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The map label for this gene is cycA [H]

Identifier: 15928016

GI number: 15928016

Start: 2498051

End: 2499091

Strand: Direct

Name: cycA [H]

Synonym: SA2226

Alternate gene names: 15928016

Gene position: 2498051-2499091 (Clockwise)

Preceding gene: 15928014

Following gene: 15928017

Centisome position: 88.75

GC content: 36.89

Gene sequence:

>1041_bases
ATGGCAAGAAAATTGCATAGAGAGTTGAATAACAGACACATCCAATTGATAGCAATTGGGGGCGCAATTGGAACTGGGTT
ATTCCTAGGATCAGGTCAAACAATATCTTTAACTGGTCCATCACTGTTATTCACATACATGATTATTGGGGTTGTACTAT
TCGCTTTTATGCGCGCATTAGGCGAATTGTTGTTGAGCAATACAAGATTTAATTCATTTGTTGATATTGCAAATGAATAT
TTAGGCCCTTTTGGTGGCTTTGTCATTGGCTGGACTTACTGGTTATGTTGGATTGTATCAAGTATGTCAGACCTAACTGC
GATGGGACAATACTTTGCATTTTGGTATCCACAAGTCCCAAATTGGATTACCGTGCTATTTATTGTTTTAATCTTGATTA
GCTTCAACTTATTAGGTGCCAGATTATTTGGTGAACTGGAGTTTTGGTTCTCTATTATTAAAGTTGTCACAATTATTGCG
ATGGTTATCGTTGGTCTTGTATTAATCTTTTTCTCATTTAAAACACATTATGGACATGCATCATTCACAAACTTAATCAG
TCACGGCGGCATGTTCCCTGGAGGAACATTTGGTTTCCTAATGTCATTCCAAATTGCTGTATATTCATTCATTGGTATTG
AACTTATAGGTGTAACTGCTGGTGAAACGAAAGATCCTGAAAAAACCTTACCGAAAGCAATTAATAATGTACCTATCCGT
ATTTTATTATTCTATATCGGTGGTCTATTAGTAATTATGTCAGTCATACCTTGGAATGATATCGATCCAAATAGTAGCCC
TTTCGTTAAACTCTTTACATTAATCGGCGTGCCATTTGCAGCAGGCGTCGTTAACTTTGTCGTGCTAACTGCCGCGGCCT
CTGCTACAAATAGTGGTATCTATTCGAATAGTCGTATCTTATTCGGACTGTCACAACAAGGGTTAGGTCCTAAAGTTTTA
AATTGGCGTGCCTTATTTATCAATGTTAGTTTCATCAATTGCATTACTTATAGCAGCCTTGTTAAACTACATTTTCCCTA
A

Upstream 100 bases:

>100_bases
AAAAAATAATTGCTTTATTAAATGGATTTCTTTAGTATTTATAATTAAGAAAACGCTTACACACAACTTTTTTATTTGCT
TTATCCTGAGGAGGAAAATT

Downstream 100 bases:

>100_bases
TGCAATTCAACTATTCATATACGTTACAACGTTATCAACTGTGTTGTTTTTAGTTGTTTGGGCAATGATTATTGTCGCTT
ATCTAATGTATTTGAAAAAG

Product: hypothetical protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MARKLHRELNNRHIQLIAIGGAIGTGLFLGSGQTISLTGPSLLFTYMIIGVVLFAFMRALGELLLSNTRFNSFVDIANEY
LGPFGGFVIGWTYWLCWIVSSMSDLTAMGQYFAFWYPQVPNWITVLFIVLILISFNLLGARLFGELEFWFSIIKVVTIIA
MVIVGLVLIFFSFKTHYGHASFTNLISHGGMFPGGTFGFLMSFQIAVYSFIGIELIGVTAGETKDPEKTLPKAINNVPIR
ILLFYIGGLLVIMSVIPWNDIDPNSSPFVKLFTLIGVPFAAGVVNFVVLTAAASATNSGIYSNSRILFGLSQQGLGPKVL
NWRALFINVSFINCITYSSLVKLHFP

Sequences:

>Translated_346_residues
MARKLHRELNNRHIQLIAIGGAIGTGLFLGSGQTISLTGPSLLFTYMIIGVVLFAFMRALGELLLSNTRFNSFVDIANEY
LGPFGGFVIGWTYWLCWIVSSMSDLTAMGQYFAFWYPQVPNWITVLFIVLILISFNLLGARLFGELEFWFSIIKVVTIIA
MVIVGLVLIFFSFKTHYGHASFTNLISHGGMFPGGTFGFLMSFQIAVYSFIGIELIGVTAGETKDPEKTLPKAINNVPIR
ILLFYIGGLLVIMSVIPWNDIDPNSSPFVKLFTLIGVPFAAGVVNFVVLTAAASATNSGIYSNSRILFGLSQQGLGPKVL
NWRALFINVSFINCITYSSLVKLHFP
>Mature_345_residues
ARKLHRELNNRHIQLIAIGGAIGTGLFLGSGQTISLTGPSLLFTYMIIGVVLFAFMRALGELLLSNTRFNSFVDIANEYL
GPFGGFVIGWTYWLCWIVSSMSDLTAMGQYFAFWYPQVPNWITVLFIVLILISFNLLGARLFGELEFWFSIIKVVTIIAM
VIVGLVLIFFSFKTHYGHASFTNLISHGGMFPGGTFGFLMSFQIAVYSFIGIELIGVTAGETKDPEKTLPKAINNVPIRI
LLFYIGGLLVIMSVIPWNDIDPNSSPFVKLFTLIGVPFAAGVVNFVVLTAAASATNSGIYSNSRILFGLSQQGLGPKVLN
WRALFINVSFINCITYSSLVKLHFP

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=335, Percent_Identity=24.1791044776119, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790653, Length=317, Percent_Identity=56.782334384858, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1786789, Length=318, Percent_Identity=49.3710691823899, Blast_Score=306, Evalue=1e-84,
Organism=Escherichia coli, GI1786302, Length=346, Percent_Identity=43.6416184971098, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1786602, Length=318, Percent_Identity=47.7987421383648, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI48994972, Length=317, Percent_Identity=46.6876971608833, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI87081915, Length=315, Percent_Identity=40.6349206349206, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI87081708, Length=317, Percent_Identity=40.0630914826498, Blast_Score=234, Evalue=6e-63,
Organism=Escherichia coli, GI1788480, Length=328, Percent_Identity=41.1585365853659, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1789017, Length=315, Percent_Identity=32.3809523809524, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI87082023, Length=293, Percent_Identity=24.5733788395904, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=340, Percent_Identity=22.0588235294118, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=337, Percent_Identity=35.9050445103858, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324924, Length=370, Percent_Identity=31.0810810810811, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6324061, Length=335, Percent_Identity=33.4328358208955, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=336, Percent_Identity=35.1190476190476, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324059, Length=338, Percent_Identity=33.7278106508876, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6324990, Length=342, Percent_Identity=30.4093567251462, Blast_Score=152, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=326, Percent_Identity=33.1288343558282, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6321053, Length=333, Percent_Identity=30.3303303303303, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321629, Length=336, Percent_Identity=30.6547619047619, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322967, Length=331, Percent_Identity=31.4199395770393, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319824, Length=347, Percent_Identity=27.6657060518732, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319608, Length=338, Percent_Identity=26.3313609467456, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6320717, Length=337, Percent_Identity=26.1127596439169, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6319543, Length=340, Percent_Identity=29.1176470588235, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319542, Length=342, Percent_Identity=25.1461988304094, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320251, Length=341, Percent_Identity=24.9266862170088, Blast_Score=109, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324981, Length=336, Percent_Identity=29.4642857142857, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6320364, Length=278, Percent_Identity=27.3381294964029, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI161077963, Length=331, Percent_Identity=22.0543806646526, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24666159, Length=331, Percent_Identity=22.3564954682779, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221512776, Length=331, Percent_Identity=22.3564954682779, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 38145; Mature: 38013

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKLHRELNNRHIQLIAIGGAIGTGLFLGSGQTISLTGPSLLFTYMIIGVVLFAFMRAL
CCHHHHHHHCCCEEEEEEECCHHHHCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
GELLLSNTRFNSFVDIANEYLGPFGGFVIGWTYWLCWIVSSMSDLTAMGQYFAFWYPQVP
HHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NWITVLFIVLILISFNLLGARLFGELEFWFSIIKVVTIIAMVIVGLVLIFFSFKTHYGHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SFTNLISHGGMFPGGTFGFLMSFQIAVYSFIGIELIGVTAGETKDPEKTLPKAINNVPIR
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHCCCHHH
ILLFYIGGLLVIMSVIPWNDIDPNSSPFVKLFTLIGVPFAAGVVNFVVLTAAASATNSGI
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
YSNSRILFGLSQQGLGPKVLNWRALFINVSFINCITYSSLVKLHFP
CCCCEEEEEECCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHEEECC
>Mature Secondary Structure 
ARKLHRELNNRHIQLIAIGGAIGTGLFLGSGQTISLTGPSLLFTYMIIGVVLFAFMRAL
CHHHHHHHCCCEEEEEEECCHHHHCEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHH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CCCCEEEEEECCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]