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The map label for this gene is dfp [H]

Identifier: 15897158

GI number: 15897158

Start: 179604

End: 180845

Strand: Reverse

Name: dfp [H]

Synonym: SSO0210

Alternate gene names: 15897158

Gene position: 180845-179604 (Counterclockwise)

Preceding gene: 15897160

Following gene: 15897157

Centisome position: 6.04

GC content: 35.1

Gene sequence:

>1242_bases
ATGCACACATACATGACGCATCCTTCAAAGAAGATAATTGGGAGCATAAGTAATGAACTAGCTGATAAGAAGATACTATT
AGCAGTAACTGGGAGCGTCGCAATATATAAGTCATTAGATTTAGCCAGAAGTTTAATGAGGAACGGTGCAGAAGTGAGTG
TCATTATAAGTAAAGACGCTGCCAAGCTAATTTCCCCAGAGATGTTTAAGTGGGCTACTGGAAATAATGTAGTTACTAAG
CTTACTGGTGACTTAGAGCATGTTTCATTGGCAGAAGACAATGACGTAATGATCGTAGCTCCATCTACTGCAAATACTAT
GGTAAAGATAGCTTATGGAATAGCTGATACACCAATAACGGCTACTGCGCTGAATTTCGTTGGGATGAAAAAGCCCTTAA
TTATAGTTCCTTCAATGCATTTACAAATGTATATTTCACCTCAAGTTGCAGATGCAGCAGATAGGTTAAAAAGGATAGGA
GTAGAGGTAATAGAACCAGAGATAGTTGGAGATTTAGCACACTATCCTAAGTTAGAATACTTAACCAGTAGAATAACCTC
ATATGTTTTAAGAGGGAAAGACTTATCTGGGTTTAATATATTAGCTACTGCTGGGCCTACACGTGAGTATTTAGATTCTG
TTAGATTTATTTCAAATCCAAGTAGCGGAACTATGGGTATATCTATTGCGAATGAGGCGTATTTCAGAGGAGCTAAAGTT
AGAGTTATTTGTGGACCTATAAGTTCTAAGATAGAACCTTATGTTAAGGATATAGTGTATGTAGAGACAACTGAGGAGAT
GCTAAATGAAGTTGTAAAAAGTATAGAAAATGGTAAGTTTAATGTTGTAATTTTAGCTGGAGCGCCTGCTGATTACAAGT
TTAAAAATAAATCTGACACTAAAATAGACAGTCATACAGAAATACCTAAAGTTGAATTAGAAAGAACACCGAAAATTTCT
GAATACATTAGGAAGTATAATGTATTGCTAGTAGGTTTTTCCGCAGAGACTGTAAATTCTGATGAAGAGCTGATTGAGAA
AGCTAAAATCAAAATGAGGAGACACGGGTTTGATTTAATCGTAGCTAATAATGTGAGAAGAAAGGATATAGGATTTTCGT
CTGAATATAATGAGGTTATAGTTATAGATAAGAATGGTGATGTAAGGAAAATACCAAAGAATTTTAAGACGGTAATAGCG
AGAAAGATATTGGATATAGTAAAGGAGCAATTAAGAAGATGA

Upstream 100 bases:

>100_bases
TCTATATCATCCATTCTTGCGTTTCTTAGTGTGAAATCTCTTCCTTTATCTTTTTCAGCGAGCTCCATATCAATATCTTT
ATATAATGTAGTTAATATAT

Downstream 100 bases:

>100_bases
TAAAAAGAAGAGTTTAAAATGAATTAGATAATGATATACAATAGCGGCTGGCTCGGGTAGCTCAGCCTGGAAGAGCGCCG
GGCTGTGGACCCGGAAGTCC

Product: DNA/pantothenate metabolism flavoprotein (dfp)

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MHTYMTHPSKKIIGSISNELADKKILLAVTGSVAIYKSLDLARSLMRNGAEVSVIISKDAAKLISPEMFKWATGNNVVTK
LTGDLEHVSLAEDNDVMIVAPSTANTMVKIAYGIADTPITATALNFVGMKKPLIIVPSMHLQMYISPQVADAADRLKRIG
VEVIEPEIVGDLAHYPKLEYLTSRITSYVLRGKDLSGFNILATAGPTREYLDSVRFISNPSSGTMGISIANEAYFRGAKV
RVICGPISSKIEPYVKDIVYVETTEEMLNEVVKSIENGKFNVVILAGAPADYKFKNKSDTKIDSHTEIPKVELERTPKIS
EYIRKYNVLLVGFSAETVNSDEELIEKAKIKMRRHGFDLIVANNVRRKDIGFSSEYNEVIVIDKNGDVRKIPKNFKTVIA
RKILDIVKEQLRR

Sequences:

>Translated_413_residues
MHTYMTHPSKKIIGSISNELADKKILLAVTGSVAIYKSLDLARSLMRNGAEVSVIISKDAAKLISPEMFKWATGNNVVTK
LTGDLEHVSLAEDNDVMIVAPSTANTMVKIAYGIADTPITATALNFVGMKKPLIIVPSMHLQMYISPQVADAADRLKRIG
VEVIEPEIVGDLAHYPKLEYLTSRITSYVLRGKDLSGFNILATAGPTREYLDSVRFISNPSSGTMGISIANEAYFRGAKV
RVICGPISSKIEPYVKDIVYVETTEEMLNEVVKSIENGKFNVVILAGAPADYKFKNKSDTKIDSHTEIPKVELERTPKIS
EYIRKYNVLLVGFSAETVNSDEELIEKAKIKMRRHGFDLIVANNVRRKDIGFSSEYNEVIVIDKNGDVRKIPKNFKTVIA
RKILDIVKEQLRR
>Mature_413_residues
MHTYMTHPSKKIIGSISNELADKKILLAVTGSVAIYKSLDLARSLMRNGAEVSVIISKDAAKLISPEMFKWATGNNVVTK
LTGDLEHVSLAEDNDVMIVAPSTANTMVKIAYGIADTPITATALNFVGMKKPLIIVPSMHLQMYISPQVADAADRLKRIG
VEVIEPEIVGDLAHYPKLEYLTSRITSYVLRGKDLSGFNILATAGPTREYLDSVRFISNPSSGTMGISIANEAYFRGAKV
RVICGPISSKIEPYVKDIVYVETTEEMLNEVVKSIENGKFNVVILAGAPADYKFKNKSDTKIDSHTEIPKVELERTPKIS
EYIRKYNVLLVGFSAETVNSDEELIEKAKIKMRRHGFDLIVANNVRRKDIGFSSEYNEVIVIDKNGDVRKIPKNFKTVIA
RKILDIVKEQLRR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=403, Percent_Identity=32.258064516129, Blast_Score=159, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 45865; Mature: 45865

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTYMTHPSKKIIGSISNELADKKILLAVTGSVAIYKSLDLARSLMRNGAEVSVIISKDA
CCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCH
AKLISPEMFKWATGNNVVTKLTGDLEHVSLAEDNDVMIVAPSTANTMVKIAYGIADTPIT
HHHCCCHHEEEECCCCEEEEECCCCCEEEECCCCCEEEEECCCCCCEEEEEECCCCCCHH
ATALNFVGMKKPLIIVPSMHLQMYISPQVADAADRLKRIGVEVIEPEIVGDLAHYPKLEY
HHHHHHHCCCCCEEEECCCEEEEEECCCHHHHHHHHHHCCCEEECHHHHHHHHHCCHHHH
LTSRITSYVLRGKDLSGFNILATAGPTREYLDSVRFISNPSSGTMGISIANEAYFRGAKV
HHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCEE
RVICGPISSKIEPYVKDIVYVETTEEMLNEVVKSIENGKFNVVILAGAPADYKFKNKSDT
EEEECCCCCCCCHHHHHEEEEECHHHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCCCC
KIDSHTEIPKVELERTPKISEYIRKYNVLLVGFSAETVNSDEELIEKAKIKMRRHGFDLI
CCCCCCCCCCEEECCCCCHHHHHHHCEEEEEEECHHCCCCHHHHHHHHHHHHHHCCCEEE
VANNVRRKDIGFSSEYNEVIVIDKNGDVRKIPKNFKTVIARKILDIVKEQLRR
EECCCCCCCCCCCCCCCEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHTYMTHPSKKIIGSISNELADKKILLAVTGSVAIYKSLDLARSLMRNGAEVSVIISKDA
CCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCH
AKLISPEMFKWATGNNVVTKLTGDLEHVSLAEDNDVMIVAPSTANTMVKIAYGIADTPIT
HHHCCCHHEEEECCCCEEEEECCCCCEEEECCCCCEEEEECCCCCCEEEEEECCCCCCHH
ATALNFVGMKKPLIIVPSMHLQMYISPQVADAADRLKRIGVEVIEPEIVGDLAHYPKLEY
HHHHHHHCCCCCEEEECCCEEEEEECCCHHHHHHHHHHCCCEEECHHHHHHHHHCCHHHH
LTSRITSYVLRGKDLSGFNILATAGPTREYLDSVRFISNPSSGTMGISIANEAYFRGAKV
HHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCEE
RVICGPISSKIEPYVKDIVYVETTEEMLNEVVKSIENGKFNVVILAGAPADYKFKNKSDT
EEEECCCCCCCCHHHHHEEEEECHHHHHHHHHHHHCCCCEEEEEEECCCCCCEECCCCCC
KIDSHTEIPKVELERTPKISEYIRKYNVLLVGFSAETVNSDEELIEKAKIKMRRHGFDLI
CCCCCCCCCCEEECCCCCHHHHHHHCEEEEEEECHHCCCCHHHHHHHHHHHHHHCCCEEE
VANNVRRKDIGFSSEYNEVIVIDKNGDVRKIPKNFKTVIARKILDIVKEQLRR
EECCCCCCCCCCCCCCCEEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]