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The map label for this gene is accC [H]

Identifier: 16126127

GI number: 16126127

Start: 2078892

End: 2080238

Strand: Direct

Name: accC [H]

Synonym: CC_1884

Alternate gene names: 16126127

Gene position: 2078892-2080238 (Clockwise)

Preceding gene: 16126126

Following gene: 16126128

Centisome position: 51.75

GC content: 65.48

Gene sequence:

>1347_bases
ATGTTCGACAAGATCCTCATTGCGAACCGGGGCGAGATCGCGCTCCGGGTTCACCGCGCCTGTAAGGAAATGGGCATCGC
CACGGTGGCGGTCCATTCCGAGGCCGACCGCAACTCTATGTGGGTGCGCCTGGCCGACGAAAGCGTCTGCATCGGGCCGG
CTCCGGCCGCCAAGAGCTATCTGAACATCCCATCGATCATCGCGGCCGCCGAGATCACCGGCGCCCAGGCGATCCACCCG
GGCTATGGCTTCCTGTCGGAAAATGCCCGCTTCGCCGAGATCGTCGGCGCGCACGGCTTCACCTTCATCGGTCCCAAGCC
CGAGCACATCCGGATGATGGGCGACAAGATCACCGCCAAGCAGGCTGTGAAGGACGCCGGCATCCCGGTCGTTCCCGGCT
CGGACGGCGGCGTGTCGACCGAGGAAGAAGCCTTCGAGGCCGCCGAGAAGATCGGCTTCCCCGTCCTGATCAAGGCCGCC
GCCGGCGGCGGTGGTCGTGGCATGAAGGTCGCCCAGACCCGTGAGGACCTGGCCGAAGCGGTCTCGACCGCCCGCGCCGA
GGCCCGCGCCGCCTTTGGCGACGACACGGTCTATATGGAGCGCTACCTCCAGAAGCCGCGCCATATCGAACTGCAGGTCA
TCGCCGACAGCCACGGCAACGTCGTGCACCTGGGCGAGCGCGACTGCTCGCTGCAGCGTCGTCACCAGAAGGTGCTGGAA
GAAGCCCCCTCGCCCGCCCTGTCGGCCGAAGGTCGCGCCAAGATCGGCAAGGTCGTGGTCGATGCGGTCAAGGCCATCGG
CTATCTCGGCGTCGGCACCATCGAGTTCCTGTGGGAGAACGACGAGTTCTTCTTCATCGAGATGAACACCCGCCTGCAGG
TCGAACACCCGGTCACCGAAGCCATCACCGGCATCGACCTGGTGCGCGAGCAGATCCGCATCGCCGCCGGCCTGCCGCTG
TCGTTCACCCAGGACGATGTCGTCTTCGAGGGTCACGCCATCGAGTGCCGGATCAACGCCGAGAACGCGCGAACCTTCAC
GCCCTCGCCGGGCGTGATCACCGACTTCCACGCCCCCGGCGGCCTGGGCGTTCGCCTGGATTCGGCGATCTACACCGGCT
ACGCGATCCCGCCGTACTACGACAGCCTGATCGGCAAACTGATCGTGCATGGGCGTGACCGCGCCGAATGCATCGCGCGT
CTGAAGCGCTGCCTGGGCGAGATGGTGGTCGGCGGTGTCGAAACCACGATTCCGCTGTTCCAGGACCTTCTGGTGCAGCC
CGATATCCTGGCCGGTGACTACAACATCCACTGGCTGGAACGCTGGATCAAAGCCCAAGAAGCTTAA

Upstream 100 bases:

>100_bases
CGATCGCCGCCCCGAAGGCCGGCAAGATCGTCGAGATCCTGGTCGAGGACGCCCAGCCCGTCGAGTTCGGCGAGCCGCTC
GTCGTCATCGAGTAACGCTC

Downstream 100 bases:

>100_bases
GGTGAGCGTGGCAGCCGGAAGTGTGAGCGGTTTCGGCGACAGCCACGCTCTAGCGCCAGAAGACCGGGCCTGTCCCTTGG
ACAGGCCCTAGGGGCGGCGA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFDKILIANRGEIALRVHRACKEMGIATVAVHSEADRNSMWVRLADESVCIGPAPAAKSYLNIPSIIAAAEITGAQAIHP
GYGFLSENARFAEIVGAHGFTFIGPKPEHIRMMGDKITAKQAVKDAGIPVVPGSDGGVSTEEEAFEAAEKIGFPVLIKAA
AGGGGRGMKVAQTREDLAEAVSTARAEARAAFGDDTVYMERYLQKPRHIELQVIADSHGNVVHLGERDCSLQRRHQKVLE
EAPSPALSAEGRAKIGKVVVDAVKAIGYLGVGTIEFLWENDEFFFIEMNTRLQVEHPVTEAITGIDLVREQIRIAAGLPL
SFTQDDVVFEGHAIECRINAENARTFTPSPGVITDFHAPGGLGVRLDSAIYTGYAIPPYYDSLIGKLIVHGRDRAECIAR
LKRCLGEMVVGGVETTIPLFQDLLVQPDILAGDYNIHWLERWIKAQEA

Sequences:

>Translated_448_residues
MFDKILIANRGEIALRVHRACKEMGIATVAVHSEADRNSMWVRLADESVCIGPAPAAKSYLNIPSIIAAAEITGAQAIHP
GYGFLSENARFAEIVGAHGFTFIGPKPEHIRMMGDKITAKQAVKDAGIPVVPGSDGGVSTEEEAFEAAEKIGFPVLIKAA
AGGGGRGMKVAQTREDLAEAVSTARAEARAAFGDDTVYMERYLQKPRHIELQVIADSHGNVVHLGERDCSLQRRHQKVLE
EAPSPALSAEGRAKIGKVVVDAVKAIGYLGVGTIEFLWENDEFFFIEMNTRLQVEHPVTEAITGIDLVREQIRIAAGLPL
SFTQDDVVFEGHAIECRINAENARTFTPSPGVITDFHAPGGLGVRLDSAIYTGYAIPPYYDSLIGKLIVHGRDRAECIAR
LKRCLGEMVVGGVETTIPLFQDLLVQPDILAGDYNIHWLERWIKAQEA
>Mature_448_residues
MFDKILIANRGEIALRVHRACKEMGIATVAVHSEADRNSMWVRLADESVCIGPAPAAKSYLNIPSIIAAAEITGAQAIHP
GYGFLSENARFAEIVGAHGFTFIGPKPEHIRMMGDKITAKQAVKDAGIPVVPGSDGGVSTEEEAFEAAEKIGFPVLIKAA
AGGGGRGMKVAQTREDLAEAVSTARAEARAAFGDDTVYMERYLQKPRHIELQVIADSHGNVVHLGERDCSLQRRHQKVLE
EAPSPALSAEGRAKIGKVVVDAVKAIGYLGVGTIEFLWENDEFFFIEMNTRLQVEHPVTEAITGIDLVREQIRIAAGLPL
SFTQDDVVFEGHAIECRINAENARTFTPSPGVITDFHAPGGLGVRLDSAIYTGYAIPPYYDSLIGKLIVHGRDRAECIAR
LKRCLGEMVVGGVETTIPLFQDLLVQPDILAGDYNIHWLERWIKAQEA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=49.5475113122172, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=49.5475113122172, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=49.5475113122172, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI116805327, Length=437, Percent_Identity=47.1395881006865, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=46.3963963963964, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=46.3963963963964, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=46.3963963963964, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI134142062, Length=506, Percent_Identity=29.8418972332016, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI38679977, Length=505, Percent_Identity=29.1089108910891, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI38679967, Length=505, Percent_Identity=29.1089108910891, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI38679971, Length=505, Percent_Identity=29.1089108910891, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI38679960, Length=505, Percent_Identity=29.1089108910891, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679974, Length=505, Percent_Identity=29.1089108910891, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI18105007, Length=256, Percent_Identity=24.21875, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=61.3839285714286, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1786216, Length=244, Percent_Identity=24.1803278688525, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=48.1900452488688, Blast_Score=407, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71987519, Length=433, Percent_Identity=47.3441108545035, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17562816, Length=446, Percent_Identity=45.067264573991, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931226, Length=496, Percent_Identity=29.2338709677419, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71997168, Length=506, Percent_Identity=27.4703557312253, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=506, Percent_Identity=27.4703557312253, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI193204318, Length=320, Percent_Identity=22.8125, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=428, Percent_Identity=43.2242990654206, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6319695, Length=441, Percent_Identity=45.3514739229025, Blast_Score=345, Evalue=6e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=441, Percent_Identity=46.2585034013605, Blast_Score=338, Evalue=9e-94,
Organism=Saccharomyces cerevisiae, GI6323863, Length=457, Percent_Identity=30.6345733041575, Blast_Score=219, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=28.6549707602339, Blast_Score=216, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24652212, Length=443, Percent_Identity=48.7584650112867, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652210, Length=443, Percent_Identity=48.7584650112867, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652214, Length=443, Percent_Identity=48.7584650112867, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI19921944, Length=443, Percent_Identity=48.7584650112867, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652216, Length=443, Percent_Identity=48.7584650112867, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI281363050, Length=443, Percent_Identity=49.2099322799097, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652224, Length=443, Percent_Identity=49.2099322799097, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652222, Length=443, Percent_Identity=49.2099322799097, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652220, Length=443, Percent_Identity=49.2099322799097, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24652218, Length=443, Percent_Identity=49.2099322799097, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24651757, Length=438, Percent_Identity=47.0319634703196, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24651759, Length=402, Percent_Identity=46.0199004975124, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI161076407, Length=500, Percent_Identity=29.8, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24586460, Length=500, Percent_Identity=29.8, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI161076409, Length=500, Percent_Identity=29.8, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24586458, Length=500, Percent_Identity=29.8, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48623; Mature: 48623

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDKILIANRGEIALRVHRACKEMGIATVAVHSEADRNSMWVRLADESVCIGPAPAAKSY
CCCCEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCEEECCCHHHHHH
LNIPSIIAAAEITGAQAIHPGYGFLSENARFAEIVGAHGFTFIGPKPEHIRMMGDKITAK
CCCCHHHHHHHHCCCCEECCCCCCCCCCCCEEHHHCCCCEEEECCCCHHHEECCCHHHHH
QAVKDAGIPVVPGSDGGVSTEEEAFEAAEKIGFPVLIKAAAGGGGRGMKVAQTREDLAEA
HHHHHCCCEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
VSTARAEARAAFGDDTVYMERYLQKPRHIELQVIADSHGNVVHLGERDCSLQRRHQKVLE
HHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSPALSAEGRAKIGKVVVDAVKAIGYLGVGTIEFLWENDEFFFIEMNTRLQVEHPVTE
HCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVREQIRIAAGLPLSFTQDDVVFEGHAIECRINAENARTFTPSPGVITDFHAPG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEECCEEEEEEEECCCCEEECCCCCEEEECCCCC
GLGVRLDSAIYTGYAIPPYYDSLIGKLIVHGRDRAECIARLKRCLGEMVVGGVETTIPLF
CCCEEECCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
QDLLVQPDILAGDYNIHWLERWIKAQEA
HHHHCCCCEEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MFDKILIANRGEIALRVHRACKEMGIATVAVHSEADRNSMWVRLADESVCIGPAPAAKSY
CCCCEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCCEEEEECCCCEEECCCHHHHHH
LNIPSIIAAAEITGAQAIHPGYGFLSENARFAEIVGAHGFTFIGPKPEHIRMMGDKITAK
CCCCHHHHHHHHCCCCEECCCCCCCCCCCCEEHHHCCCCEEEECCCCHHHEECCCHHHHH
QAVKDAGIPVVPGSDGGVSTEEEAFEAAEKIGFPVLIKAAAGGGGRGMKVAQTREDLAEA
HHHHHCCCEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
VSTARAEARAAFGDDTVYMERYLQKPRHIELQVIADSHGNVVHLGERDCSLQRRHQKVLE
HHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSPALSAEGRAKIGKVVVDAVKAIGYLGVGTIEFLWENDEFFFIEMNTRLQVEHPVTE
HCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AITGIDLVREQIRIAAGLPLSFTQDDVVFEGHAIECRINAENARTFTPSPGVITDFHAPG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEECCEEEEEEEECCCCEEECCCCCEEEECCCCC
GLGVRLDSAIYTGYAIPPYYDSLIGKLIVHGRDRAECIARLKRCLGEMVVGGVETTIPLF
CCCEEECCCEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHH
QDLLVQPDILAGDYNIHWLERWIKAQEA
HHHHCCCCEEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]