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The map label for this gene is tyrS

Identifier: 15897044

GI number: 15897044

Start: 61719

End: 62819

Strand: Direct

Name: tyrS

Synonym: SSO0078

Alternate gene names: 15897044

Gene position: 61719-62819 (Clockwise)

Preceding gene: 15897043

Following gene: 15897045

Centisome position: 2.06

GC content: 35.06

Gene sequence:

>1101_bases
TTGGGGAAACTGATTATGAGTATCGATCAAAGGTTACAGCTTATAATGAGAAATACAGCTGAAGTTATAACTATAGATGA
ATTAAGGAAAAAATTAGAATCTGATGAGAAATTAAAGGGTTATATAGGATTTGAGCCAAGTGGATTATTCCACATTGGAT
GGCTAATCTGGACACAAAAAGTGAAAGATTTAGTAGAAGCAGGCATTAATATGACATTATTAAGAGCAGCTTGGCACGCA
TGGATTAACGATAAGTTGGGTGGAGATATGAACCTAATAAAAATGGCTGCTGACTACGCAGTTGAGGTAATAAAGAATTA
CGGAGTCGACGTAGGTAAGTTGAACATAGTAGATGCTGACGATATAGTTAAGGAGAAAGATTATTGGGCTCTTGTGATAA
AAGTAGCGAAAAACGCTAGTTTAGCCAGAATAAAAAGAGCACTAACAATAATGGGAAGAAGGGCAGAAGAGGCTGAAATA
GATGCATCAAAACTGATATATCCAGCCATGCAAGTTAGTGACATATTTTATCTGGATTTAGACATAGCACTAGGAGGAAC
AGATCAGAGAAAAGCCCACATGTTAGCAAGAGATGTAGCGGAAAAAATGGGCAAGAAGAAAATAGTATCGATACACACAC
CACTTTTAGTAGGGCTTCAAGGAGGACAGAGAATGAACATAACAGAGGGAATGGAAGAAGACGATATACAAGCTGAAATA
AAAATGAGTAAATCAAAGCCAGAATCTGCGATCTTCGTTAATGATAGTAGAGAAGATGTGGAAAGAAAAATAATGGGTGC
ATATTGTCCTAAAGGTGTTGCAGAAAATAATCCAATTCTTCAAATATTAAAGTATATCATATTTCCGCGTTATAATTTTG
TAAAGATTGAAAGAGATATTAAATATGGTGGGGACGTTGAATTTAAGGATTACGAGGAATTAGAAAGGACTTATATTGAA
GGAAAAATACATCCGATGGATTTAAAGAAGACTACTGCGAGAAAACTAAATGAGATATTAGAACCTATAAGAAAAAGTTT
AGAAAAGAAACCCGAGTTCGAGGAAATGATTCAGAAGATATCCAAAAGTGTAACAAGGTAA

Upstream 100 bases:

>100_bases
GGACCTCGAGAAAAAATTGGGAAATACACATCCAGTTGTTCTCTTTTTGAAACAATTCAAAGATGATTAGTGCTTTTTTA
CTTAAACTTCTCTTTACTTT

Downstream 100 bases:

>100_bases
TGTAAAGGTGAGCTTCCAAATGAAATATGATATAAGGTTAAGATTTGAAGTAGAGGGTATAGTCGAAAAAACTGATGTAA
TAGGTGCAATATTTGGCCAG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MGKLIMSIDQRLQLIMRNTAEVITIDELRKKLESDEKLKGYIGFEPSGLFHIGWLIWTQKVKDLVEAGINMTLLRAAWHA
WINDKLGGDMNLIKMAADYAVEVIKNYGVDVGKLNIVDADDIVKEKDYWALVIKVAKNASLARIKRALTIMGRRAEEAEI
DASKLIYPAMQVSDIFYLDLDIALGGTDQRKAHMLARDVAEKMGKKKIVSIHTPLLVGLQGGQRMNITEGMEEDDIQAEI
KMSKSKPESAIFVNDSREDVERKIMGAYCPKGVAENNPILQILKYIIFPRYNFVKIERDIKYGGDVEFKDYEELERTYIE
GKIHPMDLKKTTARKLNEILEPIRKSLEKKPEFEEMIQKISKSVTR

Sequences:

>Translated_366_residues
MGKLIMSIDQRLQLIMRNTAEVITIDELRKKLESDEKLKGYIGFEPSGLFHIGWLIWTQKVKDLVEAGINMTLLRAAWHA
WINDKLGGDMNLIKMAADYAVEVIKNYGVDVGKLNIVDADDIVKEKDYWALVIKVAKNASLARIKRALTIMGRRAEEAEI
DASKLIYPAMQVSDIFYLDLDIALGGTDQRKAHMLARDVAEKMGKKKIVSIHTPLLVGLQGGQRMNITEGMEEDDIQAEI
KMSKSKPESAIFVNDSREDVERKIMGAYCPKGVAENNPILQILKYIIFPRYNFVKIERDIKYGGDVEFKDYEELERTYIE
GKIHPMDLKKTTARKLNEILEPIRKSLEKKPEFEEMIQKISKSVTR
>Mature_365_residues
GKLIMSIDQRLQLIMRNTAEVITIDELRKKLESDEKLKGYIGFEPSGLFHIGWLIWTQKVKDLVEAGINMTLLRAAWHAW
INDKLGGDMNLIKMAADYAVEVIKNYGVDVGKLNIVDADDIVKEKDYWALVIKVAKNASLARIKRALTIMGRRAEEAEID
ASKLIYPAMQVSDIFYLDLDIALGGTDQRKAHMLARDVAEKMGKKKIVSIHTPLLVGLQGGQRMNITEGMEEDDIQAEIK
MSKSKPESAIFVNDSREDVERKIMGAYCPKGVAENNPILQILKYIIFPRYNFVKIERDIKYGGDVEFKDYEELERTYIEG
KIHPMDLKKTTARKLNEILEPIRKSLEKKPEFEEMIQKISKSVTR

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily

Homologues:

Organism=Homo sapiens, GI4507947, Length=345, Percent_Identity=31.304347826087, Blast_Score=149, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71992775, Length=339, Percent_Identity=28.3185840707965, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321624, Length=366, Percent_Identity=30.8743169398907, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21357223, Length=350, Percent_Identity=31.4285714285714, Blast_Score=164, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYY_SULSO (P95982)

Other databases:

- EMBL:   Y08257
- EMBL:   AE006641
- PIR:   S75410
- RefSeq:   NP_341649.1
- ProteinModelPortal:   P95982
- SMR:   P95982
- GeneID:   1455330
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO0078
- NMPDR:   fig|273057.1.peg.72
- HOGENOM:   HBG330667
- OMA:   DVAVGGM
- PhylomeDB:   P95982
- ProtClustDB:   PRK08560
- BioCyc:   SSOL273057:SSO0078-MONOMER
- BRENDA:   6.1.1.1
- GO:   GO:0005737
- HAMAP:   MF_02009
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002307
- InterPro:   IPR015624
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11946:SF8
- PIRSF:   PIRSF006588
- PRINTS:   PR01040
- TIGRFAMs:   TIGR00234

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.1

Molecular weight: Translated: 41820; Mature: 41689

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 41-41 BINDING 167-167 BINDING 171-171 BINDING 174-174 BINDING 189-189 BINDING 244-244

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLIMSIDQRLQLIMRNTAEVITIDELRKKLESDEKLKGYIGFEPSGLFHIGWLIWTQK
CCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHH
VKDLVEAGINMTLLRAAWHAWINDKLGGDMNLIKMAADYAVEVIKNYGVDVGKLNIVDAD
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECHH
DIVKEKDYWALVIKVAKNASLARIKRALTIMGRRAEEAEIDASKLIYPAMQVSDIFYLDL
HHHCCCCHHEEEEEHHCCCHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCEEEEEEE
DIALGGTDQRKAHMLARDVAEKMGKKKIVSIHTPLLVGLQGGQRMNITEGMEEDDIQAEI
EEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCEECCCCCCCCCCCHHHE
KMSKSKPESAIFVNDSREDVERKIMGAYCPKGVAENNPILQILKYIIFPRYNFVKIERDI
EECCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECC
KYGGDVEFKDYEELERTYIEGKIHPMDLKKTTARKLNEILEPIRKSLEKKPEFEEMIQKI
CCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SKSVTR
HHHHCC
>Mature Secondary Structure 
GKLIMSIDQRLQLIMRNTAEVITIDELRKKLESDEKLKGYIGFEPSGLFHIGWLIWTQK
CCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHH
VKDLVEAGINMTLLRAAWHAWINDKLGGDMNLIKMAADYAVEVIKNYGVDVGKLNIVDAD
HHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECHH
DIVKEKDYWALVIKVAKNASLARIKRALTIMGRRAEEAEIDASKLIYPAMQVSDIFYLDL
HHHCCCCHHEEEEEHHCCCHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHCEEEEEEE
DIALGGTDQRKAHMLARDVAEKMGKKKIVSIHTPLLVGLQGGQRMNITEGMEEDDIQAEI
EEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCEECCCCCCCCCCCHHHE
KMSKSKPESAIFVNDSREDVERKIMGAYCPKGVAENNPILQILKYIIFPRYNFVKIERDI
EECCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECC
KYGGDVEFKDYEELERTYIEGKIHPMDLKKTTARKLNEILEPIRKSLEKKPEFEEMIQKI
CCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SKSVTR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726