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The map label for this gene is pepQ [H]

Identifier: 15897298

GI number: 15897298

Start: 308410

End: 309468

Strand: Direct

Name: pepQ [H]

Synonym: SSO0363

Alternate gene names: 15897298

Gene position: 308410-309468 (Clockwise)

Preceding gene: 15897297

Following gene: 15897299

Centisome position: 10.31

GC content: 35.22

Gene sequence:

>1059_bases
ATGAATAGGTTAAGAAAGCTTAAGGCAATCCTAGAAGATAAGAAAGATAGTTGTGCCATAATATTTGGTTCTCCAAATTT
ATTCTACTTCTTAGAATATTCTGGGGCAGGAGCGTTAATTTATTGTGATTCACGCTTTACCTTACTTGTCCCTGCCCTAG
AGATGTATAGAGCAGAGAATGTGAAAGATGTCGATATTGCAATTTATTATCCATCTAAAATCTTGGAGAATGTCATTGAA
GGTAATATATTTAGGGCTATTGAAAAAATTGTTAATAAGAGCAACATAATGCTAGACGTAAGCTGGGTTGAGGCAAGTAC
GTATAAGGCGTTATCAGAAAAGTATAAGGTAATTGATTTTTCTAATGAGATAGTAAGGTTAAGAGAAGTTAAGGATAACG
ATGAGATAGAAAGAATAAGAAAAGCTGGTGAAATTACTGCTGTTGCAATGAAAATTGGTATGGAGAAATTGAGCGAAGGA
ACTTCTAACGAAAAACAAGTAGCGGGTATTATAGATATGACTATGAGATCTATGGGTGCTGAAGATTATGCTTTCCCATC
AATAGTGGCATTTGGAGAGAATTCAGCGTATCCACATCACATTCCTACAGATCGTGTATTAGGAAATAATGATATTGTAC
TATTTGATATAGGTGCGAAATATAATGGTTACTGCTTTGATAGCACCAGAACTTTTGTATTTAAGAATAGTGAAGCAAAG
AAAGTTTATGAAGTAGTTTTGGAAGCACAAATGGAGGCTATAGATGCCGTTAGGGATGGAGTAATGGCTTCTGAAGTAGA
TATTACTGCTAGGAGAGTTATAGAAAAAGCTGGTTATGGTAAATATTTTATACACTCTACTGGACATGGAGTTGGAGTAG
AAATTCATGAAAGCCCTGCAGTTTCCATGAATTCCAAGCAGATATTGAAGGAAAATATGATTATTACCGTAGAACCTGGA
ATATATCTGAAAGGCAGGTTCGGTATACGTATAGAAGATACCCTTATTGTAACTAAAGGAAAGCCCATCGTGCTAGAAAC
TGCTTATAAACTGTTGTAG

Upstream 100 bases:

>100_bases
TATTGAAAGGTGAATATTCCGAAGATGTTAAAGAAGAATTATTAGGAAGAGCCTTTATGATAGCAATAGCTATTAGAGAG
CCTAACTTCAAATATAAAAT

Downstream 100 bases:

>100_bases
AAGTTTTTTAACAAAATAGTTATATTAGATTTCTTCACTAAACTATAAACGGTATGCAAAAGACAGAATTAGACGACCAA
AAATTAGTAGAAGAAATAGC

Product: Prolidase (Xaa-Pro dipeptidase) (pepQ)

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MNRLRKLKAILEDKKDSCAIIFGSPNLFYFLEYSGAGALIYCDSRFTLLVPALEMYRAENVKDVDIAIYYPSKILENVIE
GNIFRAIEKIVNKSNIMLDVSWVEASTYKALSEKYKVIDFSNEIVRLREVKDNDEIERIRKAGEITAVAMKIGMEKLSEG
TSNEKQVAGIIDMTMRSMGAEDYAFPSIVAFGENSAYPHHIPTDRVLGNNDIVLFDIGAKYNGYCFDSTRTFVFKNSEAK
KVYEVVLEAQMEAIDAVRDGVMASEVDITARRVIEKAGYGKYFIHSTGHGVGVEIHESPAVSMNSKQILKENMIITVEPG
IYLKGRFGIRIEDTLIVTKGKPIVLETAYKLL

Sequences:

>Translated_352_residues
MNRLRKLKAILEDKKDSCAIIFGSPNLFYFLEYSGAGALIYCDSRFTLLVPALEMYRAENVKDVDIAIYYPSKILENVIE
GNIFRAIEKIVNKSNIMLDVSWVEASTYKALSEKYKVIDFSNEIVRLREVKDNDEIERIRKAGEITAVAMKIGMEKLSEG
TSNEKQVAGIIDMTMRSMGAEDYAFPSIVAFGENSAYPHHIPTDRVLGNNDIVLFDIGAKYNGYCFDSTRTFVFKNSEAK
KVYEVVLEAQMEAIDAVRDGVMASEVDITARRVIEKAGYGKYFIHSTGHGVGVEIHESPAVSMNSKQILKENMIITVEPG
IYLKGRFGIRIEDTLIVTKGKPIVLETAYKLL
>Mature_352_residues
MNRLRKLKAILEDKKDSCAIIFGSPNLFYFLEYSGAGALIYCDSRFTLLVPALEMYRAENVKDVDIAIYYPSKILENVIE
GNIFRAIEKIVNKSNIMLDVSWVEASTYKALSEKYKVIDFSNEIVRLREVKDNDEIERIRKAGEITAVAMKIGMEKLSEG
TSNEKQVAGIIDMTMRSMGAEDYAFPSIVAFGENSAYPHHIPTDRVLGNNDIVLFDIGAKYNGYCFDSTRTFVFKNSEAK
KVYEVVLEAQMEAIDAVRDGVMASEVDITARRVIEKAGYGKYFIHSTGHGVGVEIHESPAVSMNSKQILKENMIITVEPG
IYLKGRFGIRIEDTLIVTKGKPIVLETAYKLL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=286, Percent_Identity=28.3216783216783, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI264681563, Length=264, Percent_Identity=30.3030303030303, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI93141226, Length=267, Percent_Identity=29.5880149812734, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI260593665, Length=336, Percent_Identity=25.297619047619, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI149589008, Length=283, Percent_Identity=26.5017667844523, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI40385867, Length=252, Percent_Identity=26.984126984127, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI260593663, Length=226, Percent_Identity=26.9911504424779, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1788728, Length=247, Percent_Identity=38.8663967611336, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789275, Length=262, Percent_Identity=29.3893129770992, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17509539, Length=264, Percent_Identity=28.4090909090909, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508215, Length=281, Percent_Identity=27.4021352313167, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71989583, Length=310, Percent_Identity=24.8387096774194, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320922, Length=345, Percent_Identity=24.6376811594203, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321118, Length=392, Percent_Identity=22.9591836734694, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19920384, Length=250, Percent_Identity=28, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357079, Length=277, Percent_Identity=24.9097472924188, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137632, Length=168, Percent_Identity=31.547619047619, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 39538; Mature: 39538

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLRKLKAILEDKKDSCAIIFGSPNLFYFLEYSGAGALIYCDSRFTLLVPALEMYRAEN
CCHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCEEEEEECCCEEEEHHHHHHHHCCC
VKDVDIAIYYPSKILENVIEGNIFRAIEKIVNKSNIMLDVSWVEASTYKALSEKYKVIDF
CCEEEEEEEECHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHCEEEEEC
SNEIVRLREVKDNDEIERIRKAGEITAVAMKIGMEKLSEGTSNEKQVAGIIDMTMRSMGA
CCCEEEEEECCCCHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
EDYAFPSIVAFGENSAYPHHIPTDRVLGNNDIVLFDIGAKYNGYCFDSTRTFVFKNSEAK
CCCCCCEEEEECCCCCCCCCCCCCCEECCCCEEEEECCCCCCCEEECCCEEEEEECCCHH
KVYEVVLEAQMEAIDAVRDGVMASEVDITARRVIEKAGYGKYFIHSTGHGVGVEIHESPA
HHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCC
VSMNSKQILKENMIITVEPGIYLKGRFGIRIEDTLIVTKGKPIVLETAYKLL
CCCCHHHHHHCCCEEEECCCEEEEEEECEEEEEEEEEECCCCEEEECHHHCC
>Mature Secondary Structure
MNRLRKLKAILEDKKDSCAIIFGSPNLFYFLEYSGAGALIYCDSRFTLLVPALEMYRAEN
CCHHHHHHHHHCCCCCCEEEEECCCCEEEEEEECCCEEEEEECCCEEEEHHHHHHHHCCC
VKDVDIAIYYPSKILENVIEGNIFRAIEKIVNKSNIMLDVSWVEASTYKALSEKYKVIDF
CCEEEEEEEECHHHHHHHHCCHHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHCEEEEEC
SNEIVRLREVKDNDEIERIRKAGEITAVAMKIGMEKLSEGTSNEKQVAGIIDMTMRSMGA
CCCEEEEEECCCCHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
EDYAFPSIVAFGENSAYPHHIPTDRVLGNNDIVLFDIGAKYNGYCFDSTRTFVFKNSEAK
CCCCCCEEEEECCCCCCCCCCCCCCEECCCCEEEEECCCCCCCEEECCCEEEEEECCCHH
KVYEVVLEAQMEAIDAVRDGVMASEVDITARRVIEKAGYGKYFIHSTGHGVGVEIHESPA
HHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCC
VSMNSKQILKENMIITVEPGIYLKGRFGIRIEDTLIVTKGKPIVLETAYKLL
CCCCHHHHHHCCCEEEECCCEEEEEEECEEEEEEEEEECCCCEEEECHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]