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The map label for this gene is tesB [H]

Identifier: 16127879

GI number: 16127879

Start: 3906776

End: 3907630

Strand: Direct

Name: tesB [H]

Synonym: CC_3649

Alternate gene names: 16127879

Gene position: 3906776-3907630 (Clockwise)

Preceding gene: 16127877

Following gene: 16127886

Centisome position: 97.26

GC content: 67.6

Gene sequence:

>855_bases
ATGCAGACGACCGAGAACCTCGCCGACATCCTGGACCTCGAACCGATCGAGGTGAACCTGTTCCGGGGCGTCAGCCCCAA
TGACGGCTTCCCCCGCATCTTCGGTGGCCTTGTCATCGCCCAGGCCCTGCTGGCGGCCTACAAGACGGTGCCCGACCGGG
TCTGTCACTCGCTGCACGCCTATTTCATCCGCCCGGGCGACGTCACAGCCCCCGTGCTTTACGAGGTGGAACGCGCCCGC
GACGGCGGCACCTTCACCACCCGCCGGGTCGCCGCCATCCAGCACGGCGAGCAGATCTTCAACCTGGCCGCCTCGTTCCA
GACGCCGGAAGACGGCTTCGAGCACCAGTCGGAGATGCCCGCCTCGGTGGATCCGGAAAGCCTGCCCACCGAGGCGGACT
TCCTGCGCAGCCTCGGCGACCAGATCCACCCGAAGATGGTGGCCATCGCCGAACGCCCGCGGCCGGTCGATATCCGCTGG
ATCGATCCGCAGAACCCGATCGCGCCGGTCAAGAAGTCGGGCACCAAGCAGGTCTGGATGCGCGCCAAGGCGCCGCTGGG
CGACGATGTGAAGATGCAGCAGGCCGCCCTGGCCTACGCGTCGGACATGGCGTTCATGGAAAGCGCCCTGCGGCCGCACG
GCCTGATCTGGACCACGCCCGGCATCCAGGCCGCCAGCCTGGACCACGCCATGTGGTTCCATCACCCGTTCAACTTCAAC
GACTGGACCCTGTTCGCCCAGGACAGCCCCAGCGCCTCGCAGGGACGCGGCCTGGTGCGCGGCCAGATGTTCAGCCAGGA
CGGAAAGCTCCTGGCCTCGGTGGCGCAGGAATGCCTGATGCGGGTGCGGAAGTAG

Upstream 100 bases:

>100_bases
TCGGTGGCGGTGCGGACATGCCTTCACGATGGGGAGCGCGGCCGCGTGACGCAAGGAGACGGGTTGCGGCGCCGCAAAAC
GCGGCTTATCGCAGTGCGCC

Downstream 100 bases:

>100_bases
GGCCTAGACGGGCTCGATTCGCGCCACCCCGGCGGCGGCGAGGCCCCGAAGCAGGGCGCTGGTCTGCATGCCGACAGTGA
GTTCGCCGGCCAGGGCCATG

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MQTTENLADILDLEPIEVNLFRGVSPNDGFPRIFGGLVIAQALLAAYKTVPDRVCHSLHAYFIRPGDVTAPVLYEVERAR
DGGTFTTRRVAAIQHGEQIFNLAASFQTPEDGFEHQSEMPASVDPESLPTEADFLRSLGDQIHPKMVAIAERPRPVDIRW
IDPQNPIAPVKKSGTKQVWMRAKAPLGDDVKMQQAALAYASDMAFMESALRPHGLIWTTPGIQAASLDHAMWFHHPFNFN
DWTLFAQDSPSASQGRGLVRGQMFSQDGKLLASVAQECLMRVRK

Sequences:

>Translated_284_residues
MQTTENLADILDLEPIEVNLFRGVSPNDGFPRIFGGLVIAQALLAAYKTVPDRVCHSLHAYFIRPGDVTAPVLYEVERAR
DGGTFTTRRVAAIQHGEQIFNLAASFQTPEDGFEHQSEMPASVDPESLPTEADFLRSLGDQIHPKMVAIAERPRPVDIRW
IDPQNPIAPVKKSGTKQVWMRAKAPLGDDVKMQQAALAYASDMAFMESALRPHGLIWTTPGIQAASLDHAMWFHHPFNFN
DWTLFAQDSPSASQGRGLVRGQMFSQDGKLLASVAQECLMRVRK
>Mature_284_residues
MQTTENLADILDLEPIEVNLFRGVSPNDGFPRIFGGLVIAQALLAAYKTVPDRVCHSLHAYFIRPGDVTAPVLYEVERAR
DGGTFTTRRVAAIQHGEQIFNLAASFQTPEDGFEHQSEMPASVDPESLPTEADFLRSLGDQIHPKMVAIAERPRPVDIRW
IDPQNPIAPVKKSGTKQVWMRAKAPLGDDVKMQQAALAYASDMAFMESALRPHGLIWTTPGIQAASLDHAMWFHHPFNFN
DWTLFAQDSPSASQGRGLVRGQMFSQDGKLLASVAQECLMRVRK

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=287, Percent_Identity=41.1149825783972, Blast_Score=195, Evalue=5e-50,
Organism=Escherichia coli, GI1786657, Length=269, Percent_Identity=47.9553903345725, Blast_Score=270, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI71988741, Length=291, Percent_Identity=35.3951890034364, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17558508, Length=302, Percent_Identity=36.4238410596026, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17531889, Length=272, Percent_Identity=33.0882352941176, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI115532456, Length=273, Percent_Identity=32.967032967033, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17531885, Length=273, Percent_Identity=32.967032967033, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI212645202, Length=268, Percent_Identity=32.8358208955224, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI71982224, Length=300, Percent_Identity=30, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 31518; Mature: 31518

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTTENLADILDLEPIEVNLFRGVSPNDGFPRIFGGLVIAQALLAAYKTVPDRVCHSLHA
CCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFIRPGDVTAPVLYEVERARDGGTFTTRRVAAIQHGEQIFNLAASFQTPEDGFEHQSEMP
EEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
ASVDPESLPTEADFLRSLGDQIHPKMVAIAERPRPVDIRWIDPQNPIAPVKKSGTKQVWM
CCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHE
RAKAPLGDDVKMQQAALAYASDMAFMESALRPHGLIWTTPGIQAASLDHAMWFHHPFNFN
EECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHCCCCCCCC
DWTLFAQDSPSASQGRGLVRGQMFSQDGKLLASVAQECLMRVRK
CEEEEECCCCCHHHCCCCEEHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTTENLADILDLEPIEVNLFRGVSPNDGFPRIFGGLVIAQALLAAYKTVPDRVCHSLHA
CCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFIRPGDVTAPVLYEVERARDGGTFTTRRVAAIQHGEQIFNLAASFQTPEDGFEHQSEMP
EEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
ASVDPESLPTEADFLRSLGDQIHPKMVAIAERPRPVDIRWIDPQNPIAPVKKSGTKQVWM
CCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHE
RAKAPLGDDVKMQQAALAYASDMAFMESALRPHGLIWTTPGIQAASLDHAMWFHHPFNFN
EECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHCCCCCCCC
DWTLFAQDSPSASQGRGLVRGQMFSQDGKLLASVAQECLMRVRK
CEEEEECCCCCHHHCCCCEEHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]