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The map label for this gene is luxQ [H]

Identifier: 16127853

GI number: 16127853

Start: 3881428

End: 3883215

Strand: Direct

Name: luxQ [H]

Synonym: CC_3623

Alternate gene names: 16127853

Gene position: 3881428-3883215 (Clockwise)

Preceding gene: 16127852

Following gene: 16127857

Centisome position: 96.63

GC content: 67.51

Gene sequence:

>1788_bases
TTGGGGGGGGGCGGAGCGCCCATGAGCGCTGAGACGAAGGATATTGACCTGGAACGCGCTGTCGCCTCGCGACGCGTCAA
TACCTATCTGCGCCTCAGCTCGACCTTTGCGATCTGCGCGACCCTGCACCTCGTCGTTGGCTTGCGCTGGGTTTGGATCT
GGGGAGCGCTCTACACCGCGATCCAGTTCCTGGAGACCTGGCTGGCGCTTCAGCTCATCAAGCGACCGCAGAGCAGCCCT
GATCGCTGGCGCCGCTTCTCCGTCATCGCCCTGCCCTTTCTAACCTCCGCCGTCTTCGGATTCCTGGCGATTCCCCTGTT
CGCGTCCGACGCCCGGTTCGCGCCGACCTTGGGCGGCATGCTGCTGGCCGGGGCGCTGATGAACGTCGTCATCGTCCACG
GCGGCCTTCGCTCAGCGACCATCGCCGCAGCGACGCCGTACGTCGGCTATCTCCTGGTCATCCCCATCGTGGCCCGGCAG
GCCAATCCCGATGCACCCCTGGCCAACGCCCTGTGGTTTGGCGCGCTCCTGCTCATCGCGGCGGTGGCGGTCGCCTCGCG
CACGCTTCACGCCGCGCTGAAAGCGGAGGCGGACGCCAAGACCGAGGCGGAGCGTCGCCGCCACGAGGCCGAGGAAGCCG
TCGCGGCGAAATCGGCCTTCGTCGCCATGATCAGTCACGAACTTCGCACGCCGATCAGCGCCATTCTCGCGGGGGCCGGC
CGCCTGCACAGCGAAGCGCCCGAAGCCAGCTCCAAGGTGCACGCCCAGCTGATCGCCGACGCGGGCGGGCTGATGCGCAC
GCTGCTCAACGACCTTCTGGACTTTTCGCGGCTCGAGGCGGGCCGGATGTCGGTGGAGAAATCGCCGTTCAACCTCCGCC
AGAGCCTGTCGGATACGCTGCGCTTCTGGCGGCCGGAGCTTGCCCGCAAGGGACTGAAGCTGCGCGTTGTCGGCGCCTCG
ACGATCCCGCAGTGGACGCTCGGCGACGCCATGCGCCTGAAGCAGGTGCTCAACAACCTATTGTCCAACGCCGCCAAGTT
CACCCGAAGCGGCGGCGTGTCGGTGACGCTGAGGGCCGAGATCGTCGGCGATCAGGTGCGGCTGGTTGTCGACGTGGTCG
ATACCGGTCCAGGCATTCCCGAAGCCGCGCTTCCGCGCCTGTTCACGCCTTTCGATCAACTCAATGAGTCGGTGGCTCGC
CTGCACGGCGGGTCCGGGCTTGGTCTGGCCATCAGCCGCGAGCTCGCGCGCCTGATGGGCGGTGATCTGACGGCGTCCAA
TGCGCTAGGCCAGGGCGCGCACTTTCGGTTTTCGGCATTGCTGGAGGCCGCCGAAGCGCCTGTGGTTCCGACGCTGGGCC
CATCGATCAGCGGCCTGCGCGTGCTGGTCGTCGACGATCACGTCGTGAACCGGCGGGCCGTCGAACTGGTCCTGCAGCCC
TTCGGCGTGGAAGCCACCCTCGCCGAATCCGGGGAAGAGGCCCTCGAACTTCTTCGCTCCGAGGTCTTCGACGCTATTCT
GATGGATGTCTACATGCCGGGTATGGACGGGCGCGAGACGACCCGCACGCTCCGCGCCGGCCAGGGCCCCAATCGCGATG
CGCCGGTCGTTGCGGTCACCGCCTCGGCCACGATCAAGGATTGGGAGGCCTGCGCGGCGGCCGGCATGAACGCCCATGTC
GCCAAGCCCATCGATCCGGCCGAACTGTTCTCGGCGCTCGCTCAAGTCATGGCGGCGCGCGACGCTGTCGGACCTTTCAG
AACCGACGTCGCCGCGAGCAGCGCCTGA

Upstream 100 bases:

>100_bases
CGCGCCGGACACCCAAGCCGTTGACGAAACGCTGGTCTTTCATTTCCTCTTAGCCCCTCGTGACTAGGGTTATTGGGTAA
GGGATTGCTCTGCGATCTCC

Downstream 100 bases:

>100_bases
AGCCGAGCGCTCAGGGCCGCTTCGTCCTTGAAGTCACACTCCCAGACCACCTGGGTCCGCCATCCGGCCTGCGCCAGAGC
CGCCAAGGCCTGTTCATCCC

Product: sensor histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MGGGGAPMSAETKDIDLERAVASRRVNTYLRLSSTFAICATLHLVVGLRWVWIWGALYTAIQFLETWLALQLIKRPQSSP
DRWRRFSVIALPFLTSAVFGFLAIPLFASDARFAPTLGGMLLAGALMNVVIVHGGLRSATIAAATPYVGYLLVIPIVARQ
ANPDAPLANALWFGALLLIAAVAVASRTLHAALKAEADAKTEAERRRHEAEEAVAAKSAFVAMISHELRTPISAILAGAG
RLHSEAPEASSKVHAQLIADAGGLMRTLLNDLLDFSRLEAGRMSVEKSPFNLRQSLSDTLRFWRPELARKGLKLRVVGAS
TIPQWTLGDAMRLKQVLNNLLSNAAKFTRSGGVSVTLRAEIVGDQVRLVVDVVDTGPGIPEAALPRLFTPFDQLNESVAR
LHGGSGLGLAISRELARLMGGDLTASNALGQGAHFRFSALLEAAEAPVVPTLGPSISGLRVLVVDDHVVNRRAVELVLQP
FGVEATLAESGEEALELLRSEVFDAILMDVYMPGMDGRETTRTLRAGQGPNRDAPVVAVTASATIKDWEACAAAGMNAHV
AKPIDPAELFSALAQVMAARDAVGPFRTDVAASSA

Sequences:

>Translated_595_residues
MGGGGAPMSAETKDIDLERAVASRRVNTYLRLSSTFAICATLHLVVGLRWVWIWGALYTAIQFLETWLALQLIKRPQSSP
DRWRRFSVIALPFLTSAVFGFLAIPLFASDARFAPTLGGMLLAGALMNVVIVHGGLRSATIAAATPYVGYLLVIPIVARQ
ANPDAPLANALWFGALLLIAAVAVASRTLHAALKAEADAKTEAERRRHEAEEAVAAKSAFVAMISHELRTPISAILAGAG
RLHSEAPEASSKVHAQLIADAGGLMRTLLNDLLDFSRLEAGRMSVEKSPFNLRQSLSDTLRFWRPELARKGLKLRVVGAS
TIPQWTLGDAMRLKQVLNNLLSNAAKFTRSGGVSVTLRAEIVGDQVRLVVDVVDTGPGIPEAALPRLFTPFDQLNESVAR
LHGGSGLGLAISRELARLMGGDLTASNALGQGAHFRFSALLEAAEAPVVPTLGPSISGLRVLVVDDHVVNRRAVELVLQP
FGVEATLAESGEEALELLRSEVFDAILMDVYMPGMDGRETTRTLRAGQGPNRDAPVVAVTASATIKDWEACAAAGMNAHV
AKPIDPAELFSALAQVMAARDAVGPFRTDVAASSA
>Mature_594_residues
GGGGAPMSAETKDIDLERAVASRRVNTYLRLSSTFAICATLHLVVGLRWVWIWGALYTAIQFLETWLALQLIKRPQSSPD
RWRRFSVIALPFLTSAVFGFLAIPLFASDARFAPTLGGMLLAGALMNVVIVHGGLRSATIAAATPYVGYLLVIPIVARQA
NPDAPLANALWFGALLLIAAVAVASRTLHAALKAEADAKTEAERRRHEAEEAVAAKSAFVAMISHELRTPISAILAGAGR
LHSEAPEASSKVHAQLIADAGGLMRTLLNDLLDFSRLEAGRMSVEKSPFNLRQSLSDTLRFWRPELARKGLKLRVVGAST
IPQWTLGDAMRLKQVLNNLLSNAAKFTRSGGVSVTLRAEIVGDQVRLVVDVVDTGPGIPEAALPRLFTPFDQLNESVARL
HGGSGLGLAISRELARLMGGDLTASNALGQGAHFRFSALLEAAEAPVVPTLGPSISGLRVLVVDDHVVNRRAVELVLQPF
GVEATLAESGEEALELLRSEVFDAILMDVYMPGMDGRETTRTLRAGQGPNRDAPVVAVTASATIKDWEACAAAGMNAHVA
KPIDPAELFSALAQVMAARDAVGPFRTDVAASSA

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87081816, Length=335, Percent_Identity=37.6119402985075, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI48994928, Length=373, Percent_Identity=30.8310991957105, Blast_Score=176, Evalue=5e-45,
Organism=Escherichia coli, GI1789149, Length=401, Percent_Identity=30.6733167082294, Blast_Score=165, Evalue=1e-41,
Organism=Escherichia coli, GI1788713, Length=392, Percent_Identity=32.1428571428571, Blast_Score=162, Evalue=7e-41,
Organism=Escherichia coli, GI145693157, Length=296, Percent_Identity=34.4594594594595, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1788393, Length=218, Percent_Identity=32.5688073394495, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786783, Length=210, Percent_Identity=29.5238095238095, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=29.5833333333333, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1790861, Length=214, Percent_Identity=33.6448598130841, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=28.0172413793103, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787894, Length=225, Percent_Identity=28.8888888888889, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=30.2127659574468, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=227, Percent_Identity=25.9911894273128, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790437, Length=138, Percent_Identity=30.4347826086957, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=36.9747899159664, Blast_Score=62, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322044, Length=139, Percent_Identity=32.3741007194245, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63332; Mature: 63201

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGGGAPMSAETKDIDLERAVASRRVNTYLRLSSTFAICATLHLVVGLRWVWIWGALYTA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQFLETWLALQLIKRPQSSPDRWRRFSVIALPFLTSAVFGFLAIPLFASDARFAPTLGGM
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LLAGALMNVVIVHGGLRSATIAAATPYVGYLLVIPIVARQANPDAPLANALWFGALLLIA
HHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AVAVASRTLHAALKAEADAKTEAERRRHEAEEAVAAKSAFVAMISHELRTPISAILAGAG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
RLHSEAPEASSKVHAQLIADAGGLMRTLLNDLLDFSRLEAGRMSVEKSPFNLRQSLSDTL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
RFWRPELARKGLKLRVVGASTIPQWTLGDAMRLKQVLNNLLSNAAKFTRSGGVSVTLRAE
HHHCHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
IVGDQVRLVVDVVDTGPGIPEAALPRLFTPFDQLNESVARLHGGSGLGLAISRELARLMG
ECCCCEEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GDLTASNALGQGAHFRFSALLEAAEAPVVPTLGPSISGLRVLVVDDHVVNRRAVELVLQP
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHC
FGVEATLAESGEEALELLRSEVFDAILMDVYMPGMDGRETTRTLRAGQGPNRDAPVVAVT
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEEEE
ASATIKDWEACAAAGMNAHVAKPIDPAELFSALAQVMAARDAVGPFRTDVAASSA
CCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC
>Mature Secondary Structure 
GGGGAPMSAETKDIDLERAVASRRVNTYLRLSSTFAICATLHLVVGLRWVWIWGALYTA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQFLETWLALQLIKRPQSSPDRWRRFSVIALPFLTSAVFGFLAIPLFASDARFAPTLGGM
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LLAGALMNVVIVHGGLRSATIAAATPYVGYLLVIPIVARQANPDAPLANALWFGALLLIA
HHHHHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AVAVASRTLHAALKAEADAKTEAERRRHEAEEAVAAKSAFVAMISHELRTPISAILAGAG
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
RLHSEAPEASSKVHAQLIADAGGLMRTLLNDLLDFSRLEAGRMSVEKSPFNLRQSLSDTL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
RFWRPELARKGLKLRVVGASTIPQWTLGDAMRLKQVLNNLLSNAAKFTRSGGVSVTLRAE
HHHCHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
IVGDQVRLVVDVVDTGPGIPEAALPRLFTPFDQLNESVARLHGGSGLGLAISRELARLMG
ECCCCEEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GDLTASNALGQGAHFRFSALLEAAEAPVVPTLGPSISGLRVLVVDDHVVNRRAVELVLQP
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHC
FGVEATLAESGEEALELLRSEVFDAILMDVYMPGMDGRETTRTLRAGQGPNRDAPVVAVT
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCEEEEE
ASATIKDWEACAAAGMNAHVAKPIDPAELFSALAQVMAARDAVGPFRTDVAASSA
CCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]