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The map label for this gene is MCM

Identifier: 15897676

GI number: 15897676

Start: 658336

End: 660396

Strand: Direct

Name: MCM

Synonym: SSO0774

Alternate gene names: 15897676

Gene position: 658336-660396 (Clockwise)

Preceding gene: 15897675

Following gene: 15897680

Centisome position: 22.0

GC content: 35.52

Gene sequence:

>2061_bases
TTGGAAATTCCTAGTAAACAGATTGACTATAGAGACGTATTTATAGAGTTTCTGACAACTTTCAAGGGTAACAATAATCA
AAACAAATATATCGAGAGGATAAACGAGCTAGTAGCGTATAGGAAAAAAAGTCTTATAATAGAATTTTCTGATGTACTTT
CGTTCAATGAAAATTTGGCTTATGAGATAATAAATAATACCAAAATTATTCTACCAATTCTGGAAGGTGCATTGTATGAT
CATATCTTGCAATTGGATCCTACATATCAACGAGATATAGAAAAAGTTCATGTTAGAATTGTAGGAATACCTAGAGTAAT
AGAACTTAGAAAAATAAGAAGTACCGATATAGGTAAACTAATAACTATTGATGGAATCTTAGTTAAAGTTACTCCGGTAA
AAGAGAGAATTTACAAGGCAACTTATAAGCACATTCACCCAGACTGTATGCAGGAGTTTGAGTGGCCAGAAGATGAAGAG
ATGCCAGAAGTATTAGAAATGCCAACTATATGTCCAAAATGTGGTAAGCCTGGACAGTTCAGACTAATCCCAGAGAAAAC
AAAGTTAATTGACTGGCAAAAAGCGGTAATCCAGGAGAGACCAGAAGAGGTACCCTCAGGTCAGTTACCTAGGCAGTTGG
AAATAATACTTGAAGATGATTTAGTTGATTCTGCGAGACCTGGAGATAGGGTAAAAGTAACGGGAATTTTAGATATAAAA
CAAGACTCCCCGGTCAAAAGGGGAAGTAGAGCAGTATTTGACATTTATATGAAAGTAAGTAGTATAGAAGTTTCACAAAA
AGTATTAGATGAGGTAATCATCTCTGAAGAAGACGAGAAAAAGATTAAAGACTTAGCTAAAGATCCTTGGATACGTGATA
GAATCATATCATCGATAGCACCATCTATTTACGGTCACTGGGAACTAAAAGAAGCTCTAGCATTAGCATTATTTGGAGGA
GTTCCTAAGGTTCTAGAAGATACGAGAATAAGAGGAGATATTCACATACTGATAATAGGTGATCCCGGTACTGCCAAATC
ACAAATGCTACAGTTTATCTCAAGAGTAGCCCCAAGGGCAGTTTACACGACCGGTAAAGGATCCACAGCTGCAGGTTTAA
CAGCTGCTGTAGTAAGAGAAAAGGGAACTGGAGAGTATTACTTAGAAGCTGGTGCGTTAGTACTTGCTGATGGTGGAATA
GCAGTTATTGATGAAATAGACAAGATGAGGGATGAAGATAGAGTAGCCATTCATGAGGCAATGGAACAACAGACAGTCTC
AATAGCAAAAGCTGGAATAGTAGCTAAATTAAACGCTAGGGCTGCAGTTATAGCTGCAGGGAATCCGAAATTCGGGAGAT
ACATAAGTGAAAGACCAGTGTCTGATAATATCAACCTACCTCCAACAATCTTGTCAAGATTTGACCTAATATTTATACTA
AAGGATCAACCAGGTGAACAAGATAGAGAACTTGCGAATTACATATTAGATGTACATTCAGGAAAATCCACAAAAAATAT
TATAGATATAGATACATTAAGAAAATATATAGCATATGCAAGGAAATACGTTACACCAAAAATTACTAGTGAGGCTAAGA
ATCTGATTACAGATTTCTTCGTAGAAATGAGGAAGAAAAGCTCAGAAACACCTGATAGCCCAATATTGATAACTCCAAGA
CAATTAGAGGCTTTAATAAGAATTTCAGAAGCCTATGCCAAGATGGCTCTTAAGGCTGAAGTCACTAGAGAAGATGCAGA
AAGAGCAATAAATATCATGAGACTTTTCCTAGAGAGTGTAGGAGTTGATATGGAAAGTGGAAAAATAGATATAGATACAA
TAATGACTGGTAAACCTAAAAGCGCTAGAGAGAAAATGATGAAAATAATAGAAATAATAGATAGTTTAGCTGTAAGTTCT
GAGTGCGCAAAAGTTAAGGACATACTAAAAGAAGCTCAACAAGTAGGCATTGAAAAAAGTAATATAGAAAAATTACTTAC
AGATATGAGAAAGAGTGGTATAATATATGAAGCAAAACCAGAATGTTACAAAAAAGTCTAG

Upstream 100 bases:

>100_bases
AACATCGATGATCAGAACTTAATTAATGGAATGACAGAAGAAGAGCTTTTAATCTATAAGACAATAAAACAACTTATTAA
GGAATTATATGGTGATATAA

Downstream 100 bases:

>100_bases
GCTAATTTCTTATATATTGGCAGAGGAGACCACATTACCCATGCTGGTACTTGCTTTATTAATTCGTAAGCTTCCTCCCA
ACCAGAGAGCCCTAACCTTT

Product: minichromosome maintenance protein MCM

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MEIPSKQIDYRDVFIEFLTTFKGNNNQNKYIERINELVAYRKKSLIIEFSDVLSFNENLAYEIINNTKIILPILEGALYD
HILQLDPTYQRDIEKVHVRIVGIPRVIELRKIRSTDIGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPEDEE
MPEVLEMPTICPKCGKPGQFRLIPEKTKLIDWQKAVIQERPEEVPSGQLPRQLEIILEDDLVDSARPGDRVKVTGILDIK
QDSPVKRGSRAVFDIYMKVSSIEVSQKVLDEVIISEEDEKKIKDLAKDPWIRDRIISSIAPSIYGHWELKEALALALFGG
VPKVLEDTRIRGDIHILIIGDPGTAKSQMLQFISRVAPRAVYTTGKGSTAAGLTAAVVREKGTGEYYLEAGALVLADGGI
AVIDEIDKMRDEDRVAIHEAMEQQTVSIAKAGIVAKLNARAAVIAAGNPKFGRYISERPVSDNINLPPTILSRFDLIFIL
KDQPGEQDRELANYILDVHSGKSTKNIIDIDTLRKYIAYARKYVTPKITSEAKNLITDFFVEMRKKSSETPDSPILITPR
QLEALIRISEAYAKMALKAEVTREDAERAINIMRLFLESVGVDMESGKIDIDTIMTGKPKSAREKMMKIIEIIDSLAVSS
ECAKVKDILKEAQQVGIEKSNIEKLLTDMRKSGIIYEAKPECYKKV

Sequences:

>Translated_686_residues
MEIPSKQIDYRDVFIEFLTTFKGNNNQNKYIERINELVAYRKKSLIIEFSDVLSFNENLAYEIINNTKIILPILEGALYD
HILQLDPTYQRDIEKVHVRIVGIPRVIELRKIRSTDIGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPEDEE
MPEVLEMPTICPKCGKPGQFRLIPEKTKLIDWQKAVIQERPEEVPSGQLPRQLEIILEDDLVDSARPGDRVKVTGILDIK
QDSPVKRGSRAVFDIYMKVSSIEVSQKVLDEVIISEEDEKKIKDLAKDPWIRDRIISSIAPSIYGHWELKEALALALFGG
VPKVLEDTRIRGDIHILIIGDPGTAKSQMLQFISRVAPRAVYTTGKGSTAAGLTAAVVREKGTGEYYLEAGALVLADGGI
AVIDEIDKMRDEDRVAIHEAMEQQTVSIAKAGIVAKLNARAAVIAAGNPKFGRYISERPVSDNINLPPTILSRFDLIFIL
KDQPGEQDRELANYILDVHSGKSTKNIIDIDTLRKYIAYARKYVTPKITSEAKNLITDFFVEMRKKSSETPDSPILITPR
QLEALIRISEAYAKMALKAEVTREDAERAINIMRLFLESVGVDMESGKIDIDTIMTGKPKSAREKMMKIIEIIDSLAVSS
ECAKVKDILKEAQQVGIEKSNIEKLLTDMRKSGIIYEAKPECYKKV
>Mature_686_residues
MEIPSKQIDYRDVFIEFLTTFKGNNNQNKYIERINELVAYRKKSLIIEFSDVLSFNENLAYEIINNTKIILPILEGALYD
HILQLDPTYQRDIEKVHVRIVGIPRVIELRKIRSTDIGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPEDEE
MPEVLEMPTICPKCGKPGQFRLIPEKTKLIDWQKAVIQERPEEVPSGQLPRQLEIILEDDLVDSARPGDRVKVTGILDIK
QDSPVKRGSRAVFDIYMKVSSIEVSQKVLDEVIISEEDEKKIKDLAKDPWIRDRIISSIAPSIYGHWELKEALALALFGG
VPKVLEDTRIRGDIHILIIGDPGTAKSQMLQFISRVAPRAVYTTGKGSTAAGLTAAVVREKGTGEYYLEAGALVLADGGI
AVIDEIDKMRDEDRVAIHEAMEQQTVSIAKAGIVAKLNARAAVIAAGNPKFGRYISERPVSDNINLPPTILSRFDLIFIL
KDQPGEQDRELANYILDVHSGKSTKNIIDIDTLRKYIAYARKYVTPKITSEAKNLITDFFVEMRKKSSETPDSPILITPR
QLEALIRISEAYAKMALKAEVTREDAERAINIMRLFLESVGVDMESGKIDIDTIMTGKPKSAREKMMKIIEIIDSLAVSS
ECAKVKDILKEAQQVGIEKSNIEKLLTDMRKSGIIYEAKPECYKKV

Specific function: Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein)

COG id: COG1241

COG function: function code L; Predicted ATPase involved in replication control, Cdc46/Mcm family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MCM domain

Homologues:

Organism=Homo sapiens, GI33356547, Length=622, Percent_Identity=37.2990353697749, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI7427519, Length=661, Percent_Identity=34.7957639939486, Blast_Score=358, Evalue=1e-98,
Organism=Homo sapiens, GI23510448, Length=618, Percent_Identity=36.5695792880259, Blast_Score=356, Evalue=4e-98,
Organism=Homo sapiens, GI33469919, Length=627, Percent_Identity=34.1307814992025, Blast_Score=355, Evalue=9e-98,
Organism=Homo sapiens, GI33469917, Length=627, Percent_Identity=34.1307814992025, Blast_Score=355, Evalue=9e-98,
Organism=Homo sapiens, GI19923727, Length=656, Percent_Identity=33.2317073170732, Blast_Score=339, Evalue=5e-93,
Organism=Homo sapiens, GI33469924, Length=643, Percent_Identity=33.5925349922239, Blast_Score=332, Evalue=6e-91,
Organism=Homo sapiens, GI33469968, Length=512, Percent_Identity=38.8671875, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI6631095, Length=650, Percent_Identity=34.4615384615385, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI33469922, Length=453, Percent_Identity=39.514348785872, Blast_Score=298, Evalue=9e-81,
Organism=Homo sapiens, GI23397546, Length=297, Percent_Identity=31.3131313131313, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI310115110, Length=268, Percent_Identity=37.6865671641791, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI310128402, Length=268, Percent_Identity=37.6865671641791, Blast_Score=157, Evalue=4e-38,
Organism=Homo sapiens, GI310119838, Length=268, Percent_Identity=37.6865671641791, Blast_Score=157, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71997752, Length=633, Percent_Identity=37.914691943128, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17508417, Length=662, Percent_Identity=34.441087613293, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17554306, Length=647, Percent_Identity=35.2395672333849, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71997563, Length=647, Percent_Identity=34.1576506955178, Blast_Score=333, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI17562702, Length=500, Percent_Identity=37, Blast_Score=332, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17562700, Length=560, Percent_Identity=36.6071428571429, Blast_Score=313, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI71997571, Length=328, Percent_Identity=45.7317073170732, Blast_Score=261, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6325276, Length=730, Percent_Identity=33.2876712328767, Blast_Score=379, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319448, Length=636, Percent_Identity=35.2201257861635, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323304, Length=554, Percent_Identity=38.4476534296029, Blast_Score=342, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6319679, Length=657, Percent_Identity=33.7899543378995, Blast_Score=300, Evalue=7e-82,
Organism=Saccharomyces cerevisiae, GI6321237, Length=335, Percent_Identity=45.3731343283582, Blast_Score=283, Evalue=8e-77,
Organism=Saccharomyces cerevisiae, GI6320803, Length=485, Percent_Identity=37.5257731958763, Blast_Score=274, Evalue=3e-74,
Organism=Drosophila melanogaster, GI17137132, Length=612, Percent_Identity=38.8888888888889, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI17137242, Length=676, Percent_Identity=33.5798816568047, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24645774, Length=645, Percent_Identity=37.2093023255814, Blast_Score=361, Evalue=1e-99,
Organism=Drosophila melanogaster, GI17530827, Length=631, Percent_Identity=35.9746434231379, Blast_Score=345, Evalue=7e-95,
Organism=Drosophila melanogaster, GI17647617, Length=724, Percent_Identity=32.5966850828729, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24639835, Length=649, Percent_Identity=33.7442218798151, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24647251, Length=298, Percent_Identity=32.5503355704698, Blast_Score=148, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MCM_SULSO (Q9UXG1)

Other databases:

- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   H90226
- RefSeq:   NP_342281.1
- PDB:   2VL6
- PDB:   3F9V
- PDBsum:   2VL6
- PDBsum:   3F9V
- ProteinModelPortal:   Q9UXG1
- SMR:   Q9UXG1
- DIP:   DIP-42884N
- MINT:   MINT-1896063
- GeneID:   1455038
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0774
- NMPDR:   fig|273057.1.peg.704
- HOGENOM:   HBG546212
- OMA:   IAPRAVY
- PhylomeDB:   Q9UXG1
- ProtClustDB:   CLSK802867
- BioCyc:   SSOL273057:SSO0774-MONOMER
- InterPro:   IPR003593
- InterPro:   IPR001208
- InterPro:   IPR012340
- InterPro:   IPR016027
- Gene3D:   G3DSA:2.40.50.140
- PRINTS:   PR01657
- SMART:   SM00382
- SMART:   SM00350

Pfam domain/function: PF00493 MCM; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 77429; Mature: 77429

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00847 MCM_1; PS50051 MCM_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIPSKQIDYRDVFIEFLTTFKGNNNQNKYIERINELVAYRKKSLIIEFSDVLSFNENLA
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEHHHHHCCCCCE
YEIINNTKIILPILEGALYDHILQLDPTYQRDIEKVHVRIVGIPRVIELRKIRSTDIGKL
EEEECCCEEEEHHHHHHHHHHHHHCCCHHHHHHHEEEEEEECCCHHHHHHHHCCCCCCCE
ITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPEDEEMPEVLEMPTICPKCGKPGQF
EEECCEEEEEEHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCE
RLIPEKTKLIDWQKAVIQERPEEVPSGQLPRQLEIILEDDLVDSARPGDRVKVTGILDIK
EECCCHHHHHHHHHHHHHHCHHCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEEC
QDSPVKRGSRAVFDIYMKVSSIEVSQKVLDEVIISEEDEKKIKDLAKDPWIRDRIISSIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHH
PSIYGHWELKEALALALFGGVPKVLEDTRIRGDIHILIIGDPGTAKSQMLQFISRVAPRA
HHHCCCHHHHHHHHHHHHCCCHHHHHCCEECCCEEEEEEECCCCCHHHHHHHHHHHCCCE
VYTTGKGSTAAGLTAAVVREKGTGEYYLEAGALVLADGGIAVIDEIDKMRDEDRVAIHEA
EEECCCCCCHHHHHHHHHHCCCCCCEEEECCEEEEECCCCHHHHHHHHHCCCHHHHHHHH
MEQQTVSIAKAGIVAKLNARAAVIAAGNPKFGRYISERPVSDNINLPPTILSRFDLIFIL
HHHHHHHHHHCCEEEEECCCEEEEECCCCCHHHHHHCCCCCCCCCCCHHHHCCCCEEEEE
KDQPGEQDRELANYILDVHSGKSTKNIIDIDTLRKYIAYARKYVTPKITSEAKNLITDFF
ECCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VEMRKKSSETPDSPILITPRQLEALIRISEAYAKMALKAEVTREDAERAINIMRLFLESV
HHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVDMESGKIDIDTIMTGKPKSAREKMMKIIEIIDSLAVSSECAKVKDILKEAQQVGIEKS
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
NIEKLLTDMRKSGIIYEAKPECYKKV
HHHHHHHHHHHCCCEEECCCHHHHCC
>Mature Secondary Structure
MEIPSKQIDYRDVFIEFLTTFKGNNNQNKYIERINELVAYRKKSLIIEFSDVLSFNENLA
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEHHHHHCCCCCE
YEIINNTKIILPILEGALYDHILQLDPTYQRDIEKVHVRIVGIPRVIELRKIRSTDIGKL
EEEECCCEEEEHHHHHHHHHHHHHCCCHHHHHHHEEEEEEECCCHHHHHHHHCCCCCCCE
ITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWPEDEEMPEVLEMPTICPKCGKPGQF
EEECCEEEEEEHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCE
RLIPEKTKLIDWQKAVIQERPEEVPSGQLPRQLEIILEDDLVDSARPGDRVKVTGILDIK
EECCCHHHHHHHHHHHHHHCHHCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEEEC
QDSPVKRGSRAVFDIYMKVSSIEVSQKVLDEVIISEEDEKKIKDLAKDPWIRDRIISSIA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHH
PSIYGHWELKEALALALFGGVPKVLEDTRIRGDIHILIIGDPGTAKSQMLQFISRVAPRA
HHHCCCHHHHHHHHHHHHCCCHHHHHCCEECCCEEEEEEECCCCCHHHHHHHHHHHCCCE
VYTTGKGSTAAGLTAAVVREKGTGEYYLEAGALVLADGGIAVIDEIDKMRDEDRVAIHEA
EEECCCCCCHHHHHHHHHHCCCCCCEEEECCEEEEECCCCHHHHHHHHHCCCHHHHHHHH
MEQQTVSIAKAGIVAKLNARAAVIAAGNPKFGRYISERPVSDNINLPPTILSRFDLIFIL
HHHHHHHHHHCCEEEEECCCEEEEECCCCCHHHHHHCCCCCCCCCCCHHHHCCCCEEEEE
KDQPGEQDRELANYILDVHSGKSTKNIIDIDTLRKYIAYARKYVTPKITSEAKNLITDFF
ECCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VEMRKKSSETPDSPILITPRQLEALIRISEAYAKMALKAEVTREDAERAINIMRLFLESV
HHHHHHCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVDMESGKIDIDTIMTGKPKSAREKMMKIIEIIDSLAVSSECAKVKDILKEAQQVGIEKS
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
NIEKLLTDMRKSGIIYEAKPECYKKV
HHHHHHHHHHHCCCEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726