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The map label for this gene is proA

Identifier: 16127660

GI number: 16127660

Start: 3674109

End: 3675350

Strand: Direct

Name: proA

Synonym: CC_3430

Alternate gene names: 16127660

Gene position: 3674109-3675350 (Clockwise)

Preceding gene: 16127658

Following gene: 16127661

Centisome position: 91.47

GC content: 71.5

Gene sequence:

>1242_bases
ATGGCGGGGATGGGCCGGACGGCCCGCGAGGGCGCGCGCGCGCTTCGCCTCGCCACGCCAGAGCAGCGCACGGCCGCCAT
CCAGGCCATGGCCGTCGCCATCCGCGAGGACGCCGACGCGATCCTCACCGCCAACGCCAAGGATTTGGCGCGCGCAGAGG
CCAACGGCGTCTCGGGCCCGATGCTGGACCGGCTGGCACTGGACGCTGCGCGTCTGGAAGGCGTCGCCGCAGGCGTAGAG
GCCGTAGCCGCCGTTCCTGATCCCGTCGGCGTCGCCACCTCGCGCTGGACCCGGCCCAACGGCCTCGATATCGCCCGCGT
GCGCACGCCGATCGGCGTGATCGCCATGATCTATGAGAGCCGCCCCAATGTGACCGCCGACGCCGCAGCGCTGTGCGTGC
GCTCGGGCAATGCGGTGATCCTGCGCGGCGGGTCGGAGTGCATCCACTCCAACCTCGCCATCCACGCCGCGATCGCGCGC
GGTCTCCAGAAGGCCGGCCTGCCCACCGCCGCCGTCCAGGCGGTGAAGACGCCCGACCGCGCCGCCGTGGGCATGATCCT
GGCCGGGCTGGACAGGACCATCGACCTGATCATTCCGCGCGGCGGCAAGAGCCTGGTGGCCCGCGTCCAGGCCGAGGCCC
GCGCCCCGGTGCTGGGCCACCTGGAAGGCCTGAACCACGTCTTCGTCCACGCCGCCGCCGACCTGAAGAAGGCCGTCGAG
GTGGTGGTGAACGCCAAGCTGCGCCGCGTTTCGGTCTGCGGCTCTGCCGAGACCCTGCTGATCGACCAGGCGGCCGCCGA
CAAGCTTCTGCCGCCGATCGCCGACGCCCTGATCAAGGCCGGTTGCGAGCTGCGCGGCGACGCCGCCGCCCGCGCCATCG
AGCCGACGATGAAGAAGGCCACGGTCGAGGACTGGACCACCGAATACTTGGCCCCGATCCTGTCGGTGGCCGTGGTCGAC
GGCGTGGCCGGCGCGGCGCGGCATATCGCCTCGTACGGCTCGGGCCACACCGACGCGATCATCACCGAGGACGCCGCCGC
CGCCGAGGCCTTCATCGCCGAGGTCGACAGCGCCATCGTTCTGGTCAACGCCTCAACCCAGTTCGCCGATGGCGGCGAGT
TCGGCTTCGGGGCCGAGATCGGCATCGCCACCGACAAGCTTCATGCCCGCGGCCCGGTTGGGGCCGAGCAACTGACGACG
TTCAAGTATGTGGTTCGCGGGACCGGCCAGACTCGTCCCTGA

Upstream 100 bases:

>100_bases
TTTCATCCGCCTCTGAAAGAGCCTAGGTAAGCCTCAACCTGAGCATAACCTTCAGGACGGGGACGAGATGGACGACGCGG
GCGCGAGCCTTCAGGCGATC

Downstream 100 bases:

>100_bases
GGCCGGCCGGCCCAACGCCCAGCGTCTGGGGTTCCACCTGGAACCCGGGATGCGCGTCGGGCTGTTCGGCGGCAGCTTCA
ACCCGGCGCACGAGGGTCAC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MAGMGRTAREGARALRLATPEQRTAAIQAMAVAIREDADAILTANAKDLARAEANGVSGPMLDRLALDAARLEGVAAGVE
AVAAVPDPVGVATSRWTRPNGLDIARVRTPIGVIAMIYESRPNVTADAAALCVRSGNAVILRGGSECIHSNLAIHAAIAR
GLQKAGLPTAAVQAVKTPDRAAVGMILAGLDRTIDLIIPRGGKSLVARVQAEARAPVLGHLEGLNHVFVHAAADLKKAVE
VVVNAKLRRVSVCGSAETLLIDQAAADKLLPPIADALIKAGCELRGDAAARAIEPTMKKATVEDWTTEYLAPILSVAVVD
GVAGAARHIASYGSGHTDAIITEDAAAAEAFIAEVDSAIVLVNASTQFADGGEFGFGAEIGIATDKLHARGPVGAEQLTT
FKYVVRGTGQTRP

Sequences:

>Translated_413_residues
MAGMGRTAREGARALRLATPEQRTAAIQAMAVAIREDADAILTANAKDLARAEANGVSGPMLDRLALDAARLEGVAAGVE
AVAAVPDPVGVATSRWTRPNGLDIARVRTPIGVIAMIYESRPNVTADAAALCVRSGNAVILRGGSECIHSNLAIHAAIAR
GLQKAGLPTAAVQAVKTPDRAAVGMILAGLDRTIDLIIPRGGKSLVARVQAEARAPVLGHLEGLNHVFVHAAADLKKAVE
VVVNAKLRRVSVCGSAETLLIDQAAADKLLPPIADALIKAGCELRGDAAARAIEPTMKKATVEDWTTEYLAPILSVAVVD
GVAGAARHIASYGSGHTDAIITEDAAAAEAFIAEVDSAIVLVNASTQFADGGEFGFGAEIGIATDKLHARGPVGAEQLTT
FKYVVRGTGQTRP
>Mature_412_residues
AGMGRTAREGARALRLATPEQRTAAIQAMAVAIREDADAILTANAKDLARAEANGVSGPMLDRLALDAARLEGVAAGVEA
VAAVPDPVGVATSRWTRPNGLDIARVRTPIGVIAMIYESRPNVTADAAALCVRSGNAVILRGGSECIHSNLAIHAAIARG
LQKAGLPTAAVQAVKTPDRAAVGMILAGLDRTIDLIIPRGGKSLVARVQAEARAPVLGHLEGLNHVFVHAAADLKKAVEV
VVNAKLRRVSVCGSAETLLIDQAAADKLLPPIADALIKAGCELRGDAAARAIEPTMKKATVEDWTTEYLAPILSVAVVDG
VAGAARHIASYGSGHTDAIITEDAAAAEAFIAEVDSAIVLVNASTQFADGGEFGFGAEIGIATDKLHARGPVGAEQLTTF
KYVVRGTGQTRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=411, Percent_Identity=40.8759124087591, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI62912457, Length=411, Percent_Identity=40.8759124087591, Blast_Score=274, Evalue=1e-73,
Organism=Escherichia coli, GI1786438, Length=405, Percent_Identity=42.7160493827161, Blast_Score=318, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI17569969, Length=412, Percent_Identity=37.8640776699029, Blast_Score=244, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI17569967, Length=412, Percent_Identity=37.8640776699029, Blast_Score=243, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6324899, Length=428, Percent_Identity=35.0467289719626, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI21357643, Length=408, Percent_Identity=38.4803921568627, Blast_Score=255, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_CAUCR (Q9A2X6)

Other databases:

- EMBL:   AE005673
- PIR:   D87674
- RefSeq:   NP_422224.1
- ProteinModelPortal:   Q9A2X6
- SMR:   Q9A2X6
- GeneID:   940829
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_3430
- NMPDR:   fig|190650.1.peg.3404
- TIGR:   CC_3430
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 42493; Mature: 42362

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGMGRTAREGARALRLATPEQRTAAIQAMAVAIREDADAILTANAKDLARAEANGVSGP
CCCCCCCHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCCH
MLDRLALDAARLEGVAAGVEAVAAVPDPVGVATSRWTRPNGLDIARVRTPIGVIAMIYES
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHCCHHEEEEEEEC
RPNVTADAAALCVRSGNAVILRGGSECIHSNLAIHAAIARGLQKAGLPTAAVQAVKTPDR
CCCCCHHHHHHEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCH
AAVGMILAGLDRTIDLIIPRGGKSLVARVQAEARAPVLGHLEGLNHVFVHAAADLKKAVE
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHCCCCEEEEHHHHHHHHHH
VVVNAKLRRVSVCGSAETLLIDQAAADKLLPPIADALIKAGCELRGDAAARAIEPTMKKA
HHHHCHHHEEEECCCCCEEEEEHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
TVEDWTTEYLAPILSVAVVDGVAGAARHIASYGSGHTDAIITEDAAAAEAFIAEVDSAIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCEEE
LVNASTQFADGGEFGFGAEIGIATDKLHARGPVGAEQLTTFKYVVRGTGQTRP
EEECCCCCCCCCCCCCCCEECEEECCCCCCCCCCHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure 
AGMGRTAREGARALRLATPEQRTAAIQAMAVAIREDADAILTANAKDLARAEANGVSGP
CCCCCCHHHHHHEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCCH
MLDRLALDAARLEGVAAGVEAVAAVPDPVGVATSRWTRPNGLDIARVRTPIGVIAMIYES
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHHHHCCHHEEEEEEEC
RPNVTADAAALCVRSGNAVILRGGSECIHSNLAIHAAIARGLQKAGLPTAAVQAVKTPDR
CCCCCHHHHHHEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCH
AAVGMILAGLDRTIDLIIPRGGKSLVARVQAEARAPVLGHLEGLNHVFVHAAADLKKAVE
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHCCCCEEEEHHHHHHHHHH
VVVNAKLRRVSVCGSAETLLIDQAAADKLLPPIADALIKAGCELRGDAAARAIEPTMKKA
HHHHCHHHEEEECCCCCEEEEEHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
TVEDWTTEYLAPILSVAVVDGVAGAARHIASYGSGHTDAIITEDAAAAEAFIAEVDSAIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHCCCEEE
LVNASTQFADGGEFGFGAEIGIATDKLHARGPVGAEQLTTFKYVVRGTGQTRP
EEECCCCCCCCCCCCCCCEECEEECCCCCCCCCCHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647