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The map label for this gene is ethA [H]

Identifier: 16126807

GI number: 16126807

Start: 2779626

End: 2781122

Strand: Direct

Name: ethA [H]

Synonym: CC_2569

Alternate gene names: 16126807

Gene position: 2779626-2781122 (Clockwise)

Preceding gene: 16126803

Following gene: 16126808

Centisome position: 69.2

GC content: 65.6

Gene sequence:

>1497_bases
ATGGCGATGGAACATGTCGACGTACTGATCGTGGGCGCGGGGCTTTCAGGGATCGGCGCGGCCTATCACCTGCAAAAGCA
CTGCCCGGGCAAGACCTACGCGATCCTCGAAGGGCGCGAGGCGATCGGCGGCACCTGGGACCTGTTCCGCTATCCCGGCA
TCCGGTCGGACAGCGACATGTATACCCTGGGCTACAGCTTCAAGCCGTGGAAGGCGGCCAAGGCCATCGCCGACGGTCCC
TCGATCCTGGACTATGTCCGCGAGACCGCCCGCGAGCACGACATCGACCGCCACATCCGCTTCCAGCATCTGGTCAAGCG
CGCCAGTTGGTCCAGCGAGACGGCGACCTGGACCGTCGAGGCCGAGCACGACGGCAAACCGGTCACCCTCACCTGCCGCT
TCCTGCATATGTGCTCGGGCTACTATCGGTACTCGGCCGGCTACACGCCGGACTTCGCCGGGACCGAGCGCTTCAAGGGC
CGGATCGTCCATCCCCAGCACTGGCCCGAAGACCTCGACTACAGCGGCAAGAAGGTCGTGGTGATAGGCAGCGGCGCCAC
CGCCGTGACCCTGGTGCCCGAGATGGCCAAGACCGCCGCCCACGTCACCATGCTGCAGCGCTCGCCGACCTATGTGGTGT
CACGTCCGGCCGAGGACGGGATCGCCAACTGGCTGCGCTCGAAGCTTCCGGCCATGACCGCCTATGGTATCACGCGGTGG
AAGAACGTGCTGTTCCAGCTGTTCTTCTTCAACCTGGCGCGCAAGAAGCCCGAGAAGGTCAAGGAACGCCTGCTGGGCAT
GGTGCGCGATCATCTGGGGCCCGGCTACGACGTCGAGACCCACTTCACGCCGCGCTACAATCCCTGGGACCAGCGCCTGT
GCCTGGTGCCCGACGCCGACCTGTTCGACGCCATCAAGAGCGGCGCGGCCTCGGTGGTGACCGACCACATCGAGACCTTC
ACCGAGACCGGCATCCAGCTGAAGTCCGGCAAGACCCTGGACGCGGACGTCATCGTCACCGCCACGGGCCTGCAGCTCCA
ATTGCTCAGCGGCATGGAGGTCGTGGTCGACGGCAAGGTCGCCGACCTGTCGCAGTCGATGAGCTACAAGGGCATGATGT
TCAGCGACGTGCCGAACCTGGCCTCGGTGTTCGGCTACACCAACGCCAGTTGGACGCTGAAGGCCGACCTGACCAGCGAA
TATGTCTGCCGCCTGCTCAACCACATGGACCGCACCGGCGCCGACTACTGCGTGCCGCGCCTCGACGGCGAGGTCGAGGC
CGCGCCGTGGCTGGACTTCTCGTCGGGCTACATCACCCGCTCGATCGGCCACTTCCCCAAGCAGGGGACGCGCAAGCCCT
GGAAGGTGCACCAGAACTATGCGCTGGACCTGATGACCCTGCGCATGGGCAAGGTCGAGGACGGCGTCATGCAGTTTGGC
CGCAAGACCGGCGCGACGGCGAAGGCCAAGCCTGAGAAGGCCTTGGAACCGGCCTGA

Upstream 100 bases:

>100_bases
GGTGAACAGCGTTCACATAAGCCGCGTCGGGTCAACCGTCGGGCGCACGCGTTGGGATCACGGAGGCGCGCCGCGCTTCC
TTCAAGGGGGCGGGACACGG

Downstream 100 bases:

>100_bases
TCTGAAACGCAAGGGGCGAAGGCATGGCTTTCGCCCCTCCGCCGGGATCGGATTGAGAGGCGAAAAGCCCTGAGATGATC
GGTCCGTCCTCCTATCTCGG

Product: monooxygenase flavin-binding family protein

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MAMEHVDVLIVGAGLSGIGAAYHLQKHCPGKTYAILEGREAIGGTWDLFRYPGIRSDSDMYTLGYSFKPWKAAKAIADGP
SILDYVRETAREHDIDRHIRFQHLVKRASWSSETATWTVEAEHDGKPVTLTCRFLHMCSGYYRYSAGYTPDFAGTERFKG
RIVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPEMAKTAAHVTMLQRSPTYVVSRPAEDGIANWLRSKLPAMTAYGITRW
KNVLFQLFFFNLARKKPEKVKERLLGMVRDHLGPGYDVETHFTPRYNPWDQRLCLVPDADLFDAIKSGAASVVTDHIETF
TETGIQLKSGKTLDADVIVTATGLQLQLLSGMEVVVDGKVADLSQSMSYKGMMFSDVPNLASVFGYTNASWTLKADLTSE
YVCRLLNHMDRTGADYCVPRLDGEVEAAPWLDFSSGYITRSIGHFPKQGTRKPWKVHQNYALDLMTLRMGKVEDGVMQFG
RKTGATAKAKPEKALEPA

Sequences:

>Translated_498_residues
MAMEHVDVLIVGAGLSGIGAAYHLQKHCPGKTYAILEGREAIGGTWDLFRYPGIRSDSDMYTLGYSFKPWKAAKAIADGP
SILDYVRETAREHDIDRHIRFQHLVKRASWSSETATWTVEAEHDGKPVTLTCRFLHMCSGYYRYSAGYTPDFAGTERFKG
RIVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPEMAKTAAHVTMLQRSPTYVVSRPAEDGIANWLRSKLPAMTAYGITRW
KNVLFQLFFFNLARKKPEKVKERLLGMVRDHLGPGYDVETHFTPRYNPWDQRLCLVPDADLFDAIKSGAASVVTDHIETF
TETGIQLKSGKTLDADVIVTATGLQLQLLSGMEVVVDGKVADLSQSMSYKGMMFSDVPNLASVFGYTNASWTLKADLTSE
YVCRLLNHMDRTGADYCVPRLDGEVEAAPWLDFSSGYITRSIGHFPKQGTRKPWKVHQNYALDLMTLRMGKVEDGVMQFG
RKTGATAKAKPEKALEPA
>Mature_497_residues
AMEHVDVLIVGAGLSGIGAAYHLQKHCPGKTYAILEGREAIGGTWDLFRYPGIRSDSDMYTLGYSFKPWKAAKAIADGPS
ILDYVRETAREHDIDRHIRFQHLVKRASWSSETATWTVEAEHDGKPVTLTCRFLHMCSGYYRYSAGYTPDFAGTERFKGR
IVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPEMAKTAAHVTMLQRSPTYVVSRPAEDGIANWLRSKLPAMTAYGITRWK
NVLFQLFFFNLARKKPEKVKERLLGMVRDHLGPGYDVETHFTPRYNPWDQRLCLVPDADLFDAIKSGAASVVTDHIETFT
ETGIQLKSGKTLDADVIVTATGLQLQLLSGMEVVVDGKVADLSQSMSYKGMMFSDVPNLASVFGYTNASWTLKADLTSEY
VCRLLNHMDRTGADYCVPRLDGEVEAAPWLDFSSGYITRSIGHFPKQGTRKPWKVHQNYALDLMTLRMGKVEDGVMQFGR
KTGATAKAKPEKALEPA

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503757, Length=265, Percent_Identity=26.4150943396226, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4503759, Length=359, Percent_Identity=25.3481894150418, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI50541965, Length=226, Percent_Identity=26.1061946902655, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI50541961, Length=226, Percent_Identity=26.1061946902655, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI221316672, Length=375, Percent_Identity=24.5333333333333, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI221316674, Length=374, Percent_Identity=24.331550802139, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555726, Length=380, Percent_Identity=23.9473684210526, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17561948, Length=381, Percent_Identity=23.6220472440945, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193202226, Length=236, Percent_Identity=25.8474576271186, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25145785, Length=354, Percent_Identity=25.1412429378531, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25150462, Length=374, Percent_Identity=24.331550802139, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541300, Length=228, Percent_Identity=25, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 55503; Mature: 55372

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMEHVDVLIVGAGLSGIGAAYHLQKHCPGKTYAILEGREAIGGTWDLFRYPGIRSDSDM
CCCCEEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCHHCCCCCHHHCCCCCCCCCCE
YTLGYSFKPWKAAKAIADGPSILDYVRETAREHDIDRHIRFQHLVKRASWSSETATWTVE
EEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEE
AEHDGKPVTLTCRFLHMCSGYYRYSAGYTPDFAGTERFKGRIVHPQHWPEDLDYSGKKVV
ECCCCCCEEEEEHHHHHHCCCEEECCCCCCCCCCCHHHCCEECCCCCCCCCCCCCCCEEE
VIGSGATAVTLVPEMAKTAAHVTMLQRSPTYVVSRPAEDGIANWLRSKLPAMTAYGITRW
EEECCCCEEEECHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHH
KNVLFQLFFFNLARKKPEKVKERLLGMVRDHLGPGYDVETHFTPRYNPWDQRLCLVPDAD
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCEEEECCCCH
LFDAIKSGAASVVTDHIETFTETGIQLKSGKTLDADVIVTATGLQLQLLSGMEVVVDGKV
HHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCCEEEEECCCEEEECCCH
ADLSQSMSYKGMMFSDVPNLASVFGYTNASWTLKADLTSEYVCRLLNHMDRTGADYCVPR
HHHHHHCCCCCEEHHCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEC
LDGEVEAAPWLDFSSGYITRSIGHFPKQGTRKPWKVHQNYALDLMTLRMGKVEDGVMQFG
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCEECCCCEEEEEEHHCCCCHHHHHHHH
RKTGATAKAKPEKALEPA
HHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AMEHVDVLIVGAGLSGIGAAYHLQKHCPGKTYAILEGREAIGGTWDLFRYPGIRSDSDM
CCCEEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCHHCCCCCHHHCCCCCCCCCCE
YTLGYSFKPWKAAKAIADGPSILDYVRETAREHDIDRHIRFQHLVKRASWSSETATWTVE
EEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEE
AEHDGKPVTLTCRFLHMCSGYYRYSAGYTPDFAGTERFKGRIVHPQHWPEDLDYSGKKVV
ECCCCCCEEEEEHHHHHHCCCEEECCCCCCCCCCCHHHCCEECCCCCCCCCCCCCCCEEE
VIGSGATAVTLVPEMAKTAAHVTMLQRSPTYVVSRPAEDGIANWLRSKLPAMTAYGITRW
EEECCCCEEEECHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCHHHHHHHHHH
KNVLFQLFFFNLARKKPEKVKERLLGMVRDHLGPGYDVETHFTPRYNPWDQRLCLVPDAD
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCEEEECCCCH
LFDAIKSGAASVVTDHIETFTETGIQLKSGKTLDADVIVTATGLQLQLLSGMEVVVDGKV
HHHHHHCCHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCCEEEEECCCEEEECCCH
ADLSQSMSYKGMMFSDVPNLASVFGYTNASWTLKADLTSEYVCRLLNHMDRTGADYCVPR
HHHHHHCCCCCEEHHCCCHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEC
LDGEVEAAPWLDFSSGYITRSIGHFPKQGTRKPWKVHQNYALDLMTLRMGKVEDGVMQFG
CCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCEECCCCEEEEEEHHCCCCHHHHHHHH
RKTGATAKAKPEKALEPA
HHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]