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The map label for this gene is ddh

Identifier: 15928103

GI number: 15928103

Start: 2596930

End: 2597985

Strand: Direct

Name: ddh

Synonym: SA2312

Alternate gene names: 15928103

Gene position: 2596930-2597985 (Clockwise)

Preceding gene: 15928101

Following gene: 15928105

Centisome position: 92.26

GC content: 33.81

Gene sequence:

>1056_bases
ATGTACATAATCTTTAATTTCACTCATTTACTTTTCAATCTTTTAAAAGCGAGGTTTTTAATAATGACAAAAATTATGTT
CTTTGGTACGCGTGATTATGAGAAAGAGATGGCATTAAATTGGGGGAAAAAGAATAATGTCGAAGTAACTACTTCTAAAG
AGCTATTATCAAGTGCTACAGTCGATCAATTAAAAGATTACGATGGCGTAACTACAATGCAATTTGGTAAGTTAGAAAAT
GACGTTTATCCTAAATTAGAATCTTACGGTATTAAACAAATTGCACAACGTACTGCTGGATTTGATATGTATGATTTAGA
TTTAGCTAAAAAACACAACATTGTGATATCTAACGTTCCTAGTTATTCACCTGAAACAATTGCAGAGTATTCTGTTTCTA
TCGCCCTACAATTAGTGCGTCGCTTCCCAGATATTGAACGCCGTGTACAAACACATGATTTTACTTGGCAAGCAGAAATC
ATGTCTAAACCAGTTAAAAATATGACTGTTGCAATTATCGGTACGGGTCGTATCGGTGCTGCTACAGCTAAAATATATGC
AGGATTTGGTGCTACAATTACAGCTTATGACGCTTATCCTAATAAAGATTTAGACTTTTTAACTTATAAAGATAGTGTTA
AAGAAGCTATTAAAGATGCCGATATTATTTCTTTACATGTTCCAGCGAACAAAGAAAGCTATCATTTATTCGATAAAGCA
ATGTTTGATCATGTGAAAAAAGGTGCAATCTTAGTTAACGCAGCACGTGGTGCAGTCATCAATACACCTGATTTAATCGC
TGCAGTGAACGATGGTACTTTGTTAGGTGCTGCGATTGATACTTATGAAAATGAAGCTGCATACTTCACAAATGACTGGA
CTAATAAAGACATTGACGATAAAACATTATTAGAGTTAATCGAACATGAAAGAATTTTAGTAACACCACATATTGCTTTC
TTCTCTGATGAAGCAGTACAAAACCTTGTTGAAGGTGGTTTAAACGCAGCATTATCTGTCATTAACACTGGTACATGTGA
AACACGTTTAAATTAA

Upstream 100 bases:

>100_bases
TATAAGTTTTCTGCAATAAAACACACTTTTGAATTTTGGAAAATTTAGTGTTATAATATATTTGTGATATTTTTCACAAT
TAAATTGTGGCGTGATTTTA

Downstream 100 bases:

>100_bases
TATATATTTAAAAGCAAAGGCGCACCATGTGCCTTTGCTTTTTATTTTGTTTATCTGTATCAAAATCGGTTTGATTAAAA
TCTGCTTTATTTTATCATCT

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: D-LDH; D-specific D-2-hydroxyacid dehydrogenase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MYIIFNFTHLLFNLLKARFLIMTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLEN
DVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQTHDFTWQAEI
MSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKA
MFDHVKKGAILVNAARGAVINTPDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAF
FSDEAVQNLVEGGLNAALSVINTGTCETRLN

Sequences:

>Translated_351_residues
MYIIFNFTHLLFNLLKARFLIMTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLEN
DVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQTHDFTWQAEI
MSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKA
MFDHVKKGAILVNAARGAVINTPDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAF
FSDEAVQNLVEGGLNAALSVINTGTCETRLN
>Mature_351_residues
MYIIFNFTHLLFNLLKARFLIMTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLEN
DVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQTHDFTWQAEI
MSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKA
MFDHVKKGAILVNAARGAVINTPDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAF
FSDEAVQNLVEGGLNAALSVINTGTCETRLN

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=286, Percent_Identity=24.4755244755245, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4557497, Length=250, Percent_Identity=27.2, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI61743967, Length=250, Percent_Identity=27.2, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580578, Length=256, Percent_Identity=26.171875, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI4557499, Length=256, Percent_Identity=26.171875, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI145580575, Length=250, Percent_Identity=26.4, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI6912396, Length=200, Percent_Identity=29.5, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1787645, Length=328, Percent_Identity=29.5731707317073, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789279, Length=243, Percent_Identity=29.2181069958848, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082289, Length=250, Percent_Identity=27.2, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87081824, Length=205, Percent_Identity=22.9268292682927, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788660, Length=229, Percent_Identity=26.6375545851528, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=326, Percent_Identity=26.0736196319018, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25147481, Length=356, Percent_Identity=25, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320925, Length=227, Percent_Identity=30.3964757709251, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=227, Percent_Identity=29.9559471365639, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=258, Percent_Identity=27.5193798449612, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=304, Percent_Identity=24.3421052631579, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=180, Percent_Identity=25.5555555555556, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646446, Length=256, Percent_Identity=28.90625, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24646448, Length=256, Percent_Identity=28.90625, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24646452, Length=256, Percent_Identity=28.90625, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24646450, Length=256, Percent_Identity=28.90625, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI62472511, Length=256, Percent_Identity=28.90625, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574286, Length=238, Percent_Identity=23.9495798319328, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45552429, Length=296, Percent_Identity=23.3108108108108, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574284, Length=296, Percent_Identity=23.3108108108108, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921140, Length=286, Percent_Identity=23.0769230769231, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24585514, Length=296, Percent_Identity=23.3108108108108, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574282, Length=296, Percent_Identity=23.3108108108108, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45551003, Length=296, Percent_Identity=23.3108108108108, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585516, Length=258, Percent_Identity=20.9302325581395, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 39322; Mature: 39322

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIIFNFTHLLFNLLKARFLIMTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSAT
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHH
VDQLKDYDGVTTMQFGKLENDVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVP
HHHHHCCCCCEEEECCCCCCCCCCCHHHCCHHHHHHHHCCCCEEECCHHCCCCEEEECCC
SYSPETIAEYSVSIALQLVRRFPDIERRVQTHDFTWQAEIMSKPVKNMTVAIIGTGRIGA
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEHHHHCCCCCCEEEEEEECCCCCH
ATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKA
HHHHEEECCCCEEEEEECCCCCCCCEEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
MFDHVKKGAILVNAARGAVINTPDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDD
HHHHHCCCEEEEEECCCCEECCCCEEEEECCCEEEEEEHHCCCCCCEEEECCCCCCCCCH
KTLLELIEHERILVTPHIAFFSDEAVQNLVEGGLNAALSVINTGTCETRLN
HHHHHHHHCCEEEEECCHHHCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MYIIFNFTHLLFNLLKARFLIMTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSAT
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHH
VDQLKDYDGVTTMQFGKLENDVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVP
HHHHHCCCCCEEEECCCCCCCCCCCHHHCCHHHHHHHHCCCCEEECCHHCCCCEEEECCC
SYSPETIAEYSVSIALQLVRRFPDIERRVQTHDFTWQAEIMSKPVKNMTVAIIGTGRIGA
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEHHHHCCCCCCEEEEEEECCCCCH
ATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKA
HHHHEEECCCCEEEEEECCCCCCCCEEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
MFDHVKKGAILVNAARGAVINTPDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDD
HHHHHCCCEEEEEECCCCEECCCCEEEEECCCEEEEEEHHCCCCCCEEEECCCCCCCCCH
KTLLELIEHERILVTPHIAFFSDEAVQNLVEGGLNAALSVINTGTCETRLN
HHHHHHHHCCEEEEECCHHHCCHHHHHHHHHCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA