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The map label for this gene is purQ

Identifier: 15897544

GI number: 15897544

Start: 543785

End: 544459

Strand: Direct

Name: purQ

Synonym: SSO0628

Alternate gene names: 15897544

Gene position: 543785-544459 (Clockwise)

Preceding gene: 15897543

Following gene: 15897545

Centisome position: 18.17

GC content: 37.78

Gene sequence:

>675_bases
ATGATTGCAATAATTAAGTTCCCAGGGACTACTTGCGAAACTGATGTCTATAAGGCATTAATAGAGGCTGGAGTTCCCAC
AGTGATAGTAAAGTACAAGGACTTCGATCCAGATAGATATAATGGAGTAATTTTACCAGGGGGATTTAGCTTTGGAGACT
ATCTAAGGGCTGGAAGTATCGCAGCTAGTACGGAAACTATGAAAAAAGTCAAGCAAATGGCAGAGGATGGAAAAATAGTA
ATTGGAATATGTAATGGTTTCCAGATCCTTGTGGAAAGCGGGCTTTTAAAAGGAGCATTGCTTCCTAATTTAAAATTAAG
ATTTATCTCGAAGTGGGTTTACCTTAAGGTAATTAGGGCTGACACAATTCTAACCAAAGGATTAGATAAGAAAATAATAA
GAATGCCCATAGCACATGCGGAAGGTCGATATTATGTGGATGATATAGATTATGCAAAGACACATATGGTTCTCCAATAC
TGTGATGAGAATGGAAATATTAGTGAAGATGTCAATCCAAATGGATCATTACTTAATATAGCCTCAATAGCTAACGAGGA
AGGGAATGTAATAGGAATGATGCCACATCCAGAAAGGGCTTCCTTTAAACTGACTTCAATTGACGGAACTGTTGACGGGT
TAATTCTTTTGAGGAGGTTAGGAGAATGGGCATAA

Upstream 100 bases:

>100_bases
ATAATGAAGAGGATGCAAAGAATTTAATTGAAAAAATTGCCAATGAGGGAAGATTATACAATCCGATAATTCATAAAATA
CTCGTTAGAGTGAGAAGAGA

Downstream 100 bases:

>100_bases
ATCTTCTCCCTATAGAGATGGACGAGATTCGAAAAAGACTAGGTAGAGAACCTAATGAGACCGAATGGAGAGTTATTGAT
GCAGTATGGTCAGAGCATTG

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MIAIIKFPGTTCETDVYKALIEAGVPTVIVKYKDFDPDRYNGVILPGGFSFGDYLRAGSIAASTETMKKVKQMAEDGKIV
IGICNGFQILVESGLLKGALLPNLKLRFISKWVYLKVIRADTILTKGLDKKIIRMPIAHAEGRYYVDDIDYAKTHMVLQY
CDENGNISEDVNPNGSLLNIASIANEEGNVIGMMPHPERASFKLTSIDGTVDGLILLRRLGEWA

Sequences:

>Translated_224_residues
MIAIIKFPGTTCETDVYKALIEAGVPTVIVKYKDFDPDRYNGVILPGGFSFGDYLRAGSIAASTETMKKVKQMAEDGKIV
IGICNGFQILVESGLLKGALLPNLKLRFISKWVYLKVIRADTILTKGLDKKIIRMPIAHAEGRYYVDDIDYAKTHMVLQY
CDENGNISEDVNPNGSLLNIASIANEEGNVIGMMPHPERASFKLTSIDGTVDGLILLRRLGEWA
>Mature_224_residues
MIAIIKFPGTTCETDVYKALIEAGVPTVIVKYKDFDPDRYNGVILPGGFSFGDYLRAGSIAASTETMKKVKQMAEDGKIV
IGICNGFQILVESGLLKGALLPNLKLRFISKWVYLKVIRADTILTKGLDKKIIRMPIAHAEGRYYVDDIDYAKTHMVLQY
CDENGNISEDVNPNGSLLNIASIANEEGNVIGMMPHPERASFKLTSIDGTVDGLILLRRLGEWA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI31657129, Length=239, Percent_Identity=25.1046025104602, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI48994899, Length=222, Percent_Identity=27.4774774774775, Blast_Score=85, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17553022, Length=231, Percent_Identity=26.4069264069264, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24582111, Length=229, Percent_Identity=27.5109170305677, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24582109, Length=229, Percent_Identity=27.5109170305677, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17137292, Length=229, Percent_Identity=27.5109170305677, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_SULSO (Q9UX21)

Other databases:

- EMBL:   Y18930
- EMBL:   AE006641
- PIR:   D90210
- RefSeq:   NP_342149.1
- ProteinModelPortal:   Q9UX21
- SMR:   Q9UX21
- GeneID:   1454906
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0628
- NMPDR:   fig|273057.1.peg.572
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BioCyc:   SSOL273057:SSO0628-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR010075
- InterPro:   IPR002818
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF01965 DJ-1_PfpI

EC number: =6.3.5.3

Molecular weight: Translated: 24686; Mature: 24686

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 84-84 ACT_SITE 196-196 ACT_SITE 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIIKFPGTTCETDVYKALIEAGVPTVIVKYKDFDPDRYNGVILPGGFSFGDYLRAGSI
CEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCHHHHHHCCCC
AASTETMKKVKQMAEDGKIVIGICNGFQILVESGLLKGALLPNLKLRFISKWVYLKVIRA
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHCCCCCCCCCCCHHHHHHHHHHEEEEEHH
DTILTKGLDKKIIRMPIAHAEGRYYVDDIDYAKTHMVLQYCDENGNISEDVNPNGSLLNI
HHHHHCCCCHHHHHCCCCCCCCCEEECCCCHHHHHHEEEEECCCCCCCCCCCCCCCEEEE
ASIANEEGNVIGMMPHPERASFKLTSIDGTVDGLILLRRLGEWA
EECCCCCCCEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MIAIIKFPGTTCETDVYKALIEAGVPTVIVKYKDFDPDRYNGVILPGGFSFGDYLRAGSI
CEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCEEEECCCCHHHHHHCCCC
AASTETMKKVKQMAEDGKIVIGICNGFQILVESGLLKGALLPNLKLRFISKWVYLKVIRA
HHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHCCCCCCCCCCCHHHHHHHHHHEEEEEHH
DTILTKGLDKKIIRMPIAHAEGRYYVDDIDYAKTHMVLQYCDENGNISEDVNPNGSLLNI
HHHHHCCCCHHHHHCCCCCCCCCEEECCCCHHHHHHEEEEECCCCCCCCCCCCCCCEEEE
ASIANEEGNVIGMMPHPERASFKLTSIDGTVDGLILLRRLGEWA
EECCCCCCCEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726