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The map label for this gene is hlb

Identifier: 15927513

GI number: 15927513

Start: 2005149

End: 2005349

Strand: Direct

Name: hlb

Synonym: SA1752

Alternate gene names: 15927513

Gene position: 2005149-2005349 (Clockwise)

Preceding gene: 15927510

Following gene: 15927514

Centisome position: 71.24

GC content: 30.85

Gene sequence:

>201_bases
ATGATGGTAAAAAAAACAAAATCCAATTCACTAAAAAAAGTTGCAACACTTGCATTAGCAAATTTATTATTAGTTGGTGC
ACTTACTGACAATAGTGCCAAAGCCGAATCTAAGAAAGATGATACTGATTTGAAGTTAGTTAGTCATAACGTTTATATGT
TATCGACCGTTTTGTATCCAAACTGGAGACTTTTAACATAA

Upstream 100 bases:

>100_bases
AACATTTACTTAAAAATATAAATTCGATTTAATAATTAATTTAAATTTAGTTAATCAATTTTGCATCTATTTTGTTGTAA
GCTATATAAAAGGAGTGATA

Downstream 100 bases:

>100_bases
AATTACTTATCATTCAAAAAGTAAAACAGCATAATATCAAGGTTTATAACTTTATCATTATCAATAATACCTCATATAAA
ATAAAATTTTAGGGACTTTT

Product: truncated beta-hemolysin

Products: NA

Alternate protein names: Beta-hemolysin; Beta-toxin; Sphingomyelinase; SMase [H]

Number of amino acids: Translated: 66; Mature: 66

Protein sequence:

>66_residues
MMVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWRLLT

Sequences:

>Translated_66_residues
MMVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWRLLT
>Mature_66_residues
MMVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYPNWRLLT

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the neutral sphingomyelinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.3 [H]

Molecular weight: Translated: 7307; Mature: 7307

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYP
CCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEECCCEEEEEEEECC
NWRLLT
CEEEEC
>Mature Secondary Structure
MMVKKTKSNSLKKVATLALANLLLVGALTDNSAKAESKKDDTDLKLVSHNVYMLSTVLYP
CCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCEEEECCCEEEEEEEECC
NWRLLT
CEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8914839 [H]