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The map label for this gene is ptpA [H]

Identifier: 16126393

GI number: 16126393

Start: 2359998

End: 2362214

Strand: Direct

Name: ptpA [H]

Synonym: CC_2154

Alternate gene names: 16126393

Gene position: 2359998-2362214 (Clockwise)

Preceding gene: 16126392

Following gene: 16126394

Centisome position: 58.75

GC content: 66.26

Gene sequence:

>2217_bases
ATGAAAAAGCCCTCGCTCACGGCGCTCGCGGCCGTTCTCGCCCTCTCTACGCCCGCCCTGGCGCAGAAACTCACCCCTGA
ACGTATTTTCGGCGATCCCAGCCTGAGCGGCCCCACCGCGCGGGGCGTCGCGCTTTCGCCGGACGGCAAGCGCGTGACCT
ATCTGAAGGGCAAGCCCGAGGCGGCCAACATCCAGGACCTGTGGGCGGCCGACGTGAAGGGCGGCGAGCCCTATCGCCTG
ATCGACAGCGCCGCGCTGTCCTCGGGCGACAAGGAGCTGTCGGAAGCCGAGAAGGCCCGCCGTGAGCGCGCCCGCGTCTC
GGCCCGCGGCATCGTCGAGTACAGCTGGGACCGCCAGGGCCGCTTCATCCTGGTCCCGCTGGACGGCGACCTCTATCTAG
ACGCCGTCGCCGACGGGAAGATCACCCGACTGACCGAAACCCCGGGCGACGAGGTCGACGCTAAGGTCTCGCCCAAGGGT
GGCTACGTCTCTTATGTCCGCGACCAGAACCTGTACATCAAGCCCGTCGCAGGCGGCGCCGAGACGGCGCTGACTACCGA
CGGCAAGGACGCGCTGTCCTTCGGCGTCGCCGAGTTCATCGTCCAGGAGGAGCTCGACCGCTTCACCGGCTACTGGTGGA
GCCCGGACGAGAGCCGCATCGTCTACACCCGAGTCGACGAAAGCGGCGTCGACATCGTGCCGCGCGCCGACATCGGTCCG
GGCGGAGCCACCGTCGTCAATCAGCGCTATCCGCGCGCCGGTCGCCCTAACGCCGTGGTGGATCTGTTCGTGCGCGACCT
GGCTTCCGGCAAGGTCACGGCCCTCGACCTCGGCGCCAACAAGGACATCTATGTCGCGCGCGTCGCCTGGTCGGCAGACG
GCAAGACCGTCTATGTCCAGCGCCTGTCGCGCGACCAGAAGACGCTCGACCTCCTGGCCTTCGACGCAGCCACCGGCGCC
GGCAAGACCATCCTTACCGATACCGATCCGCATTTCATCGAGGTCAGCAACGACTTCCGCCCGCTTACGGACGGCACGTT
CCTGTGGGGCTCGGAGAAGGACGGCAACCAGCATCTCTATCGCTACGCCGCCGACGGCAAGCTGATCGCCCAGATCACCA
AGGGCGACTGGCCGGTCATCGGCCTGGAGGGTGTCGACGAGGCCCGCAAGGTCGCCATCTTCTCGGCCTCGATCGATACG
CCGATCGAGCGTCGCCTGTATGAGGTGAGCTACGCCAAGCCGGGCAAGCCCAAGGCCCTGACCTCGGCCGGCGGCTGGTG
GGCCGCAAAGGTCGCCGACAACGGCGGCGCCTTCGCCGGCACCTACAGCGATCCCAAAACCCCGTCCCAGACCGCCCTCT
ATTCGGCCGACGGCAAGCGCGTGCGCTGGATCGAGGAGAACAAGCTGGCCGAGGGACATCCCTACTGGCCCTACGCCGCC
AATCTGCCCCAGCCCGAGTTCGGCTCGCTGAAGGCTGCGGACGGCGAAACGCTGCACTATGAGATCCTCAAGCCCATCGG
CTTCGATCCGGCCAAGAAGTACCCCGCCATCGTCTCGGTCTATGGCGGCCCGCACGCTCAGCGCGTGATGAAGAACTGGC
ATAGCCCGTCGGAGCGCACCTATCTCGAGGCCGGCTATGTGATCTTCAAGCTGGACAATCGCGGCAGCGGCAACCGCTCG
GCCAAGTTCATGCGCGCCCTGGACCGCAAGCTCGGCACCGTCGAGGTCGAGGACCAATTGCTGGGCGCCAAGTTCCTGGC
CAGCCAGCCCTATGTCGACGCCGACAAGCTGGGCGTGATGGGCTGGTCCTATGGCGGCTTCATGGCCCTGATGCTGCTGA
CCGCCGAGAACACCCCGTTCAAGGCCGGCGCCGCCGGCGCGCCGCCGACCGAGTGGAGCCTGTACGATACGGCCTACACC
GAGCGCTACATGGGCAAGCCCGACGAGAACAAGGCCGGCTACGCCTATTCGGACATCAACAACCGGATCGACAAACTGGC
GCCGGGCAGCCTGTTGCTGCTGCACGGCATGGCCGACGACAATGTGATCTTCGAGAACAGCACCCGGCTGATGGCCGCCC
TGCAACGCAAGGCGATCCTCTTCGAGATGGCCATGTATCCTGGCGAACGTCACAGCGCGCCCGGTAGCAAAACCAAGGGC
CTCAGCGTGCTGAAGACCCACCTGGACTTCTTCGATCGCAAACTGAAGGGGCGCTGA

Upstream 100 bases:

>100_bases
GACCTGACGCCGCTGGAGACCCTCTGTCGCTGAGTGCGTTGCAAGTCGGAAACAACTTCACTGCTGACAAGCGCGGCGCG
CCCGCATAGCGTCCCGCGCC

Downstream 100 bases:

>100_bases
GCCTGCGATGACCCGCGCGCCGCAACGGAGCGCGGGTCGCCCTGCGACAACACGTCCGCGGGCCCCGACCTTATGTCGCA
GGGCCTCGGGCGCGGCGGCA

Product: dipeptidyl peptidase IV

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 738; Mature: 738

Protein sequence:

>738_residues
MKKPSLTALAAVLALSTPALAQKLTPERIFGDPSLSGPTARGVALSPDGKRVTYLKGKPEAANIQDLWAADVKGGEPYRL
IDSAALSSGDKELSEAEKARRERARVSARGIVEYSWDRQGRFILVPLDGDLYLDAVADGKITRLTETPGDEVDAKVSPKG
GYVSYVRDQNLYIKPVAGGAETALTTDGKDALSFGVAEFIVQEELDRFTGYWWSPDESRIVYTRVDESGVDIVPRADIGP
GGATVVNQRYPRAGRPNAVVDLFVRDLASGKVTALDLGANKDIYVARVAWSADGKTVYVQRLSRDQKTLDLLAFDAATGA
GKTILTDTDPHFIEVSNDFRPLTDGTFLWGSEKDGNQHLYRYAADGKLIAQITKGDWPVIGLEGVDEARKVAIFSASIDT
PIERRLYEVSYAKPGKPKALTSAGGWWAAKVADNGGAFAGTYSDPKTPSQTALYSADGKRVRWIEENKLAEGHPYWPYAA
NLPQPEFGSLKAADGETLHYEILKPIGFDPAKKYPAIVSVYGGPHAQRVMKNWHSPSERTYLEAGYVIFKLDNRGSGNRS
AKFMRALDRKLGTVEVEDQLLGAKFLASQPYVDADKLGVMGWSYGGFMALMLLTAENTPFKAGAAGAPPTEWSLYDTAYT
ERYMGKPDENKAGYAYSDINNRIDKLAPGSLLLLHGMADDNVIFENSTRLMAALQRKAILFEMAMYPGERHSAPGSKTKG
LSVLKTHLDFFDRKLKGR

Sequences:

>Translated_738_residues
MKKPSLTALAAVLALSTPALAQKLTPERIFGDPSLSGPTARGVALSPDGKRVTYLKGKPEAANIQDLWAADVKGGEPYRL
IDSAALSSGDKELSEAEKARRERARVSARGIVEYSWDRQGRFILVPLDGDLYLDAVADGKITRLTETPGDEVDAKVSPKG
GYVSYVRDQNLYIKPVAGGAETALTTDGKDALSFGVAEFIVQEELDRFTGYWWSPDESRIVYTRVDESGVDIVPRADIGP
GGATVVNQRYPRAGRPNAVVDLFVRDLASGKVTALDLGANKDIYVARVAWSADGKTVYVQRLSRDQKTLDLLAFDAATGA
GKTILTDTDPHFIEVSNDFRPLTDGTFLWGSEKDGNQHLYRYAADGKLIAQITKGDWPVIGLEGVDEARKVAIFSASIDT
PIERRLYEVSYAKPGKPKALTSAGGWWAAKVADNGGAFAGTYSDPKTPSQTALYSADGKRVRWIEENKLAEGHPYWPYAA
NLPQPEFGSLKAADGETLHYEILKPIGFDPAKKYPAIVSVYGGPHAQRVMKNWHSPSERTYLEAGYVIFKLDNRGSGNRS
AKFMRALDRKLGTVEVEDQLLGAKFLASQPYVDADKLGVMGWSYGGFMALMLLTAENTPFKAGAAGAPPTEWSLYDTAYT
ERYMGKPDENKAGYAYSDINNRIDKLAPGSLLLLHGMADDNVIFENSTRLMAALQRKAILFEMAMYPGERHSAPGSKTKG
LSVLKTHLDFFDRKLKGR
>Mature_738_residues
MKKPSLTALAAVLALSTPALAQKLTPERIFGDPSLSGPTARGVALSPDGKRVTYLKGKPEAANIQDLWAADVKGGEPYRL
IDSAALSSGDKELSEAEKARRERARVSARGIVEYSWDRQGRFILVPLDGDLYLDAVADGKITRLTETPGDEVDAKVSPKG
GYVSYVRDQNLYIKPVAGGAETALTTDGKDALSFGVAEFIVQEELDRFTGYWWSPDESRIVYTRVDESGVDIVPRADIGP
GGATVVNQRYPRAGRPNAVVDLFVRDLASGKVTALDLGANKDIYVARVAWSADGKTVYVQRLSRDQKTLDLLAFDAATGA
GKTILTDTDPHFIEVSNDFRPLTDGTFLWGSEKDGNQHLYRYAADGKLIAQITKGDWPVIGLEGVDEARKVAIFSASIDT
PIERRLYEVSYAKPGKPKALTSAGGWWAAKVADNGGAFAGTYSDPKTPSQTALYSADGKRVRWIEENKLAEGHPYWPYAA
NLPQPEFGSLKAADGETLHYEILKPIGFDPAKKYPAIVSVYGGPHAQRVMKNWHSPSERTYLEAGYVIFKLDNRGSGNRS
AKFMRALDRKLGTVEVEDQLLGAKFLASQPYVDADKLGVMGWSYGGFMALMLLTAENTPFKAGAAGAPPTEWSLYDTAYT
ERYMGKPDENKAGYAYSDINNRIDKLAPGSLLLLHGMADDNVIFENSTRLMAALQRKAILFEMAMYPGERHSAPGSKTKG
LSVLKTHLDFFDRKLKGR

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI18450280, Length=725, Percent_Identity=30.2068965517241, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI37577089, Length=725, Percent_Identity=30.2068965517241, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI194394146, Length=740, Percent_Identity=28.6486486486486, Blast_Score=277, Evalue=3e-74,
Organism=Homo sapiens, GI37577091, Length=724, Percent_Identity=27.0718232044199, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI18765694, Length=625, Percent_Identity=27.36, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI16933540, Length=632, Percent_Identity=28.3227848101266, Blast_Score=226, Evalue=9e-59,
Organism=Homo sapiens, GI295842359, Length=609, Percent_Identity=27.4220032840723, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI295842403, Length=609, Percent_Identity=27.4220032840723, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI52426756, Length=609, Percent_Identity=27.4220032840723, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI85787627, Length=609, Percent_Identity=27.4220032840723, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI295849272, Length=609, Percent_Identity=27.4220032840723, Blast_Score=217, Evalue=3e-56,
Organism=Homo sapiens, GI86792863, Length=606, Percent_Identity=25.9075907590759, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI86792774, Length=606, Percent_Identity=25.9075907590759, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI86792778, Length=606, Percent_Identity=25.9075907590759, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI18450278, Length=533, Percent_Identity=25.891181988743, Blast_Score=149, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17508017, Length=348, Percent_Identity=35.3448275862069, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17508019, Length=348, Percent_Identity=35.3448275862069, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17550672, Length=597, Percent_Identity=28.8107202680067, Blast_Score=165, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17564632, Length=369, Percent_Identity=31.4363143631436, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17564634, Length=369, Percent_Identity=31.4363143631436, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17552908, Length=204, Percent_Identity=25.9803921568627, Blast_Score=66, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324793, Length=604, Percent_Identity=26.8211920529801, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321817, Length=618, Percent_Identity=27.5080906148867, Blast_Score=193, Evalue=7e-50,
Organism=Drosophila melanogaster, GI45550825, Length=747, Percent_Identity=28.9156626506024, Blast_Score=283, Evalue=4e-76,
Organism=Drosophila melanogaster, GI45553511, Length=747, Percent_Identity=28.9156626506024, Blast_Score=283, Evalue=4e-76,
Organism=Drosophila melanogaster, GI45551969, Length=727, Percent_Identity=29.0233837689133, Blast_Score=283, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24582032, Length=587, Percent_Identity=27.5979557069847, Blast_Score=194, Evalue=2e-49,
Organism=Drosophila melanogaster, GI221331178, Length=624, Percent_Identity=27.4038461538462, Blast_Score=186, Evalue=8e-47,
Organism=Drosophila melanogaster, GI161083744, Length=622, Percent_Identity=27.491961414791, Blast_Score=185, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17933704, Length=624, Percent_Identity=27.8846153846154, Blast_Score=185, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24582257, Length=233, Percent_Identity=36.0515021459227, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI45551475, Length=445, Percent_Identity=23.8202247191011, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221372263, Length=445, Percent_Identity=23.8202247191011, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221372266, Length=445, Percent_Identity=23.8202247191011, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 80593; Mature: 80593

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPSLTALAAVLALSTPALAQKLTPERIFGDPSLSGPTARGVALSPDGKRVTYLKGKPE
CCCCHHHHHHHHHHHCCHHHHHHCCHHHHCCCCCCCCCCCCCEEECCCCCEEEEEECCCC
AANIQDLWAADVKGGEPYRLIDSAALSSGDKELSEAEKARRERARVSARGIVEYSWDRQG
CCCHHHHHHHCCCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
RFILVPLDGDLYLDAVADGKITRLTETPGDEVDAKVSPKGGYVSYVRDQNLYIKPVAGGA
CEEEEEECCCEEEEEECCCEEEEEECCCCCCCCCEECCCCCEEEEEECCCEEEEEECCCC
ETALTTDGKDALSFGVAEFIVQEELDRFTGYWWSPDESRIVYTRVDESGVDIVPRADIGP
CCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEECCCCCC
GGATVVNQRYPRAGRPNAVVDLFVRDLASGKVTALDLGANKDIYVARVAWSADGKTVYVQ
CCCEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCEEEEE
RLSRDQKTLDLLAFDAATGAGKTILTDTDPHFIEVSNDFRPLTDGTFLWGSEKDGNQHLY
ECCCCCHHEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEECCCCCCCCEEE
RYAADGKLIAQITKGDWPVIGLEGVDEARKVAIFSASIDTPIERRLYEVSYAKPGKPKAL
EEECCCEEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCHHHHHEEEEECCCCCCCCEE
TSAGGWWAAKVADNGGAFAGTYSDPKTPSQTALYSADGKRVRWIEENKLAEGHPYWPYAA
ECCCCEEEEEEECCCCEEEECCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCC
NLPQPEFGSLKAADGETLHYEILKPIGFDPAKKYPAIVSVYGGPHAQRVMKNWHSPSERT
CCCCCCCCCEECCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCE
YLEAGYVIFKLDNRGSGNRSAKFMRALDRKLGTVEVEDQLLGAKFLASQPYVDADKLGVM
EEECCEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCCCCCHHHCEEE
GWSYGGFMALMLLTAENTPFKAGAAGAPPTEWSLYDTAYTERYMGKPDENKAGYAYSDIN
EECHHHHEEEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCCEEEHHHH
NRIDKLAPGSLLLLHGMADDNVIFENSTRLMAALQRKAILFEMAMYPGERHSAPGSKTKG
HHHHHCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LSVLKTHLDFFDRKLKGR
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKPSLTALAAVLALSTPALAQKLTPERIFGDPSLSGPTARGVALSPDGKRVTYLKGKPE
CCCCHHHHHHHHHHHCCHHHHHHCCHHHHCCCCCCCCCCCCCEEECCCCCEEEEEECCCC
AANIQDLWAADVKGGEPYRLIDSAALSSGDKELSEAEKARRERARVSARGIVEYSWDRQG
CCCHHHHHHHCCCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
RFILVPLDGDLYLDAVADGKITRLTETPGDEVDAKVSPKGGYVSYVRDQNLYIKPVAGGA
CEEEEEECCCEEEEEECCCEEEEEECCCCCCCCCEECCCCCEEEEEECCCEEEEEECCCC
ETALTTDGKDALSFGVAEFIVQEELDRFTGYWWSPDESRIVYTRVDESGVDIVPRADIGP
CCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCEEEECCCCCC
GGATVVNQRYPRAGRPNAVVDLFVRDLASGKVTALDLGANKDIYVARVAWSADGKTVYVQ
CCCEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEEECCCCCEEEEE
RLSRDQKTLDLLAFDAATGAGKTILTDTDPHFIEVSNDFRPLTDGTFLWGSEKDGNQHLY
ECCCCCHHEEEEEEECCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEECCCCCCCCEEE
RYAADGKLIAQITKGDWPVIGLEGVDEARKVAIFSASIDTPIERRLYEVSYAKPGKPKAL
EEECCCEEEEEEECCCCCEEECCCCCCCCEEEEEEECCCCHHHHHEEEEECCCCCCCCEE
TSAGGWWAAKVADNGGAFAGTYSDPKTPSQTALYSADGKRVRWIEENKLAEGHPYWPYAA
ECCCCEEEEEEECCCCEEEECCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCC
NLPQPEFGSLKAADGETLHYEILKPIGFDPAKKYPAIVSVYGGPHAQRVMKNWHSPSERT
CCCCCCCCCEECCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCE
YLEAGYVIFKLDNRGSGNRSAKFMRALDRKLGTVEVEDQLLGAKFLASQPYVDADKLGVM
EEECCEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEHHHHHHHHHHCCCCCCCHHHCEEE
GWSYGGFMALMLLTAENTPFKAGAAGAPPTEWSLYDTAYTERYMGKPDENKAGYAYSDIN
EECHHHHEEEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCCEEEHHHH
NRIDKLAPGSLLLLHGMADDNVIFENSTRLMAALQRKAILFEMAMYPGERHSAPGSKTKG
HHHHHCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
LSVLKTHLDFFDRKLKGR
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA