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The map label for this gene is aspC

Identifier: 15897124

GI number: 15897124

Start: 143942

End: 145231

Strand: Direct

Name: aspC

Synonym: SSO0173

Alternate gene names: 15897124

Gene position: 143942-145231 (Clockwise)

Preceding gene: 15897123

Following gene: 15897127

Centisome position: 4.81

GC content: 35.35

Gene sequence:

>1290_bases
TTGTTTAGGACACATCTAGTCTCAGAATTAAATCCTAAATTAGATGGATCAGAAGTAAAGGTAGCAGGATGGGTTCATAA
TGTAAGGAATTTAGGTGGAAAGATATTTATTTTATTAAGAGACAAGAGTGGAATAGGACAAATAGTAGTTGAAAAAGGTA
ATAATGCATATGATAAAGTCATAAATATAGGATTGGAATCGACTATCGTTGTAAATGGTGTAGTTAAAGCTGATGCGAGA
GCCCCTAATGGGGTTGAAGTACACGCAAAAGATATAGAAATACTGTCGTATGCAAGGTCTCCATTACCGTTAGATGTGAC
GGGCAAGGTTAAGGCTGATATAGATACTAGACTTAGGGAAAGATTACTAGATTTAAGAAGATTGGAGATGCAAGCAGTGT
TAAAAATACAATCGGTAGCTGTGAAATCATTTAGGGAAACATTATATAAACATGGATTTGTAGAAGTCTTTACTCCAAAG
ATAATTGCTAGTGCAACGGAAGGAGGAGCCCAATTATTTCCAGTATTATACTTTGGAAAAGAGGCATTTTTAGCTCAGAG
TCCGCAATTATACAAGGAATTATTAGCAGGTGCTATAGAAAGAGTATTTGAAATAGCTCCTGCATGGAGAGCAGAAGAGT
CAGACACACCATATCATCTCTCAGAGTTCATTAGCATGGACGTAGAAATGGCCTTTGCCGATTACAACGATATAATGGCT
TTAATAGAACAAATAATTTATAACATGATAAATGATGTAAAGAGAGAATGTGAAAATGAATTAAAGATATTGAATTATAC
TCCACCTAATGTTAGAATACCTATAAAGAAAGTCTCTTACTCAGATGCAATAGAGCTTCTGAAAAGTAAAGGTGTTAATA
TTAAATTTGGCGATGATATAGGAACGCCTGAACTGAGGGTATTATATAATGAATTAAAGGAAGATCTTTACTTCGTAACT
GATTGGCCTTGGCTAAGTAGACCATTTTATACAAAGCAGAAAAAAGATAATCCGCAGCTAAGCGAGAGCTTTGATTTAAT
TTTCAGATGGTTAGAGATTGTTTCTGGAAGTTCAAGAAATCACGTTAAAGAAGTCCTAGAGAACTCACTTAAAGTAAGAG
GACTAAATCCAGAAAGTTTTGAATTCTTCCTAAAATGGTTTGACTATGGGATGCCACCACACGCCGGTTTTGGAATGGGA
TTAGCAAGAGTAATGTTAATGTTAACTGGTCTTCAGAGCGTGAAGGAAGTAGTACCATTCCCTAGAGATAAGAAGAGACT
AACACCATAA

Upstream 100 bases:

>100_bases
TCTAGATCAGAAAGGAGATTGTTACCAGCTGAAGCACAACTTTTAGAGTCAGCACTAACTAAAATACATTCAACACCGGT
TAGAATAAGGGTAGAGTAAG

Downstream 100 bases:

>100_bases
AAGTTAAGTGAATTTTCTTGGATCTCCTCTTAAGATTTCCCTAAGTAATATTGTAGCGTACATTCCTCTTTCTAATACAA
AAGATATTGTTTTAGTTTCC

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MFRTHLVSELNPKLDGSEVKVAGWVHNVRNLGGKIFILLRDKSGIGQIVVEKGNNAYDKVINIGLESTIVVNGVVKADAR
APNGVEVHAKDIEILSYARSPLPLDVTGKVKADIDTRLRERLLDLRRLEMQAVLKIQSVAVKSFRETLYKHGFVEVFTPK
IIASATEGGAQLFPVLYFGKEAFLAQSPQLYKELLAGAIERVFEIAPAWRAEESDTPYHLSEFISMDVEMAFADYNDIMA
LIEQIIYNMINDVKRECENELKILNYTPPNVRIPIKKVSYSDAIELLKSKGVNIKFGDDIGTPELRVLYNELKEDLYFVT
DWPWLSRPFYTKQKKDNPQLSESFDLIFRWLEIVSGSSRNHVKEVLENSLKVRGLNPESFEFFLKWFDYGMPPHAGFGMG
LARVMLMLTGLQSVKEVVPFPRDKKRLTP

Sequences:

>Translated_429_residues
MFRTHLVSELNPKLDGSEVKVAGWVHNVRNLGGKIFILLRDKSGIGQIVVEKGNNAYDKVINIGLESTIVVNGVVKADAR
APNGVEVHAKDIEILSYARSPLPLDVTGKVKADIDTRLRERLLDLRRLEMQAVLKIQSVAVKSFRETLYKHGFVEVFTPK
IIASATEGGAQLFPVLYFGKEAFLAQSPQLYKELLAGAIERVFEIAPAWRAEESDTPYHLSEFISMDVEMAFADYNDIMA
LIEQIIYNMINDVKRECENELKILNYTPPNVRIPIKKVSYSDAIELLKSKGVNIKFGDDIGTPELRVLYNELKEDLYFVT
DWPWLSRPFYTKQKKDNPQLSESFDLIFRWLEIVSGSSRNHVKEVLENSLKVRGLNPESFEFFLKWFDYGMPPHAGFGMG
LARVMLMLTGLQSVKEVVPFPRDKKRLTP
>Mature_429_residues
MFRTHLVSELNPKLDGSEVKVAGWVHNVRNLGGKIFILLRDKSGIGQIVVEKGNNAYDKVINIGLESTIVVNGVVKADAR
APNGVEVHAKDIEILSYARSPLPLDVTGKVKADIDTRLRERLLDLRRLEMQAVLKIQSVAVKSFRETLYKHGFVEVFTPK
IIASATEGGAQLFPVLYFGKEAFLAQSPQLYKELLAGAIERVFEIAPAWRAEESDTPYHLSEFISMDVEMAFADYNDIMA
LIEQIIYNMINDVKRECENELKILNYTPPNVRIPIKKVSYSDAIELLKSKGVNIKFGDDIGTPELRVLYNELKEDLYFVT
DWPWLSRPFYTKQKKDNPQLSESFDLIFRWLEIVSGSSRNHVKEVLENSLKVRGLNPESFEFFLKWFDYGMPPHAGFGMG
LARVMLMLTGLQSVKEVVPFPRDKKRLTP

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI45439306, Length=440, Percent_Identity=37.0454545454545, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI4758762, Length=430, Percent_Identity=30.6976744186047, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI226491502, Length=436, Percent_Identity=26.8348623853211, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI40789249, Length=265, Percent_Identity=33.9622641509434, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI194272210, Length=466, Percent_Identity=27.0386266094421, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI5031815, Length=466, Percent_Identity=27.0386266094421, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1787161, Length=443, Percent_Identity=27.5395033860045, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789256, Length=469, Percent_Identity=25.5863539445629, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790571, Length=468, Percent_Identity=25.4273504273504, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788173, Length=309, Percent_Identity=30.0970873786408, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17551876, Length=460, Percent_Identity=33.9130434782609, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71984122, Length=426, Percent_Identity=29.1079812206573, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17556372, Length=400, Percent_Identity=26.75, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI32566633, Length=344, Percent_Identity=30.8139534883721, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71994340, Length=462, Percent_Identity=25.5411255411255, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17535925, Length=462, Percent_Identity=25.5411255411255, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17535927, Length=462, Percent_Identity=25.5411255411255, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6323011, Length=450, Percent_Identity=32.2222222222222, Blast_Score=238, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6321807, Length=429, Percent_Identity=31.2354312354312, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6319872, Length=457, Percent_Identity=27.1334792122538, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6320242, Length=469, Percent_Identity=24.7334754797441, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325153, Length=262, Percent_Identity=29.7709923664122, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17136276, Length=461, Percent_Identity=32.5379609544469, Blast_Score=251, Evalue=6e-67,
Organism=Drosophila melanogaster, GI19921528, Length=428, Percent_Identity=32.4766355140187, Blast_Score=196, Evalue=4e-50,
Organism=Drosophila melanogaster, GI19922416, Length=449, Percent_Identity=26.5033407572383, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24584738, Length=309, Percent_Identity=30.7443365695793, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24640851, Length=468, Percent_Identity=27.3504273504274, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24640849, Length=468, Percent_Identity=27.3504273504274, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SYD_SULSO (Q980V3)

Other databases:

- EMBL:   AE006641
- PIR:   H90157
- RefSeq:   NP_341729.1
- ProteinModelPortal:   Q980V3
- SMR:   Q980V3
- GeneID:   1453346
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0173
- NMPDR:   fig|273057.1.peg.152
- HOGENOM:   HBG745843
- OMA:   TDWPSEI
- PhylomeDB:   Q980V3
- ProtClustDB:   PRK05159
- BioCyc:   SSOL273057:SSO0173-MONOMER
- BRENDA:   6.1.1.12
- GO:   GO:0005737
- HAMAP:   MF_00044_A
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020780
- InterPro:   IPR004523
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00458

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.12

Molecular weight: Translated: 48770; Mature: 48770

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRTHLVSELNPKLDGSEVKVAGWVHNVRNLGGKIFILLRDKSGIGQIVVEKGNNAYDKV
CCCHHHHHHCCCCCCCCCEEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCHHHHH
INIGLESTIVVNGVVKADARAPNGVEVHAKDIEILSYARSPLPLDVTGKVKADIDTRLRE
HHCCCCCEEEEEEEEEECCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCEECCHHHHHHH
RLLDLRRLEMQAVLKIQSVAVKSFRETLYKHGFVEVFTPKIIASATEGGAQLFPVLYFGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHCCCCCHHEEHHHHCCC
EAFLAQSPQLYKELLAGAIERVFEIAPAWRAEESDTPYHLSEFISMDVEMAFADYNDIMA
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHH
LIEQIIYNMINDVKRECENELKILNYTPPNVRIPIKKVSYSDAIELLKSKGVNIKFGDDI
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHCCHHHHHHHHHHCCCEEEECCCC
GTPELRVLYNELKEDLYFVTDWPWLSRPFYTKQKKDNPQLSESFDLIFRWLEIVSGSSRN
CCHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
HVKEVLENSLKVRGLNPESFEFFLKWFDYGMPPHAGFGMGLARVMLMLTGLQSVKEVVPF
HHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PRDKKRLTP
CCCCCCCCC
>Mature Secondary Structure
MFRTHLVSELNPKLDGSEVKVAGWVHNVRNLGGKIFILLRDKSGIGQIVVEKGNNAYDKV
CCCHHHHHHCCCCCCCCCEEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCHHHHH
INIGLESTIVVNGVVKADARAPNGVEVHAKDIEILSYARSPLPLDVTGKVKADIDTRLRE
HHCCCCCEEEEEEEEEECCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCEECCHHHHHHH
RLLDLRRLEMQAVLKIQSVAVKSFRETLYKHGFVEVFTPKIIASATEGGAQLFPVLYFGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHCCCCCHHEEHHHHCCC
EAFLAQSPQLYKELLAGAIERVFEIAPAWRAEESDTPYHLSEFISMDVEMAFADYNDIMA
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHH
LIEQIIYNMINDVKRECENELKILNYTPPNVRIPIKKVSYSDAIELLKSKGVNIKFGDDI
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHCCHHHHHHHHHHCCCEEEECCCC
GTPELRVLYNELKEDLYFVTDWPWLSRPFYTKQKKDNPQLSESFDLIFRWLEIVSGSSRN
CCHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHH
HVKEVLENSLKVRGLNPESFEFFLKWFDYGMPPHAGFGMGLARVMLMLTGLQSVKEVVPF
HHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PRDKKRLTP
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726