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The map label for this gene is panC

Identifier: 16126405

GI number: 16126405

Start: 2370238

End: 2371095

Strand: Direct

Name: panC

Synonym: CC_2166

Alternate gene names: 16126405

Gene position: 2370238-2371095 (Clockwise)

Preceding gene: 16126402

Following gene: 16126410

Centisome position: 59.01

GC content: 68.88

Gene sequence:

>858_bases
ATGACCAGCCCGATCATCGTTCGCACTGTCGCCGAGATGCGCGAGCATGTGCGCGCCTGGAAGGCGGCCGGGCAACGCGT
GGCGGTCGTTCCGACCATGGGCGCCCTGCACGAGGGCCACCTGTCTCTGGTGCGTCTGGCCCAGCAGCACGCAGAGCGCG
TGATCGCCACGGTCTTCGTCAATCCCAAGCAGTTCGCCCCGCACGAGGACTTCGACGCCTATCCGCGCGGCGAGGCGGCC
GACGCTGAGAAGCTGGCCTTAGTCGGTTGCGACCTGCTGTTCGCGCCGAACGCGACCGAGATGTACGCGCCGGGCTTCTC
GACGCTGGTCAGCGTGTCGGGCGTGTCTGAACCGCTCGAGGGCGCGGCGCGCCCGCAGTTCTTCGGCGGTGTCGCGACCG
TGGTCGCCAAGCTGTTCATCCAGTCGCAGGCCGATGTCGCGGTGTTCGGCGAGAAGGACTACCAGCAGCTTCAGGTCGTT
CGTCGCATGGCGCGCGATCTGGACATCCCCGTCGAGATCATCGGCGCGCCGACCGCCCGAGCCGAGGACGGCCTCGCTCT
CTCCTCGCGCAACGCCTATCTGTCGGCGGAGGAACGCGCCGCCGCCGTGGCCCTGCCAACGGCGATGAAGGCTGCGGCTG
CGGCCGTCGCCCAGGGGGGGCCTATCGAAGACGCCGAGCGTTCGGCGGTCGCAGCCTTGCAGGCTGCGGGCTTTGGCCAG
GTGGACTATGTGGAAATACGCGAGGCGAGCGATCTATCGCGGTTGGGCCCCGGCCCCATCGGCGAGGCGTCCGGCCGAAT
CCTGGTCGCCGCGTGGCTGGGTAAGACCCGGCTGATCGACAACATGGCGGTCGGTTGA

Upstream 100 bases:

>100_bases
CCTTATTGTCGCAGGCTGTGGACGCGTTCCCGTTGGGGGATGGTGGACCTTCCCCATCTCTAAGGCCATAAGCGCTCGCC
AGTTTGCGTGGAGGCCCCGA

Downstream 100 bases:

>100_bases
CCTATCCGATCGGACGCAGCGCCAGCAGCAGACCGCCGACTAGTCCAACGAACAACATCCCCACGCCCAAGGCGGCATAG
CCGGCTTTCATGGTGACCCC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTSPIIVRTVAEMREHVRAWKAAGQRVAVVPTMGALHEGHLSLVRLAQQHAERVIATVFVNPKQFAPHEDFDAYPRGEAA
DAEKLALVGCDLLFAPNATEMYAPGFSTLVSVSGVSEPLEGAARPQFFGGVATVVAKLFIQSQADVAVFGEKDYQQLQVV
RRMARDLDIPVEIIGAPTARAEDGLALSSRNAYLSAEERAAAVALPTAMKAAAAAVAQGGPIEDAERSAVAALQAAGFGQ
VDYVEIREASDLSRLGPGPIGEASGRILVAAWLGKTRLIDNMAVG

Sequences:

>Translated_285_residues
MTSPIIVRTVAEMREHVRAWKAAGQRVAVVPTMGALHEGHLSLVRLAQQHAERVIATVFVNPKQFAPHEDFDAYPRGEAA
DAEKLALVGCDLLFAPNATEMYAPGFSTLVSVSGVSEPLEGAARPQFFGGVATVVAKLFIQSQADVAVFGEKDYQQLQVV
RRMARDLDIPVEIIGAPTARAEDGLALSSRNAYLSAEERAAAVALPTAMKAAAAAVAQGGPIEDAERSAVAALQAAGFGQ
VDYVEIREASDLSRLGPGPIGEASGRILVAAWLGKTRLIDNMAVG
>Mature_284_residues
TSPIIVRTVAEMREHVRAWKAAGQRVAVVPTMGALHEGHLSLVRLAQQHAERVIATVFVNPKQFAPHEDFDAYPRGEAAD
AEKLALVGCDLLFAPNATEMYAPGFSTLVSVSGVSEPLEGAARPQFFGGVATVVAKLFIQSQADVAVFGEKDYQQLQVVR
RMARDLDIPVEIIGAPTARAEDGLALSSRNAYLSAEERAAAVALPTAMKAAAAAVAQGGPIEDAERSAVAALQAAGFGQV
DYVEIREASDLSRLGPGPIGEASGRILVAAWLGKTRLIDNMAVG

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=286, Percent_Identity=45.4545454545455, Blast_Score=229, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322046, Length=302, Percent_Identity=36.4238410596026, Blast_Score=171, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_CAUCR (Q9A6C8)

Other databases:

- EMBL:   AE005673
- PIR:   E87517
- RefSeq:   NP_420969.1
- ProteinModelPortal:   Q9A6C8
- SMR:   Q9A6C8
- GeneID:   943091
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_2166
- NMPDR:   fig|190650.1.peg.2149
- TIGR:   CC_2166
- HOGENOM:   HBG428839
- OMA:   GQASHEE
- ProtClustDB:   PRK00380
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30053; Mature: 29921

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: ACT_SITE 40-40 BINDING 64-64 BINDING 64-64 BINDING 156-156 BINDING 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPIIVRTVAEMREHVRAWKAAGQRVAVVPTMGALHEGHLSLVRLAQQHAERVIATVFV
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEEHHEEE
NPKQFAPHEDFDAYPRGEAADAEKLALVGCDLLFAPNATEMYAPGFSTLVSVSGVSEPLE
CCHHCCCCCCCCCCCCCCCCCCHHEEEEECEEEECCCCCCEECCCHHHHHHHCCCCHHHH
GAARPQFFGGVATVVAKLFIQSQADVAVFGEKDYQQLQVVRRMARDLDIPVEIIGAPTAR
CCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCC
AEDGLALSSRNAYLSAEERAAAVALPTAMKAAAAAVAQGGPIEDAERSAVAALQAAGFGQ
CCCCCEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
VDYVEIREASDLSRLGPGPIGEASGRILVAAWLGKTRLIDNMAVG
CEEEEECCCCCHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHCCC
>Mature Secondary Structure 
TSPIIVRTVAEMREHVRAWKAAGQRVAVVPTMGALHEGHLSLVRLAQQHAERVIATVFV
CCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEEHHEEE
NPKQFAPHEDFDAYPRGEAADAEKLALVGCDLLFAPNATEMYAPGFSTLVSVSGVSEPLE
CCHHCCCCCCCCCCCCCCCCCCHHEEEEECEEEECCCCCCEECCCHHHHHHHCCCCHHHH
GAARPQFFGGVATVVAKLFIQSQADVAVFGEKDYQQLQVVRRMARDLDIPVEIIGAPTAR
CCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCC
AEDGLALSSRNAYLSAEERAAAVALPTAMKAAAAAVAQGGPIEDAERSAVAALQAAGFGQ
CCCCCEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
VDYVEIREASDLSRLGPGPIGEASGRILVAAWLGKTRLIDNMAVG
CEEEEECCCCCHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647