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The map label for this gene is argE [H]

Identifier: 16127861

GI number: 16127861

Start: 3889798

End: 3890973

Strand: Direct

Name: argE [H]

Synonym: CC_3631

Alternate gene names: 16127861

Gene position: 3889798-3890973 (Clockwise)

Preceding gene: 16127857

Following gene: 16127863

Centisome position: 96.83

GC content: 68.11

Gene sequence:

>1176_bases
ATGGTCGCCTCCTCAGAAGCCCTGTCCGCCCGCGCCATCGACATCCTGGCCAAGCTGGTGGCGTTCGACACCACCTCGCG
TCGCTCGAACCTCGCGCTGATCGAATGGGTCGAACAATATCTGGCCGAGCTGAACGTCCCGACCCGGCGCGTGCCGAACG
CGGACGGGACGAAATCGAACCTGATGGCGATGATCGGACCGGCCGTGGAGGGCGGAGTCGTGCTGTCGGGCCATACCGAC
GTGGTGCCGGTCGACGGCCAGCCCTGGTCCACCGATCCTTGGACGCTGACCGAGCGTGACGGTCGGCTATACGGACGCGG
AACCTGCGACATGAAGGGGTTCCTGGCCCTGGCGCTGGCCGCGGCGCCGGATCTGGCCCAGGCAAACCTTCGCAAGCCCG
TGCACCTGGCGTTCTCCTATGACGAAGAGGTCGGCTGCCTGGGCGCGCCCGACATGATCGACGTGATCGCCCGCGAAGTT
CCCCGCCCCGCCCTGGTGGTGGTGGGCGAGCCCACCGACATGGTGGCGGTTCGCGCCCACAAGGGCATCGCCAGCTTCAA
GGTCACCGTCACCGGCCGCGAGGCCCATTCCAGCCTGACCCATCTGGGGGTCTCGGCGAACATGGTCGCGATCAAGCTGA
TGGCCATGCTGGTCGGTCTCTCCGAAAAGCTCGAGCGGGAGGCCGATCCCAACTCGCCGTTCACGCCGAAGGGCGCGACC
CTGACGATCGGTCAGGTCAACGGCGGCACGGCGGTCAATATCCTGGCCCGCGAATGCGTGTTCATCTTCGACCTGCGCAC
GCCCGCCGGGATGGATCCGGTCGCGCTGCTGTCGGACTTCTTCGCCATGGCGTCGGCCCTGGACGCGCAGATCAAGGCCA
AGGCCCCCGAGGGCGGCGTCAAGGTCGAGCGGCGTTCGCTGACCCCGGCCTTCGCGCCGGAAGAGGACGGCGTCGCCGAG
GCCTTCGCCCGCAAGCTGGCGGGTGACAACGGCCCCGCGCGCGTCGTGCCCTACGCCGCCGAAGCCGGACAGTTCCAGGG
CGCGGGCTTCTCGACCGTGATCTGCGGACCCGGCTCGATCGACCAGGCCCACCAGCCCAACGAGTATGTCGAGATCAGCC
AGATGCAGCGCGGCGGGGCCTTCATGAGGCGGTTGGTCGAGGACCTTTCCACCTAA

Upstream 100 bases:

>100_bases
CGGCGGCGGCCTGGTCGCTCCAAGGGCATGTCCTTGCGACGCCCGGCCCTGAGGGACGCCGGGGTGGCCGATTAGGTGCA
AACGGGTCTAGGCTGGCGCC

Downstream 100 bases:

>100_bases
CGCCGCTTCCCCGGCGAAGGCCGGGGCCCAGATGGAAGAGCGCTGGAGTGAAAGCTATGAGCTCAGCGTCAATCCCGTCA
GCCCAAGCGCTTCGAGATCT

Product: acetylornithine deacetylase

Products: NA

Alternate protein names: AO; Acetylornithinase; N-acetylornithinase; NAO [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MVASSEALSARAIDILAKLVAFDTTSRRSNLALIEWVEQYLAELNVPTRRVPNADGTKSNLMAMIGPAVEGGVVLSGHTD
VVPVDGQPWSTDPWTLTERDGRLYGRGTCDMKGFLALALAAAPDLAQANLRKPVHLAFSYDEEVGCLGAPDMIDVIAREV
PRPALVVVGEPTDMVAVRAHKGIASFKVTVTGREAHSSLTHLGVSANMVAIKLMAMLVGLSEKLEREADPNSPFTPKGAT
LTIGQVNGGTAVNILARECVFIFDLRTPAGMDPVALLSDFFAMASALDAQIKAKAPEGGVKVERRSLTPAFAPEEDGVAE
AFARKLAGDNGPARVVPYAAEAGQFQGAGFSTVICGPGSIDQAHQPNEYVEISQMQRGGAFMRRLVEDLST

Sequences:

>Translated_391_residues
MVASSEALSARAIDILAKLVAFDTTSRRSNLALIEWVEQYLAELNVPTRRVPNADGTKSNLMAMIGPAVEGGVVLSGHTD
VVPVDGQPWSTDPWTLTERDGRLYGRGTCDMKGFLALALAAAPDLAQANLRKPVHLAFSYDEEVGCLGAPDMIDVIAREV
PRPALVVVGEPTDMVAVRAHKGIASFKVTVTGREAHSSLTHLGVSANMVAIKLMAMLVGLSEKLEREADPNSPFTPKGAT
LTIGQVNGGTAVNILARECVFIFDLRTPAGMDPVALLSDFFAMASALDAQIKAKAPEGGVKVERRSLTPAFAPEEDGVAE
AFARKLAGDNGPARVVPYAAEAGQFQGAGFSTVICGPGSIDQAHQPNEYVEISQMQRGGAFMRRLVEDLST
>Mature_391_residues
MVASSEALSARAIDILAKLVAFDTTSRRSNLALIEWVEQYLAELNVPTRRVPNADGTKSNLMAMIGPAVEGGVVLSGHTD
VVPVDGQPWSTDPWTLTERDGRLYGRGTCDMKGFLALALAAAPDLAQANLRKPVHLAFSYDEEVGCLGAPDMIDVIAREV
PRPALVVVGEPTDMVAVRAHKGIASFKVTVTGREAHSSLTHLGVSANMVAIKLMAMLVGLSEKLEREADPNSPFTPKGAT
LTIGQVNGGTAVNILARECVFIFDLRTPAGMDPVALLSDFFAMASALDAQIKAKAPEGGVKVERRSLTPAFAPEEDGVAE
AFARKLAGDNGPARVVPYAAEAGQFQGAGFSTVICGPGSIDQAHQPNEYVEISQMQRGGAFMRRLVEDLST

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. ArgE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=304, Percent_Identity=25.3289473684211, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790395, Length=372, Percent_Identity=34.6774193548387, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1788816, Length=204, Percent_Identity=28.921568627451, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789236, Length=321, Percent_Identity=26.4797507788162, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17551016, Length=348, Percent_Identity=24.7126436781609, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24649210, Length=388, Percent_Identity=23.7113402061856, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010169
- InterPro:   IPR001261
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.16 [H]

Molecular weight: Translated: 41422; Mature: 41422

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVASSEALSARAIDILAKLVAFDTTSRRSNLALIEWVEQYLAELNVPTRRVPNADGTKSN
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
LMAMIGPAVEGGVVLSGHTDVVPVDGQPWSTDPWTLTERDGRLYGRGTCDMKGFLALALA
HHEEECCCCCCCEEEECCCCEEECCCCCCCCCCCEEECCCCEEEECCCCCHHHHHHHHHH
AAPDLAQANLRKPVHLAFSYDEEVGCLGAPDMIDVIAREVPRPALVVVGEPTDMVAVRAH
CCCCHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEEEC
KGIASFKVTVTGREAHSSLTHLGVSANMVAIKLMAMLVGLSEKLEREADPNSPFTPKGAT
CCCEEEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
LTIGQVNGGTAVNILARECVFIFDLRTPAGMDPVALLSDFFAMASALDAQIKAKAPEGGV
EEEEECCCCCEEHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCC
KVERRSLTPAFAPEEDGVAEAFARKLAGDNGPARVVPYAAEAGQFQGAGFSTVICGPGSI
EEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCC
DQAHQPNEYVEISQMQRGGAFMRRLVEDLST
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVASSEALSARAIDILAKLVAFDTTSRRSNLALIEWVEQYLAELNVPTRRVPNADGTKSN
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
LMAMIGPAVEGGVVLSGHTDVVPVDGQPWSTDPWTLTERDGRLYGRGTCDMKGFLALALA
HHEEECCCCCCCEEEECCCCEEECCCCCCCCCCCEEECCCCEEEECCCCCHHHHHHHHHH
AAPDLAQANLRKPVHLAFSYDEEVGCLGAPDMIDVIAREVPRPALVVVGEPTDMVAVRAH
CCCCHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEEEC
KGIASFKVTVTGREAHSSLTHLGVSANMVAIKLMAMLVGLSEKLEREADPNSPFTPKGAT
CCCEEEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
LTIGQVNGGTAVNILARECVFIFDLRTPAGMDPVALLSDFFAMASALDAQIKAKAPEGGV
EEEEECCCCCEEHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCC
KVERRSLTPAFAPEEDGVAEAFARKLAGDNGPARVVPYAAEAGQFQGAGFSTVICGPGSI
EEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCC
DQAHQPNEYVEISQMQRGGAFMRRLVEDLST
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10692366 [H]