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The map label for this gene is ugd [H]

Identifier: 15897714

GI number: 15897714

Start: 696609

End: 697838

Strand: Direct

Name: ugd [H]

Synonym: SSO0810

Alternate gene names: 15897714

Gene position: 696609-697838 (Clockwise)

Preceding gene: 15897713

Following gene: 15897715

Centisome position: 23.28

GC content: 36.99

Gene sequence:

>1230_bases
ATGAGAATAGGTGTTGTAGGATTAGGTGTTGTAGGATTAGTAACGGGGGCAGTATTAGCAGATCAAGGACATGAAGTAGT
TGGAGTAGACATTGATCAAAATAAGGTTAAAGGTTTACAGTGCAACCGTTCTCCCATTTATGAACCAGGTTTAGATGAAC
TTCTCTTAAAAAATAAGAATAGATTTCTCTTCACCACAGATTACTCCGCGTTAAAAGACGTGGATATTGTCTTTATTACA
GTCGCTACACCTACCGTAGAAGGGAAGAACTATATAGGCTATGTTTTAGACGCTGCTAAGACTATGAAACCTTACCTTAA
GAGGGATGCGATCGTTGTTGTGAAAAGCACAGTAGTTCCAGGTACAAGTAGAAAAGTAAAACAGATAGTAGAGAGGGAAG
TAGTAGCTAACCCAGAATTTCTAAAAGAGGGTAGTGCTGTAATAGACACCATTAAACCTGATAGGATAGTTATTGGAAGT
GATAGTAAAGCGGCTGGAGATGTAATTGAAAACTTATGGTCATTTACAAAGACTGTGGTTTTAAGGACTTCAATTGAAGA
AGCTGAAATGATCAAATACGCTGCAAACTCTTTTTTAGCGACAAAAATTTCATTTATTAATGAAATAGCGAATTTGTGTG
AGGTAATACCTAACTGTGATGTCAATACCATAGCTAAAGCTATAGGATTAGATAAAAGGATAGCTCCCTATTTCTTAAAC
GCTGGCTTAGGTTACGGAGGTTCATGTTTCCCTAAAGATACTCTAGCTTTTGCATCCTTTGCTAGAGAATTAGGCGAGGA
ATTAAAAATAGTAGAAGCCGCGATAAAAGTTAATGAGGAAAGACCTAGAAGAGCTGTAAAGATAATGGAAGAGTTATTAG
GCGAACTAAAGGGTAAAACAATTTGTATTTTAGGTATTGCATTTAAGCCTAACACGGATGATACTAGAGAAAGTGTAGCG
TTAAAAATTGCTAAACTTTTAGTCGATATTGGGGCTAACGTCATAGCATATGATCCTAAGGCTAAAACATCGTTAGTGGA
AATGGTAAGCAGTAAGGAGGAGTGCGTGAAGAGATCAGATGGTGTAATAATAGCAACAGAATGGGATGAATTCAGAGGCA
TAGAGCATATGCTTAAAGATAAGGCTGTCTTAGATGGTAGAAGAGTTCTTGACCCTAATAAGATGTCAAGAAGTAAATAT
AGGGCAATAGGATTATCTAAGGTGAGGTAA

Upstream 100 bases:

>100_bases
CTGACATAACTAAGGCTAAGGAAAAATTGGGCTGGTATCCTAAAATTTCCTTAGAAGAGGGATTAAAACTTACCATAAAT
TGGTTTAAGGGTGTATTAAA

Downstream 100 bases:

>100_bases
ATATTCACGCAGTAATTACCGCAGCTGGTTTGGGCACTAGATTACTTCCAGCATCTAAAGAAATTCCTAAGGAAATGTTT
CCTATCCCTTTTAATGGGCA

Product: UDP-glucose 6-dehydrogenase (ugd)

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRIGVVGLGVVGLVTGAVLADQGHEVVGVDIDQNKVKGLQCNRSPIYEPGLDELLLKNKNRFLFTTDYSALKDVDIVFIT
VATPTVEGKNYIGYVLDAAKTMKPYLKRDAIVVVKSTVVPGTSRKVKQIVEREVVANPEFLKEGSAVIDTIKPDRIVIGS
DSKAAGDVIENLWSFTKTVVLRTSIEEAEMIKYAANSFLATKISFINEIANLCEVIPNCDVNTIAKAIGLDKRIAPYFLN
AGLGYGGSCFPKDTLAFASFARELGEELKIVEAAIKVNEERPRRAVKIMEELLGELKGKTICILGIAFKPNTDDTRESVA
LKIAKLLVDIGANVIAYDPKAKTSLVEMVSSKEECVKRSDGVIIATEWDEFRGIEHMLKDKAVLDGRRVLDPNKMSRSKY
RAIGLSKVR

Sequences:

>Translated_409_residues
MRIGVVGLGVVGLVTGAVLADQGHEVVGVDIDQNKVKGLQCNRSPIYEPGLDELLLKNKNRFLFTTDYSALKDVDIVFIT
VATPTVEGKNYIGYVLDAAKTMKPYLKRDAIVVVKSTVVPGTSRKVKQIVEREVVANPEFLKEGSAVIDTIKPDRIVIGS
DSKAAGDVIENLWSFTKTVVLRTSIEEAEMIKYAANSFLATKISFINEIANLCEVIPNCDVNTIAKAIGLDKRIAPYFLN
AGLGYGGSCFPKDTLAFASFARELGEELKIVEAAIKVNEERPRRAVKIMEELLGELKGKTICILGIAFKPNTDDTRESVA
LKIAKLLVDIGANVIAYDPKAKTSLVEMVSSKEECVKRSDGVIIATEWDEFRGIEHMLKDKAVLDGRRVLDPNKMSRSKY
RAIGLSKVR
>Mature_409_residues
MRIGVVGLGVVGLVTGAVLADQGHEVVGVDIDQNKVKGLQCNRSPIYEPGLDELLLKNKNRFLFTTDYSALKDVDIVFIT
VATPTVEGKNYIGYVLDAAKTMKPYLKRDAIVVVKSTVVPGTSRKVKQIVEREVVANPEFLKEGSAVIDTIKPDRIVIGS
DSKAAGDVIENLWSFTKTVVLRTSIEEAEMIKYAANSFLATKISFINEIANLCEVIPNCDVNTIAKAIGLDKRIAPYFLN
AGLGYGGSCFPKDTLAFASFARELGEELKIVEAAIKVNEERPRRAVKIMEELLGELKGKTICILGIAFKPNTDDTRESVA
LKIAKLLVDIGANVIAYDPKAKTSLVEMVSSKEECVKRSDGVIIATEWDEFRGIEHMLKDKAVLDGRRVLDPNKMSRSKY
RAIGLSKVR

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=446, Percent_Identity=34.9775784753363, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI296040443, Length=429, Percent_Identity=32.8671328671329, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI296040438, Length=324, Percent_Identity=36.4197530864198, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI1788340, Length=358, Percent_Identity=31.0055865921788, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI48994968, Length=406, Percent_Identity=26.1083743842365, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560350, Length=461, Percent_Identity=32.9718004338395, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17136908, Length=467, Percent_Identity=34.0471092077088, Blast_Score=234, Evalue=7e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 44838; Mature: 44838

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGVVGLGVVGLVTGAVLADQGHEVVGVDIDQNKVKGLQCNRSPIYEPGLDELLLKNKN
CEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCCCCCCCHHHHHHCCCC
RFLFTTDYSALKDVDIVFITVATPTVEGKNYIGYVLDAAKTMKPYLKRDAIVVVKSTVVP
CEEEEECCHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
GTSRKVKQIVEREVVANPEFLKEGSAVIDTIKPDRIVIGSDSKAAGDVIENLWSFTKTVV
CCHHHHHHHHHHHHHCCHHHHHCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
LRTSIEEAEMIKYAANSFLATKISFINEIANLCEVIPNCDVNTIAKAIGLDKRIAPYFLN
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHC
AGLGYGGSCFPKDTLAFASFARELGEELKIVEAAIKVNEERPRRAVKIMEELLGELKGKT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCE
ICILGIAFKPNTDDTRESVALKIAKLLVDIGANVIAYDPKAKTSLVEMVSSKEECVKRSD
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCHHHHHHHCC
GVIIATEWDEFRGIEHMLKDKAVLDGRRVLDPNKMSRSKYRAIGLSKVR
CEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRIGVVGLGVVGLVTGAVLADQGHEVVGVDIDQNKVKGLQCNRSPIYEPGLDELLLKNKN
CEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCCCCCCCCHHHHHHCCCC
RFLFTTDYSALKDVDIVFITVATPTVEGKNYIGYVLDAAKTMKPYLKRDAIVVVKSTVVP
CEEEEECCHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECC
GTSRKVKQIVEREVVANPEFLKEGSAVIDTIKPDRIVIGSDSKAAGDVIENLWSFTKTVV
CCHHHHHHHHHHHHHCCHHHHHCCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
LRTSIEEAEMIKYAANSFLATKISFINEIANLCEVIPNCDVNTIAKAIGLDKRIAPYFLN
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHC
AGLGYGGSCFPKDTLAFASFARELGEELKIVEAAIKVNEERPRRAVKIMEELLGELKGKT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCE
ICILGIAFKPNTDDTRESVALKIAKLLVDIGANVIAYDPKAKTSLVEMVSSKEECVKRSD
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCHHHHHHHCC
GVIIATEWDEFRGIEHMLKDKAVLDGRRVLDPNKMSRSKYRAIGLSKVR
CEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]