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The map label for this gene is trpC

Identifier: 16126142

GI number: 16126142

Start: 2094921

End: 2095709

Strand: Direct

Name: trpC

Synonym: CC_1899

Alternate gene names: 16126142

Gene position: 2094921-2095709 (Clockwise)

Preceding gene: 16126141

Following gene: 16126143

Centisome position: 52.15

GC content: 67.68

Gene sequence:

>789_bases
GTGACCGACATCCTGGCCAAGATCGCCGCCTACAAGCGTGAGGACGTGGCGGCGCGAAAAGCCGAGCGGTCTCAAGCCGA
GATCGACGCCGCCGCCAAGGCCGCTTCGGCGCCGCGCGGCTTCAAGGCCGCCCTTGAGGCGCATCACGCGCCCGGCCGTC
TCTCCCTGATCGCCGAGATCAAGAAGGCCTCGCCGTCCAAGGGCCTGATCCGCGAGGACTTCGATCCGCCGGTCCTAGCG
AAAGCCTATGAAGCCGGCGGCGCGGCCTGCCTCTCCGTGCTGACCGATGGACCGAGTTTTCAGGGCGCGGATGACTACCT
CGTCACCGCCCGGGCGGCGGTCGCCCTGCCCTGCATCCGCAAGGATTTCCTGGTCGATCCCTGGCAAGTGGCCGAAAGCC
GCGCCCTGGGCGCCGACGCGATCCTGGTGATCCTGGCGATGATCGACGACGTCCTGGCGGCGGAGCTGATGTCCGAAGCG
CGTCGGCTGGGCATGGACGCCCTTGTCGAGGTGCACGATGAGGCCGAAATGGCGCGCGCCGGCGCTTTGGGCTCGGATCT
GGTCGGCATCAACAACCGTGATCTCAAGAGCTTTGTCGTCGATCTGGCGGTGACCGAGCGCCTGTCGGCCCAGGCCCCGC
GCGACGCCCTGCTGGTCACCGAAAGCGGCATCTTCACCCATGACGATGTCGTCCGCATGGAAGCCACCGGGGCCAAGGCC
ATGCTGGTCGGCGAAAGCCTTATGCGGCACGCGGACGTGACGAGCGCCACGCGCGCCCTGATCGCTTAA

Upstream 100 bases:

>100_bases
TGGTCGAGGGCGTGGCTCTGGCGGCCGAAGCCATCGACAGCGGCCGCGCCAAGGCCGCCCTCGCCGGCCTCGTGGCCGCC
ACCAACACGGAAGTTCCTGC

Downstream 100 bases:

>100_bases
ACCCAAAACGGGCTTTCCTGACGCTGGCGCCTTGAGGCGAAACAGTCCCATCCTTCAACCATCGCCGCGCCGAGAACGCG
GATGAGGAAACGTGCATGAA

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MTDILAKIAAYKREDVAARKAERSQAEIDAAAKAASAPRGFKAALEAHHAPGRLSLIAEIKKASPSKGLIREDFDPPVLA
KAYEAGGAACLSVLTDGPSFQGADDYLVTARAAVALPCIRKDFLVDPWQVAESRALGADAILVILAMIDDVLAAELMSEA
RRLGMDALVEVHDEAEMARAGALGSDLVGINNRDLKSFVVDLAVTERLSAQAPRDALLVTESGIFTHDDVVRMEATGAKA
MLVGESLMRHADVTSATRALIA

Sequences:

>Translated_262_residues
MTDILAKIAAYKREDVAARKAERSQAEIDAAAKAASAPRGFKAALEAHHAPGRLSLIAEIKKASPSKGLIREDFDPPVLA
KAYEAGGAACLSVLTDGPSFQGADDYLVTARAAVALPCIRKDFLVDPWQVAESRALGADAILVILAMIDDVLAAELMSEA
RRLGMDALVEVHDEAEMARAGALGSDLVGINNRDLKSFVVDLAVTERLSAQAPRDALLVTESGIFTHDDVVRMEATGAKA
MLVGESLMRHADVTSATRALIA
>Mature_261_residues
TDILAKIAAYKREDVAARKAERSQAEIDAAAKAASAPRGFKAALEAHHAPGRLSLIAEIKKASPSKGLIREDFDPPVLAK
AYEAGGAACLSVLTDGPSFQGADDYLVTARAAVALPCIRKDFLVDPWQVAESRALGADAILVILAMIDDVLAAELMSEAR
RLGMDALVEVHDEAEMARAGALGSDLVGINNRDLKSFVVDLAVTERLSAQAPRDALLVTESGIFTHDDVVRMEATGAKAM
LVGESLMRHADVTSATRALIA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=261, Percent_Identity=39.0804597701149, Blast_Score=163, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322638, Length=236, Percent_Identity=38.5593220338983, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_CAUCN (B8GWP9)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002517349.1
- ProteinModelPortal:   B8GWP9
- SMR:   B8GWP9
- GeneID:   7330116
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_01976
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27671; Mature: 27540

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDILAKIAAYKREDVAARKAERSQAEIDAAAKAASAPRGFKAALEAHHAPGRLSLIAEI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHH
KKASPSKGLIREDFDPPVLAKAYEAGGAACLSVLTDGPSFQGADDYLVTARAAVALPCIR
HHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
KDFLVDPWQVAESRALGADAILVILAMIDDVLAAELMSEARRLGMDALVEVHDEAEMARA
HHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GALGSDLVGINNRDLKSFVVDLAVTERLSAQAPRDALLVTESGIFTHDDVVRMEATGAKA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEECCCCHH
MLVGESLMRHADVTSATRALIA
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDILAKIAAYKREDVAARKAERSQAEIDAAAKAASAPRGFKAALEAHHAPGRLSLIAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHH
KKASPSKGLIREDFDPPVLAKAYEAGGAACLSVLTDGPSFQGADDYLVTARAAVALPCIR
HHCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
KDFLVDPWQVAESRALGADAILVILAMIDDVLAAELMSEARRLGMDALVEVHDEAEMARA
HHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
GALGSDLVGINNRDLKSFVVDLAVTERLSAQAPRDALLVTESGIFTHDDVVRMEATGAKA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEECCCCHH
MLVGESLMRHADVTSATRALIA
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA