Click here to switch to the map view.

The map label for this gene is cobS [H]

Identifier: 16127251

GI number: 16127251

Start: 3238802

End: 3239812

Strand: Direct

Name: cobS [H]

Synonym: CC_3021

Alternate gene names: 16127251

Gene position: 3238802-3239812 (Clockwise)

Preceding gene: 16127250

Following gene: 16127252

Centisome position: 80.63

GC content: 64.99

Gene sequence:

>1011_bases
ATGCCCGAGTTCGCCGAAACCAGCTCCGCCGCCGATCCGCTGATCACCCTGGTCCCCGATAGGTGGGTGACGCTGCGCGA
TGCGTTCGGCGTCGACAGCGACATGAAGGTTCCGGCCTTCAGCCACCGCGACAGCCATGTGCCGGATATCGACCCGGCCT
ATCGCTTCGACCCGCAGACGACCAAGGCCATCTGCGCGGGCTTTGCCTATGATCGCCGCGTGATGGTCCAGGGCTATCAC
GGCACGGGCAAGTCGACCCACATCGAGCAGATCGCCGCGCGCCTGAACTGGCCGCTGGTTCGCGTGAACCTCGACAGCCA
TGTCAGCCGGATCGACCTCGTCGGCAAGGACGCCATCGTCCTGAAGGACGGCAAGCAGATCACCGAGTTCCGCGAAGGCA
TCCTGCCCTGGACCCTGCAGCGCCCTGTCGCCCTGGTGTTCGACGAATATGACGCGGGGCGCCCCGACGTGATGTTCGTG
ATCCAGCGCGTGCTGGAAGCCGGCGGCAAGCTGACCCTGCTCGATCAGAACCGCGTCATCCGCGCCAATCCGTACTTCCG
CCTGTTCGCCACGACCAACACCATCGGTCTGGGCGACACCACGGGCCTCTATCACGGCACCCAGCAGATCAACCAAGGCC
AGATGGACCGCTGGTCGATCGTCACGACGCTGAACTATCTCGAGCACGACGTCGAAGCCGCCATCGTGCTGGCCAAGAAC
CCCGGCTTTGACAGCGTCGAGGGCAAGCGCACGATCTCGGCCATGGTCCGCGTCGCCGACATGACCCGCAACGCCTTCAT
GAACGGCGACATCTCGACGGTCATGAGCCCGCGCACGGTGATCACCTGGGCCCAGAACGCCGAGATCTTCGATCACGACG
TGGCGCTGGCCTTCCGCCTGACCTTCCTGAACAAGTGCGACGAGCTGGAACGCCCGACGGTGGCCGAGTTCTTCCAGCGC
GCGTTCGGCACGGATCTTCCGGAGAGCGCCGCGCGGGTGAAGGTGGCTTAG

Upstream 100 bases:

>100_bases
CCGCGGGGAAGCCCGCCCTCGCCAGGAAAGTGAACGCCAACCCCCGCTTTGAGCGGATTTCCATTTGAAACGGGCGGGTC
CAAGGCGGTAAGCCGGAAGC

Downstream 100 bases:

>100_bases
GGGTCACTTTCGCCGCCGAGCTGACGATTTGAAACACCCGCCTCGCAGGAGGCGGGTGTTTTCTTTGGGCGGCGGGACTG
GGGGTTTGGCGGCGTGAAGC

Product: cobalamin biosynthesis protein

Products: NA

Alternate protein names: Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MPEFAETSSAADPLITLVPDRWVTLRDAFGVDSDMKVPAFSHRDSHVPDIDPAYRFDPQTTKAICAGFAYDRRVMVQGYH
GTGKSTHIEQIAARLNWPLVRVNLDSHVSRIDLVGKDAIVLKDGKQITEFREGILPWTLQRPVALVFDEYDAGRPDVMFV
IQRVLEAGGKLTLLDQNRVIRANPYFRLFATTNTIGLGDTTGLYHGTQQINQGQMDRWSIVTTLNYLEHDVEAAIVLAKN
PGFDSVEGKRTISAMVRVADMTRNAFMNGDISTVMSPRTVITWAQNAEIFDHDVALAFRLTFLNKCDELERPTVAEFFQR
AFGTDLPESAARVKVA

Sequences:

>Translated_336_residues
MPEFAETSSAADPLITLVPDRWVTLRDAFGVDSDMKVPAFSHRDSHVPDIDPAYRFDPQTTKAICAGFAYDRRVMVQGYH
GTGKSTHIEQIAARLNWPLVRVNLDSHVSRIDLVGKDAIVLKDGKQITEFREGILPWTLQRPVALVFDEYDAGRPDVMFV
IQRVLEAGGKLTLLDQNRVIRANPYFRLFATTNTIGLGDTTGLYHGTQQINQGQMDRWSIVTTLNYLEHDVEAAIVLAKN
PGFDSVEGKRTISAMVRVADMTRNAFMNGDISTVMSPRTVITWAQNAEIFDHDVALAFRLTFLNKCDELERPTVAEFFQR
AFGTDLPESAARVKVA
>Mature_335_residues
PEFAETSSAADPLITLVPDRWVTLRDAFGVDSDMKVPAFSHRDSHVPDIDPAYRFDPQTTKAICAGFAYDRRVMVQGYHG
TGKSTHIEQIAARLNWPLVRVNLDSHVSRIDLVGKDAIVLKDGKQITEFREGILPWTLQRPVALVFDEYDAGRPDVMFVI
QRVLEAGGKLTLLDQNRVIRANPYFRLFATTNTIGLGDTTGLYHGTQQINQGQMDRWSIVTTLNYLEHDVEAAIVLAKNP
GFDSVEGKRTISAMVRVADMTRNAFMNGDISTVMSPRTVITWAQNAEIFDHDVALAFRLTFLNKCDELERPTVAEFFQRA
FGTDLPESAARVKVA

Specific function: Catalyzes cobalt insertion in the corrin ring [H]

COG id: COG0714

COG function: function code R; MoxR-like ATPases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011704
- InterPro:   IPR006537 [H]

Pfam domain/function: PF07728 AAA_5 [H]

EC number: =6.6.1.2 [H]

Molecular weight: Translated: 37617; Mature: 37486

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEFAETSSAADPLITLVPDRWVTLRDAFGVDSDMKVPAFSHRDSHVPDIDPAYRFDPQT
CCCCCCCCCCCCCEEEECCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
TKAICAGFAYDRRVMVQGYHGTGKSTHIEQIAARLNWPLVRVNLDSHVSRIDLVGKDAIV
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEHHHCCCEEEECCCCEEE
LKDGKQITEFREGILPWTLQRPVALVFDEYDAGRPDVMFVIQRVLEAGGKLTLLDQNRVI
EECCCHHHHHHHCCCCEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCEE
RANPYFRLFATTNTIGLGDTTGLYHGTQQINQGQMDRWSIVTTLNYLEHDVEAAIVLAKN
EECCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEEECC
PGFDSVEGKRTISAMVRVADMTRNAFMNGDISTVMSPRTVITWAQNAEIFDHDVALAFRL
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCEECCHHHHHHHHH
TFLNKCDELERPTVAEFFQRAFGTDLPESAARVKVA
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEECC
>Mature Secondary Structure 
PEFAETSSAADPLITLVPDRWVTLRDAFGVDSDMKVPAFSHRDSHVPDIDPAYRFDPQT
CCCCCCCCCCCCEEEECCCCEEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
TKAICAGFAYDRRVMVQGYHGTGKSTHIEQIAARLNWPLVRVNLDSHVSRIDLVGKDAIV
HHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEHHHCCCEEEECCCCEEE
LKDGKQITEFREGILPWTLQRPVALVFDEYDAGRPDVMFVIQRVLEAGGKLTLLDQNRVI
EECCCHHHHHHHCCCCEECCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCEE
RANPYFRLFATTNTIGLGDTTGLYHGTQQINQGQMDRWSIVTTLNYLEHDVEAAIVLAKN
EECCCEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCEEEEEEECC
PGFDSVEGKRTISAMVRVADMTRNAFMNGDISTVMSPRTVITWAQNAEIFDHDVALAFRL
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEECCCEECCHHHHHHHHH
TFLNKCDELERPTVAEFFQRAFGTDLPESAARVKVA
HHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1917840 [H]