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The map label for this gene is atoC [H]

Identifier: 16127545

GI number: 16127545

Start: 3564265

End: 3565731

Strand: Direct

Name: atoC [H]

Synonym: CC_3315

Alternate gene names: 16127545

Gene position: 3564265-3565731 (Clockwise)

Preceding gene: 16127541

Following gene: 16127546

Centisome position: 88.73

GC content: 67.08

Gene sequence:

>1467_bases
ATGACCAAAACGGTCCTTGTCGTCGATGACGACCCGACACAACGTCGGTTGATTCAAGCGGTGCTCGAGCGCGACGGGTT
CGCGGTCTCGCACGCGGAAGGCGGCGACGCGGCGATCGCGCACCTGACGTCCGGCGCGCCCGCCGATGTCATCCTGCTGG
ATCTCGTCATGCCTGGCCTCAACGGTCAGGACGCCCTGAAGGAAATGCGCGCCCGCGGCTTCAACCAGCCCGTGATCGTG
CTGACGGCCAGCGGTGGCGTCGACACCGTGGTCAAGGCCATGCAGGCCGGCGCCTGCGACTTCTTCATCAAGCCCGCCTC
GCCCGAGCGGATCACCGTGTCGATCCGCAACGCCCTGTCGATGGGCGACCTCAAGGGCGAGGTCGAGCGGCTGACCAAGC
GCGCGGGCGGCAAGACCACCTTCGCGGACCTGATCGGCGCCTCGCCGGTCATGACCATGGTCAAGCGCATGGGCGAGCGG
GCCGCCAAGAGCGGTATCCCGGTGCTGATCACCGGCGAAAGCGGCGTCGGCAAGGAGCTGATCGCCCGCGCCGTCCACGG
CTCTTCCGACCGCGCCGGCAAGCCGTTTGTCGCGGTCAACTGCGGCGCGATCCCCGAGAACCTCGTCGAGTCGATCCTGT
TCGGCCACGAGAAGGGCTCGTTCACCGGCGCCACCGACAAGCATCTGGGCAAGTTCAAGGAGGCCGACGGCGGCACCCTG
TTCCTCGATGAGGTCGGCGAGCTGCCGCTCGACATGCAGGTCAAGCTGCTGCGCGCCCTGCAGGAGGGCGAGATCGACCC
GATCGGCTCCAAGCGCTCGATCAAGGTCGATGTCCGGATCGTGTCGGCGACCAATCGCGATCTGCAGCAGGCCGTTTCGG
GCGGCCGGTTCCGCGAAGACCTGTTTTATCGCCTGAACGTGTTCCCGATCGAGGCGCCGTCCCTGCGCGAGCGTCGCGAG
GACATCCCGGCCCTCGTCGAGGCGTTCATCCGCCGGTTCAACGTCGAAGAAGGCAAGCGCGTGATCGGCGCCTCGCCCGA
GACGATGCAACTGCTGACCAGCTTCGACTGGCCCGGCAATGTGCGCCAACTGGAAAACACCGTCTATCGCGCCATCGTGC
TGGCCGATGCGCCCTATCTGCAGCCGTTCGACTTCCCGGCGATCTCGGGCCTGGCCGCGCCGATCGAGGCCGTATCGATC
TCGCCCTCGCCGCCGCCTGCAGCCCTGTTGCAAGCCACGCATGCGGCGATGGCCGCCGCCGTCGCAGAGGCGCCTGTGCG
CATCCTCGACGATCGCGGTCACCTGCGGACCCTGGAGGAGATCGAGCGCGACCTCATCCAGCATGCGATCGACGTCTATG
CCGGCCACATGAGCGAGGTCGCGCGGCGTTTGGGCATCGGTCGCTCGACCCTCTATCGCAAGGTTCGCGAGCAGGGCATC
GAAGTCGACATGAAGGAAGCGGGCTGA

Upstream 100 bases:

>100_bases
GACACCTCTCCGAAAGCCGGTGTTTACCCGCGACCTGTATCACTCTGAACCAACAAGAGCCCTGCTCCACGTGGGCATGG
CCGGTTCTGGTGGATGTCCA

Downstream 100 bases:

>100_bases
TGAGCCCGCTGATCCTCCGCCCCCTGTCGCGCGAGCAGCGCCTGAAGGCCCTGCTCAAGCCTGCGCGCGCCGCCGCGAAA
CCCGTTCTTCGCAGAAGCTA

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTKTVLVVDDDPTQRRLIQAVLERDGFAVSHAEGGDAAIAHLTSGAPADVILLDLVMPGLNGQDALKEMRARGFNQPVIV
LTASGGVDTVVKAMQAGACDFFIKPASPERITVSIRNALSMGDLKGEVERLTKRAGGKTTFADLIGASPVMTMVKRMGER
AAKSGIPVLITGESGVGKELIARAVHGSSDRAGKPFVAVNCGAIPENLVESILFGHEKGSFTGATDKHLGKFKEADGGTL
FLDEVGELPLDMQVKLLRALQEGEIDPIGSKRSIKVDVRIVSATNRDLQQAVSGGRFREDLFYRLNVFPIEAPSLRERRE
DIPALVEAFIRRFNVEEGKRVIGASPETMQLLTSFDWPGNVRQLENTVYRAIVLADAPYLQPFDFPAISGLAAPIEAVSI
SPSPPPAALLQATHAAMAAAVAEAPVRILDDRGHLRTLEEIERDLIQHAIDVYAGHMSEVARRLGIGRSTLYRKVREQGI
EVDMKEAG

Sequences:

>Translated_488_residues
MTKTVLVVDDDPTQRRLIQAVLERDGFAVSHAEGGDAAIAHLTSGAPADVILLDLVMPGLNGQDALKEMRARGFNQPVIV
LTASGGVDTVVKAMQAGACDFFIKPASPERITVSIRNALSMGDLKGEVERLTKRAGGKTTFADLIGASPVMTMVKRMGER
AAKSGIPVLITGESGVGKELIARAVHGSSDRAGKPFVAVNCGAIPENLVESILFGHEKGSFTGATDKHLGKFKEADGGTL
FLDEVGELPLDMQVKLLRALQEGEIDPIGSKRSIKVDVRIVSATNRDLQQAVSGGRFREDLFYRLNVFPIEAPSLRERRE
DIPALVEAFIRRFNVEEGKRVIGASPETMQLLTSFDWPGNVRQLENTVYRAIVLADAPYLQPFDFPAISGLAAPIEAVSI
SPSPPPAALLQATHAAMAAAVAEAPVRILDDRGHLRTLEEIERDLIQHAIDVYAGHMSEVARRLGIGRSTLYRKVREQGI
EVDMKEAG
>Mature_487_residues
TKTVLVVDDDPTQRRLIQAVLERDGFAVSHAEGGDAAIAHLTSGAPADVILLDLVMPGLNGQDALKEMRARGFNQPVIVL
TASGGVDTVVKAMQAGACDFFIKPASPERITVSIRNALSMGDLKGEVERLTKRAGGKTTFADLIGASPVMTMVKRMGERA
AKSGIPVLITGESGVGKELIARAVHGSSDRAGKPFVAVNCGAIPENLVESILFGHEKGSFTGATDKHLGKFKEADGGTLF
LDEVGELPLDMQVKLLRALQEGEIDPIGSKRSIKVDVRIVSATNRDLQQAVSGGRFREDLFYRLNVFPIEAPSLRERRED
IPALVEAFIRRFNVEEGKRVIGASPETMQLLTSFDWPGNVRQLENTVYRAIVLADAPYLQPFDFPAISGLAAPIEAVSIS
PSPPPAALLQATHAAMAAAVAEAPVRILDDRGHLRTLEEIERDLIQHAIDVYAGHMSEVARRLGIGRSTLYRKVREQGIE
VDMKEAG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=477, Percent_Identity=40.461215932914, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1790437, Length=472, Percent_Identity=40.8898305084746, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI1790299, Length=481, Percent_Identity=42.4116424116424, Blast_Score=335, Evalue=4e-93,
Organism=Escherichia coli, GI1788905, Length=376, Percent_Identity=40.4255319148936, Blast_Score=281, Evalue=6e-77,
Organism=Escherichia coli, GI87082117, Length=275, Percent_Identity=50.1818181818182, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1789087, Length=381, Percent_Identity=40.6824146981627, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1789233, Length=335, Percent_Identity=43.2835820895522, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87082152, Length=265, Percent_Identity=47.5471698113208, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1787583, Length=342, Percent_Identity=36.5497076023392, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786524, Length=399, Percent_Identity=35.3383458646617, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI87081872, Length=207, Percent_Identity=45.8937198067633, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87081858, Length=344, Percent_Identity=31.3953488372093, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789828, Length=238, Percent_Identity=37.3949579831933, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1786599, Length=121, Percent_Identity=33.8842975206612, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788521, Length=113, Percent_Identity=38.9380530973451, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789402, Length=101, Percent_Identity=35.6435643564356, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786784, Length=118, Percent_Identity=29.6610169491525, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52589; Mature: 52458

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTVLVVDDDPTQRRLIQAVLERDGFAVSHAEGGDAAIAHLTSGAPADVILLDLVMPGL
CCCEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCC
NGQDALKEMRARGFNQPVIVLTASGGVDTVVKAMQAGACDFFIKPASPERITVSIRNALS
CCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEHHHHH
MGDLKGEVERLTKRAGGKTTFADLIGASPVMTMVKRMGERAAKSGIPVLITGESGVGKEL
HHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH
IARAVHGSSDRAGKPFVAVNCGAIPENLVESILFGHEKGSFTGATDKHLGKFKEADGGTL
HHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEE
FLDEVGELPLDMQVKLLRALQEGEIDPIGSKRSIKVDVRIVSATNRDLQQAVSGGRFRED
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCHHHHHHHCCCCHHHH
LFYRLNVFPIEAPSLRERREDIPALVEAFIRRFNVEEGKRVIGASPETMQLLTSFDWPGN
HEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHCCEEECCCCHHHHHHHHCCCCCC
VRQLENTVYRAIVLADAPYLQPFDFPAISGLAAPIEAVSISPSPPPAALLQATHAAMAAA
HHHHHHHHHHHHEEECCCCCCCCCCCHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
VAEAPVRILDDRGHLRTLEEIERDLIQHAIDVYAGHMSEVARRLGIGRSTLYRKVREQGI
HHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
EVDMKEAG
EEEHHCCC
>Mature Secondary Structure 
TKTVLVVDDDPTQRRLIQAVLERDGFAVSHAEGGDAAIAHLTSGAPADVILLDLVMPGL
CCEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHCCCC
NGQDALKEMRARGFNQPVIVLTASGGVDTVVKAMQAGACDFFIKPASPERITVSIRNALS
CCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEECCCCCEEEEEEHHHHH
MGDLKGEVERLTKRAGGKTTFADLIGASPVMTMVKRMGERAAKSGIPVLITGESGVGKEL
HHHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHH
IARAVHGSSDRAGKPFVAVNCGAIPENLVESILFGHEKGSFTGATDKHLGKFKEADGGTL
HHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEE
FLDEVGELPLDMQVKLLRALQEGEIDPIGSKRSIKVDVRIVSATNRDLQQAVSGGRFRED
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCHHHHHHHCCCCHHHH
LFYRLNVFPIEAPSLRERREDIPALVEAFIRRFNVEEGKRVIGASPETMQLLTSFDWPGN
HEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHCCEEECCCCHHHHHHHHCCCCCC
VRQLENTVYRAIVLADAPYLQPFDFPAISGLAAPIEAVSISPSPPPAALLQATHAAMAAA
HHHHHHHHHHHHEEECCCCCCCCCCCHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHH
VAEAPVRILDDRGHLRTLEEIERDLIQHAIDVYAGHMSEVARRLGIGRSTLYRKVREQGI
HHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
EVDMKEAG
EEEHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]