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The map label for this gene is hysA

Identifier: 15927782

GI number: 15927782

Start: 2273593

End: 2276022

Strand: Direct

Name: hysA

Synonym: SA2003

Alternate gene names: 15927782

Gene position: 2273593-2276022 (Clockwise)

Preceding gene: 15927778

Following gene: 15927785

Centisome position: 80.77

GC content: 33.17

Gene sequence:

>2430_bases
ATGACATATAGAATGAAGAAATGGCAAAAATTATCCACCATTACGTTATTAATGGCTGGTGTGATTACTTTGAATGGTGG
TGAATTCAGAAGTATTGATAAACATCAAATCGCTGTGGCTGATACGAATGTTCAAACGCCAGATTATGAAAAGTTGAGGA
ACACATGGTTAGATGTTAACTACGGTTATGATAAGTATGATGAGAAGAATGACGCAATGAAGAAGAAGTTTGATGCTACG
GAGAAAGAGGCAGAGAAATTACTCAGTAGCATGAAAACTGAAAGTGGAAGGACTTACTTGTGGGATAGTGCAAAAGATTT
AGATAACAAGTCTGCGGATATGACTCGTACCTATCGTAATATTGAGAAAATCGCAGAAGCGATGAGGCATCCTAAAACCA
CTTTAAATACTGACGAAAATAAGAAGAAAGTGAAAGATGCCCTTGAGTGGCTGCATAAAAATGCATATGGAAAAGAACCA
GATAATAAAGTAAAAGAATTGACTGAGAATTTTAAAATAACTGATTCATCAAAGAAAAAAGCTTTAAATTGGTGGGATTA
TGAAATTGGAACACCTAGATCATTAACAAATACGCTTATATTGCTGAATGATCAATTTTCAAATGAAGAAAAGAAAAAAT
TCACTGCCCCTATTAAAACTTTCGCCCCAAAAAGTGATGAAATATTATCTTCTGTAGGAAAAGCTGAACCTGCTAAAGGC
GGAAATTTAGTAGACATTGCTAAAGTAAAACTTTTAGAAAGTATTATCGAAGAAGATAAAGATATGATGAAAAATTCAAT
AGATTCATTTAATAAAGTCTTCACTTACGTTCAAGATTCTGCCACTGATAAAGAACGTAATGGATTTTATAAAGATGGTT
CATATATCGACCATAAAGATGTCCCATACACTGGTGCTTATGGCGTTGTACTCTTAGAGGGGATTTCTCAAATGATGCCG
ATGATAAAAGAAACACCTTTTAATGATAAAACCCAAAATAATACAACCTTAAAATCATGGATTGACGACGGATTTTTACC
ACTCATTTATAAAGGTGAAATGATGGATTTATCACGTGGTAGAGCCATTAGCCGTGAAAATGAAACGAGTCACTCAGCAT
CTGCAACTGTAATGAAATCATTGTTGAGATTAAGTGATGCCATGGATGATTCAACAAAAGCTAAGTATAAAAAAATTGTC
AAAACTTCAGTTAAATCTGATTCAAGTTACGGCCAAAATGATACATTAAGCTCTTATTCGGATATAAGCAAAATGAAGTC
TTTAATGGAAGACAGCACTATTTCTACTAACGGTTTAACACAACAACTTAAAATATATAATGACATGGATCGTGTCACCT
ATCACAATAAAGACTTAGACTTTGCATTTGGTTTAAGTATGACGTCGAAAAACGTCGCACGTTACGAAAGTATCAACGGA
GAGAACTTAAAAGGTTGGCACACTGGTGCTGGAATGTCTTATTTATACAATAGCGATGTGAAACACTACCGTGATAACTT
CTGGGCGACAGCTGATATGAAACGTTTAGCAGGTACAACAACTTTAGAAAATGAAGAACCTAAAGGTACGGATGTTAAAA
AGTCGAGTAAAACTTTTGTAGGCGGAACAAAATTCGATGACCAACATGCTAGTATCGGAATGGATTTTGAAAATCAGGAC
AAAACTTTAACTGCCAAAAAATCATATTTCATATTAAACGATAAAATTGTCTTCTTAGGAACTGGCATTAAAAGTACTGA
TTCATCAAAGAATCCAGTTACAACGATTGAAAATCGCAAAGCGAATGGGTATACGTTATATACAGACGATAAACAAACAA
CCGCTTCCGATAATCAGGGAACCAATTCCGTCTTTTTAGAGTCAACCAATAAACCTAAAAACAATATAGGCTATCATTTT
TTAAACGAATCGAAAATAACTGTAAAAAAAGAAAGTCATACTGGTAAGTGGAGTGATATAAATAAAAGTCAAAAGCAAGA
CAGTAAAACTAATCAATATTATGAAGTAACTCAAAAGCATTCTAATACAGATAGTAAATATGCATATGTGTTGTATCCAG
GCTTATCTAAAGATGACTTTAATACAAAAAAAGATAAAGTAACTGTCGTTAAACAAGATGATGACTTCCACGTTGTGAAA
GATAATGAATCGGTTTGGGCTGGTGTTAATTATAGTAATAGCACTCAAACTTTTGACATTAACAACACTAAAGTCGAAGT
TAAAGCCAAAGGAATGTTTATTCTTAAAAACAAAGATGATAACACTTATGAATGTAGCTTCTATAATCCCGAATCTACAA
ATACCGCTTCAGATATTGAATCTAAAATTTCAATAACTGGATACTCTATTACAAACAAAAATACATCAACTTCTAATGAA
TCCGGCGTACACTTTGAATTAACTAAATAA

Upstream 100 bases:

>100_bases
TAGACAGTCATTTGTATACGTTAACGAATTTTGAAAATTTGAATCATTATTTAATCATATTATTAATTGCGCACGCACAA
CATAAAAAGGAGACATGTCA

Downstream 100 bases:

>100_bases
GCAAGAAAATCTCGACACTATACCATTTTTATAGTGTCGAGATTTTATAAGTATCGCCATCATTCACCTTGTAATCCGCA
GACCACATCCCCTTTGATAA

Product: hyaluronate lyase precursor

Products: NA

Alternate protein names: Hyaluronidase; HYase [H]

Number of amino acids: Translated: 809; Mature: 808

Protein sequence:

>809_residues
MTYRMKKWQKLSTITLLMAGVITLNGGEFRSIDKHQIAVADTNVQTPDYEKLRNTWLDVNYGYDKYDEKNDAMKKKFDAT
EKEAEKLLSSMKTESGRTYLWDSAKDLDNKSADMTRTYRNIEKIAEAMRHPKTTLNTDENKKKVKDALEWLHKNAYGKEP
DNKVKELTENFKITDSSKKKALNWWDYEIGTPRSLTNTLILLNDQFSNEEKKKFTAPIKTFAPKSDEILSSVGKAEPAKG
GNLVDIAKVKLLESIIEEDKDMMKNSIDSFNKVFTYVQDSATDKERNGFYKDGSYIDHKDVPYTGAYGVVLLEGISQMMP
MIKETPFNDKTQNNTTLKSWIDDGFLPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIV
KTSVKSDSSYGQNDTLSSYSDISKMKSLMEDSTISTNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESING
ENLKGWHTGAGMSYLYNSDVKHYRDNFWATADMKRLAGTTTLENEEPKGTDVKKSSKTFVGGTKFDDQHASIGMDFENQD
KTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKANGYTLYTDDKQTTASDNQGTNSVFLESTNKPKNNIGYHF
LNESKITVKKESHTGKWSDINKSQKQDSKTNQYYEVTQKHSNTDSKYAYVLYPGLSKDDFNTKKDKVTVVKQDDDFHVVK
DNESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKNKDDNTYECSFYNPESTNTASDIESKISITGYSITNKNTSTSNE
SGVHFELTK

Sequences:

>Translated_809_residues
MTYRMKKWQKLSTITLLMAGVITLNGGEFRSIDKHQIAVADTNVQTPDYEKLRNTWLDVNYGYDKYDEKNDAMKKKFDAT
EKEAEKLLSSMKTESGRTYLWDSAKDLDNKSADMTRTYRNIEKIAEAMRHPKTTLNTDENKKKVKDALEWLHKNAYGKEP
DNKVKELTENFKITDSSKKKALNWWDYEIGTPRSLTNTLILLNDQFSNEEKKKFTAPIKTFAPKSDEILSSVGKAEPAKG
GNLVDIAKVKLLESIIEEDKDMMKNSIDSFNKVFTYVQDSATDKERNGFYKDGSYIDHKDVPYTGAYGVVLLEGISQMMP
MIKETPFNDKTQNNTTLKSWIDDGFLPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIV
KTSVKSDSSYGQNDTLSSYSDISKMKSLMEDSTISTNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESING
ENLKGWHTGAGMSYLYNSDVKHYRDNFWATADMKRLAGTTTLENEEPKGTDVKKSSKTFVGGTKFDDQHASIGMDFENQD
KTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKANGYTLYTDDKQTTASDNQGTNSVFLESTNKPKNNIGYHF
LNESKITVKKESHTGKWSDINKSQKQDSKTNQYYEVTQKHSNTDSKYAYVLYPGLSKDDFNTKKDKVTVVKQDDDFHVVK
DNESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKNKDDNTYECSFYNPESTNTASDIESKISITGYSITNKNTSTSNE
SGVHFELTK
>Mature_808_residues
TYRMKKWQKLSTITLLMAGVITLNGGEFRSIDKHQIAVADTNVQTPDYEKLRNTWLDVNYGYDKYDEKNDAMKKKFDATE
KEAEKLLSSMKTESGRTYLWDSAKDLDNKSADMTRTYRNIEKIAEAMRHPKTTLNTDENKKKVKDALEWLHKNAYGKEPD
NKVKELTENFKITDSSKKKALNWWDYEIGTPRSLTNTLILLNDQFSNEEKKKFTAPIKTFAPKSDEILSSVGKAEPAKGG
NLVDIAKVKLLESIIEEDKDMMKNSIDSFNKVFTYVQDSATDKERNGFYKDGSYIDHKDVPYTGAYGVVLLEGISQMMPM
IKETPFNDKTQNNTTLKSWIDDGFLPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIVK
TSVKSDSSYGQNDTLSSYSDISKMKSLMEDSTISTNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESINGE
NLKGWHTGAGMSYLYNSDVKHYRDNFWATADMKRLAGTTTLENEEPKGTDVKKSSKTFVGGTKFDDQHASIGMDFENQDK
TLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKANGYTLYTDDKQTTASDNQGTNSVFLESTNKPKNNIGYHFL
NESKITVKKESHTGKWSDINKSQKQDSKTNQYYEVTQKHSNTDSKYAYVLYPGLSKDDFNTKKDKVTVVKQDDDFHVVKD
NESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKNKDDNTYECSFYNPESTNTASDIESKISITGYSITNKNTSTSNES
GVHFELTK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide lyase 8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008929
- InterPro:   IPR011013
- InterPro:   IPR014718
- InterPro:   IPR011071
- InterPro:   IPR012970
- InterPro:   IPR004103
- InterPro:   IPR003159
- InterPro:   IPR012329 [H]

Pfam domain/function: PF02278 Lyase_8; PF02884 Lyase_8_C; PF08124 Lyase_8_N [H]

EC number: =4.2.2.1 [H]

Molecular weight: Translated: 91813; Mature: 91682

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYRMKKWQKLSTITLLMAGVITLNGGEFRSIDKHQIAVADTNVQTPDYEKLRNTWLDVN
CCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHCEEEEC
YGYDKYDEKNDAMKKKFDATEKEAEKLLSSMKTESGRTYLWDSAKDLDNKSADMTRTYRN
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHH
IEKIAEAMRHPKTTLNTDENKKKVKDALEWLHKNAYGKEPDNKVKELTENFKITDSSKKK
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEECCCCCCC
ALNWWDYEIGTPRSLTNTLILLNDQFSNEEKKKFTAPIKTFAPKSDEILSSVGKAEPAKG
CCCEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHCCHHHCCCCHHHHHHHHCCCCCCCC
GNLVDIAKVKLLESIIEEDKDMMKNSIDSFNKVFTYVQDSATDKERNGFYKDGSYIDHKD
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
VPYTGAYGVVLLEGISQMMPMIKETPFNDKTQNNTTLKSWIDDGFLPLIYKGEMMDLSRG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCEEEEEECCEEECCCC
RAISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIVKTSVKSDSSYGQNDTLSSYS
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
DISKMKSLMEDSTISTNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESING
HHHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHEECCCCCCEEEECCCCCCCHHHHHCCCC
ENLKGWHTGAGMSYLYNSDVKHYRDNFWATADMKRLAGTTTLENEEPKGTDVKKSSKTFV
CCCCCEECCCCCCEEECCCHHHHHHCCEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
GGTKFDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRK
CCCCCCCCCCEECCCCCCCCCEEEECCEEEEEECEEEEEECCCCCCCCCCCCCEEECCCC
ANGYTLYTDDKQTTASDNQGTNSVFLESTNKPKNNIGYHFLNESKITVKKESHTGKWSDI
CCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCEEEEEECCCCCCCCCC
NKSQKQDSKTNQYYEVTQKHSNTDSKYAYVLYPGLSKDDFNTKKDKVTVVKQDDDFHVVK
CCHHHHCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCEEEEE
DNESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKNKDDNTYECSFYNPESTNTASDIE
CCCCEEEECCCCCCCEEEECCCCEEEEEECCEEEEECCCCCEEEEEEECCCCCCCHHHHH
SKISITGYSITNKNTSTSNESGVHFELTK
CEEEEEEEEEECCCCCCCCCCCEEEEECC
>Mature Secondary Structure 
TYRMKKWQKLSTITLLMAGVITLNGGEFRSIDKHQIAVADTNVQTPDYEKLRNTWLDVN
CCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHCEEEEC
YGYDKYDEKNDAMKKKFDATEKEAEKLLSSMKTESGRTYLWDSAKDLDNKSADMTRTYRN
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHH
IEKIAEAMRHPKTTLNTDENKKKVKDALEWLHKNAYGKEPDNKVKELTENFKITDSSKKK
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEECCCCCCC
ALNWWDYEIGTPRSLTNTLILLNDQFSNEEKKKFTAPIKTFAPKSDEILSSVGKAEPAKG
CCCEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHCCHHHCCCCHHHHHHHHCCCCCCCC
GNLVDIAKVKLLESIIEEDKDMMKNSIDSFNKVFTYVQDSATDKERNGFYKDGSYIDHKD
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
VPYTGAYGVVLLEGISQMMPMIKETPFNDKTQNNTTLKSWIDDGFLPLIYKGEMMDLSRG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCEEEEEECCEEECCCC
RAISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIVKTSVKSDSSYGQNDTLSSYS
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
DISKMKSLMEDSTISTNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESING
HHHHHHHHHHCCCCCCCCCHHHHHHHHCHHHHEECCCCCCEEEECCCCCCCHHHHHCCCC
ENLKGWHTGAGMSYLYNSDVKHYRDNFWATADMKRLAGTTTLENEEPKGTDVKKSSKTFV
CCCCCEECCCCCCEEECCCHHHHHHCCEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCEEE
GGTKFDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRK
CCCCCCCCCCEECCCCCCCCCEEEECCEEEEEECEEEEEECCCCCCCCCCCCCEEECCCC
ANGYTLYTDDKQTTASDNQGTNSVFLESTNKPKNNIGYHFLNESKITVKKESHTGKWSDI
CCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCEEEEEECCCCCCCCCC
NKSQKQDSKTNQYYEVTQKHSNTDSKYAYVLYPGLSKDDFNTKKDKVTVVKQDDDFHVVK
CCHHHHCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEEECCCEEEEE
DNESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKNKDDNTYECSFYNPESTNTASDIE
CCCCEEEECCCCCCCEEEECCCCEEEEEECCEEEEECCCCCEEEEEEECCCCCCCHHHHH
SKISITGYSITNKNTSTSNESGVHFELTK
CEEEEEEEEEECCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557301 [H]