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The map label for this gene is yeiK [C]

Identifier: 16126171

GI number: 16126171

Start: 2126653

End: 2127612

Strand: Direct

Name: yeiK [C]

Synonym: CC_1928

Alternate gene names: 16126171

Gene position: 2126653-2127612 (Clockwise)

Preceding gene: 16126167

Following gene: 16126200

Centisome position: 52.94

GC content: 65.52

Gene sequence:

>960_bases
ATGCGCCTGATCATCGACACAGACACGGCGGGAGACGACGTCTTCTCCCTGATGCTCGCCCTCACCCGCACGGGTGTTGA
GTTGGAGGCCATCACCATCGCGCACGGCAATGTGGGCTTCGAGCAGCATGCCGAGAACGCCCTGGTGACCCTGGATCGCT
GCGGGCGGGCCGGCGAGGTTCCGGTCTATCTGGGCGCCCAGTTTCCCCTGATGCGCGCGCCGCTGGACGCCGCCTATGTG
TTCGGCCGCGACGGCATGAGCGATAGCGGCTTTGCGCGGACCTCCCAGCGCCCCGCCGAGGGCCATGCCGTGGATGAGCT
GGTGCGCCGGATCATGGCCGCGCCCGGCGAGATCACCCTGATCGCCCAAGCGCCGCTGACCAACATCGCCCTCGCCTACC
AACGAGAGCCACGCATCGCCAAGGCGCTGAAGCATCTGTGGGTGATGGGCGGTACAGACAACGGCGTGGGCAATGTGACC
CCGGCGGCGGAGTACAATTTCTATGCCGACCCGGAAGCCGCCAAGATCGTCGTCAATGCGGGCTTCAACCTCTCCATCGC
CACCTGGACCCTGACCCTGAAGGACGGTCTATGGACGACAGAGAAACTGGACGCGCTTGACGCGTTGGGCACCGAGAAAG
CCCGGTTCTTCACCGATGTGAACCGCGCATCGCTGGCTTTCGCGCGCGAGACCGAGGGTCTGGACGGCAGCCTACATCCC
GATGCGCTGACCTGTGCGATCGCACTGGACGAGGGACTGATCCTGGAGGCGGAAACCTGTGTCGTCGACGTTGAAACGGT
GGGCGAGCTCACGCGCGGCTATCTGAGCGTCTCGCACTCGATCCTGCCGGACATCGAGATCGCTGACCCGGCGCTCAAGC
GTCGCCCGCCGAACGCCCGCGTGATCAAGGCCATCGACCGCGAAGGCTTCTTCGCGGCGATGCGGACCGCACTGCTCTAA

Upstream 100 bases:

>100_bases
ACTGCAATCTTGTGCATTTTCTTTGCGCGGAGCGTTGGTCAGTCCCGCGCAAGCCTCGAAACGAGTGGCCAAGCCGCCGG
GAGTCGGCCAGATCAACGCC

Downstream 100 bases:

>100_bases
ACGCGTTGAAGCTCCAAGTGGCCGTCTTTCAGGGCCACCACGCGGTCCATGTAGCGCGCGAGCTCCATATTGTGCGTCGC
GATCACCGCAGCGACGCCCT

Product: inosine-uridine preferring nucleoside hydrolase

Products: cytosine; ribose; uracil [C]

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MRLIIDTDTAGDDVFSLMLALTRTGVELEAITIAHGNVGFEQHAENALVTLDRCGRAGEVPVYLGAQFPLMRAPLDAAYV
FGRDGMSDSGFARTSQRPAEGHAVDELVRRIMAAPGEITLIAQAPLTNIALAYQREPRIAKALKHLWVMGGTDNGVGNVT
PAAEYNFYADPEAAKIVVNAGFNLSIATWTLTLKDGLWTTEKLDALDALGTEKARFFTDVNRASLAFARETEGLDGSLHP
DALTCAIALDEGLILEAETCVVDVETVGELTRGYLSVSHSILPDIEIADPALKRRPPNARVIKAIDREGFFAAMRTALL

Sequences:

>Translated_319_residues
MRLIIDTDTAGDDVFSLMLALTRTGVELEAITIAHGNVGFEQHAENALVTLDRCGRAGEVPVYLGAQFPLMRAPLDAAYV
FGRDGMSDSGFARTSQRPAEGHAVDELVRRIMAAPGEITLIAQAPLTNIALAYQREPRIAKALKHLWVMGGTDNGVGNVT
PAAEYNFYADPEAAKIVVNAGFNLSIATWTLTLKDGLWTTEKLDALDALGTEKARFFTDVNRASLAFARETEGLDGSLHP
DALTCAIALDEGLILEAETCVVDVETVGELTRGYLSVSHSILPDIEIADPALKRRPPNARVIKAIDREGFFAAMRTALL
>Mature_319_residues
MRLIIDTDTAGDDVFSLMLALTRTGVELEAITIAHGNVGFEQHAENALVTLDRCGRAGEVPVYLGAQFPLMRAPLDAAYV
FGRDGMSDSGFARTSQRPAEGHAVDELVRRIMAAPGEITLIAQAPLTNIALAYQREPRIAKALKHLWVMGGTDNGVGNVT
PAAEYNFYADPEAAKIVVNAGFNLSIATWTLTLKDGLWTTEKLDALDALGTEKARFFTDVNRASLAFARETEGLDGSLHP
DALTCAIALDEGLILEAETCVVDVETVGELTRGYLSVSHSILPDIEIADPALKRRPPNARVIKAIDREGFFAAMRTALL

Specific function: Unknown

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family [H]

Homologues:

Organism=Escherichia coli, GI1788486, Length=245, Percent_Identity=32.6530612244898, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1786871, Length=311, Percent_Identity=29.903536977492, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786213, Length=316, Percent_Identity=32.9113924050633, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32565474, Length=308, Percent_Identity=31.4935064935065, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17565698, Length=293, Percent_Identity=32.4232081911263, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320608, Length=177, Percent_Identity=29.9435028248588, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24641837, Length=325, Percent_Identity=30.7692307692308, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24583915, Length=330, Percent_Identity=26.969696969697, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24641839, Length=296, Percent_Identity=29.7297297297297, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: NA

Molecular weight: Translated: 34378; Mature: 34378

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIIDTDTAGDDVFSLMLALTRTGVELEAITIAHGNVGFEQHAENALVTLDRCGRAGEV
CEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHCCCCEEEEECCCCCCCC
PVYLGAQFPLMRAPLDAAYVFGRDGMSDSGFARTSQRPAEGHAVDELVRRIMAAPGEITL
CEEECCCCCHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
IAQAPLTNIALAYQREPRIAKALKHLWVMGGTDNGVGNVTPAAEYNFYADPEAAKIVVNA
EEECCCCCEEEEECCCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCEECCCCCEEEEEEC
GFNLSIATWTLTLKDGLWTTEKLDALDALGTEKARFFTDVNRASLAFARETEGLDGSLHP
CCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHCCCHHHEEEEHHCCCCCCCCCC
DALTCAIALDEGLILEAETCVVDVETVGELTRGYLSVSHSILPDIEIADPALKRRPPNAR
CCEEEEEEECCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
VIKAIDREGFFAAMRTALL
EEEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MRLIIDTDTAGDDVFSLMLALTRTGVELEAITIAHGNVGFEQHAENALVTLDRCGRAGEV
CEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHCCCCEEEEECCCCCCCC
PVYLGAQFPLMRAPLDAAYVFGRDGMSDSGFARTSQRPAEGHAVDELVRRIMAAPGEITL
CEEECCCCCHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEE
IAQAPLTNIALAYQREPRIAKALKHLWVMGGTDNGVGNVTPAAEYNFYADPEAAKIVVNA
EEECCCCCEEEEECCCCHHHHHHHHHEEECCCCCCCCCCCCCCCCCEECCCCCEEEEEEC
GFNLSIATWTLTLKDGLWTTEKLDALDALGTEKARFFTDVNRASLAFARETEGLDGSLHP
CCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHCCCHHHEEEEHHCCCCCCCCCC
DALTCAIALDEGLILEAETCVVDVETVGELTRGYLSVSHSILPDIEIADPALKRRPPNAR
CCEEEEEEECCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCC
VIKAIDREGFFAAMRTALL
EEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cytidine; H2O; uridine [C]

Specific reaction: cytidine + H2O = cytosine + ribose uridine + H2O = uracil + ribose [C]

General reaction: Pyrimidine-specific nucleoside hydrolase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA