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The map label for this gene is pcnA-1 [H]

Identifier: 15897339

GI number: 15897339

Start: 355009

End: 355788

Strand: Direct

Name: pcnA-1 [H]

Synonym: SSO0405

Alternate gene names: 15897339

Gene position: 355009-355788 (Clockwise)

Preceding gene: 15897337

Following gene: 15897340

Centisome position: 11.86

GC content: 34.23

Gene sequence:

>780_bases
ATGATATATCTTAAATCTTTTGAAAGGAATATAAGATTGATTAACATGAAAGTAGTTTACGATGATGTAAGGGTTCTTAA
AGATATCATACAAGCCTTAGCCAGGTTAGTTGATGAAGCGGTATTAAAGTTTAAGCAAGACAGCGTAGAGTTAGTCGCGC
TAGATAGAGCTCATATTTCCCTTATATCAGTAAACTTGCCTAGAGAGATGTTTAAGGAGTATGATGTAAATGACGAATTT
AAATTTGGCTTTAATACTCAATATTTAATGAAAATTTTGAAAGTAGCCAAGAGAAAAGAGGCAATAGAGATAGCTAGTGA
ATCTCCAGACAGTGTTATCATAAATATTATAGGGAGTACTAATAGAGAATTTAATGTTAGGAACCTAGAGGTATCTGAAC
AAGAGATACCAGAGATCAATCTACAATTTGATATATCAGCGACTATTTCCTCAGATGGTTTTAAGTCTGCTATATCAGAA
GTTTCCACAGTTACGGATAATGTAGTTGTAGAGGGCCACGAAGATAGAATACTAATTAAGGCTGAAGGTGAAAGCGAGGT
TGAAGTTGAATTTTCAAAAGATACCGGAGGTCTTCAAGATTTGGAATTCTCTAAAGAGTCCAAGAATTCATATTCCGCGG
AATATCTTGATGACGTCTTATCTTTAACTAAACTTTCAGATTATGTGAAGATTTCATTCGGTAATCAGAAGCCCCTTCAG
TTATTCTTTAATATGGAGGGAGGGGGGAAAGTTACTTATTTATTAGCTCCAAAAGTTTGA

Upstream 100 bases:

>100_bases
TCCACTTCTATCTGATGATAACAATATCCTTTTCATTGCTATTAGAAGTATATATTTAAAAGGTAGTTAAATCTTGTGAA
TCTTTAGTTAAATTGAAAGT

Downstream 100 bases:

>100_bases
TAATGAATGTGAAAAAAGCCTTAGTGGGTAGTTTTCCAAAAAATCCAAAATTAGGGAAAGTAATTTCATGGTACAATACA
GGCAAGATAAATAAGGAGAA

Product: proliferating cell nuclear antigen

Products: NA

Alternate protein names: Proliferating cell nuclear antigen homolog A; PCNA A [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MIYLKSFERNIRLINMKVVYDDVRVLKDIIQALARLVDEAVLKFKQDSVELVALDRAHISLISVNLPREMFKEYDVNDEF
KFGFNTQYLMKILKVAKRKEAIEIASESPDSVIINIIGSTNREFNVRNLEVSEQEIPEINLQFDISATISSDGFKSAISE
VSTVTDNVVVEGHEDRILIKAEGESEVEVEFSKDTGGLQDLEFSKESKNSYSAEYLDDVLSLTKLSDYVKISFGNQKPLQ
LFFNMEGGGKVTYLLAPKV

Sequences:

>Translated_259_residues
MIYLKSFERNIRLINMKVVYDDVRVLKDIIQALARLVDEAVLKFKQDSVELVALDRAHISLISVNLPREMFKEYDVNDEF
KFGFNTQYLMKILKVAKRKEAIEIASESPDSVIINIIGSTNREFNVRNLEVSEQEIPEINLQFDISATISSDGFKSAISE
VSTVTDNVVVEGHEDRILIKAEGESEVEVEFSKDTGGLQDLEFSKESKNSYSAEYLDDVLSLTKLSDYVKISFGNQKPLQ
LFFNMEGGGKVTYLLAPKV
>Mature_259_residues
MIYLKSFERNIRLINMKVVYDDVRVLKDIIQALARLVDEAVLKFKQDSVELVALDRAHISLISVNLPREMFKEYDVNDEF
KFGFNTQYLMKILKVAKRKEAIEIASESPDSVIINIIGSTNREFNVRNLEVSEQEIPEINLQFDISATISSDGFKSAISE
VSTVTDNVVVEGHEDRILIKAEGESEVEVEFSKDTGGLQDLEFSKESKNSYSAEYLDDVLSLTKLSDYVKISFGNQKPLQ
LFFNMEGGGKVTYLLAPKV

Specific function: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication [H]

COG id: COG0592

COG function: function code L; DNA polymerase sliding clamp subunit (PCNA homolog)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PCNA family [H]

Homologues:

Organism=Homo sapiens, GI33239451, Length=247, Percent_Identity=24.2914979757085, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4505641, Length=247, Percent_Identity=24.2914979757085, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319564, Length=253, Percent_Identity=22.5296442687747, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585303, Length=242, Percent_Identity=23.9669421487603, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17136790, Length=249, Percent_Identity=23.6947791164659, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45552759, Length=249, Percent_Identity=23.6947791164659, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000730
- InterPro:   IPR022649
- InterPro:   IPR022659
- InterPro:   IPR022648 [H]

Pfam domain/function: PF02747 PCNA_C; PF00705 PCNA_N [H]

EC number: NA

Molecular weight: Translated: 29352; Mature: 29352

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS01251 PCNA_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYLKSFERNIRLINMKVVYDDVRVLKDIIQALARLVDEAVLKFKQDSVELVALDRAHIS
CEEEECCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEE
LISVNLPREMFKEYDVNDEFKFGFNTQYLMKILKVAKRKEAIEIASESPDSVIINIIGST
EEEECCCHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
NREFNVRNLEVSEQEIPEINLQFDISATISSDGFKSAISEVSTVTDNVVVEGHEDRILIK
CCEEEEEEEEECHHHCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCEEEEE
AEGESEVEVEFSKDTGGLQDLEFSKESKNSYSAEYLDDVLSLTKLSDYVKISFGNQKPLQ
ECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCEE
LFFNMEGGGKVTYLLAPKV
EEEEECCCCEEEEEECCCC
>Mature Secondary Structure
MIYLKSFERNIRLINMKVVYDDVRVLKDIIQALARLVDEAVLKFKQDSVELVALDRAHIS
CEEEECCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEE
LISVNLPREMFKEYDVNDEFKFGFNTQYLMKILKVAKRKEAIEIASESPDSVIINIIGST
EEEECCCHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECC
NREFNVRNLEVSEQEIPEINLQFDISATISSDGFKSAISEVSTVTDNVVVEGHEDRILIK
CCEEEEEEEEECHHHCCEEEEEEEEEEEECCCHHHHHHHHHHHCCCCEEEECCCCEEEEE
AEGESEVEVEFSKDTGGLQDLEFSKESKNSYSAEYLDDVLSLTKLSDYVKISFGNQKPLQ
ECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCEE
LFFNMEGGGKVTYLLAPKV
EEEEECCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10438605; 11427726 [H]