Click here to switch to the map view.

The map label for this gene is map

Identifier: 15897059

GI number: 15897059

Start: 79467

End: 80372

Strand: Reverse

Name: map

Synonym: SSO0098

Alternate gene names: 15897059

Gene position: 80372-79467 (Counterclockwise)

Preceding gene: 15897064

Following gene: 15897058

Centisome position: 2.69

GC content: 34.11

Gene sequence:

>906_bases
ATGACTGAGGATGAACTCAATAAGCTTTTATTAGCAGGTAAGATTGCAGCTAAGGCTAGAGATGAAGTTTCATTAGACGT
TAAAGCTAGTGCTAAGGTTTTAGATATTTGTGAAGAGGTTGAAAGTATAATAATCGAAAATAAAGCGTTTCCATCATTTC
CATGTAATATATCAATTAATTCGGAAGCTGCTCATTATAGTCCAACTATAAATGATGAAAAGAGAATTCCAGAAGGTGCT
GTAGTTAAGTTAGATTTAGGAGCTCATATTGATGGTTTTATTAGCGATACTGCAATTACTATTAGTTTAGACTCTAGGTA
TCAAAGACTATTAGATGCATCTAAAACTGCTCTTGAGGCTGCAATTACTAATTTTAAAGCTGGATTAAGTATAGGTGAGA
TTGGTAGGGTTATTGAAAAGGTGATACGAGCTCAGGGATATAAGCCGATAAGGAACTTAGGAGGTCATCTTATAAGACGC
TATGAACTTCACGCTGGTGTGTTTATACCCAATGTTTACGAGAGAGGATTAGGCGTTATACAATCTGATTCTGTTTACGC
GATAGAACCATTTGCCACTGATGGTGGCGGAGAGGTAGTAGAAGGTAAGTCTATTACAATATATTCCTTAAAAAATCCTA
ATATAAAAGGTCTTTCTTCAAGAGAGAATGAGCTTATAGATTTTATATATACCCGTTTTAATTATTTACCGTTTTCAGAG
AGATGGCTTAAGGAATTTTCTACTAATGTTGACGAATTAAGAAATAATATAAAAAATTTAGTTAAAAAAGGTGCATTAAG
AGGATATCCGATCTTAATTGAGATCAAGAAAGGCGTAGTTTCTCAGTTCGAGCACACCGTTATAGTTAAGGGTGATTCAA
TTATAGTGTCTACAAAGTCTCTTTGA

Upstream 100 bases:

>100_bases
AATGTCAACAAGGTTGCAGCATGGCCTAACCATCTTAACTGTGCCATACAAAAGATTTCTATGAGAAAAAAATAAAGCTT
ATACCCCGAAAACTACATTC

Downstream 100 bases:

>100_bases
AAAAAGTTTAATTAATTCGAATGAGTAAAGGTTAACGATAAAAATGAGTTTAATTGCTTTAGCACAAACATCTTTAAATC
AAGCAAACTCTCTTTACTAC

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTEDELNKLLLAGKIAAKARDEVSLDVKASAKVLDICEEVESIIIENKAFPSFPCNISINSEAAHYSPTINDEKRIPEGA
VVKLDLGAHIDGFISDTAITISLDSRYQRLLDASKTALEAAITNFKAGLSIGEIGRVIEKVIRAQGYKPIRNLGGHLIRR
YELHAGVFIPNVYERGLGVIQSDSVYAIEPFATDGGGEVVEGKSITIYSLKNPNIKGLSSRENELIDFIYTRFNYLPFSE
RWLKEFSTNVDELRNNIKNLVKKGALRGYPILIEIKKGVVSQFEHTVIVKGDSIIVSTKSL

Sequences:

>Translated_301_residues
MTEDELNKLLLAGKIAAKARDEVSLDVKASAKVLDICEEVESIIIENKAFPSFPCNISINSEAAHYSPTINDEKRIPEGA
VVKLDLGAHIDGFISDTAITISLDSRYQRLLDASKTALEAAITNFKAGLSIGEIGRVIEKVIRAQGYKPIRNLGGHLIRR
YELHAGVFIPNVYERGLGVIQSDSVYAIEPFATDGGGEVVEGKSITIYSLKNPNIKGLSSRENELIDFIYTRFNYLPFSE
RWLKEFSTNVDELRNNIKNLVKKGALRGYPILIEIKKGVVSQFEHTVIVKGDSIIVSTKSL
>Mature_300_residues
TEDELNKLLLAGKIAAKARDEVSLDVKASAKVLDICEEVESIIIENKAFPSFPCNISINSEAAHYSPTINDEKRIPEGAV
VKLDLGAHIDGFISDTAITISLDSRYQRLLDASKTALEAAITNFKAGLSIGEIGRVIEKVIRAQGYKPIRNLGGHLIRRY
ELHAGVFIPNVYERGLGVIQSDSVYAIEPFATDGGGEVVEGKSITIYSLKNPNIKGLSSRENELIDFIYTRFNYLPFSER
WLKEFSTNVDELRNNIKNLVKKGALRGYPILIEIKKGVVSQFEHTVIVKGDSIIVSTKSL

Specific function: Removes the amino-terminal methionine from nascent proteins

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family

Homologues:

Organism=Homo sapiens, GI5803092, Length=307, Percent_Identity=30.6188925081433, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI124494254, Length=281, Percent_Identity=25.2669039145907, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI164420681, Length=210, Percent_Identity=24.2857142857143, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786364, Length=212, Percent_Identity=27.3584905660377, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17544396, Length=292, Percent_Identity=29.1095890410959, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17542840, Length=318, Percent_Identity=26.4150943396226, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319380, Length=259, Percent_Identity=31.2741312741313, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17137568, Length=305, Percent_Identity=30.8196721311475, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24658585, Length=313, Percent_Identity=26.517571884984, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24583427, Length=207, Percent_Identity=26.5700483091787, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355531, Length=207, Percent_Identity=23.6714975845411, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): AMPM_SULSO (P95963)

Other databases:

- EMBL:   Y08257
- EMBL:   AE006641
- PIR:   S75391
- RefSeq:   NP_341664.1
- ProteinModelPortal:   P95963
- MEROPS:   M24.002
- GeneID:   1453282
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0098
- NMPDR:   fig|273057.1.peg.87
- HOGENOM:   HBG318153
- OMA:   IEPFATN
- PhylomeDB:   P95963
- ProtClustDB:   PRK08671
- BioCyc:   SSOL273057:SSO0098-MONOMER
- BRENDA:   3.4.11.18
- GO:   GO:0006508
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991
- Gene3D:   G3DSA:3.90.230.10
- Gene3D:   G3DSA:1.10.10.10
- PANTHER:   PTHR10804:SF9
- PANTHER:   PTHR10804
- PRINTS:   PR00599
- TIGRFAMs:   TIGR00501

Pfam domain/function: PF00557 Peptidase_M24; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.11.18

Molecular weight: Translated: 33253; Mature: 33121

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS01202 MAP_2

Important sites: BINDING 65-65 BINDING 164-164

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDELNKLLLAGKIAAKARDEVSLDVKASAKVLDICEEVESIIIENKAFPSFPCNISIN
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEC
SEAAHYSPTINDEKRIPEGAVVKLDLGAHIDGFISDTAITISLDSRYQRLLDASKTALEA
CCCCCCCCCCCCHHCCCCCCEEEEECCCCCCCEECCEEEEEEECHHHHHHHHHHHHHHHH
AITNFKAGLSIGEIGRVIEKVIRAQGYKPIRNLGGHLIRRYELHAGVFIPNVYERGLGVI
HHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEECCCHHHHCCCEE
QSDSVYAIEPFATDGGGEVVEGKSITIYSLKNPNIKGLSSRENELIDFIYTRFNYLPFSE
ECCCEEEEECEECCCCCCEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
RWLKEFSTNVDELRNNIKNLVKKGALRGYPILIEIKKGVVSQFEHTVIVKGDSIIVSTKS
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHCCCEEEEECCEEEEEECC
L
C
>Mature Secondary Structure 
TEDELNKLLLAGKIAAKARDEVSLDVKASAKVLDICEEVESIIIENKAFPSFPCNISIN
CHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEC
SEAAHYSPTINDEKRIPEGAVVKLDLGAHIDGFISDTAITISLDSRYQRLLDASKTALEA
CCCCCCCCCCCCHHCCCCCCEEEEECCCCCCCEECCEEEEEEECHHHHHHHHHHHHHHHH
AITNFKAGLSIGEIGRVIEKVIRAQGYKPIRNLGGHLIRRYELHAGVFIPNVYERGLGVI
HHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEECCCHHHHCCCEE
QSDSVYAIEPFATDGGGEVVEGKSITIYSLKNPNIKGLSSRENELIDFIYTRFNYLPFSE
ECCCEEEEECEECCCCCCEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCHH
RWLKEFSTNVDELRNNIKNLVKKGALRGYPILIEIKKGVVSQFEHTVIVKGDSIIVSTKS
HHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHCCCEEEEECCEEEEEECC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726