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The map label for this gene is folE [H]

Identifier: 15897299

GI number: 15897299

Start: 309522

End: 310148

Strand: Direct

Name: folE [H]

Synonym: SSO0364

Alternate gene names: 15897299

Gene position: 309522-310148 (Clockwise)

Preceding gene: 15897298

Following gene: 15897300

Centisome position: 10.34

GC content: 36.36

Gene sequence:

>627_bases
ATGCAAAAGACAGAATTAGACGACCAAAAATTAGTAGAAGAAATAGCTAGAAGGATTAGAGAAATTCTAGAACTACTGGG
TGAGAATCCGGAGAGAGAAGGGCTTAAAGAGACGCCTGAAAGAGTAGCAAAGGCTTTATTAGAAATGACCTCAGGGTTGA
GAACACCGCCTCCTCAAATAAAGGTTTTCAATTTAGGCGACGATGGTGAAGTATACGAAAAGAATCAAATAGTACTAATA
AAAGACGTTAACTTTTCGTCATTGTGTGAGCATCACATGTTGCCAATTATCGGAAAAATTCATGTAGCGTATATTGTTAG
TAATAGCGGTAAGGTAGCTGGTTTTAGCAAAATAATTAGAATTGTGAATTACTATTCTTCACGTCTCCAAATCCAAGAGA
GATTAGTAGAACAAATAGCTGATGCGATAATGAATAGCGAAATAAAGCCTAAAGGTGTCATGGTGATCGGGAACGCAATA
CATATGTGTTCATATGTCAGGGGAGTAAAGGATAAAGAGGCTAAGTTAGTTTCAGTAGCTTACAGAGGACTGTTTAAGAC
TAATAGGGCTTTACAAAATCATGTATTTAGGCTACTCGATAATGCAAATAAGGTAAACTTATTATAG

Upstream 100 bases:

>100_bases
CTAAAGGAAAGCCCATCGTGCTAGAAACTGCTTATAAACTGTTGTAGAAGTTTTTTAACAAAATAGTTATATTAGATTTC
TTCACTAAACTATAAACGGT

Downstream 100 bases:

>100_bases
AGTTTTTTAGAATAATTAATTGTTAATGGGCAGTAAAGATAAAGTTATATCTATATTGAAGGAAAAAGGTCCTATATCCC
AAACTGAATTAAGTAAACTT

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MQKTELDDQKLVEEIARRIREILELLGENPEREGLKETPERVAKALLEMTSGLRTPPPQIKVFNLGDDGEVYEKNQIVLI
KDVNFSSLCEHHMLPIIGKIHVAYIVSNSGKVAGFSKIIRIVNYYSSRLQIQERLVEQIADAIMNSEIKPKGVMVIGNAI
HMCSYVRGVKDKEAKLVSVAYRGLFKTNRALQNHVFRLLDNANKVNLL

Sequences:

>Translated_208_residues
MQKTELDDQKLVEEIARRIREILELLGENPEREGLKETPERVAKALLEMTSGLRTPPPQIKVFNLGDDGEVYEKNQIVLI
KDVNFSSLCEHHMLPIIGKIHVAYIVSNSGKVAGFSKIIRIVNYYSSRLQIQERLVEQIADAIMNSEIKPKGVMVIGNAI
HMCSYVRGVKDKEAKLVSVAYRGLFKTNRALQNHVFRLLDNANKVNLL
>Mature_208_residues
MQKTELDDQKLVEEIARRIREILELLGENPEREGLKETPERVAKALLEMTSGLRTPPPQIKVFNLGDDGEVYEKNQIVLI
KDVNFSSLCEHHMLPIIGKIHVAYIVSNSGKVAGFSKIIRIVNYYSSRLQIQERLVEQIADAIMNSEIKPKGVMVIGNAI
HMCSYVRGVKDKEAKLVSVAYRGLFKTNRALQNHVFRLLDNANKVNLL

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=198, Percent_Identity=36.8686868686869, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI4503949, Length=198, Percent_Identity=36.8686868686869, Blast_Score=134, Evalue=6e-32,
Organism=Homo sapiens, GI66932970, Length=168, Percent_Identity=38.0952380952381, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI66932972, Length=155, Percent_Identity=39.3548387096774, Blast_Score=111, Evalue=4e-25,
Organism=Escherichia coli, GI1788476, Length=201, Percent_Identity=33.3333333333333, Blast_Score=101, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17560486, Length=181, Percent_Identity=36.4640883977901, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321706, Length=184, Percent_Identity=39.1304347826087, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24656791, Length=197, Percent_Identity=37.5634517766497, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24656782, Length=197, Percent_Identity=37.5634517766497, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24656796, Length=197, Percent_Identity=37.5634517766497, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 23579; Mature: 23579

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKTELDDQKLVEEIARRIREILELLGENPEREGLKETPERVAKALLEMTSGLRTPPPQI
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
KVFNLGDDGEVYEKNQIVLIKDVNFSSLCEHHMLPIIGKIHVAYIVSNSGKVAGFSKIIR
EEEECCCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHH
IVNYYSSRLQIQERLVEQIADAIMNSEIKPKGVMVIGNAIHMCSYVRGVKDKEAKLVSVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHCCCCHHHHHHHHH
YRGLFKTNRALQNHVFRLLDNANKVNLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQKTELDDQKLVEEIARRIREILELLGENPEREGLKETPERVAKALLEMTSGLRTPPPQI
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
KVFNLGDDGEVYEKNQIVLIKDVNFSSLCEHHMLPIIGKIHVAYIVSNSGKVAGFSKIIR
EEEECCCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHH
IVNYYSSRLQIQERLVEQIADAIMNSEIKPKGVMVIGNAIHMCSYVRGVKDKEAKLVSVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHCCCCHHHHHHHHH
YRGLFKTNRALQNHVFRLLDNANKVNLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA