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The map label for this gene is fadD-1 [H]

Identifier: 15897304

GI number: 15897304

Start: 313601

End: 314965

Strand: Reverse

Name: fadD-1 [H]

Synonym: SSO0369

Alternate gene names: 15897304

Gene position: 314965-313601 (Counterclockwise)

Preceding gene: 15897309

Following gene: 15897303

Centisome position: 10.53

GC content: 37.58

Gene sequence:

>1365_bases
GTGAGTCTTGCAACATTACTCTATAAATGGTTTAAAGAAACGCCTTCAAAAACCTTTTTAATTGACAAAAATCAGTCACT
TACCTATGAACAAGTTACGAGAGAAGTAGTATATGTAGCTTCCAACATCTCACCTGGAGATACTGTAGTCCATATAATGT
TAAACTCTCTGCAGTCAGTGATTAATTACTTAGCAATATTTTGGGCAGGCGGTAAGGCAGTTGCAGTTGACCCGCAAACT
TCAGCAGAAGATTTAAAGTTCATATTGGAGGATTCAAACCCTGACCTAATAGTAACCGACGAGGAGATATACAAGAGAGA
GTACGATATTCTCAAATCGTACCAGGTGATAGTGAATAAGAGAGGAAAAGACGTTTTTACAAAACCTTATGAGTACAGAG
AGGATGAGGTCGGCTTAGTTTACTATTATGCTGGAATAGTAGGAAGGACAATGCAAGTACTGCATAGCGCTAACAGAGTT
GAACTCAATTCTGCGACGCTCTACAATTCTATTGGCCTTAAAGAGATTAGGGGAATACTAACAGTTCCTTTAGCTCACGT
CTTAGGAAATAGCGTGTTAGGTATTACCTTGGAAGCTGGTGGCAAGTTATATATTATGAGTAAGTTTAACGTCGATGAGG
CTATTGAAAGTATAAACAAATATAACATAAATTATCTATCAACTGTCCCAACTGTTTACGATTACTTAAATAACGAGGAA
AAAAGGAAAGTAGATAGTTTAGAACTGTGTGTAAGTTCTGCTGCACCACTGTATCCATCGACCGTAAATACATTTAAGAG
TAAATACGGAAAGGATATTGTTCAACAATACGGCTTTACTGAGGGTTTAATTCTAACTTTCCAACCCAAAGAGCTATCTG
GAGTAATTTCGATAGGAAAACCTTTGCCTGGCGTTGAGATAAAGATAGTAGATGATAAGGGCAATGAGAATAATGAGGGA
GAATTGTGGGTTAAGGCTCCTTGGCTCATGCTAGGATATAAAGATAGAGAGGAGACGGCCAGAGTATTTAATGAGGGGTG
GCTAAGAACAGGTGATTTAGTTAAGATTGATGAAAAGGGCTTATTGTATTTTAGAGGAGTCAAAAAGAGGATGTTGAAAT
TTAAGGGCTACCCGATATTTCCAAGAGATTTAGAAGAGATCTTAAAGACTCATCCAATGGTTGAAGACGTAAAAGTTATA
GGGGAAGATGCTGGAAATCTAGGACAGCAACCCGTTGCCTTAGTTAAGGTAAAGGAGCACAAAGCCGGAATTGAGGATGA
ATTACTTAATTATGTAAATTCTAGGGTAGCTTTTTATAAGAGATTGAAGAAAGTTTATGTGGTAGATAGGATTGAGCGAA
ATTGA

Upstream 100 bases:

>100_bases
CATATTTTCCCTCAAGATCAAACAAGGTAATATGAATTCGTGATAATCCGACGATCTTTATCATAAGAATTAATAAGATT
GTGTAATAAAAAAGGAAACT

Downstream 100 bases:

>100_bases
CTCATTAATTAAGGAGGTTGCTGAAAGATTACAAAAGAAGGCTGAGGAATATGGTAAAAAGAAGGAGGATGTTACATTAG
TCTTAACTGAAGAGAACTTC

Product: acyl-CoA synthase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSLATLLYKWFKETPSKTFLIDKNQSLTYEQVTREVVYVASNISPGDTVVHIMLNSLQSVINYLAIFWAGGKAVAVDPQT
SAEDLKFILEDSNPDLIVTDEEIYKREYDILKSYQVIVNKRGKDVFTKPYEYREDEVGLVYYYAGIVGRTMQVLHSANRV
ELNSATLYNSIGLKEIRGILTVPLAHVLGNSVLGITLEAGGKLYIMSKFNVDEAIESINKYNINYLSTVPTVYDYLNNEE
KRKVDSLELCVSSAAPLYPSTVNTFKSKYGKDIVQQYGFTEGLILTFQPKELSGVISIGKPLPGVEIKIVDDKGNENNEG
ELWVKAPWLMLGYKDREETARVFNEGWLRTGDLVKIDEKGLLYFRGVKKRMLKFKGYPIFPRDLEEILKTHPMVEDVKVI
GEDAGNLGQQPVALVKVKEHKAGIEDELLNYVNSRVAFYKRLKKVYVVDRIERN

Sequences:

>Translated_454_residues
MSLATLLYKWFKETPSKTFLIDKNQSLTYEQVTREVVYVASNISPGDTVVHIMLNSLQSVINYLAIFWAGGKAVAVDPQT
SAEDLKFILEDSNPDLIVTDEEIYKREYDILKSYQVIVNKRGKDVFTKPYEYREDEVGLVYYYAGIVGRTMQVLHSANRV
ELNSATLYNSIGLKEIRGILTVPLAHVLGNSVLGITLEAGGKLYIMSKFNVDEAIESINKYNINYLSTVPTVYDYLNNEE
KRKVDSLELCVSSAAPLYPSTVNTFKSKYGKDIVQQYGFTEGLILTFQPKELSGVISIGKPLPGVEIKIVDDKGNENNEG
ELWVKAPWLMLGYKDREETARVFNEGWLRTGDLVKIDEKGLLYFRGVKKRMLKFKGYPIFPRDLEEILKTHPMVEDVKVI
GEDAGNLGQQPVALVKVKEHKAGIEDELLNYVNSRVAFYKRLKKVYVVDRIERN
>Mature_453_residues
SLATLLYKWFKETPSKTFLIDKNQSLTYEQVTREVVYVASNISPGDTVVHIMLNSLQSVINYLAIFWAGGKAVAVDPQTS
AEDLKFILEDSNPDLIVTDEEIYKREYDILKSYQVIVNKRGKDVFTKPYEYREDEVGLVYYYAGIVGRTMQVLHSANRVE
LNSATLYNSIGLKEIRGILTVPLAHVLGNSVLGITLEAGGKLYIMSKFNVDEAIESINKYNINYLSTVPTVYDYLNNEEK
RKVDSLELCVSSAAPLYPSTVNTFKSKYGKDIVQQYGFTEGLILTFQPKELSGVISIGKPLPGVEIKIVDDKGNENNEGE
LWVKAPWLMLGYKDREETARVFNEGWLRTGDLVKIDEKGLLYFRGVKKRMLKFKGYPIFPRDLEEILKTHPMVEDVKVIG
EDAGNLGQQPVALVKVKEHKAGIEDELLNYVNSRVAFYKRLKKVYVVDRIERN

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=506, Percent_Identity=25.4940711462451, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI187761343, Length=506, Percent_Identity=25.4940711462451, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI156151445, Length=498, Percent_Identity=25.1004016064257, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI42544132, Length=265, Percent_Identity=27.5471698113208, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI38505220, Length=466, Percent_Identity=21.4592274678112, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI115511026, Length=345, Percent_Identity=25.2173913043478, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI157311624, Length=340, Percent_Identity=23.8235294117647, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI157311622, Length=340, Percent_Identity=23.8235294117647, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI58082049, Length=459, Percent_Identity=22.4400871459695, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI122937307, Length=420, Percent_Identity=22.6190476190476, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788107, Length=471, Percent_Identity=25.6900212314225, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI145693145, Length=511, Percent_Identity=23.8747553816047, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1786810, Length=450, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788595, Length=265, Percent_Identity=25.6603773584906, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI32563687, Length=468, Percent_Identity=26.0683760683761, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17531443, Length=478, Percent_Identity=24.8953974895398, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17559526, Length=279, Percent_Identity=31.1827956989247, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17558820, Length=476, Percent_Identity=24.3697478991597, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560140, Length=501, Percent_Identity=25.3493013972056, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=439, Percent_Identity=25.7403189066059, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17557194, Length=459, Percent_Identity=23.9651416122004, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71985884, Length=333, Percent_Identity=27.027027027027, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17538037, Length=459, Percent_Identity=23.5294117647059, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71994703, Length=504, Percent_Identity=22.2222222222222, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71994694, Length=504, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71994690, Length=504, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17556552, Length=182, Percent_Identity=29.6703296703297, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=459, Percent_Identity=23.7472766884532, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI18859661, Length=347, Percent_Identity=30.5475504322767, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21355181, Length=342, Percent_Identity=28.3625730994152, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24581924, Length=314, Percent_Identity=28.0254777070064, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356947, Length=495, Percent_Identity=24.040404040404, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI20130357, Length=346, Percent_Identity=25.4335260115607, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24653035, Length=186, Percent_Identity=35.4838709677419, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24648253, Length=199, Percent_Identity=30.6532663316583, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI161076582, Length=133, Percent_Identity=36.8421052631579, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356441, Length=393, Percent_Identity=23.9185750636132, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648255, Length=199, Percent_Identity=30.1507537688442, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 51563; Mature: 51432

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLATLLYKWFKETPSKTFLIDKNQSLTYEQVTREVVYVASNISPGDTVVHIMLNSLQSV
CCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHH
INYLAIFWAGGKAVAVDPQTSAEDLKFILEDSNPDLIVTDEEIYKREYDILKSYQVIVNK
HHHHHHHEECCEEEEECCCCCHHHHHEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHCC
RGKDVFTKPYEYREDEVGLVYYYAGIVGRTMQVLHSANRVELNSATLYNSIGLKEIRGIL
CCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCEEECCHHHHHCCCHHHHHHHH
TVPLAHVLGNSVLGITLEAGGKLYIMSKFNVDEAIESINKYNINYLSTVPTVYDYLNNEE
HHHHHHHHCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHCCCEEEHHHHHHHHHHCCHH
KRKVDSLELCVSSAAPLYPSTVNTFKSKYGKDIVQQYGFTEGLILTFQPKELSGVISIGK
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHCCEEECCC
PLPGVEIKIVDDKGNENNEGELWVKAPWLMLGYKDREETARVFNEGWLRTGDLVKIDEKG
CCCCCEEEEECCCCCCCCCCEEEEECCEEEECCCCHHHHHHHHHCCCCCCCCEEEECCCC
LLYFRGVKKRMLKFKGYPIFPRDLEEILKTHPMVEDVKVIGEDAGNLGQQPVALVKVKEH
EEEEHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEEEHH
KAGIEDELLNYVNSRVAFYKRLKKVYVVDRIERN
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLATLLYKWFKETPSKTFLIDKNQSLTYEQVTREVVYVASNISPGDTVVHIMLNSLQSV
CHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHH
INYLAIFWAGGKAVAVDPQTSAEDLKFILEDSNPDLIVTDEEIYKREYDILKSYQVIVNK
HHHHHHHEECCEEEEECCCCCHHHHHEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHCC
RGKDVFTKPYEYREDEVGLVYYYAGIVGRTMQVLHSANRVELNSATLYNSIGLKEIRGIL
CCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHCCCCEEECCHHHHHCCCHHHHHHHH
TVPLAHVLGNSVLGITLEAGGKLYIMSKFNVDEAIESINKYNINYLSTVPTVYDYLNNEE
HHHHHHHHCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHCCCEEEHHHHHHHHHHCCHH
KRKVDSLELCVSSAAPLYPSTVNTFKSKYGKDIVQQYGFTEGLILTFQPKELSGVISIGK
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHCCEEECCC
PLPGVEIKIVDDKGNENNEGELWVKAPWLMLGYKDREETARVFNEGWLRTGDLVKIDEKG
CCCCCEEEEECCCCCCCCCCEEEEECCEEEECCCCHHHHHHHHHCCCCCCCCEEEECCCC
LLYFRGVKKRMLKFKGYPIFPRDLEEILKTHPMVEDVKVIGEDAGNLGQQPVALVKVKEH
EEEEHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEEEEHH
KAGIEDELLNYVNSRVAFYKRLKKVYVVDRIERN
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]