATTGG
CTAAGAAAGAAGGATTTGAAGTTTACGAGATAGATGAAGCAGTGAGGAGGTCCGATGTCGCGTTGCTTTTAATTCCAGAT
GAAGTAATGAAAGAAGTTTATGAAAAGAAGATAGCTCCAGTTTTACAAGGGAAAAAGGAGTTCGTGTTAGATTTTGCAAG
CGGGTATAATGTAGCTTTTGGGCTCATTAGACCCCCTAAAAGTGTTGATACTATAATGGTTGCTCCCAGAATGGTTGGGG
AGGGGATTATGGATTTGCACAAGCAAGGTAAAGGTTACCCTGTACTGTTAGGAGTTAAACAAGATGCGTCTGGAAAGGCG
TGGGACTACGCTAAAGCAATAGCTAAGGGTATAGGTGCGATACCAGGTGGGATTGCTGTGATTTCCTCATTTGAGGAGGA
GGCGTTATTGGACTTAATGAGTGAGCACACTTGGGTACCAATACTATTTGGGGCAATAAAGGCTTGTTATGACATTGCCG
TAAAGGAATATGGAGTATCTCCAGAAGCTGCGTTATTGGAGTTTTACGCTTCTGGAGAGTTAGCGGAAATCGCTAGACTA
ATTGCTGAAGAGGGAATATTTAACCAAATGGTGCATCACAGTACTACTAGCCAATACGGTACTTTAACAAGAATGTTCAA
GTATTATGACGTGGTAAGGAGAATTGTTGAGAATGAAGCTAAGTATATATGGGATGGTAGTTTCGCTAAGGAGTGGTCTT
TGGAGCAACAAGCTGGTTATCCAGTATTCTATAGATTATGGGAATTAGCTACGCAGAGTGAAATGGCTAAGGCTGAAAAG
GAGTTATATAAGCTTCTGGGAAGAAAGGTTAAAAATGATTAG

Upstream 100 bases:

>100_bases
TCCAATGATGTGGGCAATGGATCAAGTGAGGAAGATAGGTTCTTCTTCATCCTTATAAGTACGGATTCATATTTTTATTT
TCGTACTCCAGTACTTTTTT

Downstream 100 bases:

>100_bases
ATCTTCTCTTTTTCAAAGATCTTACTGGCAGAGTAGAGTGTTAAAAGTTTAGCTTTGTTACGCTTAAGGATACTTTCGTA
GTCCTTTTTTATGTATAACT

Product: ketol-acid reductoisomerase (ilvC-2)

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase 2; Alpha-keto-beta-hydroxylacil reductoisomerase 2

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MDKTVLDANLDPLKGKTIGVIGYGNQGRVQATIMRENGLNVIVGNVKDKYYELAKKEGFEVYEIDEAVRRSDVALLLIPD
EVMKEVYEKKIAPVLQGKKEFVLDFASGYNVAFGLIRPPKSVDTIMVAPRMVGEGIMDLHKQGKGYPVLLGVKQDASGKA
WDYAKAIAKGIGAIPGGIAVISSFEEEALLDLMSEHTWVPILFGAIKACYDIAVKEYGVSPEAALLEFYASGELAEIARL
IAEEGIFNQMVHHSTTSQYGTLTRMFKYYDVVRRIVENEAKYIWDGSFAKEWSLEQQAGYPVFYRLWELATQSEMAKAEK
ELYKLLGRKVKND

Sequences:

>Translated_333_residues
MDKTVLDANLDPLKGKTIGVIGYGNQGRVQATIMRENGLNVIVGNVKDKYYELAKKEGFEVYEIDEAVRRSDVALLLIPD
EVMKEVYEKKIAPVLQGKKEFVLDFASGYNVAFGLIRPPKSVDTIMVAPRMVGEGIMDLHKQGKGYPVLLGVKQDASGKA
WDYAKAIAKGIGAIPGGIAVISSFEEEALLDLMSEHTWVPILFGAIKACYDIAVKEYGVSPEAALLEFYASGELAEIARL
IAEEGIFNQMVHHSTTSQYGTLTRMFKYYDVVRRIVENEAKYIWDGSFAKEWSLEQQAGYPVFYRLWELATQSEMAKAEK
ELYKLLGRKVKND
>Mature_333_residues
MDKTVLDANLDPLKGKTIGVIGYGNQGRVQATIMRENGLNVIVGNVKDKYYELAKKEGFEVYEIDEAVRRSDVALLLIPD
EVMKEVYEKKIAPVLQGKKEFVLDFASGYNVAFGLIRPPKSVDTIMVAPRMVGEGIMDLHKQGKGYPVLLGVKQDASGKA
WDYAKAIAKGIGAIPGGIAVISSFEEEALLDLMSEHTWVPILFGAIKACYDIAVKEYGVSPEAALLEFYASGELAEIARL
IAEEGIFNQMVHHSTTSQYGTLTRMFKYYDVVRRIVENEAKYIWDGSFAKEWSLEQQAGYPVFYRLWELATQSEMAKAEK
ELYKLLGRKVKND

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=230, Percent_Identity=30.8695652173913, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323387, Length=265, Percent_Identity=32.4528301886792, Blast_Score=90, Evalue=5e-19,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC2_SULSO (Q97YJ9)

Other databases:

- EMBL:   AE006641
- PIR:   A99288
- RefSeq:   NP_342770.1
- ProteinModelPortal:   Q97YJ9
- SMR:   Q97YJ9
- GeneID:   1454339
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO1322
- NMPDR:   fig|273057.1.peg.1193
- HOGENOM:   HBG286525
- ProtClustDB:   CLSK339264
- BioCyc:   SSOL273057:SSO1322-MONOMER
- BRENDA:   1.1.1.86
- GO:   GO:0005488
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013116
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37185; Mature: 37185

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTVLDANLDPLKGKTIGVIGYGNQGRVQATIMRENGLNVIVGNVKDKYYELAKKEGFE
CCCCEECCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHCCCE
VYEIDEAVRRSDVALLLIPDEVMKEVYEKKIAPVLQGKKEFVLDFASGYNVAFGLIRPPK
EEEHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCEEEEECCCCC
SVDTIMVAPRMVGEGIMDLHKQGKGYPVLLGVKQDASGKAWDYAKAIAKGIGAIPGGIAV
CCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHH
ISSFEEEALLDLMSEHTWVPILFGAIKACYDIAVKEYGVSPEAALLEFYASGELAEIARL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHH
IAEEGIFNQMVHHSTTSQYGTLTRMFKYYDVVRRIVENEAKYIWDGSFAKEWSLEQQAGY
HHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHCCCHHHCCC
PVFYRLWELATQSEMAKAEKELYKLLGRKVKND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKTVLDANLDPLKGKTIGVIGYGNQGRVQATIMRENGLNVIVGNVKDKYYELAKKEGFE
CCCCEECCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHCCCE
VYEIDEAVRRSDVALLLIPDEVMKEVYEKKIAPVLQGKKEFVLDFASGYNVAFGLIRPPK
EEEHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCEEEEECCCCC
SVDTIMVAPRMVGEGIMDLHKQGKGYPVLLGVKQDASGKAWDYAKAIAKGIGAIPGGIAV
CCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHH
ISSFEEEALLDLMSEHTWVPILFGAIKACYDIAVKEYGVSPEAALLEFYASGELAEIARL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHH
IAEEGIFNQMVHHSTTSQYGTLTRMFKYYDVVRRIVENEAKYIWDGSFAKEWSLEQQAGY
HHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHCCCHHHCCC
PVFYRLWELATQSEMAKAEKELYKLLGRKVKND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726