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The map label for this gene is virB11 [H]

Identifier: 16126662

GI number: 16126662

Start: 2628764

End: 2629732

Strand: Direct

Name: virB11 [H]

Synonym: CC_2423

Alternate gene names: 16126662

Gene position: 2628764-2629732 (Clockwise)

Preceding gene: 16126661

Following gene: 16126664

Centisome position: 65.44

GC content: 66.98

Gene sequence:

>969_bases
ATGAGCACGGGGGTCTATCTCGCCGCCTACCTGGCGCCGCTGCAGCCTTGGCTGGACCGCGCTGACGTCACGGACATTTG
GGTCAACCGGCCCGGCGAGGTATGGATCGAGACCACCAAGGGGGTGACCTCACGCCTCGCTGCGCCGGACCTCACCGATC
AGGCGTTGCAGCGTCTGGCCCGCCAGATCGCCGCCGCCAGCCACCAGGGCGTCAGTCGCGAACAGCCGCTGCTCAGCGCC
AGTCTGCCAAACGGCGCCCGCGTACAGATCATTGCGCCGCCAGCCACGCGCGGCGACCTTGCCCTGGCCATCCGCAAACA
CACGCTCAGCGACCTCAGCCTCAGCGACCTCGCCATCGGCGGGACCCTGGCGCCCCCGGCCTTGACCGGTCGGGCCGATG
CGGACGCTCAGTTGCGCGCCTTGCTGAGCGCCGGCGACGTCGAAGGTTTTCTTCGAACCGCCATCCAACGCCGCAAGACG
ATCGTCCTGTCGGGCGGCACGTCCTCGGGCAAAACCACCTTGCTCAACGCTCTGGTCAAGGAGATCCCGGCGCACGAGCG
CCTCGTCCTGATCGAAGACGCCCCCGAAATCCAACTGCGTCACGAGAACGCGATCGGCCTGATCGCCGCGCGCAGCGACA
CGGGTGAGGCCCAGGTCGACGCCGAGGATCTCCTTCAAGCCAGCCTGCGGATGCGCCCTGACCGGATCTTGCTGGGCGAG
TTGCGCGGTCGTGAGGCCTTCGCTTTCCTACGGGCGGTCAATACCGGCCATCCCGGCTCCATCACCACGGTCCATGCCGA
TAGTCCGCAAGGCGCCCTGGATCAGATCGCGCTGCTTTCGCTGCTCGCGGGCGTGGACCTAGGCTGGGACACAGTTCGCA
ACTATGTGCGCCAGGTCGTCGATATCGTGGTGCAACTCAATCGGGTTGGCGGCGGCCGCAAGGTGACGGCGGTGGAGTTT
CTGTGTTGA

Upstream 100 bases:

>100_bases
AGATCGATATCCCCACGACTATCACCGTCGCCCAAGGAGCGCCGATCCGCGTGTTCGTGGCGCGCGATCTTGATTTTTCC
GGCGTGGTTCAAAAGACGCG

Downstream 100 bases:

>100_bases
GCCGAACTTTCGATTAAGTCAGGCCTCACGATAACATGTTGAACAGAAAGCATAAATTCGAGTGACGGGTGGTGACGTGC
CCCCCCCTGAAACTCCTCCA

Product: type IV secretion system protein B11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSTGVYLAAYLAPLQPWLDRADVTDIWVNRPGEVWIETTKGVTSRLAAPDLTDQALQRLARQIAAASHQGVSREQPLLSA
SLPNGARVQIIAPPATRGDLALAIRKHTLSDLSLSDLAIGGTLAPPALTGRADADAQLRALLSAGDVEGFLRTAIQRRKT
IVLSGGTSSGKTTLLNALVKEIPAHERLVLIEDAPEIQLRHENAIGLIAARSDTGEAQVDAEDLLQASLRMRPDRILLGE
LRGREAFAFLRAVNTGHPGSITTVHADSPQGALDQIALLSLLAGVDLGWDTVRNYVRQVVDIVVQLNRVGGGRKVTAVEF
LC

Sequences:

>Translated_322_residues
MSTGVYLAAYLAPLQPWLDRADVTDIWVNRPGEVWIETTKGVTSRLAAPDLTDQALQRLARQIAAASHQGVSREQPLLSA
SLPNGARVQIIAPPATRGDLALAIRKHTLSDLSLSDLAIGGTLAPPALTGRADADAQLRALLSAGDVEGFLRTAIQRRKT
IVLSGGTSSGKTTLLNALVKEIPAHERLVLIEDAPEIQLRHENAIGLIAARSDTGEAQVDAEDLLQASLRMRPDRILLGE
LRGREAFAFLRAVNTGHPGSITTVHADSPQGALDQIALLSLLAGVDLGWDTVRNYVRQVVDIVVQLNRVGGGRKVTAVEF
LC
>Mature_321_residues
STGVYLAAYLAPLQPWLDRADVTDIWVNRPGEVWIETTKGVTSRLAAPDLTDQALQRLARQIAAASHQGVSREQPLLSAS
LPNGARVQIIAPPATRGDLALAIRKHTLSDLSLSDLAIGGTLAPPALTGRADADAQLRALLSAGDVEGFLRTAIQRRKTI
VLSGGTSSGKTTLLNALVKEIPAHERLVLIEDAPEIQLRHENAIGLIAARSDTGEAQVDAEDLLQASLRMRPDRILLGEL
RGREAFAFLRAVNTGHPGSITTVHADSPQGALDQIALLSLLAGVDLGWDTVRNYVRQVVDIVVQLNRVGGGRKVTAVEFL
C

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 34398; Mature: 34267

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGVYLAAYLAPLQPWLDRADVTDIWVNRPGEVWIETTKGVTSRLAAPDLTDQALQRLA
CCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCHHHHHCCCCHHHHHHHHHH
RQIAAASHQGVSREQPLLSASLPNGARVQIIAPPATRGDLALAIRKHTLSDLSLSDLAIG
HHHHHHHCCCCCCCCCCEECCCCCCCEEEEECCCCCCCCEEEEEEHHHHCCCCHHHEEEC
GTLAPPALTGRADADAQLRALLSAGDVEGFLRTAIQRRKTIVLSGGTSSGKTTLLNALVK
CCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHH
EIPAHERLVLIEDAPEIQLRHENAIGLIAARSDTGEAQVDAEDLLQASLRMRPDRILLGE
HCCCCCEEEEEECCCCEEEEECCCEEEEEECCCCCCCEECHHHHHHHHHHCCCCEEEEEH
LRGREAFAFLRAVNTGHPGSITTVHADSPQGALDQIALLSLLAGVDLGWDTVRNYVRQVV
HCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
DIVVQLNRVGGGRKVTAVEFLC
HHHHHHHHCCCCCEEEEEEECC
>Mature Secondary Structure 
STGVYLAAYLAPLQPWLDRADVTDIWVNRPGEVWIETTKGVTSRLAAPDLTDQALQRLA
CCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCHHHHHCCCCHHHHHHHHHH
RQIAAASHQGVSREQPLLSASLPNGARVQIIAPPATRGDLALAIRKHTLSDLSLSDLAIG
HHHHHHHCCCCCCCCCCEECCCCCCCEEEEECCCCCCCCEEEEEEHHHHCCCCHHHEEEC
GTLAPPALTGRADADAQLRALLSAGDVEGFLRTAIQRRKTIVLSGGTSSGKTTLLNALVK
CCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHH
EIPAHERLVLIEDAPEIQLRHENAIGLIAARSDTGEAQVDAEDLLQASLRMRPDRILLGE
HCCCCCEEEEEECCCCEEEEECCCEEEEEECCCCCCCEECHHHHHHHHHHCCCCEEEEEH
LRGREAFAFLRAVNTGHPGSITTVHADSPQGALDQIALLSLLAGVDLGWDTVRNYVRQVV
HCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
DIVVQLNRVGGGRKVTAVEFLC
HHHHHHHHCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]