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The map label for this gene is thiD-1 [H]

Identifier: 15896974

GI number: 15896974

Start: 889

End: 2091

Strand: Direct

Name: thiD-1 [H]

Synonym: SSO0002

Alternate gene names: 15896974

Gene position: 889-2091 (Clockwise)

Preceding gene: 15896973

Following gene: 15896975

Centisome position: 0.03

GC content: 35.0

Gene sequence:

>1203_bases
GTGCACACTAGACCAGTAGTTGCCACAATAGCTGGGAGTGACAGTGGAGGAGGTGCTGGATTACAGGCTGATCTAAAGAC
GTTTAGCGCATTAGGAGTTTTTGGTACAACAATAATAACCGGTTTAACAGCACAGAATACAAGAACAGTTACAAAAGTAT
TAGAGATACCATTAGATTTCATTGAAGCTCAGTTTGATGCGGTTTGCCTAGATTTACATCCAACTCACGCCAAAACTGGA
ATGTTAGCTTCTGGTAAAGTGGTAGAACTTGTACTGAGAAAAATTAGAGAGTATAACATAAAACTAGTTTTAGATCCAGT
GATGGTTGCGAAATCTGGATCATTATTGGTAACAGAGGATATCTCGGAGCAAATAAAAAAGGCGATGAAGGAGGCCATAA
TATCTACTCCAAACAGATATGAAGCTGAGATAATAAATAAGACAAAGATTAATAGTCAAGATGATGTTATAAAAGCGGCA
AGGGAAATTTATTCTAAGTATGGGAATGTTGTAGTTAAAGGATTTAATGGAGTAGATTACGCCATAATTGACGGAGAAGA
AATAGAGTTAAAAGGTGATTACATCAGTACTAAAAATACACATGGTAGTGGAGACGTATTTTCTGCCTCCATAACTGCAT
ATCTTGCCTTGGGATACAAACTTAAAGATGCATTAATAAGAGCTAAAAAATTCGCTACAATGACAGTCAAATACGGTTTG
GACTTAGGAGGAGGATATGGACCAGTAGATCCCTTTGCCCCTATAGAGTCCATAGTGAAGAGAGAAGAAGGAAGAAATCA
GCTAGAAAACTTACTTTGGTACTTAGAGTCTAATCTTAACGTTATACTTAAACTAATTAACGATACCTCGAAAGTAAATG
TGGCATATATGACAAAGTATAATGATGTATTAAGTTTAGCTGGAGGATTAATAAAATATTTGGACAAGCTGAAGATTGAT
GGACCGATACTTAATAATGTAAATAACGAGATAACTAGAATCATGAGAGAAACACCAGATGAGAAAATAGGAATATTATT
GCCATTTACTGATAAAATATTAGACGCTGCGGAAAAAGGTAAAATAAAATTAAATAAAAGTGGTATTAATGGGGACGCAA
TACTACGAGATAATATGGTATTAATTATAGCCAAGGATAAGGATGAGTTAATAAGAAAGTTAAAAGAGGTAGCTATAGGT
TGA

Upstream 100 bases:

>100_bases
TCACCTAGATTCAACTGGGAATGTAAATATTGCATATTTTCCGTCATTTGCCCAGCTAAACTAACCTAAAATTAAAATCT
CTCATCGATATAATTAAATT

Downstream 100 bases:

>100_bases
TAATCGTAGTAGGAAGTTACAACGTTGATGTAATATTGAAAGTTAATAAAATACCTGAAATTGGAGAAACTGTAATAGCT
GATGAATTATACATAACGCA

Product: phosphomethylpyrimidine kinase (thiD-1)

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MHTRPVVATIAGSDSGGGAGLQADLKTFSALGVFGTTIITGLTAQNTRTVTKVLEIPLDFIEAQFDAVCLDLHPTHAKTG
MLASGKVVELVLRKIREYNIKLVLDPVMVAKSGSLLVTEDISEQIKKAMKEAIISTPNRYEAEIINKTKINSQDDVIKAA
REIYSKYGNVVVKGFNGVDYAIIDGEEIELKGDYISTKNTHGSGDVFSASITAYLALGYKLKDALIRAKKFATMTVKYGL
DLGGGYGPVDPFAPIESIVKREEGRNQLENLLWYLESNLNVILKLINDTSKVNVAYMTKYNDVLSLAGGLIKYLDKLKID
GPILNNVNNEITRIMRETPDEKIGILLPFTDKILDAAEKGKIKLNKSGINGDAILRDNMVLIIAKDKDELIRKLKEVAIG

Sequences:

>Translated_400_residues
MHTRPVVATIAGSDSGGGAGLQADLKTFSALGVFGTTIITGLTAQNTRTVTKVLEIPLDFIEAQFDAVCLDLHPTHAKTG
MLASGKVVELVLRKIREYNIKLVLDPVMVAKSGSLLVTEDISEQIKKAMKEAIISTPNRYEAEIINKTKINSQDDVIKAA
REIYSKYGNVVVKGFNGVDYAIIDGEEIELKGDYISTKNTHGSGDVFSASITAYLALGYKLKDALIRAKKFATMTVKYGL
DLGGGYGPVDPFAPIESIVKREEGRNQLENLLWYLESNLNVILKLINDTSKVNVAYMTKYNDVLSLAGGLIKYLDKLKID
GPILNNVNNEITRIMRETPDEKIGILLPFTDKILDAAEKGKIKLNKSGINGDAILRDNMVLIIAKDKDELIRKLKEVAIG
>Mature_400_residues
MHTRPVVATIAGSDSGGGAGLQADLKTFSALGVFGTTIITGLTAQNTRTVTKVLEIPLDFIEAQFDAVCLDLHPTHAKTG
MLASGKVVELVLRKIREYNIKLVLDPVMVAKSGSLLVTEDISEQIKKAMKEAIISTPNRYEAEIINKTKINSQDDVIKAA
REIYSKYGNVVVKGFNGVDYAIIDGEEIELKGDYISTKNTHGSGDVFSASITAYLALGYKLKDALIRAKKFATMTVKYGL
DLGGGYGPVDPFAPIESIVKREEGRNQLENLLWYLESNLNVILKLINDTSKVNVAYMTKYNDVLSLAGGLIKYLDKLKID
GPILNNVNNEITRIMRETPDEKIGILLPFTDKILDAAEKGKIKLNKSGINGDAILRDNMVLIIAKDKDELIRKLKEVAIG

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=255, Percent_Identity=36.078431372549, Blast_Score=145, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6325378, Length=257, Percent_Identity=32.295719844358, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324997, Length=262, Percent_Identity=32.4427480916031, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324517, Length=257, Percent_Identity=32.295719844358, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 43746; Mature: 43746

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTRPVVATIAGSDSGGGAGLQADLKTFSALGVFGTTIITGLTAQNTRTVTKVLEIPLDF
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
IEAQFDAVCLDLHPTHAKTGMLASGKVVELVLRKIREYNIKLVLDPVMVAKSGSLLVTED
HHHHHCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEEECCCCEEEEHH
ISEQIKKAMKEAIISTPNRYEAEIINKTKINSQDDVIKAAREIYSKYGNVVVKGFNGVDY
HHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCEE
AIIDGEEIELKGDYISTKNTHGSGDVFSASITAYLALGYKLKDALIRAKKFATMTVKYGL
EEECCCEEEEECCEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECC
DLGGGYGPVDPFAPIESIVKREEGRNQLENLLWYLESNLNVILKLINDTSKVNVAYMTKY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHEECCCCCCEEEEEEECH
NDVLSLAGGLIKYLDKLKIDGPILNNVNNEITRIMRETPDEKIGILLPFTDKILDAAEKG
HHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCHHHHHCHHHCC
KIKLNKSGINGDAILRDNMVLIIAKDKDELIRKLKEVAIG
CEEEECCCCCCCEEEECCEEEEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure
MHTRPVVATIAGSDSGGGAGLQADLKTFSALGVFGTTIITGLTAQNTRTVTKVLEIPLDF
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
IEAQFDAVCLDLHPTHAKTGMLASGKVVELVLRKIREYNIKLVLDPVMVAKSGSLLVTED
HHHHHCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEEEEECCCCEEEEHH
ISEQIKKAMKEAIISTPNRYEAEIINKTKINSQDDVIKAAREIYSKYGNVVVKGFNGVDY
HHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCEE
AIIDGEEIELKGDYISTKNTHGSGDVFSASITAYLALGYKLKDALIRAKKFATMTVKYGL
EEECCCEEEEECCEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECC
DLGGGYGPVDPFAPIESIVKREEGRNQLENLLWYLESNLNVILKLINDTSKVNVAYMTKY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHEECCCCCCEEEEEEECH
NDVLSLAGGLIKYLDKLKIDGPILNNVNNEITRIMRETPDEKIGILLPFTDKILDAAEKG
HHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHCCCCCEEEEECCHHHHHCHHHCC
KIKLNKSGINGDAILRDNMVLIIAKDKDELIRKLKEVAIG
CEEEECCCCCCCEEEECCEEEEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]