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The map label for this gene is cycA [H]

Identifier: 15928017

GI number: 15928017

Start: 2499033

End: 2499446

Strand: Direct

Name: cycA [H]

Synonym: SA2227

Alternate gene names: 15928017

Gene position: 2499033-2499446 (Clockwise)

Preceding gene: 15928016

Following gene: 15928018

Centisome position: 88.78

GC content: 30.43

Gene sequence:

>414_bases
ATGTTAGTTTCATCAATTGCATTACTTATAGCAGCCTTGTTAAACTACATTTTCCCTAATGCAATTCAACTATTCATATA
CGTTACAACGTTATCAACTGTGTTGTTTTTAGTTGTTTGGGCAATGATTATTGTCGCTTATCTAATGTATTTGAAAAAGC
ATCCTGAGGCACATAAAAACAGTAAATTTAAGTTGATTGGTGGTAAGCCTATTGCTTACATTATTCTAGCGTTCTTCTTC
TTTGTATTCATTTTATTATTCTTTAGTGACGAAACAAGAGCAGCTATTTATATTTCACCATTCTGGTTTATATTTTTATT
TTTCTTTTATAAAAAATACAAAACGAATGCTGAAAAGCTCGCGTATGAACAACGACAAAATGACAGCGGTCATTTCAGAT
ATGACAATCAATAA

Upstream 100 bases:

>100_bases
GCTACAAATAGTGGTATCTATTCGAATAGTCGTATCTTATTCGGACTGTCACAACAAGGGTTAGGTCCTAAAGTTTTAAA
TTGGCGTGCCTTATTTATCA

Downstream 100 bases:

>100_bases
TTTAAACATCTCGCTCTAGTATCAGTTCAACCGATACTAGAGTTTTTTTTGAAAATAACTTCATTTTATCAATATATCTA
TGTCATTATGCCTTAAAAGT

Product: hypothetical protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MLVSSIALLIAALLNYIFPNAIQLFIYVTTLSTVLFLVVWAMIIVAYLMYLKKHPEAHKNSKFKLIGGKPIAYIILAFFF
FVFILLFFSDETRAAIYISPFWFIFLFFFYKKYKTNAEKLAYEQRQNDSGHFRYDNQ

Sequences:

>Translated_137_residues
MLVSSIALLIAALLNYIFPNAIQLFIYVTTLSTVLFLVVWAMIIVAYLMYLKKHPEAHKNSKFKLIGGKPIAYIILAFFF
FVFILLFFSDETRAAIYISPFWFIFLFFFYKKYKTNAEKLAYEQRQNDSGHFRYDNQ
>Mature_137_residues
MLVSSIALLIAALLNYIFPNAIQLFIYVTTLSTVLFLVVWAMIIVAYLMYLKKHPEAHKNSKFKLIGGKPIAYIILAFFF
FVFILLFFSDETRAAIYISPFWFIFLFFFYKKYKTNAEKLAYEQRQNDSGHFRYDNQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790653, Length=120, Percent_Identity=38.3333333333333, Blast_Score=92, Evalue=1e-20,
Organism=Escherichia coli, GI48994972, Length=124, Percent_Identity=28.2258064516129, Blast_Score=59, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 16199; Mature: 16199

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSSIALLIAALLNYIFPNAIQLFIYVTTLSTVLFLVVWAMIIVAYLMYLKKHPEAHKN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SKFKLIGGKPIAYIILAFFFFVFILLFFSDETRAAIYISPFWFIFLFFFYKKYKTNAEKL
CCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCHHHH
AYEQRQNDSGHFRYDNQ
HHHHHCCCCCCEEECCC
>Mature Secondary Structure
MLVSSIALLIAALLNYIFPNAIQLFIYVTTLSTVLFLVVWAMIIVAYLMYLKKHPEAHKN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SKFKLIGGKPIAYIILAFFFFVFILLFFSDETRAAIYISPFWFIFLFFFYKKYKTNAEKL
CCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCHHHH
AYEQRQNDSGHFRYDNQ
HHHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]