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The map label for this gene is gyaR [H]

Identifier: 16127952

GI number: 16127952

Start: 3977131

End: 3978165

Strand: Direct

Name: gyaR [H]

Synonym: CC_3722

Alternate gene names: 16127952

Gene position: 3977131-3978165 (Clockwise)

Preceding gene: 16127946

Following gene: 16127953

Centisome position: 99.01

GC content: 65.02

Gene sequence:

>1035_bases
TTGCTACAGCTTTCAAACGCCTGTCAGAGAGAGCTTTTCAAACCGCCCATGGCCGCCCGCAAGCTCAAAGTCATCGTCAC
CCGCAAACTCCCCGATCCGGTGGAGACGCGGATGTGCGAACTGTTCGACACCGAACTGAACGTCTCCGACAAGCCCATGA
CGGCGGACGAGTTGGTTGACGCGATGAGCCGCGCCGACGTGCTGGTGCCGACGATCACGGATCGTATCGATTCCCGCCTT
TTGTCGCGATCCGGCGACCGCCTCAAGCTGATCGCCAATTTTGGCGCCGGCGTGGACAATATCGACGTCGCGACGGCCAA
TGCCCGCGGCATCATCGTCACCAACACCCCCGGCGTGCTGACCGAAGACACCGCCGACCTGACCATGACCCTGATCATGG
CCGCTTCGCGTCGGATCGTAGAGGGCGCGGAAGTCGTCAAGGCCGGCGGTTTCCACGGCTGGTCGCCGACCTGGATGATG
GGCCGCCGTCTTTGGGGCAAGCGCCTGGGCATCATCGGCATGGGTCGCATTGGCCAAGCCGTGGCCCGCCGCGCCAAGGC
GTTCGGCATGCAGGTCCACTACCATAACCGCAAGCCGGTCAGCCCGCGCATCGCCGAGGAACTGGGCTGCACCTACTGGG
AAAGCCTCGACCAGATGCTGGCCCGGATGGACTTCGTGTCGGTCAACTGCCCGCACACCCCGGCCACCTACCACCTGCTG
TCGGCCCGCCGCCTGAAGCTGCTGCGCCCGCACGCCGTGGTGGTCAACACCGCGCGGGGCGAAGTGATCGACGAAGGCGC
CCTGGCCAACATGCTGGCCAAGGGCGAGATCGCCGGGGCCGGTCTCGACGTCTACGAGCACGAGCCGGCTATCAATCCCA
AGCTCCTGAAGCTGCCCAACGTCGTGCTGCTGCCCCATATGGGCTCGGCCACGGTCGAGGGCCGCATCGACATGGGCGAG
AAGGTCATCGTCAACGTGAAGACCTTCATGGACGGGCACAGGCCGCCGGATCGGGTCATCCCGGCGATGCTGTAG

Upstream 100 bases:

>100_bases
CCGCTCCCGCCGCAATTCCGACCATGACACGCGTCAAACCCATTCGAGACGAACCTTGTTCTGTTTTTGACCGCATGTTG
CTTGGCCCCCACCGGCCCCT

Downstream 100 bases:

>100_bases
ACGCGGCCTTAGCGCCTTCGCGCCGCCGACGATCGAGACACTTGCTTGTGGCGACTTCCCTCAATACGCTCGCCTGAGTT
GAGGGGGACAGAGCCATGCT

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MLQLSNACQRELFKPPMAARKLKVIVTRKLPDPVETRMCELFDTELNVSDKPMTADELVDAMSRADVLVPTITDRIDSRL
LSRSGDRLKLIANFGAGVDNIDVATANARGIIVTNTPGVLTEDTADLTMTLIMAASRRIVEGAEVVKAGGFHGWSPTWMM
GRRLWGKRLGIIGMGRIGQAVARRAKAFGMQVHYHNRKPVSPRIAEELGCTYWESLDQMLARMDFVSVNCPHTPATYHLL
SARRLKLLRPHAVVVNTARGEVIDEGALANMLAKGEIAGAGLDVYEHEPAINPKLLKLPNVVLLPHMGSATVEGRIDMGE
KVIVNVKTFMDGHRPPDRVIPAML

Sequences:

>Translated_344_residues
MLQLSNACQRELFKPPMAARKLKVIVTRKLPDPVETRMCELFDTELNVSDKPMTADELVDAMSRADVLVPTITDRIDSRL
LSRSGDRLKLIANFGAGVDNIDVATANARGIIVTNTPGVLTEDTADLTMTLIMAASRRIVEGAEVVKAGGFHGWSPTWMM
GRRLWGKRLGIIGMGRIGQAVARRAKAFGMQVHYHNRKPVSPRIAEELGCTYWESLDQMLARMDFVSVNCPHTPATYHLL
SARRLKLLRPHAVVVNTARGEVIDEGALANMLAKGEIAGAGLDVYEHEPAINPKLLKLPNVVLLPHMGSATVEGRIDMGE
KVIVNVKTFMDGHRPPDRVIPAML
>Mature_344_residues
MLQLSNACQRELFKPPMAARKLKVIVTRKLPDPVETRMCELFDTELNVSDKPMTADELVDAMSRADVLVPTITDRIDSRL
LSRSGDRLKLIANFGAGVDNIDVATANARGIIVTNTPGVLTEDTADLTMTLIMAASRRIVEGAEVVKAGGFHGWSPTWMM
GRRLWGKRLGIIGMGRIGQAVARRAKAFGMQVHYHNRKPVSPRIAEELGCTYWESLDQMLARMDFVSVNCPHTPATYHLL
SARRLKLLRPHAVVVNTARGEVIDEGALANMLAKGEIAGAGLDVYEHEPAINPKLLKLPNVVLLPHMGSATVEGRIDMGE
KVIVNVKTFMDGHRPPDRVIPAML

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=302, Percent_Identity=39.0728476821192, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI23308577, Length=311, Percent_Identity=32.475884244373, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI61743967, Length=258, Percent_Identity=35.2713178294574, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI4557497, Length=258, Percent_Identity=35.2713178294574, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI145580578, Length=255, Percent_Identity=34.5098039215686, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI4557499, Length=255, Percent_Identity=34.5098039215686, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI145580575, Length=255, Percent_Identity=34.5098039215686, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI87082289, Length=327, Percent_Identity=37.0030581039755, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1789279, Length=255, Percent_Identity=30.5882352941176, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787645, Length=334, Percent_Identity=26.9461077844311, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1788660, Length=305, Percent_Identity=25.9016393442623, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=306, Percent_Identity=31.6993464052288, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI25147481, Length=262, Percent_Identity=30.9160305343511, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=269, Percent_Identity=38.6617100371747, Blast_Score=163, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320925, Length=345, Percent_Identity=28.695652173913, Blast_Score=133, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322116, Length=308, Percent_Identity=29.8701298701299, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321253, Length=173, Percent_Identity=31.2138728323699, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=201, Percent_Identity=28.3582089552239, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=218, Percent_Identity=27.5229357798165, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571528, Length=317, Percent_Identity=37.5394321766561, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI28574284, Length=333, Percent_Identity=32.7327327327327, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI45552429, Length=316, Percent_Identity=33.5443037974684, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI19921140, Length=312, Percent_Identity=32.3717948717949, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24585514, Length=316, Percent_Identity=33.5443037974684, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI28574282, Length=316, Percent_Identity=33.5443037974684, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI45551003, Length=316, Percent_Identity=33.5443037974684, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI28574286, Length=291, Percent_Identity=32.3024054982818, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24646446, Length=255, Percent_Identity=36.8627450980392, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646448, Length=255, Percent_Identity=36.8627450980392, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646452, Length=255, Percent_Identity=36.8627450980392, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24646450, Length=255, Percent_Identity=36.8627450980392, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI62472511, Length=255, Percent_Identity=36.8627450980392, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585516, Length=320, Percent_Identity=29.0625, Blast_Score=142, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 37809; Mature: 37809

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQLSNACQRELFKPPMAARKLKVIVTRKLPDPVETRMCELFDTELNVSDKPMTADELVD
CCCCCHHHHHHHCCCCHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHH
AMSRADVLVPTITDRIDSRLLSRSGDRLKLIANFGAGVDNIDVATANARGIIVTNTPGVL
HHHHCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEECCCCEEEEECCCCCE
TEDTADLTMTLIMAASRRIVEGAEVVKAGGFHGWSPTWMMGRRLWGKRLGIIGMGRIGQA
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHH
VARRAKAFGMQVHYHNRKPVSPRIAEELGCTYWESLDQMLARMDFVSVNCPHTPATYHLL
HHHHHHHHCEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHH
SARRLKLLRPHAVVVNTARGEVIDEGALANMLAKGEIAGAGLDVYEHEPAINPKLLKLPN
HHHHHHHCCCCEEEEECCCCCEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCC
VVLLPHMGSATVEGRIDMGEKVIVNVKTFMDGHRPPDRVIPAML
EEEEECCCCCEEECCCCCCCEEEEEEHHHHCCCCCHHHCCCCCC
>Mature Secondary Structure
MLQLSNACQRELFKPPMAARKLKVIVTRKLPDPVETRMCELFDTELNVSDKPMTADELVD
CCCCCHHHHHHHCCCCHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHH
AMSRADVLVPTITDRIDSRLLSRSGDRLKLIANFGAGVDNIDVATANARGIIVTNTPGVL
HHHHCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEECCCCEEEEECCCCCE
TEDTADLTMTLIMAASRRIVEGAEVVKAGGFHGWSPTWMMGRRLWGKRLGIIGMGRIGQA
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHH
VARRAKAFGMQVHYHNRKPVSPRIAEELGCTYWESLDQMLARMDFVSVNCPHTPATYHLL
HHHHHHHHCEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHHHHEEEECCCCCCHHHHHH
SARRLKLLRPHAVVVNTARGEVIDEGALANMLAKGEIAGAGLDVYEHEPAINPKLLKLPN
HHHHHHHCCCCEEEEECCCCCEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCC
VVLLPHMGSATVEGRIDMGEKVIVNVKTFMDGHRPPDRVIPAML
EEEEECCCCCEEECCCCCCCEEEEEEHHHHCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA