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The map label for this gene is ipdC [H]

Identifier: 15925892

GI number: 15925892

Start: 212901

End: 214541

Strand: Reverse

Name: ipdC [H]

Synonym: SA0182

Alternate gene names: 15925892

Gene position: 214541-212901 (Counterclockwise)

Preceding gene: 15925893

Following gene: 15925891

Centisome position: 7.62

GC content: 36.62

Gene sequence:

>1641_bases
ATGAAACAACGCATTGGAGCTTACTTAATTGACGCTTTTCATCGAGCAGGCGTCGATAAAATTTTTGGTGTTCCTGGTGA
TTTTAATCTCGCTTTTCTAGACGATATTATCAGCAATCCCAATGTAGATTGGGTAGGAAATACAAATGAATTAAACGCAA
GTTACGCAGCGGACGGTTATGCCCGTCTTAATGGACTCGCTGCATTAGTTACTACATTTGGTGTTGGCGAATTAAGTGCC
GTCAACGGTATCGCAGGTTCATATGCTGAACGCATACCTGTCATTGCGATTACAGGTGCGCCGACACGTGCTGTTGAACA
AGCCGGTAAATATGTACATCACTCACTTGGTGAAGGTACATTTGACGACTACCGAAAAATGTTTGCACATATAACCGTTG
CACAAGGTTATATCACACCTGAAAATGCAACAACCGAAATACCACGTTTAATTAATACAGCAATCGCCGAAAGACGCCCA
GTTCATTTACATTTACCAATCGATGTCGCAATCTCTGAAATTGAGATACCGACACCATTTGAAGTGACGGCAACTAAAGA
TACGGATGCATCAACATATATAGAGTTATTAGCAACTAAACTGCATCAAGCGAAGCAGCCTATCATCATTACTGGACATG
AAATTAACAGTTTTCACCTCCATCAAGAATTAGAAGATTTTGTAAATCAAACACAGATACCAGTAGCACAACTTTCATTA
GGAAAAGGTGCTTTTAATGAGGAAAATCCATATTATATGGGTATTTACGACGGGAAAATTGCCGAAGATAAAATACGAGA
TTATGTGGACAACAGCGATTTAATTTTAAATATTGGAGCCAAATTAACAGATTCAGCAACAGCAGGATTTTCATACCAAT
TCAATATCGATGATGTCGTTATGTTAAATCATCACAATATCAAAATTGATGATGTTACAAATGATGAAATATCTCTACCA
TCGTTGTTAAAACAGTTATCCAATATTTCATATACGAACAGTGCAACGTTCCCTGCGTATCATCGTCCAACATCACCCGA
TTATACTGTTGGCACAGAACCATTAACACAACAAACTTATTTTAAAATGATGCAAAATTTCTTAAAACCAAATGATGTCA
TTATTGCTGATCAAGGTACATCATTCTTTGGTGCTTATGATTTAGCATTATACAAAAACAATACTTTTATAGGGCAACCG
TTATGGGGTTCTATCGGCTATACATTACCTGCAACATTAGGTTCACAATTAGCAGACAAAGATCGTCGTAACTTATTATT
AATTGGTGATGGCTCATTGCAACTAACTGTTCAAGCTATTTCAACTATGATTAGACAGCATATTAAACCGGTATTATTTG
TGATTAATAATGACGGCTATACGGTAGAACGACTTATTCACGGCATGTATGAACCTTATAATGAAATTCACATGTGGGAT
TATAAAGCTTTACCAGCTGTATTTGGTGGTAAAAATGTTGAAATTCATGACGTTGAATCATCAAAAGATTTACAAGACAC
GTTTAATGCAATTAATGGTCATCCCGATGTGATGCATTTTGTCGAAGTCAAAATGTCTGTCGAAGACGCACCGAAGAAAC
TGATCGATATCGCTAAAGCTTTTTCACAACAAAATAAATAA

Upstream 100 bases:

>100_bases
CTATTGTTAGCGTTTTCACAACAAAGTCAACTTCCTTGACCTTACACTGTATTCGAGGCTATCATTTTAAGTGTAAATAT
AGAGAAAAGGTGGTTTTTTT

Downstream 100 bases:

>100_bases
TTTCATCGTATACAGGGTATAAGTTTAAGCGAATACTTTATTAAACGAAAAGGACTCTGATATAAGATGATTAATTTTAA
TAAAACCGCTTTAGTGTTAA

Product: hypothetical protein

Products: NA

Alternate protein names: Indolepyruvate decarboxylase [H]

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MKQRIGAYLIDAFHRAGVDKIFGVPGDFNLAFLDDIISNPNVDWVGNTNELNASYAADGYARLNGLAALVTTFGVGELSA
VNGIAGSYAERIPVIAITGAPTRAVEQAGKYVHHSLGEGTFDDYRKMFAHITVAQGYITPENATTEIPRLINTAIAERRP
VHLHLPIDVAISEIEIPTPFEVTATKDTDASTYIELLATKLHQAKQPIIITGHEINSFHLHQELEDFVNQTQIPVAQLSL
GKGAFNEENPYYMGIYDGKIAEDKIRDYVDNSDLILNIGAKLTDSATAGFSYQFNIDDVVMLNHHNIKIDDVTNDEISLP
SLLKQLSNISYTNSATFPAYHRPTSPDYTVGTEPLTQQTYFKMMQNFLKPNDVIIADQGTSFFGAYDLALYKNNTFIGQP
LWGSIGYTLPATLGSQLADKDRRNLLLIGDGSLQLTVQAISTMIRQHIKPVLFVINNDGYTVERLIHGMYEPYNEIHMWD
YKALPAVFGGKNVEIHDVESSKDLQDTFNAINGHPDVMHFVEVKMSVEDAPKKLIDIAKAFSQQNK

Sequences:

>Translated_546_residues
MKQRIGAYLIDAFHRAGVDKIFGVPGDFNLAFLDDIISNPNVDWVGNTNELNASYAADGYARLNGLAALVTTFGVGELSA
VNGIAGSYAERIPVIAITGAPTRAVEQAGKYVHHSLGEGTFDDYRKMFAHITVAQGYITPENATTEIPRLINTAIAERRP
VHLHLPIDVAISEIEIPTPFEVTATKDTDASTYIELLATKLHQAKQPIIITGHEINSFHLHQELEDFVNQTQIPVAQLSL
GKGAFNEENPYYMGIYDGKIAEDKIRDYVDNSDLILNIGAKLTDSATAGFSYQFNIDDVVMLNHHNIKIDDVTNDEISLP
SLLKQLSNISYTNSATFPAYHRPTSPDYTVGTEPLTQQTYFKMMQNFLKPNDVIIADQGTSFFGAYDLALYKNNTFIGQP
LWGSIGYTLPATLGSQLADKDRRNLLLIGDGSLQLTVQAISTMIRQHIKPVLFVINNDGYTVERLIHGMYEPYNEIHMWD
YKALPAVFGGKNVEIHDVESSKDLQDTFNAINGHPDVMHFVEVKMSVEDAPKKLIDIAKAFSQQNK
>Mature_546_residues
MKQRIGAYLIDAFHRAGVDKIFGVPGDFNLAFLDDIISNPNVDWVGNTNELNASYAADGYARLNGLAALVTTFGVGELSA
VNGIAGSYAERIPVIAITGAPTRAVEQAGKYVHHSLGEGTFDDYRKMFAHITVAQGYITPENATTEIPRLINTAIAERRP
VHLHLPIDVAISEIEIPTPFEVTATKDTDASTYIELLATKLHQAKQPIIITGHEINSFHLHQELEDFVNQTQIPVAQLSL
GKGAFNEENPYYMGIYDGKIAEDKIRDYVDNSDLILNIGAKLTDSATAGFSYQFNIDDVVMLNHHNIKIDDVTNDEISLP
SLLKQLSNISYTNSATFPAYHRPTSPDYTVGTEPLTQQTYFKMMQNFLKPNDVIIADQGTSFFGAYDLALYKNNTFIGQP
LWGSIGYTLPATLGSQLADKDRRNLLLIGDGSLQLTVQAISTMIRQHIKPVLFVINNDGYTVERLIHGMYEPYNEIHMWD
YKALPAVFGGKNVEIHDVESSKDLQDTFNAINGHPDVMHFVEVKMSVEDAPKKLIDIAKAFSQQNK

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=474, Percent_Identity=23.4177215189873, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1787096, Length=572, Percent_Identity=22.3776223776224, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786717, Length=474, Percent_Identity=21.3080168776371, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788716, Length=465, Percent_Identity=20.2150537634409, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323073, Length=560, Percent_Identity=39.4642857142857, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321524, Length=557, Percent_Identity=38.9587073608618, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6323163, Length=566, Percent_Identity=37.9858657243816, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320123, Length=566, Percent_Identity=32.5088339222615, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6320588, Length=601, Percent_Identity=27.9534109816972, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323755, Length=505, Percent_Identity=23.5643564356436, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017764
- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.74 [H]

Molecular weight: Translated: 60528; Mature: 60528

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRIGAYLIDAFHRAGVDKIFGVPGDFNLAFLDDIISNPNVDWVGNTNELNASYAADGY
CCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCH
ARLNGLAALVTTFGVGELSAVNGIAGSYAERIPVIAITGAPTRAVEQAGKYVHHSLGEGT
HHHHHHHHHHHHCCCCCHHHHHCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCC
FDDYRKMFAHITVAQGYITPENATTEIPRLINTAIAERRPVHLHLPIDVAISEIEIPTPF
HHHHHHHHHHEEEECCEECCCCCCHHHHHHHHHHHHCCCCEEEEECCEEEEEEEECCCCC
EVTATKDTDASTYIELLATKLHQAKQPIIITGHEINSFHLHQELEDFVNQTQIPVAQLSL
EEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHEEC
GKGAFNEENPYYMGIYDGKIAEDKIRDYVDNSDLILNIGAKLTDSATAGFSYQFNIDDVV
CCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCEEE
MLNHHNIKIDDVTNDEISLPSLLKQLSNISYTNSATFPAYHRPTSPDYTVGTEPLTQQTY
EEECCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
FKMMQNFLKPNDVIIADQGTSFFGAYDLALYKNNTFIGQPLWGSIGYTLPATLGSQLADK
HHHHHHHCCCCCEEEECCCCCEEEEEEEEEEECCEEECCCCCCCCCCCCHHHHHHHHHCC
DRRNLLLIGDGSLQLTVQAISTMIRQHIKPVLFVINNDGYTVERLIHGMYEPYNEIHMWD
CCCCEEEEECCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCHHHEEEEC
YKALPAVFGGKNVEIHDVESSKDLQDTFNAINGHPDVMHFVEVKMSVEDAPKKLIDIAKA
CHHCHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHEEEEHEEECHHHHHHHHHHHHHH
FSQQNK
HHHCCC
>Mature Secondary Structure
MKQRIGAYLIDAFHRAGVDKIFGVPGDFNLAFLDDIISNPNVDWVGNTNELNASYAADGY
CCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCH
ARLNGLAALVTTFGVGELSAVNGIAGSYAERIPVIAITGAPTRAVEQAGKYVHHSLGEGT
HHHHHHHHHHHHCCCCCHHHHHCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCC
FDDYRKMFAHITVAQGYITPENATTEIPRLINTAIAERRPVHLHLPIDVAISEIEIPTPF
HHHHHHHHHHEEEECCEECCCCCCHHHHHHHHHHHHCCCCEEEEECCEEEEEEEECCCCC
EVTATKDTDASTYIELLATKLHQAKQPIIITGHEINSFHLHQELEDFVNQTQIPVAQLSL
EEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHEEC
GKGAFNEENPYYMGIYDGKIAEDKIRDYVDNSDLILNIGAKLTDSATAGFSYQFNIDDVV
CCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCEEEEECCCEEE
MLNHHNIKIDDVTNDEISLPSLLKQLSNISYTNSATFPAYHRPTSPDYTVGTEPLTQQTY
EEECCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
FKMMQNFLKPNDVIIADQGTSFFGAYDLALYKNNTFIGQPLWGSIGYTLPATLGSQLADK
HHHHHHHCCCCCEEEECCCCCEEEEEEEEEEECCEEECCCCCCCCCCCCHHHHHHHHHCC
DRRNLLLIGDGSLQLTVQAISTMIRQHIKPVLFVINNDGYTVERLIHGMYEPYNEIHMWD
CCCCEEEEECCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCHHHEEEEC
YKALPAVFGGKNVEIHDVESSKDLQDTFNAINGHPDVMHFVEVKMSVEDAPKKLIDIAKA
CHHCHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCHHEEEEHEEECHHHHHHHHHHHHHH
FSQQNK
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034209 [H]