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The map label for this gene is tdcB [H]

Identifier: 16127865

GI number: 16127865

Start: 3893829

End: 3895031

Strand: Direct

Name: tdcB [H]

Synonym: CC_3635

Alternate gene names: 16127865

Gene position: 3893829-3895031 (Clockwise)

Preceding gene: 16127864

Following gene: 16127867

Centisome position: 96.94

GC content: 67.75

Gene sequence:

>1203_bases
ATGACCCTCGACCTCGCCGCTATCCAGGCCGCCGCCGGCCGTCTCCAGGGCCAGATCGAGCGCACGCCGTGCCGCCACTC
CAAGACCCTCTCGAAGATCACCGGCGCCGAGGTGTGGGTGAAGTTCGAGAACCTGCAGTTCACCGCCGCCTACAAGGAGC
GCGGCGCGCTCAACAAGCTGATGCTCCTCTCGGAGACCGAGAAGCAGCGCGGCGTCATCGCCGCCAGCGCCGGCAACCAC
GCCCAGGGCTTGGCCTATCACGGCGCGCGCCTCGGCGTGCCGGTCACCATCGTCATGCCCAAGACCACGCCTTTCGTGAA
GGTGCAGCACACCCGCGACTTCGGCGCGACCGTGGTCATCGAGGGCGAGACCTATGACGACGCCAACGCCCATGCCCGCA
AGCTGCGCGACGAGCAGGGCCTGACCTTCGTCCACCCGTTCGACGACTACGACATCATGGCCGGACAGGGCACCATCGCC
CTGGAAATGCTGGAAGACGCGCCCGATCTGGAGATCCTGCCCGTGCCGATCGGCGGCGGCGGCCTGATCAGCGGCGTGGC
GACGGCGGCCAAGGCGCTGAAGCCGGATATCCGCATCATCGGCTGCGAGCCGGCCATGTATCCGTCCTTCACCGCCAAGA
TGCGCGGTGTCGCCGCCCACTGCGGCGGCCAGACCATCGCCGAAGGGGTCGCGGTCAAGCAGGTCGGCGAGCTGACCTAT
GGCGTCGTTCGCCCGTTGCTGGACGACGTGCTGCTGCTGGAAGAGCCCTATCTGGAGCAGGCCGTCTCGCTCTATTGCAA
TGTCGAGAAGACCATCGCCGAGGGCGCGGGCGCAGCCTCGCTGGCCGCTTTGCTGGCCTATCCCGAACGCTTCCGGGGCA
AGAAGTGCGGCCTGATCCTGTGCGGCGGCAATATCGACACCCGCCTCTTGGCCTCGGTGCTGACCCGCGAACTGGTGCGC
GCCCAGCGCCTGGCCAGCTTGCGAATCATCGGCGACGACCGTCCGGGCCTGTTGTCGACCGTCGCCTCGGTCATCGGCGC
CATGGGCGCCAACATCATCGAAGTGAATCACAACCGCCTGGCCCTGGACGTGCCGGCCAAGGGCGCGGAGTTCGACATCA
CCATCGAAACCCGCGACGCCCAGCACACCCAGGAGGTCATGGAGGCCCTGCGCGAGAGCGGCTACCCGCCGCGGGTGGTT
TGA

Upstream 100 bases:

>100_bases
AAAGCTGCTGCGTGAAGCCCCCTAAGAGACGTGAACGGAACGCCCTGGCGTGCTAGAGGCCCCGCCACGGCAGTTTCTCG
CCGCGACAGAAGTGGACGAC

Downstream 100 bases:

>100_bases
TCCAAAGCCCTCCCCCTCAGGGGGAGGATTTTCATTCCTTCGGCTTGCCCGGACCGATGCGGTTCACGTCGAGCAGTTCG
ATCCGGAAGATCATCACGCT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTLDLAAIQAAAGRLQGQIERTPCRHSKTLSKITGAEVWVKFENLQFTAAYKERGALNKLMLLSETEKQRGVIAASAGNH
AQGLAYHGARLGVPVTIVMPKTTPFVKVQHTRDFGATVVIEGETYDDANAHARKLRDEQGLTFVHPFDDYDIMAGQGTIA
LEMLEDAPDLEILPVPIGGGGLISGVATAAKALKPDIRIIGCEPAMYPSFTAKMRGVAAHCGGQTIAEGVAVKQVGELTY
GVVRPLLDDVLLLEEPYLEQAVSLYCNVEKTIAEGAGAASLAALLAYPERFRGKKCGLILCGGNIDTRLLASVLTRELVR
AQRLASLRIIGDDRPGLLSTVASVIGAMGANIIEVNHNRLALDVPAKGAEFDITIETRDAQHTQEVMEALRESGYPPRVV

Sequences:

>Translated_400_residues
MTLDLAAIQAAAGRLQGQIERTPCRHSKTLSKITGAEVWVKFENLQFTAAYKERGALNKLMLLSETEKQRGVIAASAGNH
AQGLAYHGARLGVPVTIVMPKTTPFVKVQHTRDFGATVVIEGETYDDANAHARKLRDEQGLTFVHPFDDYDIMAGQGTIA
LEMLEDAPDLEILPVPIGGGGLISGVATAAKALKPDIRIIGCEPAMYPSFTAKMRGVAAHCGGQTIAEGVAVKQVGELTY
GVVRPLLDDVLLLEEPYLEQAVSLYCNVEKTIAEGAGAASLAALLAYPERFRGKKCGLILCGGNIDTRLLASVLTRELVR
AQRLASLRIIGDDRPGLLSTVASVIGAMGANIIEVNHNRLALDVPAKGAEFDITIETRDAQHTQEVMEALRESGYPPRVV
>Mature_399_residues
TLDLAAIQAAAGRLQGQIERTPCRHSKTLSKITGAEVWVKFENLQFTAAYKERGALNKLMLLSETEKQRGVIAASAGNHA
QGLAYHGARLGVPVTIVMPKTTPFVKVQHTRDFGATVVIEGETYDDANAHARKLRDEQGLTFVHPFDDYDIMAGQGTIAL
EMLEDAPDLEILPVPIGGGGLISGVATAAKALKPDIRIIGCEPAMYPSFTAKMRGVAAHCGGQTIAEGVAVKQVGELTYG
VVRPLLDDVLLLEEPYLEQAVSLYCNVEKTIAEGAGAASLAALLAYPERFRGKKCGLILCGGNIDTRLLASVLTRELVRA
QRLASLRIIGDDRPGLLSTVASVIGAMGANIIEVNHNRLALDVPAKGAEFDITIETRDAQHTQEVMEALRESGYPPRVV

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=340, Percent_Identity=31.4705882352941, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI33469958, Length=146, Percent_Identity=34.9315068493151, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI19923959, Length=144, Percent_Identity=34.0277777777778, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789505, Length=310, Percent_Identity=39.6774193548387, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1790207, Length=381, Percent_Identity=35.1706036745407, Blast_Score=171, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI71991565, Length=394, Percent_Identity=39.0862944162437, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17537387, Length=407, Percent_Identity=34.1523341523341, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17508781, Length=280, Percent_Identity=31.4285714285714, Blast_Score=131, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6322631, Length=307, Percent_Identity=36.8078175895765, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320930, Length=394, Percent_Identity=31.4720812182741, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6319788, Length=188, Percent_Identity=28.7234042553192, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355833, Length=389, Percent_Identity=39.3316195372751, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24645328, Length=298, Percent_Identity=36.241610738255, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 42842; Mature: 42711

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDLAAIQAAAGRLQGQIERTPCRHSKTLSKITGAEVWVKFENLQFTAAYKERGALNKL
CCCCHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCEEEEEEECEEEEEEHHHCCCHHHE
MLLSETEKQRGVIAASAGNHAQGLAYHGARLGVPVTIVMPKTTPFVKVQHTRDFGATVVI
EEEECCHHHCCEEEECCCCCCCCEEECCCCCCCCEEEEECCCCCEEEEEECCCCCCEEEE
EGETYDDANAHARKLRDEQGLTFVHPFDDYDIMAGQGTIALEMLEDAPDLEILPVPIGGG
ECCCCCCCHHHHHHHHHHCCCEEEECCCCCEEEECCCCEEEEEECCCCCCEEEEEECCCC
GLISGVATAAKALKPDIRIIGCEPAMYPSFTAKMRGVAAHCGGQTIAEGVAVKQVGELTY
HHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GVVRPLLDDVLLLEEPYLEQAVSLYCNVEKTIAEGAGAASLAALLAYPERFRGKKCGLIL
HHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCHHHHCCCCCCEEE
CGGNIDTRLLASVLTRELVRAQRLASLRIIGDDRPGLLSTVASVIGAMGANIIEVNHNRL
ECCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCEE
ALDVPAKGAEFDITIETRDAQHTQEVMEALRESGYPPRVV
EEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TLDLAAIQAAAGRLQGQIERTPCRHSKTLSKITGAEVWVKFENLQFTAAYKERGALNKL
CCCHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCEEEEEEECEEEEEEHHHCCCHHHE
MLLSETEKQRGVIAASAGNHAQGLAYHGARLGVPVTIVMPKTTPFVKVQHTRDFGATVVI
EEEECCHHHCCEEEECCCCCCCCEEECCCCCCCCEEEEECCCCCEEEEEECCCCCCEEEE
EGETYDDANAHARKLRDEQGLTFVHPFDDYDIMAGQGTIALEMLEDAPDLEILPVPIGGG
ECCCCCCCHHHHHHHHHHCCCEEEECCCCCEEEECCCCEEEEEECCCCCCEEEEEECCCC
GLISGVATAAKALKPDIRIIGCEPAMYPSFTAKMRGVAAHCGGQTIAEGVAVKQVGELTY
HHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GVVRPLLDDVLLLEEPYLEQAVSLYCNVEKTIAEGAGAASLAALLAYPERFRGKKCGLIL
HHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCHHHHCCCCCCEEE
CGGNIDTRLLASVLTRELVRAQRLASLRIIGDDRPGLLSTVASVIGAMGANIIEVNHNRL
ECCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCEE
ALDVPAKGAEFDITIETRDAQHTQEVMEALRESGYPPRVV
EEECCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA