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The map label for this gene is trpB-like

Identifier: 15898001

GI number: 15898001

Start: 986048

End: 987337

Strand: Direct

Name: trpB-like

Synonym: SSO1145

Alternate gene names: 15898001

Gene position: 986048-987337 (Clockwise)

Preceding gene: 15897995

Following gene: 15898002

Centisome position: 32.95

GC content: 41.16

Gene sequence:

>1290_bases
ATGGCTATGAGAATAAGAATAGATTTACCTCAAGATGAAATACCCGCACAATGGTATAATATCCTACCAGACTTACCGGA
GGAACTACCCCCGCCACAAGATCCCACTGGCAAATCCTTAGAACTATTGAAGGAAGTTTTACCGAGCAAGGTGCTGGAGT
TAGAGTTCGCTAAGGAAAGATACGTAAAAATTCCAGATGAGGTTCTGGAGAGATATTTACAAGTTGGAAGACCGACTCCA
ATAATTAGGGCAAAAAGGTTAGAGGAGTACTTAGGAAATAATATCAAAATCTATCTGAAGATGGAGAGCTACACTTACAC
TGGTTCTCACAAAATCAACAGTGCCTTAGCACATGTATATTACGCTAAATTGGATAACGCGAAATTCGTTACGACAGAAA
CTGGAGCTGGTCAGTGGGGATCATCAGTTGCACTAGCCTCAGCCCTATTTAGGATGAAAGCACACATATTTATGGTTAGG
ACTAGCTATTATGCAAAGCCTTACAGAAAATATATGATGCAGATGTATGGAGCGGAAGTTCATCCTTCTCCTTCAGATTT
AACAGAATTCGGTAGACAATTATTGGCCAAAGACTCCAATCATCCTGGATCTTTAGGCATCGCAATAAGTGATGCAGTAG
AATATGCTCATAAAAACGGTGGAAAATACGTTGTAGGTAGTGTGGTAAATTCAGATATAATGTTTAAAACGATTGCCGGA
ATGGAGGCTAAGAAGCAAATGGAACTGATTGGTGAAGATCCAGATTACATTATAGGAGTAGTAGGAGGGGGATCAAATTA
CGCAGCATTAGCTTATCCATTCTTAGGAGATGAGCTGAGGAGTGGAAAGGTTAGGAGGAAGTATATTGCCTCTGGATCCT
CAGAAGTTCCAAAAATGACTAAGGGTGTTTATAAATACGATTATCCAGACACTGCGAAATTGTTGCCAATGCTAAAAATG
TACACAATAGGGTCGGACTTCGTACCACCTCCAGTTTATGCAGGTGGGCTAAGATATCATGGAGTAGCCCCAACTCTCAG
TCTATTAATTAGCAAGGGAATTGTACAAGCAAGAGATTACTCTCAAGAGGAGTCGTTCAAATGGGCTAAATTATTCTCAG
AACTGGAGGGATATATACCAGCTCCAGAGACTTCTCACGCATTGCCAATATTGGCTGAAATAGCTGAAGAGGCTAAGAAG
AGCGGAGAAAGGAAGACAGTACTGGTTAGCTTCTCTGGGCATGGACTACTAGATTTGGGCAACTACGCCTCAGTGTTATT
TAAGGAGTAG

Upstream 100 bases:

>100_bases
TGACATACATTACAATCCTTTTTTCTGATTGAGTCCTTTTAAATTTTTCGTTAATAGTTAAAAAATAGGAGAAAAAAGTA
TAAACTTCTCTAACGTAGTA

Downstream 100 bases:

>100_bases
AAAATGAGGACTTTAGTAGGAAGTATACTCTTAACAATTTCCCAATGGTACGCCTTCTTTTTATTTTCCCAGCTCTCTTT
CATAGAATTTAACGTTATAA

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MAMRIRIDLPQDEIPAQWYNILPDLPEELPPPQDPTGKSLELLKEVLPSKVLELEFAKERYVKIPDEVLERYLQVGRPTP
IIRAKRLEEYLGNNIKIYLKMESYTYTGSHKINSALAHVYYAKLDNAKFVTTETGAGQWGSSVALASALFRMKAHIFMVR
TSYYAKPYRKYMMQMYGAEVHPSPSDLTEFGRQLLAKDSNHPGSLGIAISDAVEYAHKNGGKYVVGSVVNSDIMFKTIAG
MEAKKQMELIGEDPDYIIGVVGGGSNYAALAYPFLGDELRSGKVRRKYIASGSSEVPKMTKGVYKYDYPDTAKLLPMLKM
YTIGSDFVPPPVYAGGLRYHGVAPTLSLLISKGIVQARDYSQEESFKWAKLFSELEGYIPAPETSHALPILAEIAEEAKK
SGERKTVLVSFSGHGLLDLGNYASVLFKE

Sequences:

>Translated_429_residues
MAMRIRIDLPQDEIPAQWYNILPDLPEELPPPQDPTGKSLELLKEVLPSKVLELEFAKERYVKIPDEVLERYLQVGRPTP
IIRAKRLEEYLGNNIKIYLKMESYTYTGSHKINSALAHVYYAKLDNAKFVTTETGAGQWGSSVALASALFRMKAHIFMVR
TSYYAKPYRKYMMQMYGAEVHPSPSDLTEFGRQLLAKDSNHPGSLGIAISDAVEYAHKNGGKYVVGSVVNSDIMFKTIAG
MEAKKQMELIGEDPDYIIGVVGGGSNYAALAYPFLGDELRSGKVRRKYIASGSSEVPKMTKGVYKYDYPDTAKLLPMLKM
YTIGSDFVPPPVYAGGLRYHGVAPTLSLLISKGIVQARDYSQEESFKWAKLFSELEGYIPAPETSHALPILAEIAEEAKK
SGERKTVLVSFSGHGLLDLGNYASVLFKE
>Mature_428_residues
AMRIRIDLPQDEIPAQWYNILPDLPEELPPPQDPTGKSLELLKEVLPSKVLELEFAKERYVKIPDEVLERYLQVGRPTPI
IRAKRLEEYLGNNIKIYLKMESYTYTGSHKINSALAHVYYAKLDNAKFVTTETGAGQWGSSVALASALFRMKAHIFMVRT
SYYAKPYRKYMMQMYGAEVHPSPSDLTEFGRQLLAKDSNHPGSLGIAISDAVEYAHKNGGKYVVGSVVNSDIMFKTIAGM
EAKKQMELIGEDPDYIIGVVGGGSNYAALAYPFLGDELRSGKVRRKYIASGSSEVPKMTKGVYKYDYPDTAKLLPMLKMY
TIGSDFVPPPVYAGGLRYHGVAPTLSLLISKGIVQARDYSQEESFKWAKLFSELEGYIPAPETSHALPILAEIAEEAKKS
GERKTVLVSFSGHGLLDLGNYASVLFKE

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG1350

COG function: function code R; Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=402, Percent_Identity=27.8606965174129, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321412, Length=404, Percent_Identity=30.4455445544554, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB2_SULSO (Q97TX6)

Other databases:

- EMBL:   AE006641
- PIR:   E90267
- RefSeq:   NP_342606.1
- ProteinModelPortal:   Q97TX6
- GeneID:   1454175
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO1145
- NMPDR:   fig|273057.1.peg.1029
- HOGENOM:   HBG303148
- OMA:   RYHAVAP
- ProtClustDB:   PRK12391
- BioCyc:   SSOL273057:SSO1145-MONOMER
- BRENDA:   4.2.1.20
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006316
- InterPro:   IPR006653
- InterPro:   IPR023026
- TIGRFAMs:   TIGR01415

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 47779; Mature: 47647

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMRIRIDLPQDEIPAQWYNILPDLPEELPPPQDPTGKSLELLKEVLPSKVLELEFAKER
CEEEEEEECCCCCCCHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YVKIPDEVLERYLQVGRPTPIIRAKRLEEYLGNNIKIYLKMESYTYTGSHKINSALAHVY
HCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEECEEECCCHHHHHHHHHHH
YAKLDNAKFVTTETGAGQWGSSVALASALFRMKAHIFMVRTSYYAKPYRKYMMQMYGAEV
HEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHCCCC
HPSPSDLTEFGRQLLAKDSNHPGSLGIAISDAVEYAHKNGGKYVVGSVVNSDIMFKTIAG
CCCHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCEEEEEHHCCCHHHHHHHC
MEAKKQMELIGEDPDYIIGVVGGGSNYAALAYPFLGDELRSGKVRRKYIASGSSEVPKMT
CCHHHHHHHCCCCCCEEEEEEECCCCCEEEEECHHCCHHHCCCHHHHHHHCCCCCCCHHH
KGVYKYDYPDTAKLLPMLKMYTIGSDFVPPPVYAGGLRYHGVAPTLSLLISKGIVQARDY
CCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHCHHHHHCC
SQEESFKWAKLFSELEGYIPAPETSHALPILAEIAEEAKKSGERKTVLVSFSGHGLLDLG
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEECC
NYASVLFKE
CHHHHHCCC
>Mature Secondary Structure 
AMRIRIDLPQDEIPAQWYNILPDLPEELPPPQDPTGKSLELLKEVLPSKVLELEFAKER
EEEEEEECCCCCCCHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YVKIPDEVLERYLQVGRPTPIIRAKRLEEYLGNNIKIYLKMESYTYTGSHKINSALAHVY
HCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEEECEEECCCHHHHHHHHHHH
YAKLDNAKFVTTETGAGQWGSSVALASALFRMKAHIFMVRTSYYAKPYRKYMMQMYGAEV
HEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHCCCC
HPSPSDLTEFGRQLLAKDSNHPGSLGIAISDAVEYAHKNGGKYVVGSVVNSDIMFKTIAG
CCCHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCEEEEEHHCCCHHHHHHHC
MEAKKQMELIGEDPDYIIGVVGGGSNYAALAYPFLGDELRSGKVRRKYIASGSSEVPKMT
CCHHHHHHHCCCCCCEEEEEEECCCCCEEEEECHHCCHHHCCCHHHHHHHCCCCCCCHHH
KGVYKYDYPDTAKLLPMLKMYTIGSDFVPPPVYAGGLRYHGVAPTLSLLISKGIVQARDY
CCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHHHHHHHHCHHHHHCC
SQEESFKWAKLFSELEGYIPAPETSHALPILAEIAEEAKKSGERKTVLVSFSGHGLLDLG
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEECC
NYASVLFKE
CHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726