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The map label for this gene is moaA [H]

Identifier: 15897297

GI number: 15897297

Start: 307487

End: 308413

Strand: Direct

Name: moaA [H]

Synonym: SSO0362

Alternate gene names: 15897297

Gene position: 307487-308413 (Clockwise)

Preceding gene: 15897296

Following gene: 15897298

Centisome position: 10.28

GC content: 33.01

Gene sequence:

>927_bases
ATGATTGATAGATTTGGTAGACCATTAGAAGATCTTAGAATAACGTTAACACACGCATGTAACTTTGAATGTTTCTTCTG
CCATATGGAGGGAGAAGAAGGAGATAATTATCTTTTAAGTAAAGAGGATATTTTATTAGTTGCTAAAGTTGCTAGGAAAT
TTGGTATAAACTCTGTAAAATTAACTGGAGGAGAACCGACATTACGACGAGATTTAGTTGAAATAGTTCGAGGGCTTAAG
CAATTAGGGTATGAAGACGTTTCTATGACAACTAATGGTTTTCTCCTAAAAGATTTAGCTCACAAATTAAAGCTAGCTGG
GCTTGATAGGATTAATATCAGCCTTCATGCTGTTTCAAGGGATACATTTAAGAAAATTACGGGTGTAGATGCTTTTGATA
GAGTAATTGAAGGGATAAAAAGTGCCATAGATGTGGGTTTAGTACCAGTTAAGTTAAATTTTGTTGTAAATAGGAGAAAT
CGTGAAGAAGCCTTCAAGTTCATTGAGCTATCCCAAAATTTAGGTGTAAATGAGATACACCTTATAGAACTGCATCCGGT
AGGGTTAGGAAAATTAGCTTTTAAGGAACATGATGATTTAAGAGAAATAGAAGAATATATTGAGAAAATATCTATTAAAA
AACTAATTAGGAAAAAGCATTTTAGACCACGTTATGTTTTACCCTCTGGATTAATAGTCGAAGTAGTTAAGCCCTATGCG
AATCCGATATTCTGTGCTGGATGTAACAGGATCAGATTATCTGTTGATGGAAAGTTAAAGACGTGTTTATACAGAGAAGA
TAACGTAATAGATGTATTAGATATATTGAAAGGTGAATATTCCGAAGATGTTAAAGAAGAATTATTAGGAAGAGCCTTTA
TGATAGCAATAGCTATTAGAGAGCCTAACTTCAAATATAAAATATGA

Upstream 100 bases:

>100_bases
CTTTCAGATTCCGCAATGAAGTCCATTCTAATTCTGCATTTTGGACAAATTACTGCATTCATACATGTGTTTATAATCTT
TTGAGGTAAAAAAGCTATTA

Downstream 100 bases:

>100_bases
ATAGGTTAAGAAAGCTTAAGGCAATCCTAGAAGATAAGAAAGATAGTTGTGCCATAATATTTGGTTCTCCAAATTTATTC
TACTTCTTAGAATATTCTGG

Product: molybdenum cofactor biosynthesis protein A (moaA)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MIDRFGRPLEDLRITLTHACNFECFFCHMEGEEGDNYLLSKEDILLVAKVARKFGINSVKLTGGEPTLRRDLVEIVRGLK
QLGYEDVSMTTNGFLLKDLAHKLKLAGLDRINISLHAVSRDTFKKITGVDAFDRVIEGIKSAIDVGLVPVKLNFVVNRRN
REEAFKFIELSQNLGVNEIHLIELHPVGLGKLAFKEHDDLREIEEYIEKISIKKLIRKKHFRPRYVLPSGLIVEVVKPYA
NPIFCAGCNRIRLSVDGKLKTCLYREDNVIDVLDILKGEYSEDVKEELLGRAFMIAIAIREPNFKYKI

Sequences:

>Translated_308_residues
MIDRFGRPLEDLRITLTHACNFECFFCHMEGEEGDNYLLSKEDILLVAKVARKFGINSVKLTGGEPTLRRDLVEIVRGLK
QLGYEDVSMTTNGFLLKDLAHKLKLAGLDRINISLHAVSRDTFKKITGVDAFDRVIEGIKSAIDVGLVPVKLNFVVNRRN
REEAFKFIELSQNLGVNEIHLIELHPVGLGKLAFKEHDDLREIEEYIEKISIKKLIRKKHFRPRYVLPSGLIVEVVKPYA
NPIFCAGCNRIRLSVDGKLKTCLYREDNVIDVLDILKGEYSEDVKEELLGRAFMIAIAIREPNFKYKI
>Mature_308_residues
MIDRFGRPLEDLRITLTHACNFECFFCHMEGEEGDNYLLSKEDILLVAKVARKFGINSVKLTGGEPTLRRDLVEIVRGLK
QLGYEDVSMTTNGFLLKDLAHKLKLAGLDRINISLHAVSRDTFKKITGVDAFDRVIEGIKSAIDVGLVPVKLNFVVNRRN
REEAFKFIELSQNLGVNEIHLIELHPVGLGKLAFKEHDDLREIEEYIEKISIKKLIRKKHFRPRYVLPSGLIVEVVKPYA
NPIFCAGCNRIRLSVDGKLKTCLYREDNVIDVLDILKGEYSEDVKEELLGRAFMIAIAIREPNFKYKI

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=307, Percent_Identity=35.5048859934853, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI22027536, Length=307, Percent_Identity=35.5048859934853, Blast_Score=148, Evalue=7e-36,
Organism=Escherichia coli, GI1786999, Length=315, Percent_Identity=31.1111111111111, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17561210, Length=287, Percent_Identity=34.4947735191638, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI32566331, Length=304, Percent_Identity=32.5657894736842, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI32566329, Length=304, Percent_Identity=32.5657894736842, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=36.3057324840764, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI28574488, Length=314, Percent_Identity=36.3057324840764, Blast_Score=147, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013485
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 35197; Mature: 35197

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRFGRPLEDLRITLTHACNFECFFCHMEGEEGDNYLLSKEDILLVAKVARKFGINSVK
CCCCCCCCHHHHEEEEEEECCCEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHCCCEEE
LTGGEPTLRRDLVEIVRGLKQLGYEDVSMTTNGFLLKDLAHKLKLAGLDRINISLHAVSR
EECCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEEEEECCH
DTFKKITGVDAFDRVIEGIKSAIDVGLVPVKLNFVVNRRNREEAFKFIELSQNLGVNEIH
HHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHCCCCCCEEE
LIELHPVGLGKLAFKEHDDLREIEEYIEKISIKKLIRKKHFRPRYVLPSGLIVEVVKPYA
EEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHCC
NPIFCAGCNRIRLSVDGKLKTCLYREDNVIDVLDILKGEYSEDVKEELLGRAFMIAIAIR
CEEEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHCCCEEEEEEEEE
EPNFKYKI
CCCCCCCC
>Mature Secondary Structure
MIDRFGRPLEDLRITLTHACNFECFFCHMEGEEGDNYLLSKEDILLVAKVARKFGINSVK
CCCCCCCCHHHHEEEEEEECCCEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHCCCEEE
LTGGEPTLRRDLVEIVRGLKQLGYEDVSMTTNGFLLKDLAHKLKLAGLDRINISLHAVSR
EECCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEEEEECCH
DTFKKITGVDAFDRVIEGIKSAIDVGLVPVKLNFVVNRRNREEAFKFIELSQNLGVNEIH
HHHHHHCCCCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHCCCCCCEEE
LIELHPVGLGKLAFKEHDDLREIEEYIEKISIKKLIRKKHFRPRYVLPSGLIVEVVKPYA
EEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHCC
NPIFCAGCNRIRLSVDGKLKTCLYREDNVIDVLDILKGEYSEDVKEELLGRAFMIAIAIR
CEEEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHCCCEEEEEEEEE
EPNFKYKI
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA