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The map label for this gene is ilvR

Identifier: 16127275

GI number: 16127275

Start: 3264436

End: 3265326

Strand: Direct

Name: ilvR

Synonym: CC_3045

Alternate gene names: 16127275

Gene position: 3264436-3265326 (Clockwise)

Preceding gene: 16127273

Following gene: 16127276

Centisome position: 81.27

GC content: 71.38

Gene sequence:

>891_bases
ATGGACATCCGCCAGTTCCGCCATTTCGCCGCCGTGGCCGAGACCCTGCACTTCGGGCGGGCGGCCGAGCGCCTGGGCAT
CACCCAGCCGCCGCTCAGCCAGTCGATCCAGGCGCTGGAAAAGGCGCTGGGCGCGCCGCTGTTCGCCCGCACCAAGCGGC
ACGTGGAGCTGACCGCGCTGGGCCGGCAGTGGCTGCCGCATGTGCTCGAGGCGCTGGCGGCGGTCGACGCCCTGCCCGAC
ACCGCAAGGCGGCTGCGCGACGGCCAGACCGGCTATCTGTCGCTGTCGTTCGTCAGCACCGCCGACTACAGCGTCCTGCC
CGACCTCGTCCGACGCTACGCGGAGGCGTTTCCGGGTGTCGAGATCCAGCTGGTCGAGGCCACCAGCGACGTCCAGGTGC
CGGCCATTCAGGCGGGCGAGCGGCATGCGGGCATCATCATCCCGCCGCCGAACCGGTCCCTGCCCGCAGCCCTGGCCTAT
CGGCGACTTGTGTCCGAGCCCCTGGTGGCCGTCACGCCCGAGGCGTGGGGCGCCGAAGGGCCGCTGGATCTGGCCGCCCT
GGCGGACGTTCCGCTGGTGCTGTTTCCCCGAACCGTGGCGCCGGCGTTCCACGACCTTGTCACCGGCTATGTGGCCGCGC
GCGGACAGCCCGTCCGGATCGTCCAGGAAGCGATCCAGATGCAGACGATCATCAGCCTGGTCTCGGCGGGCCTCGGCATG
GCGCTGGCGCCCGCCTCGCTGCGGAAACTGGCTCGCGTAGGGGTTCGCTATGTCGACCTCGTCGATCCCCCGATCCTGGA
GACGGGCCTTGTCTGGCGACGCGACGAGGCGGCCCCGACGTTGCAGGGTCTGCTGCGCCTCGTGACCGAGGACGGGTCCG
CCCCGGATTGA

Upstream 100 bases:

>100_bases
ATGGGGTCAATCCAATGTCGGTCGTAAGGTCTTTTACGCGAGGTCGGATCGATCAAAAAATATATTAATTGGCGGTGATT
AAGTCGCTAGACCTATAACA

Downstream 100 bases:

>100_bases
CGCCGGCCAAGGCGCGTGGCTGGCTCGGAAAAACCTCTTAGGGAGCTTCCATGGCCAACCTGATCCTCAGCGTCGTCGGC
AGCGACCGGCCCGGCCTCAC

Product: isoleucine biosynthesis transcriptional activator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MDIRQFRHFAAVAETLHFGRAAERLGITQPPLSQSIQALEKALGAPLFARTKRHVELTALGRQWLPHVLEALAAVDALPD
TARRLRDGQTGYLSLSFVSTADYSVLPDLVRRYAEAFPGVEIQLVEATSDVQVPAIQAGERHAGIIIPPPNRSLPAALAY
RRLVSEPLVAVTPEAWGAEGPLDLAALADVPLVLFPRTVAPAFHDLVTGYVAARGQPVRIVQEAIQMQTIISLVSAGLGM
ALAPASLRKLARVGVRYVDLVDPPILETGLVWRRDEAAPTLQGLLRLVTEDGSAPD

Sequences:

>Translated_296_residues
MDIRQFRHFAAVAETLHFGRAAERLGITQPPLSQSIQALEKALGAPLFARTKRHVELTALGRQWLPHVLEALAAVDALPD
TARRLRDGQTGYLSLSFVSTADYSVLPDLVRRYAEAFPGVEIQLVEATSDVQVPAIQAGERHAGIIIPPPNRSLPAALAY
RRLVSEPLVAVTPEAWGAEGPLDLAALADVPLVLFPRTVAPAFHDLVTGYVAARGQPVRIVQEAIQMQTIISLVSAGLGM
ALAPASLRKLARVGVRYVDLVDPPILETGLVWRRDEAAPTLQGLLRLVTEDGSAPD
>Mature_296_residues
MDIRQFRHFAAVAETLHFGRAAERLGITQPPLSQSIQALEKALGAPLFARTKRHVELTALGRQWLPHVLEALAAVDALPD
TARRLRDGQTGYLSLSFVSTADYSVLPDLVRRYAEAFPGVEIQLVEATSDVQVPAIQAGERHAGIIIPPPNRSLPAALAY
RRLVSEPLVAVTPEAWGAEGPLDLAALADVPLVLFPRTVAPAFHDLVTGYVAARGQPVRIVQEAIQMQTIISLVSAGLGM
ALAPASLRKLARVGVRYVDLVDPPILETGLVWRRDEAAPTLQGLLRLVTEDGSAPD

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787879, Length=284, Percent_Identity=38.0281690140845, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1788887, Length=295, Percent_Identity=30.1694915254237, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI2367136, Length=295, Percent_Identity=28.135593220339, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI145693105, Length=284, Percent_Identity=24.6478873239437, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1790399, Length=280, Percent_Identity=28.2142857142857, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790208, Length=173, Percent_Identity=32.3699421965318, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI157672245, Length=281, Percent_Identity=28.4697508896797, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788748, Length=246, Percent_Identity=26.8292682926829, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87081904, Length=205, Percent_Identity=27.3170731707317, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082132, Length=245, Percent_Identity=25.7142857142857, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=141, Percent_Identity=29.7872340425532, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787806, Length=296, Percent_Identity=24.3243243243243, Blast_Score=61, Evalue=9e-11,
Organism=Escherichia coli, GI1787530, Length=268, Percent_Identity=25.7462686567164, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): ILVR_CAUCR (P52670)

Other databases:

- EMBL:   L24392
- EMBL:   AE005673
- PIR:   A53372
- RefSeq:   NP_421839.1
- ProteinModelPortal:   P52670
- SMR:   P52670
- GeneID:   943886
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_3045
- NMPDR:   fig|190650.1.peg.3019
- TIGR:   CC_3045
- HOGENOM:   HBG685425
- OMA:   ARTGVRY
- ProtClustDB:   CLSK807409
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00039

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate

EC number: NA

Molecular weight: Translated: 31903; Mature: 31903

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRQFRHFAAVAETLHFGRAAERLGITQPPLSQSIQALEKALGAPLFARTKRHVELTAL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHH
GRQWLPHVLEALAAVDALPDTARRLRDGQTGYLSLSFVSTADYSVLPDLVRRYAEAFPGV
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
EIQLVEATSDVQVPAIQAGERHAGIIIPPPNRSLPAALAYRRLVSEPLVAVTPEAWGAEG
EEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCC
PLDLAALADVPLVLFPRTVAPAFHDLVTGYVAARGQPVRIVQEAIQMQTIISLVSAGLGM
CCCHHHHHCCCCEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCH
ALAPASLRKLARVGVRYVDLVDPPILETGLVWRRDEAAPTLQGLLRLVTEDGSAPD
HCCHHHHHHHHHHCCHHHHHCCCCHHHHCCEEECCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDIRQFRHFAAVAETLHFGRAAERLGITQPPLSQSIQALEKALGAPLFARTKRHVELTAL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHH
GRQWLPHVLEALAAVDALPDTARRLRDGQTGYLSLSFVSTADYSVLPDLVRRYAEAFPGV
HHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCC
EIQLVEATSDVQVPAIQAGERHAGIIIPPPNRSLPAALAYRRLVSEPLVAVTPEAWGAEG
EEEEEECCCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCC
PLDLAALADVPLVLFPRTVAPAFHDLVTGYVAARGQPVRIVQEAIQMQTIISLVSAGLGM
CCCHHHHHCCCCEEECHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCH
ALAPASLRKLARVGVRYVDLVDPPILETGLVWRRDEAAPTLQGLLRLVTEDGSAPD
HCCHHHHHHHHHHCCHHHHHCCCCHHHHCCEEECCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647