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The map label for this gene is fumC

Identifier: 16126348

GI number: 16126348

Start: 2318561

End: 2319952

Strand: Direct

Name: fumC

Synonym: CC_2109

Alternate gene names: 16126348

Gene position: 2318561-2319952 (Clockwise)

Preceding gene: 16126345

Following gene: 16126349

Centisome position: 57.72

GC content: 65.88

Gene sequence:

>1392_bases
ATGACCGCCACGCGTATCGAGACCGACACCTTTGGCCCGATCGAAGTCGCCGCCGACCGCTACTGGGGCGCGCAAGCTCA
GCGCAGCCTGGGCAACTTCAAGATCGGCTGGGAAAAGCAGCCCCTGCCCGTCGTCCGCGCCCTGGGCATCGTCAAGCGCG
CCGCCGCCGAGGCCAACCTCGCCTTGGGCAAGCTGGACCCGAAGATCGCCGAGACGATCATCGCCGCCGCCAACGAAGTG
ATCGAGGGCAAGCTGAACGACCACTTCCCGCTGGTGGTCTGGCAGACCGGCTCGGGCACCCAGTCGAACATGAACGCCAA
CGAGGTGATCTCGAACCGCGCCATCGAGATGCTGGGCGGTGAGATGGGCAGCAAGAAGCCCGTCCACCCCAACGACCACG
TCAATATGAGCCAGTCGTCGAACGACACCTTCCCGACGGCCATGCACATCGCCTGCGCCGAACAGGTGGTCCACGACCTG
CTGCCCGCGCTGAAGCACCTGCACAAGGCCCTGGCCGCCAAGGCCGCCGAGTGGAAGGACATCATCAAGATCGGCCGCAC
CCACACCCAGGACGCCACCCCGCTGACGCTGGGCCAGGAGTTCGGCGGCTACGCTCAGCAGATCGAGAACGGCATCGCTC
GTATCGAGATGACCCTGCCGATGCTGATGCAACTGGCCCAGGGCGGCACCGCCGTCGGCACCGGCCTGAACGCCCCCGTG
GGCTTCGCCGAGCTGGTCGCCGAGCAGATCGCCGGCATCACGGGCCTAGGCTTCACCACGGCCCCGAACAAGTTCGAGGC
CCTGGCCGCCCACGACGCCATGGTCTTCACCCACGGCGCCATCAACACGGTGGCCGCCAGCCTGTTCAAGATCGCCAACG
ACATCCGCTTCCTGGGCTCTGGCCCGCGCGCCGGTCTCGGCGAGCTTTCCCTGCCGGAAAATGAGCCGGGCAGCTCGATC
ATGCCGGGCAAGGTCAATCCGACCCAGTCCGAAGCCCTGACCCAGGTCTGCGCCCAGGTGTTCGGCAACCACTCGACCCT
GACCTTCGCCGGCAGCCAGGGCCATTTCGAGCTGAACGTCTTCAACCCGGTGATGGCCTATAACTTCCTGCAGTCGGTCC
GTCTGGTCGCCGACGCGGCGATCAGCTTCACCGACAACTGCGTGGTCGGCATCGAGCCGCGTGTCGACAACATCAAGAAG
GGCGTCGAGAACAGCCTGATGCTGGTCACGGCCCTGAACGGCAAGCTCGGCTACGACGCCTGCGCCAAGATCGCCAAGAC
CGCGCACAAGAACGGCACCACCCTGCGCGAGGAGGCCGTCGGCGGCGGCTATCTGACGAACGAAGAGTTCGAACAGTACG
TCCGCCCCGAAAAGATGATCTCGCCGGGCTGA

Upstream 100 bases:

>100_bases
CGAGGCGTAGGCTCGCCTGGCGCTTATCGCAACCGCGAACATTGCCCTCTCGCCGCGCAAGGTCTAGACCGCGCTCGACC
GTTTTTGGGAGACACGCCGC

Downstream 100 bases:

>100_bases
ACCTGACGTGCTCCAGCTCGTCCGCATTTTCGACGAGCTGCCGGACGGCTTTGGCGACCTGGTCGCCGAAGCCTCCGGCA
AAGGCGTGCGCAACATGGCC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTATRIETDTFGPIEVAADRYWGAQAQRSLGNFKIGWEKQPLPVVRALGIVKRAAAEANLALGKLDPKIAETIIAAANEV
IEGKLNDHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGEMGSKKPVHPNDHVNMSQSSNDTFPTAMHIACAEQVVHDL
LPALKHLHKALAAKAAEWKDIIKIGRTHTQDATPLTLGQEFGGYAQQIENGIARIEMTLPMLMQLAQGGTAVGTGLNAPV
GFAELVAEQIAGITGLGFTTAPNKFEALAAHDAMVFTHGAINTVAASLFKIANDIRFLGSGPRAGLGELSLPENEPGSSI
MPGKVNPTQSEALTQVCAQVFGNHSTLTFAGSQGHFELNVFNPVMAYNFLQSVRLVADAAISFTDNCVVGIEPRVDNIKK
GVENSLMLVTALNGKLGYDACAKIAKTAHKNGTTLREEAVGGGYLTNEEFEQYVRPEKMISPG

Sequences:

>Translated_463_residues
MTATRIETDTFGPIEVAADRYWGAQAQRSLGNFKIGWEKQPLPVVRALGIVKRAAAEANLALGKLDPKIAETIIAAANEV
IEGKLNDHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGEMGSKKPVHPNDHVNMSQSSNDTFPTAMHIACAEQVVHDL
LPALKHLHKALAAKAAEWKDIIKIGRTHTQDATPLTLGQEFGGYAQQIENGIARIEMTLPMLMQLAQGGTAVGTGLNAPV
GFAELVAEQIAGITGLGFTTAPNKFEALAAHDAMVFTHGAINTVAASLFKIANDIRFLGSGPRAGLGELSLPENEPGSSI
MPGKVNPTQSEALTQVCAQVFGNHSTLTFAGSQGHFELNVFNPVMAYNFLQSVRLVADAAISFTDNCVVGIEPRVDNIKK
GVENSLMLVTALNGKLGYDACAKIAKTAHKNGTTLREEAVGGGYLTNEEFEQYVRPEKMISPG
>Mature_462_residues
TATRIETDTFGPIEVAADRYWGAQAQRSLGNFKIGWEKQPLPVVRALGIVKRAAAEANLALGKLDPKIAETIIAAANEVI
EGKLNDHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGGEMGSKKPVHPNDHVNMSQSSNDTFPTAMHIACAEQVVHDLL
PALKHLHKALAAKAAEWKDIIKIGRTHTQDATPLTLGQEFGGYAQQIENGIARIEMTLPMLMQLAQGGTAVGTGLNAPVG
FAELVAEQIAGITGLGFTTAPNKFEALAAHDAMVFTHGAINTVAASLFKIANDIRFLGSGPRAGLGELSLPENEPGSSIM
PGKVNPTQSEALTQVCAQVFGNHSTLTFAGSQGHFELNVFNPVMAYNFLQSVRLVADAAISFTDNCVVGIEPRVDNIKKG
VENSLMLVTALNGKLGYDACAKIAKTAHKNGTTLREEAVGGGYLTNEEFEQYVRPEKMISPG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=67.8260869565217, Blast_Score=621, Evalue=1e-178,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=52.3809523809524, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=56.7391304347826, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=39.2624728850325, Blast_Score=328, Evalue=3e-91,
Organism=Escherichia coli, GI1790398, Length=226, Percent_Identity=30.0884955752212, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=68.5344827586207, Blast_Score=637, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=69.4189602446483, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6324993, Length=463, Percent_Identity=65.0107991360691, Blast_Score=604, Evalue=1e-174,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=65.7266811279826, Blast_Score=612, Evalue=1e-175,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=65.7266811279826, Blast_Score=612, Evalue=1e-175,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=63.0669546436285, Blast_Score=598, Evalue=1e-171,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=61.038961038961, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=53.1317494600432, Blast_Score=500, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUMC_CAUCR (Q9A6I5)

Other databases:

- EMBL:   AE005673
- PIR:   D87510
- RefSeq:   NP_420912.1
- ProteinModelPortal:   Q9A6I5
- SMR:   Q9A6I5
- GeneID:   943033
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_2109
- NMPDR:   fig|190650.1.peg.2092
- TIGR:   CC_2109
- HOGENOM:   HBG284369
- OMA:   RIEKDTM
- ProtClustDB:   PRK00485
- BRENDA:   4.2.1.2
- HAMAP:   MF_00743
- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00979

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.2.1.2

Molecular weight: Translated: 49345; Mature: 49214

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: BINDING 100-100

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATRIETDTFGPIEVAADRYWGAQAQRSLGNFKIGWEKQPLPVVRALGIVKRAAAEANL
CCCCEECCCCCCCHHHHHHHHCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
ALGKLDPKIAETIIAAANEVIEGKLNDHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGG
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EMGSKKPVHPNDHVNMSQSSNDTFPTAMHIACAEQVVHDLLPALKHLHKALAAKAAEWKD
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPLTLGQEFGGYAQQIENGIARIEMTLPMLMQLAQGGTAVGTGLNAPV
HHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCEECCCCCCCC
GFAELVAEQIAGITGLGFTTAPNKFEALAAHDAMVFTHGAINTVAASLFKIANDIRFLGS
CHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHCC
GPRAGLGELSLPENEPGSSIMPGKVNPTQSEALTQVCAQVFGNHSTLTFAGSQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEE
FNPVMAYNFLQSVRLVADAAISFTDNCVVGIEPRVDNIKKGVENSLMLVTALNGKLGYDA
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCEEEEEECCCCCCHHH
CAKIAKTAHKNGTTLREEAVGGGYLTNEEFEQYVRPEKMISPG
HHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TATRIETDTFGPIEVAADRYWGAQAQRSLGNFKIGWEKQPLPVVRALGIVKRAAAEANL
CCCEECCCCCCCHHHHHHHHCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHH
ALGKLDPKIAETIIAAANEVIEGKLNDHFPLVVWQTGSGTQSNMNANEVISNRAIEMLGG
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EMGSKKPVHPNDHVNMSQSSNDTFPTAMHIACAEQVVHDLLPALKHLHKALAAKAAEWKD
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHTQDATPLTLGQEFGGYAQQIENGIARIEMTLPMLMQLAQGGTAVGTGLNAPV
HHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCEECCCCCCCC
GFAELVAEQIAGITGLGFTTAPNKFEALAAHDAMVFTHGAINTVAASLFKIANDIRFLGS
CHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHCC
GPRAGLGELSLPENEPGSSIMPGKVNPTQSEALTQVCAQVFGNHSTLTFAGSQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEE
FNPVMAYNFLQSVRLVADAAISFTDNCVVGIEPRVDNIKKGVENSLMLVTALNGKLGYDA
CCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCEEEEEECCCCCCHHH
CAKIAKTAHKNGTTLREEAVGGGYLTNEEFEQYVRPEKMISPG
HHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647