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The map label for this gene is hisN [H]

Identifier: 16126491

GI number: 16126491

Start: 2450018

End: 2450854

Strand: Direct

Name: hisN [H]

Synonym: CC_2252

Alternate gene names: 16126491

Gene position: 2450018-2450854 (Clockwise)

Preceding gene: 16126490

Following gene: 16126495

Centisome position: 60.99

GC content: 68.82

Gene sequence:

>837_bases
ATGACGCTTTCCGCTGATCGGCTCGCGGCGCTCGACGCCTTCATCCTCGACCTGAACCGGGCTTCGGCGGACGTGATCCT
GCCGCTGTTCCGGGCCGACCATGGCCTTGAGGACAAGGGCGCAGGCAAGAACCTGCCGCGCGACACCCACGCCGCCTTCG
ATCCGGTCACCGAGGCCGATCGCGGCGCCGAGGCGGCCATTCGCGCGCTGATCGCCCAGCGTTTTCCCGATCACGGCGTG
ATCGGCGAGGAGTATGGCGAAGACCGCCCCGACGCCGAGTTCGTCTGGGTGCTCGACCCGATCGACGGCACCCGAGCCTT
TATCGCGGGCCTGCCGCTCTGGACCACCTTGATCGGCCTTCGCCACGAAGGGCGTCCGGTGCTGGGCTCGATCGGCCAGC
CTTACGTCAATGAGATCTTCATCGGCCACGCCGGCGGGGCGCGCCTCGTCTCTGGCGGCGAAGCACGGCCGATCCGCGTG
CGCGAGTGCGCCAACATCAATGACGCCGTCATCGCCACCACCGATCCCGACGCCTGTTTCGACGGCGCCGAGCGCGGCGC
GTGGCTACAGGTCCGCGCGGCCGCCAAGCTGGCGCGCCTGGGCTGCGACGCCTACGCCTACGCCATGGTCGCCATGGGCA
AGATGGACATGGTCATCGAAGCGGGCCTGAAATCCTGGGACATCGAGGCGGCCATCCCCCTGATCGAGGGCGCCGGCGGC
ATGGTCACCAACTGGCGCGGCGAGCCCGTCGGCCCGAACGGTGGCCAGATGGTCATCTCGGGTGATCGCCGCCCGCTGGA
CGAGGCGCTGGTCAGTCTGAGACGTTCGGCGAAATAA

Upstream 100 bases:

>100_bases
AGTCGCTGAACGGCGGCGCCGAGCACGCCGACGCCTAAAGTCGACCACCGCGTACAGTCACTGGTAGCGTACCTGCGGCG
GGGAGGTTAAATCCCCGCCC

Downstream 100 bases:

>100_bases
GCGGTTCGCGCGCAGCGATCGGATCGACCGTCTCGTCGAAGGCCTGCCAGAACAGCGCGCGGCGGGCGTCGGTCTCGACC
AGAATCTCGTGGAAGGCCCC

Product: inositol monophosphatase family protein

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MTLSADRLAALDAFILDLNRASADVILPLFRADHGLEDKGAGKNLPRDTHAAFDPVTEADRGAEAAIRALIAQRFPDHGV
IGEEYGEDRPDAEFVWVLDPIDGTRAFIAGLPLWTTLIGLRHEGRPVLGSIGQPYVNEIFIGHAGGARLVSGGEARPIRV
RECANINDAVIATTDPDACFDGAERGAWLQVRAAAKLARLGCDAYAYAMVAMGKMDMVIEAGLKSWDIEAAIPLIEGAGG
MVTNWRGEPVGPNGGQMVISGDRRPLDEALVSLRRSAK

Sequences:

>Translated_278_residues
MTLSADRLAALDAFILDLNRASADVILPLFRADHGLEDKGAGKNLPRDTHAAFDPVTEADRGAEAAIRALIAQRFPDHGV
IGEEYGEDRPDAEFVWVLDPIDGTRAFIAGLPLWTTLIGLRHEGRPVLGSIGQPYVNEIFIGHAGGARLVSGGEARPIRV
RECANINDAVIATTDPDACFDGAERGAWLQVRAAAKLARLGCDAYAYAMVAMGKMDMVIEAGLKSWDIEAAIPLIEGAGG
MVTNWRGEPVGPNGGQMVISGDRRPLDEALVSLRRSAK
>Mature_277_residues
TLSADRLAALDAFILDLNRASADVILPLFRADHGLEDKGAGKNLPRDTHAAFDPVTEADRGAEAAIRALIAQRFPDHGVI
GEEYGEDRPDAEFVWVLDPIDGTRAFIAGLPLWTTLIGLRHEGRPVLGSIGQPYVNEIFIGHAGGARLVSGGEARPIRVR
ECANINDAVIATTDPDACFDGAERGAWLQVRAAAKLARLGCDAYAYAMVAMGKMDMVIEAGLKSWDIEAAIPLIEGAGGM
VTNWRGEPVGPNGGQMVISGDRRPLDEALVSLRRSAK

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788882, Length=229, Percent_Identity=31.4410480349345, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790659, Length=240, Percent_Identity=26.6666666666667, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI193202570, Length=209, Percent_Identity=29.1866028708134, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193202572, Length=207, Percent_Identity=27.536231884058, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320493, Length=290, Percent_Identity=27.9310344827586, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321836, Length=276, Percent_Identity=26.4492753623188, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664918, Length=265, Percent_Identity=28.6792452830189, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357957, Length=233, Percent_Identity=27.4678111587983, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357329, Length=220, Percent_Identity=28.1818181818182, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664926, Length=213, Percent_Identity=27.6995305164319, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24664922, Length=204, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357303, Length=206, Percent_Identity=27.1844660194175, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 29689; Mature: 29558

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSADRLAALDAFILDLNRASADVILPLFRADHGLEDKGAGKNLPRDTHAAFDPVTEAD
CCCCHHHHHHHHHHHHHCCCCCCHHEEEHHHCCCCCCCCCCCCCCCCCCHHHCCCCHHCC
RGAEAAIRALIAQRFPDHGVIGEEYGEDRPDAEFVWVLDPIDGTRAFIAGLPLWTTLIGL
CCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEEECCCCCCHHHHHHCHHHHHHHHH
RHEGRPVLGSIGQPYVNEIFIGHAGGARLVSGGEARPIRVRECANINDAVIATTDPDACF
CCCCCCHHCCCCCCCHHEEEEECCCCCEEECCCCCCCEEHHHHCCCCCEEEEECCCHHHH
DGAERGAWLQVRAAAKLARLGCDAYAYAMVAMGKMDMVIEAGLKSWDIEAAIPLIEGAGG
CCCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCCCCCEECEEEECCCC
MVTNWRGEPVGPNGGQMVISGDRRPLDEALVSLRRSAK
CEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TLSADRLAALDAFILDLNRASADVILPLFRADHGLEDKGAGKNLPRDTHAAFDPVTEAD
CCCHHHHHHHHHHHHHCCCCCCHHEEEHHHCCCCCCCCCCCCCCCCCCHHHCCCCHHCC
RGAEAAIRALIAQRFPDHGVIGEEYGEDRPDAEFVWVLDPIDGTRAFIAGLPLWTTLIGL
CCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEEECCCCCCHHHHHHCHHHHHHHHH
RHEGRPVLGSIGQPYVNEIFIGHAGGARLVSGGEARPIRVRECANINDAVIATTDPDACF
CCCCCCHHCCCCCCCHHEEEEECCCCCEEECCCCCCCEEHHHHCCCCCEEEEECCCHHHH
DGAERGAWLQVRAAAKLARLGCDAYAYAMVAMGKMDMVIEAGLKSWDIEAAIPLIEGAGG
CCCCCCCEEEHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHCCCCCCCCEECEEEECCCC
MVTNWRGEPVGPNGGQMVISGDRRPLDEALVSLRRSAK
CEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]