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The map label for this gene is moeA-1 [C]

Identifier: 15897583

GI number: 15897583

Start: 579806

End: 580975

Strand: Direct

Name: moeA-1 [C]

Synonym: SSO0676

Alternate gene names: 15897583

Gene position: 579806-580975 (Clockwise)

Preceding gene: 15897579

Following gene: 15897584

Centisome position: 19.38

GC content: 33.93

Gene sequence:

>1170_bases
GTGGCACTAATTCCAGTTGAAGAGGCTAGAAAAATAATAAGCAATACTAATTTTGAGGTAAAGAGAAGAGAAAAGTACGT
TGAAATCTTTCAAGCACTAGGTAAAATAGCAGTAGAAGATATACTTGCAGTAAAAAGTATGCCCGAAAGATCATTATCAG
CAATGGATGGATATGCAATCAAATATGATGACTATCTAAAATATGGAAAGTTAAGAGTCGTAGGAAAACTATATCCAAGC
ACGTCAAATATTCCAGAATTAAAAGAAGGAGAAACCTATTACGTAACCACCGGTTCACCTTTACCACTATATGCTGATAG
TGTAGTACCAGTTGAAAATTCTAGACTTGAGGGAGAGTATGTTATATTTAAAGGAGAGGTAAAAAAGGGTAAGAACATAA
GGGAAGAGGGAGAAGACATTAACATAGGACAGATAATAATACAAAAAGGTACTGAAATAACTCCCTATTATTTAGGAATT
CTAATACAACAAAAAATCTTTCATGTTAAGGTTTCAGATTTAAAGTTTACAGTTTTTGCTAATGGAGACGAAATAACTAG
CTTTGAAAATCCACAGAAAAATAAGATTATAGATTCCATCTCACCGATACTGATCAAAATTCTCGAGAAATTCGGTAGTG
TGAAATATATGGGAGTTGCGAAGGACGATTTAAATGATGTAACGGAAAAAATTGAAAAATCATTAGAAATTTCGGATGTA
ATAATATCTGTAGGAGGATCATCGGTTGGCGAAAAAGATTACGTAAAAAAGGCCGTAAATAAACTGGGAGAGGTGCTATT
CGATGGCGTATCCGTAAATACAATTAAGAGAGGTAGTGTGGGCAGAATTCAAGGAAAACCAATATTGATATTACCAGGAC
AAGTAGTATCTGCTATAACTGCGTTTCATGAATTTGGTCTTTCAGTATTGTCTAATATATTAGGTACTAATCTAAAGAAG
TTTATAAAAAGTACTCTTGTAGAGGACATCTATGTTAATCACTCTATGGATTCAGTATACCTATTTAATGTTAAGGGGAA
CTCAGCATTTCCGCTTAGATGGGGCGTAGGTTTGTACAGCGAATTAGCTAAAGCTAATGGATTTGCAATTCTCAAGAGAG
GTTTAACTTATAAGAAAGGGGAAGAAGTTGAGTTACAACAACTCATATGA

Upstream 100 bases:

>100_bases
ATACGCTCTCAATAACACTTGTCTTTCCCGTATCTTTTTTACCTATAATATGAAATATGCATGCCATATCATATATTAAT
GTGGGGTAAAATATTAAATT

Downstream 100 bases:

>100_bases
TGTTATAATACTAGCTGGGGGACTATCGAAAAGATTTGGAGCTGATAAATGTTGCTTCGAGGTAAATTCAAAGACAATGT
TGGATAGGTTACTAGAGCAA

Product: molybdopterin biosynthesis protein (moeA-1)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MALIPVEEARKIISNTNFEVKRREKYVEIFQALGKIAVEDILAVKSMPERSLSAMDGYAIKYDDYLKYGKLRVVGKLYPS
TSNIPELKEGETYYVTTGSPLPLYADSVVPVENSRLEGEYVIFKGEVKKGKNIREEGEDINIGQIIIQKGTEITPYYLGI
LIQQKIFHVKVSDLKFTVFANGDEITSFENPQKNKIIDSISPILIKILEKFGSVKYMGVAKDDLNDVTEKIEKSLEISDV
IISVGGSSVGEKDYVKKAVNKLGEVLFDGVSVNTIKRGSVGRIQGKPILILPGQVVSAITAFHEFGLSVLSNILGTNLKK
FIKSTLVEDIYVNHSMDSVYLFNVKGNSAFPLRWGVGLYSELAKANGFAILKRGLTYKKGEEVELQQLI

Sequences:

>Translated_389_residues
MALIPVEEARKIISNTNFEVKRREKYVEIFQALGKIAVEDILAVKSMPERSLSAMDGYAIKYDDYLKYGKLRVVGKLYPS
TSNIPELKEGETYYVTTGSPLPLYADSVVPVENSRLEGEYVIFKGEVKKGKNIREEGEDINIGQIIIQKGTEITPYYLGI
LIQQKIFHVKVSDLKFTVFANGDEITSFENPQKNKIIDSISPILIKILEKFGSVKYMGVAKDDLNDVTEKIEKSLEISDV
IISVGGSSVGEKDYVKKAVNKLGEVLFDGVSVNTIKRGSVGRIQGKPILILPGQVVSAITAFHEFGLSVLSNILGTNLKK
FIKSTLVEDIYVNHSMDSVYLFNVKGNSAFPLRWGVGLYSELAKANGFAILKRGLTYKKGEEVELQQLI
>Mature_388_residues
ALIPVEEARKIISNTNFEVKRREKYVEIFQALGKIAVEDILAVKSMPERSLSAMDGYAIKYDDYLKYGKLRVVGKLYPST
SNIPELKEGETYYVTTGSPLPLYADSVVPVENSRLEGEYVIFKGEVKKGKNIREEGEDINIGQIIIQKGTEITPYYLGIL
IQQKIFHVKVSDLKFTVFANGDEITSFENPQKNKIIDSISPILIKILEKFGSVKYMGVAKDDLNDVTEKIEKSLEISDVI
ISVGGSSVGEKDYVKKAVNKLGEVLFDGVSVNTIKRGSVGRIQGKPILILPGQVVSAITAFHEFGLSVLSNILGTNLKKF
IKSTLVEDIYVNHSMDSVYLFNVKGNSAFPLRWGVGLYSELAKANGFAILKRGLTYKKGEEVELQQLI

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=369, Percent_Identity=26.2872628726287, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI66932975, Length=369, Percent_Identity=26.2872628726287, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1787049, Length=295, Percent_Identity=29.8305084745763, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25147659, Length=330, Percent_Identity=29.3939393939394, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17562606, Length=223, Percent_Identity=28.2511210762332, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17136978, Length=348, Percent_Identity=29.5977011494253, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24638841, Length=348, Percent_Identity=29.5977011494253, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43236; Mature: 43104

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIPVEEARKIISNTNFEVKRREKYVEIFQALGKIAVEDILAVKSMPERSLSAMDGYAI
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEE
KYDDYLKYGKLRVVGKLYPSTSNIPELKEGETYYVTTGSPLPLYADSVVPVENSRLEGEY
EEHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCEECCCEECCCCCCCCCCE
VIFKGEVKKGKNIREEGEDINIGQIIIQKGTEITPYYLGILIQQKIFHVKVSDLKFTVFA
EEEECCCCCCCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHEEEEEECEEEEEEE
NGDEITSFENPQKNKIIDSISPILIKILEKFGSVKYMGVAKDDLNDVTEKIEKSLEISDV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHCCCHHHE
IISVGGSSVGEKDYVKKAVNKLGEVLFDGVSVNTIKRGSVGRIQGKPILILPGQVVSAIT
EEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCEEEEECHHHHHHHH
AFHEFGLSVLSNILGTNLKKFIKSTLVEDIYVNHSMDSVYLFNVKGNSAFPLRWGVGLYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECHHHHH
ELAKANGFAILKRGLTYKKGEEVELQQLI
HHHHCCCHHEECCCCCCCCCCCCHHHHCC
>Mature Secondary Structure 
ALIPVEEARKIISNTNFEVKRREKYVEIFQALGKIAVEDILAVKSMPERSLSAMDGYAI
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEE
KYDDYLKYGKLRVVGKLYPSTSNIPELKEGETYYVTTGSPLPLYADSVVPVENSRLEGEY
EEHHHHHCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCCCEECCCEECCCCCCCCCCE
VIFKGEVKKGKNIREEGEDINIGQIIIQKGTEITPYYLGILIQQKIFHVKVSDLKFTVFA
EEEECCCCCCCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHEEEEEECEEEEEEE
NGDEITSFENPQKNKIIDSISPILIKILEKFGSVKYMGVAKDDLNDVTEKIEKSLEISDV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHCCCHHHE
IISVGGSSVGEKDYVKKAVNKLGEVLFDGVSVNTIKRGSVGRIQGKPILILPGQVVSAIT
EEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCEEEEECHHHHHHHH
AFHEFGLSVLSNILGTNLKKFIKSTLVEDIYVNHSMDSVYLFNVKGNSAFPLRWGVGLYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECHHHHH
ELAKANGFAILKRGLTYKKGEEVELQQLI
HHHHCCCHHEECCCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]