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The map label for this gene is uppS

Identifier: 15897113

GI number: 15897113

Start: 135566

End: 136354

Strand: Direct

Name: uppS

Synonym: SSO0163

Alternate gene names: 15897113

Gene position: 135566-136354 (Clockwise)

Preceding gene: 15897112

Following gene: 15897114

Centisome position: 4.53

GC content: 31.94

Gene sequence:

>789_bases
ATGGCAAAAGATCTAACTAGAGGCCTTCTCTTTAAGCCTATTTATAAACTGTATGAGTTAGTATTATGGAATCAGATTCG
TAATGGTCCATTGCCAGATCACGTGGGAATTATACCAGATGGAAATAGAAGATGGGCTAGAGATAATAATCTTTCGCTTA
ATGACGCCTATTTCTATGGTTATAAAAAATTGAAAGAGGTCTTAATATGGTTGCTAGAACTTGGTATAAAAAATATAACA
GTTTTTGTGCTATCTACAGAAAATTGTGACAAGAGAAAACAAAATGAGCTATCAATAATAACAACATATATTAAGAGAGG
TATACAAGATTTACTAGAAGATCCCATCGTAGATAAGTATGAAGTTAAAGTAAGTGCAATAGGTAAACTAGATAAATTAC
CAAAAGATCTTATTGATTATCTAAACAGAGTAGTAGAGAAAACCTCAAACTATGATAAAAGAAAACTTACGTTAGCTATT
TGCTATGGAGGTAGACAAGAAATATTAGATGCAGTCGTTAGACTTCTGGATGATTATAGAAATGGAAAAATTGTCAAAAG
TGAGATAAATGAAGAAACGTTTAGAAAATATTTTTATGATAGTGAATTACAAGATATTGATCTAGTAATTAGAACTTCGG
GTGAAGTGAGAATTAGTAACTTTTTACTTTGGCACGTGGCATACTCTGAGTTATTCTTCTGTGAGGCGTATTGGCCAGAA
TTTAGAAAAATCGATCTATGGAGAGCAATAAGGTCGTTTCAAAAAAGAAAACGTAACTTTGGGGCCTAA

Upstream 100 bases:

>100_bases
GTCCTGGAAATTCTATGCTAGAACATACTACTCAAGAAAAAATTAGCTTGGATGAAATATATATAGGAGTAAAAACTTAT
ATGTTGGCAATAGAAGAGCT

Downstream 100 bases:

>100_bases
GTTTTTTAATCCTTTATTACACACTTTTAAAGAGGCGTAAATTATGGGATTTTACCAAGGTCCAGATAATAGGAAAATTA
CCGGTGGTTTAAAAGGAAAG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MAKDLTRGLLFKPIYKLYELVLWNQIRNGPLPDHVGIIPDGNRRWARDNNLSLNDAYFYGYKKLKEVLIWLLELGIKNIT
VFVLSTENCDKRKQNELSIITTYIKRGIQDLLEDPIVDKYEVKVSAIGKLDKLPKDLIDYLNRVVEKTSNYDKRKLTLAI
CYGGRQEILDAVVRLLDDYRNGKIVKSEINEETFRKYFYDSELQDIDLVIRTSGEVRISNFLLWHVAYSELFFCEAYWPE
FRKIDLWRAIRSFQKRKRNFGA

Sequences:

>Translated_262_residues
MAKDLTRGLLFKPIYKLYELVLWNQIRNGPLPDHVGIIPDGNRRWARDNNLSLNDAYFYGYKKLKEVLIWLLELGIKNIT
VFVLSTENCDKRKQNELSIITTYIKRGIQDLLEDPIVDKYEVKVSAIGKLDKLPKDLIDYLNRVVEKTSNYDKRKLTLAI
CYGGRQEILDAVVRLLDDYRNGKIVKSEINEETFRKYFYDSELQDIDLVIRTSGEVRISNFLLWHVAYSELFFCEAYWPE
FRKIDLWRAIRSFQKRKRNFGA
>Mature_261_residues
AKDLTRGLLFKPIYKLYELVLWNQIRNGPLPDHVGIIPDGNRRWARDNNLSLNDAYFYGYKKLKEVLIWLLELGIKNITV
FVLSTENCDKRKQNELSIITTYIKRGIQDLLEDPIVDKYEVKVSAIGKLDKLPKDLIDYLNRVVEKTSNYDKRKLTLAIC
YGGRQEILDAVVRLLDDYRNGKIVKSEINEETFRKYFYDSELQDIDLVIRTSGEVRISNFLLWHVAYSELFFCEAYWPEF
RKIDLWRAIRSFQKRKRNFGA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=242, Percent_Identity=36.3636363636364, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI45580742, Length=242, Percent_Identity=36.3636363636364, Blast_Score=153, Evalue=2e-37,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=31.4410480349345, Blast_Score=129, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71993029, Length=233, Percent_Identity=32.1888412017167, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=232, Percent_Identity=33.6206896551724, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=248, Percent_Identity=26.2096774193548, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18857969, Length=234, Percent_Identity=31.6239316239316, Blast_Score=127, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_SULSO (Q980W4)

Other databases:

- EMBL:   AE006641
- EMBL:   BK000545
- PIR:   E90156
- RefSeq:   NP_341718.1
- ProteinModelPortal:   Q980W4
- SMR:   Q980W4
- GeneID:   1453335
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0163
- NMPDR:   fig|273057.1.peg.141
- HOGENOM:   HBG627837
- OMA:   YGGQQEI
- ProtClustDB:   CLSK802588
- BioCyc:   SSOL273057:SSO0163-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 31017; Mature: 30886

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 40-40

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDLTRGLLFKPIYKLYELVLWNQIRNGPLPDHVGIIPDGNRRWARDNNLSLNDAYFYG
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
YKKLKEVLIWLLELGIKNITVFVLSTENCDKRKQNELSIITTYIKRGIQDLLEDPIVDKY
HHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
EVKVSAIGKLDKLPKDLIDYLNRVVEKTSNYDKRKLTLAICYGGRQEILDAVVRLLDDYR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHC
NGKIVKSEINEETFRKYFYDSELQDIDLVIRTSGEVRISNFLLWHVAYSELFFCEAYWPE
CCEEEHHHCCHHHHHHHHCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCH
FRKIDLWRAIRSFQKRKRNFGA
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKDLTRGLLFKPIYKLYELVLWNQIRNGPLPDHVGIIPDGNRRWARDNNLSLNDAYFYG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
YKKLKEVLIWLLELGIKNITVFVLSTENCDKRKQNELSIITTYIKRGIQDLLEDPIVDKY
HHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
EVKVSAIGKLDKLPKDLIDYLNRVVEKTSNYDKRKLTLAICYGGRQEILDAVVRLLDDYR
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHC
NGKIVKSEINEETFRKYFYDSELQDIDLVIRTSGEVRISNFLLWHVAYSELFFCEAYWPE
CCEEEHHHCCHHHHHHHHCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCH
FRKIDLWRAIRSFQKRKRNFGA
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726; 12042311