Click here to switch to the map view.

The map label for this gene is lepB [H]

Identifier: 16126389

GI number: 16126389

Start: 2356373

End: 2357140

Strand: Direct

Name: lepB [H]

Synonym: CC_2150

Alternate gene names: 16126389

Gene position: 2356373-2357140 (Clockwise)

Preceding gene: 16126388

Following gene: 16126391

Centisome position: 58.66

GC content: 66.54

Gene sequence:

>768_bases
ATGACCCAGACATCCTCCCCCGCCGTCCCCGCGCCGAACACGCTGCGCCAGGAGTTCCTCGAAACGCTTCGGATCGCCGG
AGCGGGGCTCGCCATCGCGATGACCTTGCGCATCGTGATTTTTCAGCCCTTCACCATCCCATCGTCCTCGATGGAGCCGG
CACTGGTGATCGGCGACTACATCATCGTTTCAAAGTTCGCCTATGGCTGGAGCCGGGCGTCCCTGCCCTTCAATCCTCCG
CTGCCCGACGGTCGCCTGCTGGGCAAGGGCGCCGAACGCGGCGACGTTGTGGTGTTCCGTCTCCCGCGTGATCCAAGCCA
GACCTGGATCAAGCGGGTGATCGGCCTTCCGGGCGACAGAGTCCGCGTGGCGGGCGGCCAAGTGTACGTCAACGAAGTTC
CGATACCTCAGACGCCGCTGGGTCTGACCCAGGATCACGACGCGCCCGACCGTACGGTCCTGCAAGTGCGCGAACGGCAG
GCCGATGGGCGCGGCTACGTCACCTACGACGGCGGCGCGGGTCAGCCGGGCGACGACACCGAGAGCTATGTCGTGCCGGC
CGGCCAGTACTTCATGATGGGCGACAATCGCGATAACTCGCTCGACAGCCGCTGGTCCGGTGAGGTCGGCGTCGGCTTCC
TGCCGGCCGACCACATCATCGGCGAGGCCAGCTTCGTGCTCGCCTCCTGGAAGCCGGGTGCGGCGCTCTACAAGCCCTGG
ACCTGGCTGAACTTCCAGTGGGACCGCTTCGCGCGCCCGATCCGCTAG

Upstream 100 bases:

>100_bases
TGCGTCGAACGAGCAGCTCCAAGCTTGTCCGGACACGATATCCGGCTGTCCCGACACGGTCTTGCTGGCGAAAGACAAGT
TGCCTGGGCTGACTGGCGCC

Downstream 100 bases:

>100_bases
AGCAACTAGCGGGCGCGGAACTCTTCAATGCTGAGGACGCCGTCATGATTGACGTCCAGACGCTCGAAGGTCGCGTCCGA
GGTCGCGGTGCGAGCGAGCG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MTQTSSPAVPAPNTLRQEFLETLRIAGAGLAIAMTLRIVIFQPFTIPSSSMEPALVIGDYIIVSKFAYGWSRASLPFNPP
LPDGRLLGKGAERGDVVVFRLPRDPSQTWIKRVIGLPGDRVRVAGGQVYVNEVPIPQTPLGLTQDHDAPDRTVLQVRERQ
ADGRGYVTYDGGAGQPGDDTESYVVPAGQYFMMGDNRDNSLDSRWSGEVGVGFLPADHIIGEASFVLASWKPGAALYKPW
TWLNFQWDRFARPIR

Sequences:

>Translated_255_residues
MTQTSSPAVPAPNTLRQEFLETLRIAGAGLAIAMTLRIVIFQPFTIPSSSMEPALVIGDYIIVSKFAYGWSRASLPFNPP
LPDGRLLGKGAERGDVVVFRLPRDPSQTWIKRVIGLPGDRVRVAGGQVYVNEVPIPQTPLGLTQDHDAPDRTVLQVRERQ
ADGRGYVTYDGGAGQPGDDTESYVVPAGQYFMMGDNRDNSLDSRWSGEVGVGFLPADHIIGEASFVLASWKPGAALYKPW
TWLNFQWDRFARPIR
>Mature_254_residues
TQTSSPAVPAPNTLRQEFLETLRIAGAGLAIAMTLRIVIFQPFTIPSSSMEPALVIGDYIIVSKFAYGWSRASLPFNPPL
PDGRLLGKGAERGDVVVFRLPRDPSQTWIKRVIGLPGDRVRVAGGQVYVNEVPIPQTPLGLTQDHDAPDRTVLQVRERQA
DGRGYVTYDGGAGQPGDDTESYVVPAGQYFMMGDNRDNSLDSRWSGEVGVGFLPADHIIGEASFVLASWKPGAALYKPWT
WLNFQWDRFARPIR

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=247, Percent_Identity=34.0080971659919, Blast_Score=119, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 28041; Mature: 27910

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTSSPAVPAPNTLRQEFLETLRIAGAGLAIAMTLRIVIFQPFTIPSSSMEPALVIGDY
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCCCCCCCCCEEEECCC
IIVSKFAYGWSRASLPFNPPLPDGRLLGKGAERGDVVVFRLPRDPSQTWIKRVIGLPGDR
CEEHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCE
VRVAGGQVYVNEVPIPQTPLGLTQDHDAPDRTVLQVRERQADGRGYVTYDGGAGQPGDDT
EEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
ESYVVPAGQYFMMGDNRDNSLDSRWSGEVGVGFLPADHIIGEASFVLASWKPGAALYKPW
CCEEECCCCEEEEECCCCCCCCCCCCCCCCEEEECHHHHHCCCEEEEEECCCCCCEECCE
TWLNFQWDRFARPIR
EEEEEEHHHHCCCCC
>Mature Secondary Structure 
TQTSSPAVPAPNTLRQEFLETLRIAGAGLAIAMTLRIVIFQPFTIPSSSMEPALVIGDY
CCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHEEEEEEEECCCCCCCCCCCCEEEECCC
IIVSKFAYGWSRASLPFNPPLPDGRLLGKGAERGDVVVFRLPRDPSQTWIKRVIGLPGDR
CEEHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCE
VRVAGGQVYVNEVPIPQTPLGLTQDHDAPDRTVLQVRERQADGRGYVTYDGGAGQPGDDT
EEEECCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
ESYVVPAGQYFMMGDNRDNSLDSRWSGEVGVGFLPADHIIGEASFVLASWKPGAALYKPW
CCEEECCCCEEEEECCCCCCCCCCCCCCCCEEEECHHHHHCCCEEEEEECCCCCCEECCE
TWLNFQWDRFARPIR
EEEEEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA